Abstracts tagged "Biologics and rheumatoid arthritis (RA)"

Abstract Number: 2832 • 2017 ACR/ARHP Annual Meeting
Finding the Optimal Treatment Strategy for Disease Activity-Guided Dose Reduction of Adalimumab and Etanercept in Rheumatoid Arthritis: A Modelling Study
D.P.G. Bos¹, L.M. Verhoef¹, C.H.M. van den Ende^1,2, F.H.J. van den Hoogen^1,2, Bruno Fautrel^3,4, M.E.J.L. Hulscher⁵, W. Kievit⁶ and A.A. Den Broeder^1,2, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Rheumatology, Radboud university medical centre, Nijmegen, Netherlands, ³UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ⁴Paris VI Pierre et Marie Curie University, Paris, France, ⁵Radboud Institute for Health Sciences, IQ healthcare, Radboud university medical centre, Nijmegen, Netherlands, ⁶Department for Health Evidence, Radboud university medical centre, Nijmegen, Netherlands
Background/Purpose: Although bDMARDs are often able to control the RA, they are expensive and associated with adverse effects. Therefore, it is important to use the…
Abstract Number: 599 • 2016 ACR/ARHP Annual Meeting
Real World United States-Based Clinical Experience with Prior Biologic Use Among First Time Golimumab Intravenous and Infliximab Treated Rheumatoid Arthritis Patients
Sergio Schwartzman¹, Dennis Parenti², Shawn Black², Kehzen Tang³, Yanli Wang³ and Shelly Kafka², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Janssen Scientific Affairs, LLC, Horsham, PA, ³Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: AWARE (Comparative and Pragmatic Study of Golimumab IV Versus Infliximab in Rheumatoid Arthritis) is a Phase 4 comparator study designed to provide a real-world…
Abstract Number: 1611 • 2016 ACR/ARHP Annual Meeting
In Vitro Cellular Profiling of Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, Reveals a Distinct Phenotypic Signature Compared to Tocilizumab, an Anti–IL-6 Receptor Monoclonal Antibody
Konstantia-Maria Chavele¹, Debbie Gardner², Matthew J Loza², Bidisha Dasgupta², Martin Sims¹, David Shealy², Juliet Reid¹ and Ravi Rao¹, ¹GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom, ²Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: IL-6 plays a central pathogenic role in rheumatoid arthritis (RA). IL-6 signals through a complex of transmembrane IL-6R or soluble IL-6R (sIL-6R) with gp130…
Abstract Number: 444 • 2015 ACR/ARHP Annual Meeting
TNF Inhibitor Use Across Countries in Two Time Periods Using the Meteor Database
Karen Salomon-Escoto¹, Nisha Kini¹, Sharina D. Person¹, J.A.P. da Silva², Gianfranco Ferraccioli³, T. W. J. Huizinga⁴, Robert B.M. Landewé⁵, RJ Moots⁶, D. van der Heijde⁷, Douglas J. Veale⁸, Ellen M. Gravallese¹ and Jonathan Kay¹, ¹University of Massachussets Medical School, Worcester, MA, ²Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal, ³Rheumatology and Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy, ⁴Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ⁶Department of Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: Biologic agents are effective treatment for rheumatoid arthritis (RA), but factors exist that may influence the prescription of these drugs in different countries. We…
Abstract Number: 1649 • 2015 ACR/ARHP Annual Meeting
Long-Term Safety and Efficacy of Olokizumab in Patients with Moderate-to-Severe Rheumatoid Arthritis Who Have Previously Failed Anti-TNF Treatment
Mark C. Genovese¹, Roy Fleischmann², Yoshiya Tanaka³, Daniel E. Furst⁴, Hisashi Yamanaka⁵, Rajesh Joshi⁶, Wei Zhu⁷, Jing Shao⁸, Hideki Mashimo⁸ and Tsutomu Takeuchi⁹, ¹Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA, ²Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Department of Medicine, Dallas, TX, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁶Quintiles Inc., Mumbai, India, ⁷UCB Pharma, Raleigh, NC, ⁸UCB Pharma, Tokyo, Japan, ⁹Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Olokizumab (OKZ) is a humanized anti-interleukin-6 monoclonal antibody in development for moderate-to-severe rheumatoid arthritis (RA) treatment. OKZ efficacy and safety were assessed in the…
Abstract Number: 2775 • 2015 ACR/ARHP Annual Meeting
What Factors Are Associated with Starting an Intravenous Vs. Sub-Cutaneous Biologic in Patients with RA?
Kaleb Michaud^1,2, Sofia Pedro² and Steven Peterson³, ¹Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Janssen Global Services, LLC, Malvern, PA
Background/Purpose: To characterize which factors are associated with RA patients' preferences for biologic administration: sub-cutaneous or intravenous.Methods: Using a large US observational cohort, the National…
Abstract Number: 499 • 2014 ACR/ARHP Annual Meeting
Biologic Discontinuation in Rheumatoid Arthritis: Experience from a Canadian Clinic
Denis Choquette¹, Louis Coupal¹, Marie-Claude Laliberté² and Olivier Desjardins², ¹Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ²AbbVie, St. Laurent, QC, Canada
Background/Purpose: Adherence and persistence to treatment are a cornerstone of treatment success in chronic diseases such as rheumatoid arthritis (RA). The purpose of this study…
Abstract Number: 2529 • 2014 ACR/ARHP Annual Meeting
Efficacy of Infliximab, Adalimumab, and Tocilizumab Can be Improved Under the Baseline ADAMTS5 Selection
Kensei Tsuzaka^1,2, Yoko Akiyama² and Masayoshi Nagata¹, ¹Division of Rheumatology, Iruma Heart Hospital, Iruma, Saitama, Japan, ²Kaytee Bio, Co&Ltd, Funabashi, Chiba, Japan
a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) mRNA level. In this study presented here, we investigated whether the efficacy of these biologics could…
Abstract Number: 996 • 2014 ACR/ARHP Annual Meeting
Memory B Cell Subtype Modulation in Patients with Rheumatoid Arthritis
Zafar Mahmood¹, Marc Schmalzing², Thomas Dörner³ and Hans-Peter Tony², ¹Rheumatology and Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, ³Charité Universitätmedizin Berlin and DRFZ, Berlin, Germany
Background/Purpose . Memory B cells have been shown to play important roles in the pathogenesis of rheumatoid arthritis (RA). With the advent of B cell…
Abstract Number: 466 • 2013 ACR/ARHP Annual Meeting
Biologic Monotherapy in French Rheumatoid Arthritis (RA) Patients From a Real-Life Clinical Practice Compared To Patients Treated with a Combination Therapy (Biologic + DMARD)
Philippe Dieude¹, Chantal Deslandre², Emilie Desfleurs³, Jeanne Antheaume³ and Jean-Charles Balblanc⁴, ¹Rheumatology, Rheumatology departement & INSERM U699, Paris Diderot university, APHP, Bichat hospital, Paris, France, ²Rheumatology, Cochin Hospital, Paris, France, ³Rheumatology, Roche SAS, Boulogne-Billancourt, France, ⁴Rheumatology, Centre Hospitalier Général de Belfort, Belfort, France
Background/Purpose: Combination therapy (Biologic+non-biologic (nb)DMARDs) is the recommended therapeutic strategy in biologic-based RA treatment. However, biologics in montherapy represent around 30% of the biologic-treated patients…
Abstract Number: 435 • 2013 ACR/ARHP Annual Meeting
Final 5-Year Safety and Efficacy Results Of a Phase 3, Randomized, Placebo-Controlled Trial Of Golimumab In Methotrexate-naïve Patients With Rheumatoid Arthritis
Paul Emery¹, Roy Fleischmann², Ingrid Strusberg³, Patrick Durez⁴, Peter Nash⁵, Eric Amante⁶, Melvin A. Churchill⁷, Won Park⁸, Bernardo Pons-Estel⁹, Chenglong Han¹⁰, Timothy A. Gathany¹⁰, Yiying Zhou¹¹, Stephen Xu¹² and Elizabeth C. Hsia¹², ¹Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and NIHR LMBRU, Leeds, United Kingdom, ²University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ³Instituto Reumatológico Strusberg, Cordoba, Argentina, ⁴Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, ⁵University of Queensland, Brisbane, Australia, ⁶University of Phillipines General Hospital, Manila, Philippines, ⁷Arthritis Center of Nebraska, Lincoln, NE, ⁸Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, ⁹Sanatorio Parque, Rosario, Argentina, ¹⁰Janssen Global Services, LLC., Malvern, PA, ¹¹Biostatistics, Janssen Research & Development, LLC., Spring House, PA, ¹²Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: Final 5yr safety and efficacy results of subcutaneous golimumab (GLM)+/-MTX evaluated in a phase 3 trial (GO-BEFORE) of MTX-naïve pts with rheumatoid arthritis (RA)…

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