Abstracts tagged "Biomarkers"

Abstract Number: 1456 • 2018 ACR/ARHP Annual Meeting
Neutrophil Activation Is Associated with Disease Activity and Predicts Development of Erosive Disease and Extra Articular Manifestations in Rheumatoid Arthritis
Mary Bach^1,2, Tiffany Pan³, J. Lee Nelson^3,4 and Christian Lood⁵, ¹VA Puget Sound Health Care System, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Fred Hutchinson Cancer Research Center, Seattle, WA, ⁴Division of Rheumatology, University of Washington, SEATTLE, WA, ⁵Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Neutrophil activation is associated with inflammation and autoimmunity, including rheumatoid arthritis (RA), where neutrophil infiltration into joints participates in tissue destruction and development of…
Abstract Number: 2002 • 2018 ACR/ARHP Annual Meeting
Dynamic Compression of Articular Cartilage Explants Increases Formation and Decreases Degradation of Type II Collagen
Amalie Engstrøm^1,2, Anne C. Bay-Jensen², Morten A. Karsdal² and Christian S. Thudium², ¹Department of Biomedical Science, University of Copenhagen, København, Denmark, ²Nordic Bioscience, Herlev, Denmark
Background/Purpose: Mechanical loading is recognized as a major factor in initiation and progression of osteoarthritis (OA). Conversely loading is believed to play an essential role…
Abstract Number: 2821 • 2018 ACR/ARHP Annual Meeting
Dose Tapering and Discontinuation of Biological Therapy in Rheumatoid Arthritis Patients in Routine Care – 2-Year Outcomes and Predictors
Cecilie Heegaard Brahe¹, Simon Krabbe¹, Mikkel Østergaard¹, Lykke Midtbøll Ørnbjerg¹, Daniel Glinatsi¹, Henrik Rogind¹, Hanne Slott Jensen², Annette Hansen³, Jesper Nørregaard⁴, Søren Jacobsen⁵, Lene Terslev¹, Tuan Khai Huynh⁴, Dorte Vendelbo Jensen⁶, Natalia Manilo², Karsten Asmussen², Per Brown-Frandsen⁵, Mikael Boesen⁷, Zoreh Rastiemadabadi⁷, Lone Morsel-Carlsen⁷, Jakob M. Møller⁸, Niels Steen Krogh⁹ and Merete Lund Hetland¹⁰, ¹Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, ²Center for Rheumatology and Spine Diseases, Bispebjerg-Frederiksberg Hospital, Copenhagen, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Gentofte, Denmark, Copenhagen, Denmark, ⁴Center for Rheumatology and Spine Diseases, Nordsjællands Hospital, Hillerød, Denmark, Hillerød, Denmark, ⁵Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ⁶Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Gentofte, Copenhagen, Denmark, ⁷Department of Radiology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Copenhagen, Denmark, ⁸Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, ⁹ZiteLab ApS, Copenhagen, Denmark, ¹⁰DANBIO Registry, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Glostrup, Denmark
Dose tapering and discontinuation of biological therapy in rheumatoid arthritis patients in routine care – 2-year outcomes and predictors Background/Purpose: A cohort of routine care…
Abstract Number: 618 • 2018 ACR/ARHP Annual Meeting
Blood Lymphocytes Subtypes As Biomarkers for Early Identification of Optimal Responders to Anti-TNF Treatment in Rheumatoid Arthritis
Cristina Sobrino¹, Borja Hernández-Breijo², Israel Gañán-Nieto¹, Carlota García-Hoz¹, Victoria Navarro-Compán², Ana Martínez², Javier Bachiller¹, María Gema Bonilla Hernán², Dora Pascual-Salcedo², Garbiñe Roy¹, Mónica Vázquez¹, Alejandro Balsa², Luisa María Villar¹, Chamaida Plasencia² and Eulalia Rodríguez-Martín¹, ¹Immuno-Rheumatology research group, IRYCIS. Ramón y Cajal University Hospital, Madrid, Spain, ²Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain
Background/Purpose: TNF inhibitors (TNFi) are the most common biologicalagents used as disease-modifying treatment in rheumatoid arthritis (RA). Although these drugs have contributed to change the…
Abstract Number: 1077 • 2018 ACR/ARHP Annual Meeting
Identification of Biomarkers Involved in the Resolution Phase of Inflammation: Specialized Pro-Resolving Mediator Receptors Expression in Rheumatoid Arthritis
Simone Perniola¹, Liliana Dinoia¹, Nunzia Lacarpia¹, Dorotea Natuzzi¹, Rita Bizzoca¹ and Florenzo Iannone², ¹Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy
Background/Purpose: Inflammation is part of the complex biological response of body tissues to harmful stimuli, involving immune cells, blood vessels, and molecular mediators. At the…
Abstract Number: 1467 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Activity Monitoring and Multiplex Biomarker Verification By Tageted Proteomics
Lucía González-Rodríguez¹, Valentina Calamia¹, Patricia Fernández², Cristina Ruiz-Romero³, Antonio Julià⁴, Antonio Fernández-Nebro⁵, Jesús Tornero⁶, Sara Marsal⁴ and Francisco J Blanco³, ¹Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, ³Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Spain, ⁵UGC Reumatología, Instituto de Investigación Biomédica (IBIMA), Hospital Regional Universitario de Málaga, Spain., Málaga, Spain, ⁶Hospital Universitario Guadalajara, Guadalajara, Spain., Guadalajara, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a long-lasting inflammatory autoimmune disorder that ultimately leads to the destruction of joint architecture. The activity of this disease is…
Abstract Number: 2008 • 2018 ACR/ARHP Annual Meeting
Vascular Adhesion Protein-1 (VAP-1) As Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis
Eirini Bournazou¹, Jonathan Samuels², Hua Zhou³, Svetlana Krasnokutsky Samuels⁴, Jyoti Patel⁵, Jenny Bencardino⁶, Leon Rybak⁷, Steven Abamson⁸, Uwe Junker⁹, Karen Brown¹ and Mukundan Attur⁵, ¹Roche Innovation Center, New York, NY, ²Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY, ³Bioinformatics, New York University, New York, NY, ⁴NYU School of Medicine, New York, NY, ⁵Rheumatology Research, NYU Langone Orthopedic Hospital, New York, NY, ⁶Radiology, NYU Langone Medical Center, New York, NY, ⁷Department of Radiology, NYU Langone Medical Center, New York, NY, ⁸Rheumatology, NYU Langone Health, New York, NY, ⁹Roche Innovation Center, Basel, Switzerland
Background/Purpose: To investigate the expression of vascular adhesion protein -1 (VAP-1) in joint tissues and serum in knee osteoarthritis (OA) patients and examine whether VAP-1…
Abstract Number: 2833 • 2018 ACR/ARHP Annual Meeting
Complement Activation Is a Feature of Diseases in the Lupus Spectrum
Rosalind Ramsey-Goldman¹, Roberta Alexander², Elena Massarotti³, Daniel J. Wallace⁴, Sonali Narain⁵, Cristina Arriens⁶, Christopher E. Collins⁷, Amit Saxena⁸, Chaim Putterman⁹, Kenneth C. Kalunian¹⁰, Armida Sace², Rowena Lafon², Tyler O'Malley², JoAnne Ligayon², Claudia Ibarra², John Conklin², Thierry Dervieux² and Arthur Weinstein⁷, ¹FSM, Northwestern University, Chicago, IL, ²Exagen Diagnostics, Inc., Vista, CA, ³Brigham and Women's Hospital, Boston, MA, ⁴Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Northwell Health, Great Neck, NY, ⁶Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ⁸NYU Langone Health, New York, NY, ⁹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, ¹⁰Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: We showed previously that complement activation - cell-bound complement activation products (CB-CAPS) or multi-analyte assay panel (MAP) - is a sensitive and specific biomarker…
Abstract Number: 713 • 2018 ACR/ARHP Annual Meeting
Soluble ST2 and CXCL-10 May Serve As Biomarkers of Diastolic Dysfunction in SLE and Correlate with Disease Activity and Damage
Udi Chorin¹, Aviram Hochstadt¹, David Levartovsky², Irena Litinsky³, Ofir Elalouf⁴, Ari Polachek⁵, Ilana Kaufman⁶, Uri Arad⁷, Valerie Aloush⁷, Sara Borok Lev-Ran⁸, Irena Wigler⁷, Jonathan Wollman⁷, Dan Caspi², Yael Lahat², Or Carmi², Shlomo Berliner⁹, Ori Elkayam⁷, Yan Topilsky¹ and Daphna Paran², ¹Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ²Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ³Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv Univrsity, Tel Aviv, Israel, ⁶Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ⁷Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, ⁸Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel AViv, Israel, ⁹Internal Medicine E, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Background/Purpose: Subclinical myocardial dysfunction has been reported to occur earlyin SLE. The pathogenesis and prognosis of this finding is not clear. The study aims to…
Abstract Number: 1081 • 2018 ACR/ARHP Annual Meeting
Associations between Daily Alcohol Intake and SLE-Related Cytokines and Chemokines U.S. Female Nurses without SLE
Cianna Leatherwood¹, Xinyi Liu¹, Susan Malspeis², Andrea Roberts³, Jeffrey A. Sparks¹, Elizabeth Karlson¹, Candace H. Feldman¹, Judith A. James⁴, Laura Kubzansky⁵ and Karen Costenbader¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, MA, ⁴OMRF & OUHSC, Oklahoma City, OK, ⁵Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Low or no alcohol intake (0-5 gm/day or <0.5 drinks/day) has been associated with increased SLE risk among women. Several cytokines and chemokines are…
Abstract Number: 1482 • 2018 ACR/ARHP Annual Meeting
Is 14.3.3η a Predictor of Development of Rheumatoid Arthritis in Patients with Early Undifferentiated Arthritis?
Karen Marie Carlsen¹, Nina Schmidt², Anne Duer³, Kim Hørslev-Petersen⁴, Cecilie Heegaard Brahe⁵, Merete Lund Hetland², Norma K Biln⁶, Michelle L Zaharik⁷, Bo Jannik Ejbjerg⁸, Lene Bak⁹, Michael Sejer Hansen¹⁰, Julia Sidenius Johansen¹¹, Hanne Merete Lindegaard¹², Jakob M. Møller¹³ and Mikkel Østergaard¹⁴, ¹Center for Rheumatology and Spine Diseases,, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Hillerød, Denmark, Hillerød, Denmark, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ³Department of Radiology, Rigshospitalet Glostrup, Denmark, Glostrup, Denmark, ⁴King Christian the Xth Hospital for Rheumatic Diseases, Denmark, Graasten, Denmark, ⁵Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, ⁶Augurex Life Sciences Corp, Vancouver, BC, Canada, ⁷Augurex Life Sciences Corp, Vancouver, DC, Canada, ⁸Rheumatology, Department of Rheumatology, Køge Hospital, Denmark, Køge, Denmark, ⁹Department of Radiology, Odense University Hospital, Denmark, Odense, Denmark, ¹⁰Reuma-Klinik Roskilde, Denmark, Roskilde, Denmark, ¹¹Dept. of Oncology, Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark, ¹²Dept. of Rheumatology, Department of Rheumatology, Odense University Hospital, Denmark, Odense, Denmark, ¹³Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, ¹⁴Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Copenhagen, Denmark
Background/Purpose: Optimal management of rheumatoid arthritis (RA) requires early diagnosis and therefore sensitive methods for early identification of RA to prevent joint damage and disability.…
Abstract Number: 2019 • 2018 ACR/ARHP Annual Meeting
Investigating Urine S100A4 and Podocyte Proteins As Biomarkers of Lupus Nephritis Activity
Jessica Turnier¹, Jianghong Deng², Pinar Ozge Avar Aydin³, David Witte⁴, Prasad Devarajan⁵, Matthew Fenchel⁶, Michael Bennett⁷ and Hermine I. Brunner⁸, ¹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Beijing Children’s Hospital and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁴Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁶Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: We lack accurate clinical tools to identify the degree of active renal inflammation in childhood-onset SLE (cSLE). In this study, we investigated urine S100A4…
Abstract Number: 2884 • 2018 ACR/ARHP Annual Meeting
Correlation between Salivary Gland Ultrasonography, Minor Salivary Gland Histhopatology and Sialometry: Towards a Composite Assessment of Salivary Gland Involvement in Primary Sjögren’s Syndrome
Chiara Baldini¹, Nicoletta Luciano¹, Francesco Ferro¹, Antonella Cecchettini², Valentina Donati³, Marta Mosca¹ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²IFC, CNR, Pisa, Italy, ³Pathology Unit, University of Pisa, Pisa, Italy
Background/Purpose:: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease that specifically involves salivary glands. Several complementary tools including salivary gland ultrasonography (SGUS), histology and…
Abstract Number: 724 • 2018 ACR/ARHP Annual Meeting
Are Traditional Biomarkers of Lupus Associated with Renal Pathology in Lupus Nephritis?
Kelly Liang¹, Kimberly P. Liang², Yaming Li³, Alex Hurd³, Douglas Landsittel⁴ and Sheldon Bastacky⁵, ¹Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Biostatistics, University of Pittsburgh, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Traditional biomarkers for systemic lupus erythematosus (SLE) and lupus nephritis (LN) include serum creatinine (Cr), complement levels (C3/C4), double-stranded DNA antibody (dsDNA), erythrocyte sedimentation…
Abstract Number: 1084 • 2018 ACR/ARHP Annual Meeting
Dysfunction of the DNASE1L3 Pathway and Antigen Accumulation in Lupus Nephritis
Johannes Hartl¹, Robert M. Clancy¹, Peter M. Izmirly², H. Michael Belmont¹, Nicole Kaiden³, Nicole Bornkamp³, Vanja Sisirak¹, Benjamin Sally¹, Jill P. Buyon¹ and Boris Reizis¹, ¹NYU School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY
Background/Purpose: DNASE1L3 is a unique secreted DNase that is capable of degrading DNA complexed with proteins and/or encapsulated in membranes, such as chromatin within microparticles…

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