Abstracts tagged "Biomarkers"

Abstract Number: 0332 • ACR Convergence 2024
Predictors of Long-term Radiographic Changes in Patients with Idiopathic Inflammatory Myopathies Using Quantitative Imaging Analysis: Real World Experience from a Single Center Longitudinal Cohort
Sangmee Bae¹, Daniela Macrovic², Auguestine Chung², Jessica Channick², Andrea Oh¹, Jennifer Wang¹, Ani Shahbazian², Tiffany De Leon², Yuna Lee², Grace Kim², Donald Tashkin², Jonathan Goldin² and christina Charles-Schoeman³, ¹UCLA, Los Angeles, CA, ²UCLA, Los Angeles, ³UCLA Medical Center, Santa Monica, CA
Background/Purpose: Interstitial lung disease (ILD) is a major cause of mortality in idiopathic inflammatory myopathies (IIM), and high-resolution computed tomography (HRCT) is a key modality…
Abstract Number: 0493 • ACR Convergence 2024
An Algorithm Pipeline for Automated Metrical Analysis of Joint Swelling in Rheumatoid Arthritis via Smartphone Hand Photographs
Cinja Koller¹, Marc Blanchard², Jules Maglione³, Patrick Hermann⁴ and Thomas Huegle³, ¹Doctoral School, Faculty of Biology and Medicine, University of Lausanne, Genève, Vaud, Switzerland, ²CHUV - Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, Perroy, Switzerland, ³Lausanne University Hospital, Lausanne, Switzerland, ⁴Lausanne University Hospital, Lausanne, Vaud, Switzerland
Background/Purpose: Advancement in technology has fostered Remote Patient Monitoring (RPM), but it is mainly subjectively measured by patient reported outcomes or non-specifically via wearable data.…
Abstract Number: 0640 • ACR Convergence 2024
7000-Plex Proteomic Screen of Urine for Flare Monitoring and Treatment Response Biomarkers in Active Lupus Nephritis
kamala Vanarsa¹, Yewei Ma², Mohammad Daouk², Vinaika Maruvada², Ramesh Saxena³ and Chandra Mohan⁴, ¹University of Houston, houstton, ²University of Houston, Houston, ³UT Southwestern Medical Center, Dallas, ⁴University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with lupus. Since the kidney biopsy is invasive, better, more predictive…
Abstract Number: 0763 • ACR Convergence 2024
Transcriptional Analysis of Both Normal and Abnormal TABs in Biopsy-proven GCA Reveals a Shared Gene Expression Profile Compared to Clinically Diverse Controls
Ingrid Lindquist¹, Dongseok Choi², Suzanne Fei³, Kiana Vakil-Gilani⁴, Daniela Ghetie¹, David Wilson⁵, Diva Salomao⁶, Hillary Stiefel⁷, Daniel Albert⁷, James Rosenbaum⁸ and Marcia Friedman¹, ¹OHSU, Division of Arthritis and Rheumatic Diseases, Portland, OR, ²OHSU, School of Public Halth, Portland, OR, ³OHSU, Oregon National Primate Research Center, Portland, OR, ⁴OHSU, Division of Arthritis and Rheumatic Diseases, Porltand, OR, ⁵OHSU, Casey Eye Institute, Porrtland, OR, ⁶Mayo Clinic, Division of Anatomic Pathology, Rochester, MN, ⁷OHSU, Casey Eye Institute, Portland, OR, ⁸Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR
Background/Purpose: Giant cell arteritis (GCA) is the most common vasculitis in people over 50 years old and is a clinical diagnosis bolstered by pathologic findings on temporal…
Abstract Number: 0893 • ACR Convergence 2024
Uncovering Common and Distinctive Molecular Profiles Between Early and Stablished Rheumatoid Arthritis Through Integrative Multi-omics Analysis and Its Association with Disease Status and Clinical Response
Ismael Sánchez Pareja¹, Carlos Perez-Sanchez¹, Dani Toro-Domínguez², Laura Muñoz-Barrera¹, Tomás Cerdó¹, Elena Moreno-Caño³, Rafaela Ortega-Castro⁴, Jerusalem Calvo Gutierrez⁵, María Lourdes Ladehesa-Pineda⁶, Concepción Aranda-Valera³, María Carmen Ábalos-Aguilera⁷, Christian Merlo-Ruiz⁷, Mª Angeles Aguirre-Zamorano⁸, Nuria Barbarroja¹, Marta Alarcon-Riquelme⁹, Alejandro Escudero-Contreras¹ and Chary Lopez-Pedrera⁶, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Fundación Progreso y Salud, Andalusian Government, Granada, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Andalucia, Spain, ⁴Hospital Reina Sofía, Cordoba, Andalucia, Spain, ⁵HU Reina Sofia, Cordoba, Spain, ⁶IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Andalucia, Spain, ⁷IMIBIC/Reina Sofia Hospital/University of Cordoba, CÓRDOBA, Spain, ⁸IMIBIC/Reina Sofia Hospital/University of Cordoba, CÓRDOBA, Andalucia, Spain, ⁹Fundación Progreso y Salud, Andalusian Government, Granada, Spain
Background/Purpose: Characterize the molecular landscape of RA patients using a multi-omic approach encompassing transcriptomics and proteomics and assess its association with disease stage and therapeutic…
Abstract Number: 1144 • ACR Convergence 2024
Autoantibody and Radiological Profiles as Prognostic Indicators in Idiopathic Inflammatory Myopathies: Insights into Mortality and Interstitial Lung Disease Development
cristiana sieiro santos¹, Miriam Retuerto², Laura Sierra², Jose Ordas Martínez³, Paula Pérez García², Pedro Baenas², Clara Moriano Morales² and Elvira Díez Álvarez⁴, ¹Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, ²Complejo Asistencial Universitario de León, León, Spain, ³Complejo Asistencial Universitario de Leon, Leon, ⁴Complejo Asistencial Universitario de León, Leon, Spain
Background/Purpose: The idiopathic inflammatory myopathies (IIMs) constitute a diverse group of acquired muscle disorders, often involving multiple organs such as the skin, heart, and lungs.…
Abstract Number: 1418 • ACR Convergence 2024
Soluble Immune Checkpoint Molecules as Biomarkers for Extraglandular Sjögren’s Disease
Arman Aue¹, Franziska Szelinski¹, Héctor Rincón-Arévalo¹, Jacob Ritter¹, Annika Wiedemann¹, Léa-Sophie Dreveton¹, Eva Vanessa Schrezenmeier², Andreia C. Lino³, Thomas Dörner⁴ and Ana-Luisa Stefanski¹, ¹Department of Medicine/Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Department of Nephrology and Intensive Medical Care, Charité Universitätsmedizin Berlin, Berlin, Germany, ³Deutsches Rheumaforschungszentrum (DRFZ), Berlin, Germany, Berlin, Germany, ⁴Department of Medicine, Rheumatology and Clinical Immunology,Charite Universitätsmedizin Berlin, Germany and DRFZ, Berlin, Berlin, Germany
Background/Purpose: Primary Sjögren’s disease (pSD) is a chronic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, leading to sicca symptoms and several extraglandular…
Abstract Number: 1662 • ACR Convergence 2024
Using Circulating Soluble Serum Mediator Profiles to Understand the Mechanisms Driving Disease Flare and Drug-free Remission in Rheumatoid Arthritis
Amy Anderson¹, Fiona Rayner², Abbie Degnan¹, Imogen Wilson¹, Julie Diboll¹, Jasmine Sim¹, Andrew Melville³, Stefan Siebert³, Iain McInnes⁴, Carl Goodyear³, Catharien Hilkens¹, Andrew Filer⁵, Karim Raza⁵, Christopher Buckley⁶, Kenneth Baker¹, Arthur Pratt² and John Isaacs¹, ¹Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ²Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England, United Kingdom, ³School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁴University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, ⁵Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Birmingham, United Kingdom, ⁶Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
Background/Purpose: Little is known of the factors that trigger disease relapses/flares in patients with rheumatoid arthritis (RA). The underpinning mechanisms have been difficult to study…
Abstract Number: 1956 • ACR Convergence 2024
Artificial Intelligence Enhanced Analysis of Nailfold Capillaries by Dermatoscopy in Rheumatology Centers
Genessis Maldonado¹, Eduardo Ramos-ibañez², Borja del Carmelo Gracia-Tello³, Radic Mislav⁴ and Tracy Frech¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²University of Zaragoza, Zaragoza, Spain, ³Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain, ⁴University Hospital of Split, Split, Croatia
Background/Purpose: The use of dermatoscopes in rheumatology has been established for several years. However, the application of artificial intelligence for the detection of abnormalities in…
Abstract Number: 2244 • ACR Convergence 2024
Unveiling Synovial Protein Contributions to Serum Inflammation, Disease Activity, and Treatment Outcomes in RA Patients
Chary Lopez-Pedrera¹, Sagrario Corrales², Julio Osuna³, Rafaela Ortega-Castro⁴, Jerusalén Calvo³, María Lourdes Ladehesa-Pineda¹, Ismael Sánchez Pareja², Laura Muñoz-Barrera², Desiree Ruiz-Vilchez³, Christian Merlo⁵, Mª Angeles Aguirre-Zamorano⁶, Nuria Barbarroja², Tomás Cerdó², Rosa ortega³, Marta Alarcon-Riquelme⁷, Carlos Perez-Sanchez², Alejandro Escudero-Contreras² and Concepción Aranda-Valera⁸, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Andalucia, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁴Hospital Reina Sofía, Cordoba, Andalucia, Spain, ⁵Rheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain, ⁶IMIBIC/Reina Sofia Hospital/University of Cordoba, CÓRDOBA, Andalucia, Spain, ⁷Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ⁸IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Andalucia, Spain
Background/Purpose: Characterize synovial tissue-secreted proteins in RA patients that contibute to serum inflammatory profiles based on immune cell infiltration.Identify RA patient subsets with distinctive serum…
Abstract Number: 2426 • ACR Convergence 2024
Multi-OMICs Analysis Including Lipidomics to Correlate Baseline OMICs Profiles with Disease Activity and Response to Different Immunomodulatory Treatments in Patients with Systemic Lupus Erythematosus – An Exploratory Pilot Study Using a Multi-OMICs Approach
Michaela Koehm¹, Samuel Rischke², Robert Gurke³, Gerd Geißlinger⁴ and Frank Behrens¹, ¹University Hospital Goethe University Frankfurt and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany, ²Goethe University Frankfurt, Institute of Clinical Pharmacology, Frankfurt, Germany, ³Goethe University Frankfurt, Institute of Clinical Pharmacology and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, ⁴Goethe University Frankfurt, Institute of Clinical Pharmacology and Fraunhofer Insitute for Translational Medicine and Pharmacology ITMP, Frankfurt
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a very heterogeneous clinical presentation and severity. Despite the variety of treatment options available,…
Abstract Number: 2641 • ACR Convergence 2024
Identification of Systemic Sclerosis Intrinsic Subtypes in the ASSET Clinical Trial Using PBC Gene Expression
Zhiyun Gong¹, Timothy Sullivan², Tammara Wood³, David Fox⁴, Dinesh Khanna⁵ and Michael Whitfield⁶, ¹Dartmouth College, Lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Dartmouth, Hanover, NH, ⁴University of Michigan, Dexter, MI, ⁵University of Michigan, Ann Arbor, MI, ⁶Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic sclerosis (SSc) is molecularly heterogeneous and distinct subtypes of patients have been identified based on gene expression in skin. Although treatments have improved,…
Abstract Number: 0043 • ACR Convergence 2024
Inflammatory and Angiogenic Serum Profile of Refractory Rheumatoid Arthritis
Manon Lesturgie-Talarek¹, Virginie Gonzalez², ALICE COMBIER³, Marion THOMAS⁴, Margaux Boisson⁵, Sandrine Carves³, Sarah Wanono³, Lucie Poiroux³, Anne Cauvet¹, Sophie Hecquet⁶, Yannick Allanore⁷ and Jérôme Avouac⁸, ¹Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, ²Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, ³Hôpital Cochin - Université Paris Cité, Paris, France, ⁴APHP, Paris, France, ⁵Hôpital Cochin - Université Paris Cité, Paris, ⁶Cochin Hospital, Paris, France, ⁷Université Paris Cité, Paris, France, ⁸Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France
Background/Purpose: Despite the emergence of new therapies, a considerable proportion of individuals with rheumatoid arthritis (RA) still endure symptoms, giving rise to the concept of…
Abstract Number: 0334 • ACR Convergence 2024
Normal Creatine Kinase in Idiopathic Inflammatory Myopathies- Patient Characteristics and Disease Activity
shiri keret¹, Tanya Chandra², Lisa Kaly³, Raisa Silva⁴, Eugenia Gkiaouraki⁵, Nantakarn Pongtarakulpanit⁶, shreya Sriram⁵, Rajesh Gopalarathinam⁷, Siamak Mogahadam⁶, Chester Oddis⁶ and Rohit Aggarwal⁸, ¹Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Atlit, Israel, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Haifa, Israel, ⁴Internal medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Division of Rheumatology, Wrightington Wigan and Leigh Teaching Hospitals NHS Foundation Trust, Wigan, United Kingdom, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA
Background/Purpose: Creatine kinase (CK) is an important biomarker for the diagnosis and monitoring of Idiopathic Inflammatory Myopathies (IIM). However, in some cases, CK levels might…
Abstract Number: 0494 • ACR Convergence 2024
Usefulness of the Neutrophil-to-Lymphocyte Ratio, the Platelet-to-Lymphocyte Ratio and the Systemic Immune Inflammatory Index in Assessing Disease Activity in Rheumatoid Arthritis Patients
Yelitza Cecilia Velarde Mejia¹, Ventura Mejia², guillermo velarde² and Graciela Alarcon³, ¹Hncase, Arequipa, Peru, ²UNIVERSIDAD NACIONAL DE SAN AGUSTIN, arequipa, Peru, ³The University of Alabama at Birmingham, Oakland, CA
Background/Purpose: Rheumatoid arthritis (RA) causes systemic inflammation that leads to specific changes in the patients’ blood cells; this offers the opportunity to measure inflammatory activity…

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