Abstracts tagged "Biologics"

Abstract Number: 630 • 2016 ACR/ARHP Annual Meeting
Strategies for Biological Drug Quantification in Biological Drug Immune Responses
Michael Kruse Meyer^1,2, Marlene Andersen^1,3, Troels Vindbæk Stausbo⁴, Tue Bjerg Bennike^4,5, Grethe Neumann Andersen^1,6 and Allan Stensballe^3,4, ¹Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark, ²Laboratory for Medical Mass Spectrometry, Aalborg University, Aalborg, Denmark, ³Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, ⁴Laboratory of Medical Mass Spectrometry, Aalborg University, Aalborg, Denmark, ⁵Research Unit for Molecular Diagnostic and Clinical Research, Harvard Medical School, Boston, MA, ⁶Center for Clinical Science, Aalborg University, Hjørring, Denmark
Background/Purpose: The development of the biological DMARDs has benefitted patients, who previously had no treatment options. Currently no method for stratifying patients to these drugs…
Abstract Number: 1687 • 2016 ACR/ARHP Annual Meeting
Effect of Concomitant Conventional Disease-Modifying Antirheumatic Drugs (DMARDs) on the Efficacy and Safety of Ixekizumab in Biologic DMARD-Naive Patients with Active Psoriatic Arthritis
Alice B. Gottlieb¹, Laura C. Coates², Catherine L. Shuler³, Chen-Yen Lin³, Susan R. Moriarty³, Chin H. Lee³ and Philip J Mease⁴, ¹Tufts University School of Medicine, Boston, MA, ²University of Leeds, Leeds, United Kingdom, ³Eli Lilly and Company, Indianapolis, IN, ⁴Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: PsA is a chronic immune-mediated inflammatory disease associated with psoriasis, peripheral arthritis, enthesitis, dactylitis, and spondylitis. Ixekizumab (IXE) is an IgG4 mAb that binds…
Abstract Number: 2654 • 2016 ACR/ARHP Annual Meeting
Association Between Rheumatoid Factor Positivity and Effects of Treatment with a First Biologic Agent in Rheumatoid Arthritis
Yoshikazu Ogawa¹, Nobunori Takahashi², Toshihisa Kojima³ and Naoki Ishiguro⁴, ¹orthopedic surgery, Sakashita Hospital, Nakatsugawa, Japan, ²Nagoya Univ. Grad. Schl. of Med., Nagoya, Japan, ³Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, ⁴Nagoya University, Nagoya, Japan
Background/Purpose: The presence of rheumatoid factor (RF) plays an important role in the diagnosis of rheumatoid arthritis (RA). However, whether RF positivity is related to…
Abstract Number: 644 • 2016 ACR/ARHP Annual Meeting
Seroprevalence and Its Impact on Radiographic Damage in Korean Rheumatoid Arthritis Patients Starting Biologics
Kichul Shin¹, Seongjun Ha², Inkyung Jung³, Hyoun-Ah Kim⁴ and Shin-Seok Lee⁵, ¹Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of, ²Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, The Republic of, ³Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea, The Republic of, ⁴Ajou University Hospital, Suwon, South Korea, ⁵Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, The Republic of
Background/Purpose: High titers of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACCP) are poor prognostic factors for rheumatoid arthritis (RA) patients. Only few studies…
Abstract Number: 1688 • 2016 ACR/ARHP Annual Meeting
Ixekizumab Provides Sustained Improvement up to 52 Weeks of Disease Activity As Assessed By Composite Measure Scores in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients with Active Psoriatic Arthritis
Laura C. Coates¹, M. Elaine Husni², Catherine L. Shuler³, Hilde Carlier³, Chen-Yen Lin³, Jiani Mou³, Chin H. Lee³ and Philip J Mease⁴, ¹University of Leeds, Leeds, United Kingdom, ²Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ³Eli Lilly and Company, Indianapolis, IN, ⁴Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: PsA, a chronic immune-mediated inflammatory disease, can be progressive and destructive, resulting in physical deformities, impaired function, decreased quality of life, and increased mortality.…
Abstract Number: 2728 • 2016 ACR/ARHP Annual Meeting
Discontinuation of Biologic Therapy in Patients with Ankylosing Spondylitis—Data from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry
Philip J Mease¹, Désirée van der Heijde², Chitra Karki³, Mei Liu³, Renganayaki Pandurengan³, Yujin Park⁴ and Jeffrey D. Greenberg^3,5, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Corrona, LLC, Southborough, MA, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁵New York University School of Medicine, New York, NY
Background/Purpose: Clinical trials have demonstrated the efficacy of biologic therapy in improving the clinical and patient-reported outcomes in patients with ankylosing spondylitis (AS); however, there…
Abstract Number: 765 • 2016 ACR/ARHP Annual Meeting
High Baseline B Lymphocyte Stimulator (BLyS) Levels Predict Response While Smoking and Organ Damage at Baseline Predict Failure to Belimumab in Three Swedish Clinical Practice Settings
Ioannis Parodis¹, Christopher Sjöwall², Andreas Jönsen³, Agneta Zickert¹, Daniel Ramsköld¹, Martina Frodlund², Laurent Arnaud¹, Vivianne Malmström¹, Anders A. Bengtsson³ and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology/AIR, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ³Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden
Background/Purpose: Belimumab is a biologic drug approved to treat Systemic Lupus Erythematosus (SLE). The efficacy of belimumab has been demonstrated in phase III clinical trials.…
Abstract Number: 1689 • 2016 ACR/ARHP Annual Meeting
Ixekizumab Provides Improvements through 52 Weeks in Physical Function, Quality of Life, and Work Productivity in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients with Active Psoriatic Arthritis
Alice B. Gottlieb¹, M. Elaine Husni², Catherine L. Shuler³, Russel T. Burge³, Chen-Yen Lin³, Chin H. Lee³ and D Gladman⁴, ¹Tufts University School of Medicine, Boston, MA, ²Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ³Eli Lilly and Company, Indianapolis, IN, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: PsA has a negative impact on patients’ quality of life, physical function, and work productivity. Ixekizumab (IXE) is an IgG4 mAb that binds with…
Abstract Number: 2735 • 2016 ACR/ARHP Annual Meeting
Regional Variability of Minimal Disease Activity Among Psoriatic Arthritis Patients in Canada: An Analysis from a Prospective, Observational Registry
Proton Rahman¹, Dalton Sholter², Michelle Teo³, Regan Arendse⁴, Denis Choquette⁵, Mary Bell⁶, Angeliki Karellis⁷, Eliofotisti Psaradellis⁸, Francois Nantel⁹, Allen J Lehman¹⁰, Cathy Tkaczyk¹¹, Karina Maslova¹⁰ and Brendan Osborne¹¹, ¹Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ²University of Alberta, Edmonton, AB, Canada, ³Balfour Medical Clinic, Penticton, BC, Canada, ⁴University of Saskatchewan, Saskatoon, ON, Canada, ⁵Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, ⁶University of Toronto, Toronto, ON, Canada, ⁷Department of Surgery, McGill University, Montreal, QC, Canada, ⁸JSS Medical Research, Montreal, QC, Canada, ⁹19 Green belt Dr, Janssen Inc., Toronto, ON, Canada, ¹⁰Janssen Inc., Toronto, ON, Canada, ¹¹Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Although remission remains the ultimate treatment goal in psoriatic arthritis (PsA) management, minimal disease activity (MDA), which encompasses remission and low disease activity, constitutes…
Abstract Number: 959 • 2016 ACR/ARHP Annual Meeting
Efficacy and Safety of Ixekizumab in Patients with Active Psoriatic Arthritis: 52 Week Results from a Phase 3 Study
Philip J Mease¹, Masato Okada², Mitsumasa Kishimoto², Catherine L. Shuler³, Hilde Carlier³, Chen-Yen Lin³, Jiani Mou³, Susan R Moriarty³, Chin H. Lee³ and Dafna D Gladman⁴, ¹Rheumatology and Internal Medicine, Swedish Medical Center and University of Washington, Seattle, WA, ²Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ³Eli Lilly and Company, Indianapolis, IN, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Ixekizumab (IXE) is an IgG4 monoclonal antibody that binds with high affinity and specificity to the proinflammatory cytokine IL-17A. In this phase 3 study…
Abstract Number: 1691 • 2016 ACR/ARHP Annual Meeting
The Comparative Immunogenicity of Biologic Therapy and Its Clinical Relevance in Psoriatic Arthritis: A Systematic Review of the Literature
Alejandro Balsa¹, Sadiq Lula², Lisa Marshall³, Piotr Szczypa⁴ and Laraine Aikman⁵, ¹Rheumatology, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain, ²Envision Pharma Group, London, United Kingdom, ³Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ⁴Pfizer Ltd, Sandwich, United Kingdom, ⁵Pfizer Ltd, Walton Oaks, United Kingdom
Background/Purpose: Anti-inflammatory biologic agents have been shown to provide significant benefit in controlling disease activity in psoriatic arthritis (PsA) and inhibiting progression of joint damage.…
Abstract Number: 2757 • 2016 ACR/ARHP Annual Meeting
Secukinumab Provides Sustained Improvements in the Signs and Symptoms of Active Psoriatic Arthritis: 104 Weeks Results from a Phase 3 Trial
Iain B McInnes¹, Philip J Mease², Christopher T. Ritchlin³, Proton Rahman⁴, Alice B Gottlieb⁵, Bruce Kirkham⁶, Radhika Kajekar⁷, Evie Maria Delicha⁸, Luminita Pricop⁹ and Shephard Mpofu⁸, ¹University of Glasgow, Glasgow, Great Britain, ²Swedish Medical Center and University of Washington, Seattle, WA, ³Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ⁵Tufts University School of Medicine, Boston, MA, ⁶Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, ⁷One Health Plaza, Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Secukinumab, a fully human anti–IL-17A monoclonal antibody, significantly improved signs and symptoms of psoriatic arthritis (PsA) over 52 weeks (wks) in FUTURE 2 study (NCT01752634).1,2 Here…
Abstract Number: 1322 • 2016 ACR/ARHP Annual Meeting
Use of Biologics in Arthritis Patients with Hepatitis B and C ‏: A Multicentral Retrospective Case Series
Sultana Abdulaziz¹, Hessein Halabi², Mohammed Omair³, Suzan Attar⁴, Mohammed Shabrawishi⁵, Abdulwahab Neyazi⁶, Haneen Alnazzawi⁷, Noha Meraiani⁸ and Hani Almoallim⁹, ¹Dept of Medicine/Unit of Rheumatology, King Fahad Hospital, Jeddah, Saudi Arabia, ²Department of Medicine, King Faisal Specialist Hospital,, Jeddah, Saudi Arabia, ³Dept of Medicine, Div of Rheumatology, King Saud University, Riyadh, Saudi Arabia, ⁴Internal Medicine, FRCPC, ABIM, Professor in Medicine, Jeddah, Saudi Arabia, ⁵Department of Medicine, King Faisal Specialist Hospital, Jeddah, Saudi Arabia, ⁶Department of Medicine, King Abdullah Medical City, Jeddah, Saudi Arabia, ⁷King Faisal Specialist Hospital, JEDDAH, Saudi Arabia, ⁸Department of Medicine, National Guard Hospital, JEDDAH, Saudi Arabia, ⁹Department of Medicine, Umm Alqura University, Makkah, Saudi Arabia, Makkah, Saudi Arabia
Use of biologics in arthritis patients with Hepatitis B and C ‏: a multicentral retrospective case series Abstract Background/Purpose: Reactivation of viral hepatitis B…
Abstract Number: 1702 • 2016 ACR/ARHP Annual Meeting
Baseline Patient Characteristics Associated with Response to Biologic Therapy in Patients with Psoriatic Arthritis Enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry
Philip J Mease¹, Chitra Karki², Mei Liu², Arthur Kavanaugh³, Christopher T. Ritchlin⁴, Doquyen H. Huynh³, Renganayaki Pandurengan², Jacqueline B. Palmer⁵ and Jeffrey D. Greenberg^2,6, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Corrona, LLC, Southborough, MA, ³University of California San Diego, La Jolla, CA, ⁴Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶New York University School of Medicine, New York, NY
Background/Purpose: The objective of this analysis was to investigate differences in baseline demographic and clinical characteristics of patients with psoriatic arthritis (PsA) who responded to…
Abstract Number: 2763 • 2016 ACR/ARHP Annual Meeting
New Treatment Option for SAPHO?
Jan Leipe¹, Dorothee Hauler², Johanna Meier¹, Matthias Witt¹, Mathias Grunke¹, Claudia Dechant³ and Hendrik Schulze-Koops¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, munich, Germany, ³Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease characterized by inflammatory osteoarticular and cutaneous manifestations. Despite improvements in…

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