ACR Meeting Abstracts

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Abstracts tagged "Biomarkers"

  • Abstract Number: 0638 • ACR Convergence 2024

    Soluble TNF RII in Lupus Nephritis as a Biomarker of Disease Activity and Treatment Response

    Ranjan Gupta1, Sonam Rajput2, Jayanth Kumar2 and Dipendra K Mitra2, 1All India Institute of Medical Sciences, New Delhi, Delhi, India, 2All India Institute of Medical Sciences, New Delhi, New Delhi, India

    Background/Purpose: Lupus Nephritis (LN) affects almost 60-70% patients of Systemic Lupus Erythematosus (SLE). Conventional markers of renal involvement i.e. proteinuria and renal biopsy have limitations…
  • Abstract Number: 0741 • ACR Convergence 2024

    Serum Markers of Disease Activity in Polymyalgia Rheumatica

    Patricia Harkins1, Sharon Cowley2, seoidin McKittrick3, Robert Harrington4, David Kane5 and Richard Conway6, 1Trinity College Dublin, Dublin 8, Dublin, Ireland, 2Tallaght University Hospital, Dublin, Dublin, Dublin, Ireland, 3University of Limerick, Limerick, Ireland, 4St. James's Hospital, Dublin, Dublin, Ireland, 5Tallaght University Hospital & Trinity College Dublin, D24, Ireland, 6Trinity College Dublin, Dublin, Ireland

    Background/Purpose: A significant unmet need in Polymyalgia Rheumatica (PMR) is the lack of a disease specific serum biomarker for diagnosis, and monitoring of disease activity.…
  • Abstract Number: 0883 • ACR Convergence 2024

    The Study of 62 Circulating Soluble Factors Is Able to Predict the Lack of Response to MTX Treatment in Recently Diagnosed DMARD Naïve Rheumatoid Arthritis Smoker and Non-Smoker Patients

    Jorge Monserrat1, Cristina Bohorquez2, Ana Maria Gómez3, Elena Rabadán Rubio4, Raquel Sánchez3, Atusa Movasat5, Lucia Ruiz4, Fernando Albarran Hernandez6, Miguel Ángel Ortega1, Ana Perez6 and Melchor Alvarez-Mon7, 1Universidad de Alcalá. IRYCIS, Alcalá de Henares, Madrid, Spain, 2Hospital Universitario Príncipe de Asturias, Alcalá De Henares, Madrid, Spain, 3Universidad de Alcalá, Alcalá de Henares, Madrid, Spain, 4Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain, 5Hospital Universitario Príncipe de Asturias, Madrid, Spain, 6Hospital Universitario Principe de Asturias, Alcala de Henares, Madrid, Spain, 7Universidad de Alcalá. HUPA. IRYCIS, Madrid, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a highly inflammatory severe chronic autoimmune disorder with an inadequate activation of the immune cells. These cells are responsible for…
  • Abstract Number: 1122 • ACR Convergence 2024

    Clinical Realities in Patients with Adult Onset Still’s Disease: Real-World Diagnosis and Management

    Chloe Heiting1, Karen Gambina2 and Bella Mehta3, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medical College, New York, NY, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: Adult Onset Still’s Disease (AOSD) is a rare systemic inflammatory disorder characterized by inflammatory polyarthritis, daily fever, and a transient salmon-pink maculopapular rash. Diagnosis…
  • Abstract Number: 1388 • ACR Convergence 2024

    CXC Chemokine Ligand 13 and Rheumatoid Factor as Pharmacodynamic Biomarkers for Abatacept Treatment in Patients with Rheumatoid Arthritis

    Ting Wang1, Ryan Stultz1, Natalia Giltiay2, Christian Lood1 and Bobby Kwanghoon Han1, 1University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, USA, Seattle, WA

    Background/Purpose: Abatacept, a CTLA-4-Ig fusion protein, is widely used as a treatment for rheumatoid arthritis (RA). We conducted this study to identify novel predictive and…
  • Abstract Number: 1654 • ACR Convergence 2024

    CRTAC1 in Osteoarthritis: Implications for Disease Severity and miRNA Regulation

    Aneta Prokopcová1, Jiri Baloun2, Adéla Navrátilová3, Klára Mocová2, Lucia Ondrejčáková4, Jana Juhaszova2, Tereza Kropáčková1, Hana Storkanova5, Michal Tomcik5, Jindriska Gatterova2, Olga Sleglova2, Olga Ruzickova2, Eva Kriegova6, Jiri Gallo7, Rastislav Ballay8, Petr Fulin9, Jiří Vencovský1 and Ladislav Šenolt1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 31st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia, Olomouc, Czech Republic, 7Department of Orthopaedics, University Hospital Olomouc, Olomouc, Czech Republic, 81st Faculty of Medicine, Charles University, Prague, Czechia, Prague, Czech Republic, 91st Department of Orthopaedics, First Faculty of Medicine of Charles University and Motol University Hospital, Prague, Czechia, Prague, Czech Republic

    Background/Purpose: Cartilage acidic protein1 (CRTAC1) is a potential biomarker linked to osteoarthritis (OA) and cartilage degeneration. This study aimed to compare CRTAC1 levels in the…
  • Abstract Number: 1905 • ACR Convergence 2024

    Combining Three Peripheral Biomarkers to Stratify Rheumatoid Arthritis-Associated Interstitial Lung Disease Risk

    Bryant England1, Austin Wheeler1, Brent Luedders1, Michael Duryee1, Halie Frideres2, Katherine Wysham3, grant Cannon4, Gary Kunkel5, Dana Ascherman6, Paul Monach7, Gail Kerr8, Andreas Reimold9, Joshua Baker10, Geoffrey Thiele1 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC Department of Rheumatology, Omaha, NE, 3VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 6Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, 7VA Boston Healthcare System, Boston, MA, 8Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 9Dallas VA Medical Center, Dallas, TX, 10Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Several peripheral biomarkers for RA-associated interstitial lung disease (RA-ILD) have been evaluated to enhance early RA-ILD identification. The MUC5B rs35705950 promoter variant, matrix metalloproteinase-7…
  • Abstract Number: 2234 • ACR Convergence 2024

    Pulmonary Damage Biomarkers and Progression of Rheumatoid Arthritis-associated Interstitial Lung Disease in a Prospective Longitudinal Cohort

    Sung Hae Chang1, Yong-Beom Park2, Gregory McDermott3, Misti Paudel4, Keigo Hayashi3, You-Jung Ha5, Jeong Seok Lee6, Min Uk Kim7, Chan Ho Park8, Sang Wan Chung9, Ji-Won Kim10, Jang Woo Ha11, Sung Won Lee12, Eun Ha Kang5, Yeon-Ah Lee13, Jung-Yoon Choe14, Eun Young Lee15 and Jeffrey Sparks16, and the KOrean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) group, 1Brigham and Women's Hospital/Soonchunhyang University, College of Medicine, Boston, MA, 2Yonsei University College of Medicine, Seoul, Republic of Korea, 3Brigham and Women's Hospital, Brookline, MA, 4Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 5Seoul National University Bundang Hospital, Seongnam, South Korea, 6Korea Advanced Institute of Science and Technology, KAIST,, Daejeon, Republic of Korea, 7SMG-SNU Boramae Medical Center, Seoul, Republic of Korea, 8Soonchunhyang University College of Medicine,, Cheonan-si, Republic of Korea, 9Kyung Hee University Hospital, Seoul, Republic of Korea, 10Daegu Catholic University School of Medicine, Nam-gu, Daegu, South Korea, 11Yonsei university college of medicine, Seodaemun-gu, Seoul, South Korea, 12Soonchunhyang University Cheonan Hospital, Seoul, South Korea, 13Kyung Hee University Hospital, Seoul, South Korea, 14Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, 153Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea, 16Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA

    Background/Purpose: RA-associated interstitial lung disease (ILD) is a heterogeneous disease with a chronic course and potential for flares. Serum biomarkers are needed to identify those…
  • Abstract Number: 2425 • ACR Convergence 2024

    Ianalumab Induced Durable Depletion of Circulating B Cell Subsets and Associated Changes in B Cell and Neutrophil Transcriptomic and Proteomic Profiles in Patients with Systemic Lupus Erythematosus: 52-Week Treatment Results from a Phase 2 Trial

    Marianna Rowlands1, Thomas Dörner2, Diego Saldana Miranda3, Justin McMullen3, Aida Santos da Costa3, Ulrike Sommer3, Rainer Hillenbrand3, Andre Nogueira da Costa3, Claire Bonal3, Isabelle Isnardi3, Edward Khokhlovich1 and Stephen J Oliver3, 1Biomedical Research, Novartis, Cambridge, MA, 2Department of Medicine, Rheumatology and Clinical Immunology,Charite Universitätsmedizin Berlin, Germany and DRFZ, Berlin, Berlin, Germany, 3Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Ianalumab (VAY736), a B cell activating factor receptor (BAFFR) targeting mAb, depletes B cells via both antibody dependent cellular cytotoxicity and blockade of BAFF:BAFFR…
  • Abstract Number: 2637 • ACR Convergence 2024

    Chaperone-mediated Autophagy in Synovitis Distinguishes Psoriatic Arthritis from Rheumatoid Arthritis

    Vincenzo Venerito1, Gerardo Cazzato2, Fabio Cacciapaglia3, Eleonora Ceglie4, Sergio Del Vescovo4, Teresa Caferri4, Giuseppe Lopalco4, Francesco Girolamo5 and Florenzo Iannone1, 1Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 2Pathology Unit - University of Bari "Aldo Moro", IT, Bari, Italy, 3Rheumatology Unit � DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 4Rheumatology Unit - University of Bari "Aldo Moro", IT, Bari, Italy, 5Human Anatomy Department - University of Bari "Aldo Moro", IT, Bari, Italy

    Background/Purpose: Recent studies have suggested that autophagy may play different roles in the pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Lysosome-associated membrane protein type 2A…
  • Abstract Number: 0043 • ACR Convergence 2024

    Inflammatory and Angiogenic Serum Profile of Refractory Rheumatoid Arthritis

    Manon Lesturgie-Talarek1, Virginie Gonzalez2, ALICE COMBIER3, Marion THOMAS4, Margaux Boisson5, Sandrine Carves3, Sarah Wanono3, Lucie Poiroux3, Anne Cauvet1, Sophie Hecquet6, Yannick Allanore7 and Jérôme Avouac8, 1Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, 2Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, 3Hôpital Cochin - Université Paris Cité, Paris, France, 4APHP, Paris, France, 5Hôpital Cochin - Université Paris Cité, Paris, 6Cochin Hospital, Paris, France, 7Université Paris Cité, Paris, France, 8Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France

    Background/Purpose: Despite the emergence of new therapies, a considerable proportion of individuals with rheumatoid arthritis (RA) still endure symptoms, giving rise to the concept of…
  • Abstract Number: 0334 • ACR Convergence 2024

    Normal Creatine Kinase in Idiopathic Inflammatory Myopathies- Patient Characteristics and Disease Activity

    shiri keret1, Tanya Chandra2, Lisa Kaly3, Raisa Silva4, Eugenia Gkiaouraki5, Nantakarn Pongtarakulpanit6, shreya Sriram5, Rajesh Gopalarathinam7, Siamak Mogahadam6, Chester Oddis6 and Rohit Aggarwal8, 1Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Atlit, Israel, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Haifa, Israel, 4Internal medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, 6Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 7Division of Rheumatology, Wrightington Wigan and Leigh Teaching Hospitals NHS Foundation Trust, Wigan, United Kingdom, 8Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA

    Background/Purpose: Creatine kinase (CK) is an important biomarker for the diagnosis and monitoring of Idiopathic Inflammatory Myopathies (IIM). However, in some cases, CK levels might…
  • Abstract Number: 0494 • ACR Convergence 2024

    Usefulness of the Neutrophil-to-Lymphocyte Ratio, the Platelet-to-Lymphocyte Ratio and the Systemic Immune Inflammatory Index in Assessing Disease Activity in Rheumatoid Arthritis Patients

    Yelitza Cecilia Velarde Mejia1, Ventura Mejia2, guillermo velarde2 and Graciela Alarcon3, 1Hncase, Arequipa, Peru, 2UNIVERSIDAD NACIONAL DE SAN AGUSTIN, arequipa, Peru, 3The University of Alabama at Birmingham, Oakland, CA

    Background/Purpose: Rheumatoid arthritis (RA) causes systemic inflammation that leads to specific changes in the patients’ blood cells; this offers the opportunity to measure inflammatory activity…
  • Abstract Number: 0640 • ACR Convergence 2024

    7000-Plex Proteomic Screen of Urine for Flare Monitoring and Treatment Response Biomarkers in Active Lupus Nephritis

    kamala Vanarsa1, Yewei Ma2, Mohammad Daouk2, Vinaika Maruvada2, Ramesh Saxena3 and Chandra Mohan4, 1University of Houston, houstton, 2University of Houston, Houston, 3UT Southwestern Medical Center, Dallas, 4University of Houston, Houston, TX

    Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with lupus. Since the kidney biopsy is invasive, better, more predictive…
  • Abstract Number: 0763 • ACR Convergence 2024

    Transcriptional Analysis of Both Normal and Abnormal TABs in Biopsy-proven GCA Reveals a Shared Gene Expression Profile Compared to Clinically Diverse Controls

    Ingrid Lindquist1, Dongseok Choi2, Suzanne Fei3, Kiana Vakil-Gilani4, Daniela Ghetie1, David Wilson5, Diva Salomao6, Hillary Stiefel7, Daniel Albert7, James Rosenbaum8 and Marcia Friedman1, 1OHSU, Division of Arthritis and Rheumatic Diseases, Portland, OR, 2OHSU, School of Public Halth, Portland, OR, 3OHSU, Oregon National Primate Research Center, Portland, OR, 4OHSU, Division of Arthritis and Rheumatic Diseases, Porltand, OR, 5OHSU, Casey Eye Institute, Porrtland, OR, 6Mayo Clinic, Division of Anatomic Pathology, Rochester, MN, 7OHSU, Casey Eye Institute, Portland, OR, 8Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: Giant cell arteritis (GCA) is the most common vasculitis in people over 50 years old and is a clinical diagnosis bolstered by pathologic findings on temporal…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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