Abstracts tagged "Biomarkers"

Abstract Number: 1138 • 2014 ACR/ARHP Annual Meeting
Vasoactive Intestinal Peptide (VIP) Genetic Variants Determine VIP Serum Levels and Could be Used As a Prognosis Biomarker
Amalia Lamana¹, Iria Valino-Seoane², Luis Rodriguez-Rodriguez³, Javier Leceta², Yasmina Juarranz², Ana M. Ortiz Garcia¹, Carmen Martinez-Mora⁴, Benjamín Fernández-Gutiérrez³, Isidoro González-Alvaro⁵, Rosa P Gomariz² and Rosario Garcia-Vicuña⁵, ¹Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, ²Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ³Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ⁴Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, ⁵Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: VIP has shown immunoregulatory properties in assays performed with human or murine cells. VIP has demonstrated a therapeutic effect in a murine model of…
Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis
Natasja Stæhr Gudman¹, Heidi Lausten Munk², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Morten A. Karsdal⁶, Anne C. Bay-Jensen⁷, Yi He⁸, Anne Sofie Siebuhr⁹ and Peter Junker², ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Department of Rheumatology, Odense University Hospital, Odense, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, ⁶Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁷Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁸Nordic Bioscience, Herlev, Denmark, ⁹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…
Abstract Number: 222 • 2014 ACR/ARHP Annual Meeting
OA Phenotypes Rather Than Disease Stage Drive Structural Progression – Identification of Structural Progressors from 2 Phase III Randomized Clinical studies with Symptomatic Knee OA
Morten Asser Karsdal¹, Anne C. Bay-Jensen², Asger Bihlet³, Peter Alexandersen⁴, Inger Byrjalsen³, Bente J. Riis³ and Claus Christiansen³, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Center for Clinical and Basic Research, Vejle, Denmark
Background/Purpose: Osteoarthritis (OA) is a heterogeneous disorder, with several possible drivers of disease progression. Up to 50% of OA patients do not structurally progress, emphasizing…
Abstract Number: 2147 • 2014 ACR/ARHP Annual Meeting
Automatically Extracted Quantitative Biomarkers for Assessing Connective Tissue Disease Using Nailfold Capillaroscopy
Michael Berks¹, Graham Dinsdale², Andrea Murray², Tonia Moore³, Chris Taylor¹ and Ariane Herrick², ¹Centre for Imaging Sciences, University of Manchester, Institute of Population Health, Manchester, United Kingdom, ²Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ³Salford Royal Hospital NHS Foundation Trust, Salford, United Kingdom
Background/Purpose Videomicroscopy can capture high-magnification images of nailfold capillaries, allowing non-invasive assessment of microvasculature change indicative of connective tissue disease. Whilst images may be qualitatively…
Abstract Number: 1631 • 2014 ACR/ARHP Annual Meeting
Cell Bound Complement Activation Products and Their Relationship to Disease Activity and Quality of Life Measures in Systemic Lupus Erythematosus
Richard Furie¹, Jill P. Buyon², R. Ramsey-Goldman³, Chaim Putterman⁴, Kenneth Kalunian⁵, Tyler O'Malley⁶, John Conklin⁷, Derren Barken⁸ and Thierry Dervieux⁹, ¹Division of Rheumatology, North Shore-LIJ Health System, Great Neck, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵UCSD School of Medicine, La Jolla, CA, ⁶Research and Development, Exagen Diagnostics, Inc., Vista, CA, ⁷1261 Liberty Way Suite C, Exagen Diagnostics, Inc., Vista, CA, ⁸Exagen Diagnostics, Inc., Vista, CA, ⁹rd, Exagen Diagnostics, Inc., Vista, CA
Background/Purpose: To assess the association between cell bound complement activation products (CBCAPS) and measures of disease activity and quality of life in systemic lupus erythematosus…
Abstract Number: 1135 • 2014 ACR/ARHP Annual Meeting
Genes Involved in Cartilage Synthesis and Risk to Knee Osteoarthritis
Abhishek Mishra Sr., Rajeshwar Srivastava II, Divya Sanghi III, Ajai Singh IV and Devendra Parmar V, Deptt of Orthopaedic Surgery, King George's Medical University,, Lucknow, India
Background/Purpose Osteoarthritis (OA), characterized by gradual loss of articular cartilage in the joint, is a leading cause of disability among the elderly people. Though the…
Abstract Number: 628 • 2014 ACR/ARHP Annual Meeting
The Predictive Value of Cardiovascular and Metabolic Biomarkers for Progression of Atherosclerosis in Psoriatic Disease
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose The pathophysiologic mechanisms underlying the accelerated atherosclerosis in patients with psoriatic disease (PsD) are unknown. We aimed to investigate candidate pathways involved in this…
Abstract Number: 137 • 2014 ACR/ARHP Annual Meeting
Evaluation of Metalloproteinase-3 As a Soluble Biomarker of Synovitis Using Weighted Joint Counts Assessed Clinically and on Ultrasound Imaging
Agata Burska^1,2, Elizabeth Hensor^2,3, Jackie L. Nam³, Lukasz Kozera⁴, Richard J. Wakefield³, Paul Emery³ and Ann W Morgan⁵, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom, ²joint first authorship, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Faculty of Pharmacy and Laboratory Diagnostics, Wroclaw Medical University, Wroclaw, Poland, Wroclaw, Poland, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: Synovial inflammation is known to play a central role in articular cartilage degradation in rheumatoid arthritis (RA); it could be a passive marker of…
Abstract Number: 2099 • 2014 ACR/ARHP Annual Meeting
Serum C-X-C Motif Chemokine 10 (CXCL10) Is Elevated in Psoriasis Patients Prior to Psoriatic Arthritis Onset
Remy Pollock¹, Fatima Abji¹, Husain Shakil¹, Kun Liang², Vinod Chandran¹ and Dafna D. Gladman^1,3, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a potentially destructive disease that develops in about 30% of patients with cutaneous psoriasis. Biomarkers that can predict which psoriasis…
Abstract Number: 1611 • 2014 ACR/ARHP Annual Meeting
Modular Transcriptional Neutrophil Signature As Predictive of Nephritis and of Its Severity in SLE Patients
Noémie Jourde-Chiche Sr.¹, Stéphane Burtey², Nathalie Bardin³, Elizabeth Whalen⁴, Bertrand Gondouin⁵, Scott Presnell⁶, Bertrand Dussol⁷, Gilles Kaplanski⁸, Jean-Robert Harle⁹, Yvon Berland², Virginia Pascual¹⁰, Damien Chaussabel⁴ and Laurent Chiche¹¹, ¹Nephrology, Aix-Marseille Université - APHM, Marseille, France, ²Nephrology, APHM, Marseille, France, ³Hopital de la Conception, Marseille, France, ⁴BRI, seattle, WA, ⁵Department of Nephrology, APHM, Marseille, France, ⁶bri, seattle, WA, ⁷AP Marseille, Marseille, France, ⁸INSERM U608, Marseille, France, ⁹Internal Medicine, APHM, Marseille, France, ¹⁰Baylor University, Dallas, TX, ¹¹147 Boulevard Baille, CHU Marseille, Marseille, France
Background/Purpose: Lupus nephritis (LN) is a serious complication of SLE. Reliable biomarkers to assess and/or predict renal involvement in SLE patients are needed. The aim…
Abstract Number: 1127 • 2014 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging Revealed Potential Lipid Chondrogenic Biomarkers for Cell-Based Therapy in Cartilage
Beatriz Rocha¹, Berta Cillero-Pastor², Gert Eijkel², Valentina Calamia¹, Lucia Lourido¹, Carolina Fernández-Costa¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Cristina Ruiz-Romero^1,3, Ron MA Heeren² and Francisco J. Blanco Garcia¹, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²1Biomolecular Imaging Mass Spectrometry (BIMS) Molecular Nanophotonics Department, AMOLF, Amsterdam, Netherlands, ³CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Recent studies highlight the importance of lipid metabolism in the modulation of chondrogenesis. Specifically, the positive chondrogenic effect of acid ceramidase, which is necessary…
Abstract Number: 541 • 2014 ACR/ARHP Annual Meeting
Collagen II Neo-Epitopes in Spondyloarthritis.
Heidi Lausten Munk¹, Natasja Staehr Gudmann², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Anne C. Bay-Jensen², Anne Sofie Siebuhr² and Peter Junker¹, ¹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark
Background/Purpose Spondyloarthritis (SpA) is characterized by aseptic inflammation of the axial skeleton which may ultimately lead to irreversible deformities due to bony ankylosis. Occasionally, peripheral…
Abstract Number: 136 • 2014 ACR/ARHP Annual Meeting
Serum Calprotectin (S100A8/9) Is an Independent Predictor of Ultrasound Synovitis in Patients with Rheumatoid Arthritis
Jana Hurnakova¹, Jakub Zavada¹, Petra Hanova², Hana Hulejova¹, Martin Klein¹, Herman F. Mann¹, Olga Sleglova¹, Martina Olejarova¹, Sarka Forejtova³, Olga Ruzickova¹, Martin Komarc⁴, Karel Pavelka¹ and Ladislav Senolt³, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ²Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁴Institute of biophysics and informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose Serological biomarkers specifically reflecting pathological processes may have added value in assessing joint inflammation in rheumatoid arthritis (RA). Calprotectin (S100A8/9 protein) has been demonstrated…
Abstract Number: 2097 • 2014 ACR/ARHP Annual Meeting
Identification of Diagnostic and Activity Metabolomic Urine Biomarkers in Six Immune-Mediated Inflammatory Diseases
Arnald Alonso¹, Jesús Tornero², Antonio Fernandez Nebro³, Juan D. Cañete⁴, Eugeni Domènech⁵, Javier P. Gisbert⁶, Carlos Ferrándiz⁵, Eduardo Fonseca⁷, Valle García⁸, Francisco Blanco⁷, Jesus Rodriguez⁹, Jordi Gratacós¹⁰, Patricia Carreira¹¹, Toni Julia¹, Raül Tortosa¹, María América López-Lasanta¹, Xavier Correig¹² and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain, ⁵Hospital Universitari Germans Trias I Pujol, Badalona, Spain, ⁶Hospital Universitario de la Princesa, Madrid, Spain, ⁷Complejo Hospitalario Juan Canalejo, A Coruña, Spain, ⁸Hospital Universitario Reina Sofía, Córdoba, Spain, ⁹Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁰Hospital Parc Taulí, Sabadell, Spain, ¹¹Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ¹²CIBERDEM, Metabolomics Platform, Reus, Spain
Background/Purpose: Metabolomics is an emergent research field within the omics sciences aimed at characterizing the metabolome in complex biological samples. It provides a powerful approach…
Abstract Number: 1620 • 2014 ACR/ARHP Annual Meeting
Antibody to Malondialdehyde-Acetaldehyde Adducts (MAA) As a Potential Biomarker of Inflammation in Systemic Lupus Erythrematosus (SLE)
Andy Hollins¹, Michael Duryee², Michelene Hearth-Holmes³, Ted R. Mikuls¹, Zhixin Zhang⁴, Kaihong Su⁵ and Geoffrey M. Thiele⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ⁵Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose Studies have shown that malondialdehyde-acetaldehyde (MAA) is formed as a result of lipid peroxidation of cellular membranes and is capable of binding or adducting…

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