Abstracts tagged "Biomarkers and systemic sclerosis"

Abstract Number: 734 • 2017 ACR/ARHP Annual Meeting
Correlation of the American College of Rheumatology Provisional Composite Response Index in Systemic Sclerosis with Serum Biomarkers of Fibrogenesis in an Observational Cohort
Giuseppina Abignano¹, Sookhoe Eng², Maya H. Buch³, Paul Emery⁴, Dinesh Khanna⁵ and Francesco Del Galdo², ¹Rheumatology Department of Lucania,, Rheumatology Institute of Lucania (IReL), San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera,, Potenza, Italy, ²Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: The CRISS is a composite index of response in diffuse cutaneous systemic sclerosis (dcSSC). It is a 2-step process for the probability of improvement…
Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting
Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis
Mohammed Tikly¹, Jacqueline Frost², Michèle Ramsay³, Eulalia Marti Puig⁴, Raquel Rabionet⁴, Xavier Estivill⁴ and Marc Friedländer⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ²University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Center for Genomic Regulation, Barcelona, Spain, ⁵Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
Abstract Number: 813 • 2016 ACR/ARHP Annual Meeting
Identifying and Assessing Subgroups in Systemic Sclerosis Patients Based on Comprehensive Autoantibody Profiling
Petra Budde¹, Hans-Dieter Zucht¹, Heike Göhler¹, Klaus Marquart¹, Peter Schulz-Knappe¹, Matthias Schneider² and Nicolas Hunzelmann³, ¹Protagen AG, Dortmund, Germany, ²Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ³Department of Dermatology, University of Cologne, Cologne, Germany
Background/Purpose: Systemic sclerosis (SSc) is a remarkably heterogeneous autoimmune disease, for which effective disease-modifying therapies are still lacking. The most widely used classification divides SSc…
Abstract Number: 815 • 2016 ACR/ARHP Annual Meeting
The Novel Anti-BICD2 Autoantibody Potentially Predicts a Favorable Disease Course in SSc
Johannes Schulte-Pelkum¹, Daniel Wirtz¹, Petra Budde¹, Hans-Dieter Zucht¹, Peter Schulz-Knappe¹, Prof. Dr. Matthias Schneider², Suzana Jordan³, Oliver Distler³, Britta Maurer³ and Nicolas Hunzelmann⁴, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Dermatology, University of Cologne, Cologne, Germany
Background/Purpose: To evaluate clinical associations of our recently discovered systemic sclerosis-specific auto-antigen BICD2 in clinically well characterized systemic sclerosis (SSc) cohorts from two tertiary referral…
Abstract Number: 849 • 2016 ACR/ARHP Annual Meeting
Collagen Formation/Degradation Neoepitopes Are Promising Biomarkers for Systemic Sclerosis
Rucsandra Dobrota¹, Suzana Jordan¹, Pernille Juhl², Lukas Wildi¹, Britta Maurer¹, Anne C. Bay-Jensen³, Morten Asser Karsdal³, Anne Sofie Siebuhr³ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Biomarkers & Research, Nordic Bioscience, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease with extensive fibrosis of the skin and internal organs in which extracellular matrix (ECM) remodeling is…
Abstract Number: 1900 • 2016 ACR/ARHP Annual Meeting
Anti-Topoisomerase Positive Systemic Sclerosis – Prognosis Infaust?
Maaike Boonstra¹, Gaia A. Beerends², Hans U. Scherer², Tom W.J. Huizinga¹ and Jeska K. de Vries-Bouwstra¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-topoisomerase antibodies (ATA) in systemic sclerosis have been associated with poorer prognosis including diffuse skin involvement, pulmonary fibrosis, cardiac involvement and increased mortality. However,…
Abstract Number: 2908 • 2016 ACR/ARHP Annual Meeting
Anti-Vinculin Antibodies: A Novel Biomarker in Systemic Sclerosis, and Its Association with Vascular Involvement
Yossra A Suliman¹, Suzanne Kafaja², Mohamed Alemam³, Isela Valera⁴, Walter Morales⁵, Mark Pimentel⁶ and Daniel E. Furst⁷, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Clinical Pathology and Laboratory Medicine Department, Assistant Lecturer, Qena, Egypt, ⁴UCLA, Los Angeles, CA, ⁵GI Motility Program, Research associate, Los Angeles, CA, ⁶Gastrointestinal, Cedar Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Vascular involvement has a major impact on the pathogenesis of Systemic sclerosis (SSc) and there is evidence that microvascular damage with endothelial cell activation …
Abstract Number: 1903 • 2015 ACR/ARHP Annual Meeting
Assessment of Subclinical Atherosclerosis in Patients with Systemic Sclerosis: Results from a Multicentric Cohort
Codrina Ancuta^1,2, Codruta Belibou³, Cristina Pomirleanu^1,4, Carina Mihai⁵, Ioan Ancuta⁵, Patricia E. Carreira⁶, Jose Luis Rosales Alexander⁷, Juan José Alegre⁸, Valeria Riccieri⁹, Maria J. Salvador¹⁰ and Rodica Chirieac⁴, ¹Rheumatology, Gr.T.Popa University of Medicine and Pharmacy, Iasi, Romania, ²Rheumatology 2, Clinical Rehablitation Hospital, Iasi, Romania, ³Research Department, Clinical Rehabilitation Hospital, Iasi, Romania, ⁴Rheumatology 2, Clinical Rehabilitation Hospital, Iasi, Romania, ⁵Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ⁶Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, ⁷Rheumatology, Hospiten Health Network, Tenerife, Spain, ⁸Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ⁹Cattedra di Reumatologia, Dip Clinica e Terapia Medica, Sapienza Università di Roma, Roma, Italy, ¹⁰Rheumatology, Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal
Background/Purpose: Although numerous studies have reported different findings on subclinical and definite atherosclerosis (AS) in autoimmune rheumatic diseases, data in systemic sclerosis (SSc) are still…
Abstract Number: 1711 • 2014 ACR/ARHP Annual Meeting
The Relationship Between Vascular Biomarkers and Disease Characteristics in Systemic Sclerosis: Elevated MCP-1 Is Associated with Predominantly Fibrotic Manifestations
Yasemin Yalcinkaya¹, Suzan Cinar², Sevil Kamali¹, Lale Ocal¹, Gunnur Deniz² and Murat Inanc³, ¹Istanbul Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey, ²DETAE, Istanbul University, Istanbul, Turkey, ³Division of Rheumatology, Department of Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Background/Purpose: To determine the relationship between vascular biomarkers reflecting the vascular injury and organ involvement in systemic sclerosis (SSc). Methods : Seventy-two SSc patients (66…
Abstract Number: 758 • 2014 ACR/ARHP Annual Meeting
Assessment of mRNA Gene Expression Based on Forearm Skin Score in Systemic Sclerosis Patients
Lisa Rice¹, Giuseppina Stifano¹, Jessica Ziemek² and Robert Lafyatis³, ¹Rheumatology, Boston University Medical Center, Boston, MA, ²Rheumatology/Arthritis Center, Boston University School of Medicine, Boston, MA, ³Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: The extent of skin disease in patients with systemic sclerosis is typically measured through physical examination of patients at 17 sites and involvement is…
Abstract Number: 736 • 2014 ACR/ARHP Annual Meeting
Serum Galectin-3 Levels in Early Diffuse Systemic Sclerosis and the Relationship to Skin Score and Skin Score Change
Siamak Moghadam-Kia¹, Thomas A. Medsger Jr.² and Robyn T. Domsic³, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose Galectin-3 is a β-galactoside-binding animal lectin which is associated with inflammation, angiogenesis and fibrosis. Galectin-3 is upregulated in hepatic fibrosis, idiopathic pulmonary fibrosis and…
Abstract Number: 2561 • 2013 ACR/ARHP Annual Meeting
Multiplex Cytokine Analysis Of Dermal Interstitial Blister Fluid In Systemic Sclerosis Defines Potential Pathogenic Pathways and Differentiates Clinical Subsets
Kristina E.N. Clark¹, Henry Lopez², Joanna Nikotorowicz-Buniak¹, Xu Shiwen^1,3, Korsa Khan⁴, George Martin⁵, David J. Abraham¹, Christopher P. Denton¹ and Richard J. Stratton¹, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Murigenics, Vallejo, CA, ³Rheumatology, Royal Free Hospital, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom, ⁵Aero Dap, Vallejo, CA
Background/Purpose: Clinical diversity in systemic sclerosis (SSc) is likely to reflect multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a…
Abstract Number: 664 • 2013 ACR/ARHP Annual Meeting
Formate, Acetate and Acetone : News Biomarkers in Systemic Sclerosis identified by Metabolomics
Emmanuel Chatelus¹, Francois Marie Moussallieh², Christelle Sordet¹, Arnaud Theulin¹, Alain Meyer¹, Karim El Bayed³, Jean Francois Kleinmann¹, Jean Sibilia¹, Jacques-Eric Gottenberg⁴ and Izzie Jacques Namer², ¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Nuclear Medicine, Strasbourg University Hospital, Strasbourg, France, ³UMR 7177 CNRS/Strasbourg University, Strasbourg, France, ⁴Strasbourg University Hospital, Strasbourg, France
Background/Purpose: High throughput study of metabolic pathways might help identify new biomarkers and therapeutic targets in autoimmune diseases. Systemic sclerosis (SSc) currently lacks prognostic biomarkers…

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