ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 1277 • ACR Convergence 2025

    Combination Therapy with Rituximab and Cyclophosphamide for Treating Pediatric Patients with Severe Manifestations of Rheumatic Disease

    Eileen Rife1, Daniel Reiff2, John Bridges3, Emily Smitherman1, randy Cron1, Matthew Stoll1, Melissa Mannion1, Peter Weiser4 and Livie Timmerman5, 1University of Alabama at Birmingham, birmingham, AL, 2Boys Town Hospital, Omaha, 3University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, 4University of Alabama at Birmingham, Birmingham, 5University of Alabama at Birmingham, Gardendale, AL

    Background/Purpose: Current practice guidelines recommend either rituximab (RTX) or cyclophosphamide (CYC) for treatment of organ-threatening manifestations of systemic vasculitis or connective tissue disease (e.g., diffuse…
  • Abstract Number: 1437 • ACR Convergence 2025

    Characterization of ORKA-002, a Novel Extended Half-life Monoclonal Antibody Targeting IL-17A/F for the Treatment of Psoriasis and Other Indications

    Byron Kwan1, Joseph Merola2, Andrew Blauvelt3, Daniel Rios1, Joana Ministro1, Jacob Milligan1, Ghassan Fayad1, Christopher Finch4, Eugenia Levi5, Joseph Senn5, Jason Oh1 and Hussam Shaheen1, 1Paragon Therapeutics, Waltham, MA, 2UT Southwestern Medical Center, Dallas, TX, 3Blauvelt Consulting, LLC, Annapolis, MD, 4Oruka Therapeutics, Menlo Park, CA, 5Oruka Therapeutics, Waltham, MA

    Background/Purpose: Interleukin 17 (IL-17) is a pro-inflammatory cytokine that has been implicated in the pathogenesis of multiple autoimmune conditions, including psoriasis and psoriatic arthritis (PsA).…
  • Abstract Number: 1536 • ACR Convergence 2025

    Evaluating Systemic Lupus Erythematosus Remission Among Patients Initiating Belimumab in a Real-World Setting in the USA

    Aarat M Patel1, Renee L. Gennarelli2, Temitope Bello2, Ali Bonakdar2 and Karen Worley3, 1GSK, US Medical Affairs, Durham, NC, 2Cencora, Real-World Evidence, Conshohocken, PA, 3GSK, Global Real-World Evidence & Health Outcomes Research, Collegeville, PA

    Background/Purpose: The Definition Of Remission In SLE (DORIS) criteria were developed to provide alignment on defining remission in patients with SLE.1,2 Belimumab (BEL) treatment increases…
  • Abstract Number: 1878 • ACR Convergence 2025

    Customized Therapy for SLE: How Disease Severity Influences the Use of Corticosteroids and Biologics in Patients with SLE in the Lupus Federated Data Network (LupusNet) and a US Claims Database

    Ashley Orillion1, Federico Zazzetti2, Anna Sheahan3, Clair Blacketer1, Michel van Speybroeck4, Sarah Gasman1, Reyhan Sonmez5, Erika Noss1, Manuel Ugarte-Gil6, Rocío Gamboa-Cárdenas7, Víctor Pimentel-Quiroz8, Kaleb Michaud9, Patti Katz10, Rangi Kandane-Rathnayake11, Eric Morand12, Worawit Louthrenoo13, Alberta Hoi14, Yi-Hsing Chen15, Jiacai Cho16, Laniyati Hamijoyo17, Shue Fen Luo18, Sandra Navarra19, Mandana Nikpour20, José María Pego-Reigosa21, Iñigo Rúa-Figueroa22, Zulema Plaza23, María Galindo-Izquierdo24, Julia Martínez Barrio25, Jaime Calvo26, Antonio Fernández-Nebro27, Raúl Menor Almagro28, EVA GLORIA TOMERO MURIEL29, Javier Narváez30 and Chetan S. Karyekar31, 1Johnson & Johnson, Spring House, PA, USA, Spring House, PA, 2Johnson & Johnson, Horsham, PA, USA, Ambler, PA, 3Johnson & Johnson, Horsham, PA, USA, Horhsam, PA, 4Johnson & Johnson, Beerse, Belgium, Beerse, Belgium, 5Capgemini Consulting, Zurich, Switzerland, Zurich, Switzerland, 6Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru; Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, Lima, Peru, 7Universidad Científica del Sur, Lima, Peru, 8Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Perú; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú, Lima, Peru, 9University of Nebraska Medical Center, Omaha, NE, 10UCSF, San Rafael, CA, 11Center for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia, 12Centre for Inflammatory Diseases, Monash University and Monash Health, Melbourne, Victoria, Australia, 13Chiang Mai University Hospital, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai, Thailand, Chiang Mai, Thailand, 14Centre for Inflammatory Diseases, Monash University and Department of Rheumatology, Monash Health, Clayton, Victoria, Australia, 15Taichung Veterans General Hospital, Division of Allergy, Immunology and Rheumatology, Taichung, Taiwan, Taichung, Taiwan (Republic of China), 16National University Hospital, Rheumatology Division, Department of Medicine, Singapore, Singapore, Singapore, Singapore, 17Padjadjaran University/Hasan Sadikin General Hospital, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Bandung, Indonesia, Badung, Indonesia, 18Chang Gung Memorial Hospital, Chang Gung University, Department of Rheumatology, Allergy and Immunology, Taipei, Taiwan, Taoyuan, Taiwan (Republic of China), 19University of Santo Tomas, Manila, Philippines, 20University of Sydney, School of Public Health, Faculty of Medicine and Health, Sydney, New South Wales, Australia; St Vincent’s Hospital Melbourne, Department of Rheumatology, Fitzroy, Victoria, Australia, Melbourne, Victoria, Australia, 21Department of Rheumatology, University Hospital of Vigo, Vigo, Spain; IRIDIS Group (Investigation in Rheumatology and Immune-Diseases), Galicia Sur Health Research Institute, Vigo, Spain, 22Hospital de Gran Canaria Doctor Negrin, Las Palmas GC, Spain, 23Research Unit, Spanish Society of Rheumatology, Madrid, Spain, Madrid, Spain, 24Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, Madrid, Madrid, Spain, 25Department of Rheumatology, Hospital Gregorio Marañón, Madrid, Spain, Madrid, Madrid, Spain, 26Department of Rheumatology, Hospital Universitario Araba, School of Medicne, Universidad del País Vasco, BIOARABA Health Research Institute, Vitoria, Spain, Vitoria, Pais Vasco, Spain, 27Hospital Regional Universitario de Malaga, Malaga, Spain, Malaga, Spain, 28Department of Rheumatology, Hospital de Jerez, Spain, Puerto De Santa María, Spain, 29Hospital Universitario de la Princesa, Madrid, Spain, 30Hospital Universitario de Bellvitge, Barcelona, Spain, 31Johnson & Johnson, Spring House, PA, USA, Spring House

    Background/Purpose: The management of SLE varies worldwide. Current SLE treatment goals focus on preventing flares, controlling disease activity, and preventing organ damage accrual. LupusNet is…
  • Abstract Number: 2280 • ACR Convergence 2025

    Changes of B Cell Subsets During Treatment with Abatacept in Patients with Rheumatoid Arthritis

    Athanasios Mavropoulos1, Christos Liaskos2, Ioannis Alexiou3, Christina Katsiari4, Dimitrios Bogdanos5 and Lazaros Sakkas6, 1University of Thessaly, Volos, Greece, 2University of Thessaly, Faculty of Medicine, Larisa, Greece, 3University General Hospital of larissa, Larissa, Greece, 4University General Hospital of Larisa, University of Thessaly Faculty of Medicine, Larisa, Greece, 5Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece, 6Department of Rheumatology, University of Thessaly, Larissa, Greece

    Background/Purpose: Abatacept, an efficacious therapy for rheumatoid arthritis (RA), inhibits the interaction between CD28 on T cells and CD80/CD86 on antigen-presenting cells (APCs). The aim…
  • Abstract Number: 2447 • ACR Convergence 2025

    Longitudinal Disease Activity Trajectories in Patients with Systemic Lupus Erythematosus Treated with Belimumab

    Fumin Qi1, Yin Zhao2, Wei Bian1, Jian Hao1, Na zhang1 and Wei Wei1, 1Tianjin Medical University General Hospital, Tianjin, China (People's Republic), 2Affiliated Hospital of Yunnan University, Yunnan, China (People's Republic)

    Background/Purpose: To investigate the longitudinal disease activity trajectories in patients with systemic lupus erythematosus (SLE) treated with belimumab.Methods: A prospective cohort of SLE treated with…
  • Abstract Number: 2610 • ACR Convergence 2025

    Imaging remission in aortitis associated with giant cell arteritis. Multicenter study with tocilizumab in monotherapy and combined therapy

    Adrian Martin-Gutierrez1, Javier Loricera2, Diana Prieto-Peña3, Vicente Aldasoro Cáceres4, Olga Maiz5, Eugenio de Miguel6, Eva Galíndez Agirregoikoa7, Ivan Ferraz Amaro8, Santos Castañeda9 and Ricardo Blanco10, 1Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain., Renedo de Piélagos, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander , Spain, Santander, Spain, 3Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain., Santander, Spain, 4Hospital Universitario de Navarra, Pamplona, Spain, 5Hospital Universitario de Donosti, Donostia, Spain, 6Hospital Universitario La Paz, Madrid, Spain, 7BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 8Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 9Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 10Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain

    Background/Purpose: Aortitis is a frequent and potential severe complication of giant cell arteritis (GCA)(GCA-aortitis). Tocilizumab (TCZ) was approved for the treatment of GCA, but its…
  • Abstract Number: 0153 • ACR Convergence 2025

    Patient Experience and Implementation of an Electronic Patient-Reported Outcome Measures (ePROM) System for Remote Monitoring in BIOBADASER

    Isabel Castrejón Fernández1, Lucia Otero2, Antonio Mera-Valera3, Alicia Garcia4, Silvia Gomez-Sabater5, Raquel Martín-Domenech6, Jose Alvaro-Gracia7, Juan Camilo Sarmiento-Monroy8, Beatriz Ventosa2 and Fernando Sánchez-Alonso9, 1Department of Rheumatology. Hospital General Universitario Gregorio Marañon. IiSGM. Universidad Complutense Madrid, Madrid, Spain, 2Spanish Society of Rheumatology, Madrid, Spain, 3H. Clínico Universitario de Santiago, Santiago de Compostela, 4Rheumatologist, La Laguna, Spain, 5Rheumatology Department, Dr. Balmis General University Hospital, Alicante, Spain., Alicante, Spain, 6H. Universitario de Elda, Elda, Spain, 7Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Faculty of Medicine, Complutense University of Madrid, Madrid, Spain, 8Hospital Clínic Barcelona, Barcelona, Spain, 9Sociedad Española de Reumatología, Madrid, Spain

    Background/Purpose: Patient-Reported Outcome Measures (PROMs) are integral to shared decision-making and quality improvement in rheumatology. They are recommended for monitoring treatment response, assessing quality of…
  • Abstract Number: 0479 • ACR Convergence 2025

    Risk of Arrhythmias Following IL-6 Inhibitor Use; A Pharmacosurvellience Study of FDA Adverse Event Reporting System (FAERS)

    Asim Khanfar1, Omar Hamdan2, Shiamak Cooper3, Sanjana Thimmannagari1 and Anthony Ocon4, 1Rochester General Hospital, Rochester, NY, 2University of Jordan, Az-Zarqa, Jordan, 3Rochester General Hospital, Irondequoit, NY, 4Rochester Regional Health, Fairport, NY

    Background/Purpose: Interleukin-6 (IL-6) inhibitors, including tocilizumab and sarilumab, are immunomodulatory agents commonly used in the treatment of rheumatoid arthritis and COVID-19. Prior studies have implicated…
  • Abstract Number: 0801 • ACR Convergence 2025

    Achieving Sustained Lupus Low Disease Activity State and Remission With Ianalumab (VAY736) in Patients with Systemic Lupus Erythematosus: A post hoc Analysis From a Phase II Study

    Eric Morand1, Corine Gaillez2, Stephen Oliver3, Swati Ghanshani4, Marilia Pozzobon5, Weibin Bao6 and Ed Vital7, 1Centre for Inflammatory Diseases, Monash University and Monash Health, Melbourne, Victoria, Australia, 2Novartis Pharma AG, Basel, Switzerland, Croissy Sur Seine, France, 3Novartis Pharma AG, Basel, Switzerland, 4Novartis Healthcare Private Limited, Hyderabad, India, Hyderabad, India, 5Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland, 6Novartis Pharmaceuticals Corporation, Hanover, NJ, 7University of Leeds, Leeds, England, United Kingdom

    Background/Purpose: Ianalumab, a fully human monoclonal antibody against the B cell–activating factor receptor (BAFF-R), has a dual mechanism of action of B cell depletion through…
  • Abstract Number: 0585 • ACR Convergence 2025

    Fungal Infections, Including Candida, in Patients With Active Axial Spondyloarthritis Treated With Secukinumab: A Pooled Analysis of 10 Phase 3 Trials

    Shikha Singla1, Linda Grinnell-Merrick2, Weibin Bao3, Artem Zharkov4 and Abhijeet Danve5, 1Medical College of Wisconsin, Milwaukee, WI, 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, Hanover, NJ, 4Novartis Pharma AG, Basel, Switzerland, 5Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT

    Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic disease characterized by inflammatory low back pain and is often accompanied by inflammation of the peripheral joints and…
  • Abstract Number: 1065 • ACR Convergence 2025

    Age of Disease Onset and Risk of Serious Infection with anti-TNF Use in Older Adults with Rheumatoid Arthritis

    Jiha Lee1, Sofia Pedro2 and Kaleb Michaud3, 1University of Michigan, Ann Arbor, MI, 2Forward, The National Databank for Rheumatic Diseases, Wichita, KS, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Older age is a recognized risk factor for serious infection (SI) associated with anti-TNF therapy in rheumatoid arthritis (RA). Among older adults with RA,…
  • Abstract Number: 1282 • ACR Convergence 2025

    Real-world use of belimumab in childhood-onset SLE in Spain: cross-sectional analysis from a multicenter study (JULES registry)

    Alina-Lucica Boteanu1, Clara Udaondo2, Joan Calzada3, Daniel Clemente Garulo4, Juan Carlos Nieto Gonzáles5, Eugenia Enriquez6, inmaculada Calvo Penades7, Lourdes Villalobos8, Belen Sevilla9, Sara Murias10, Berta Magallares11, Ana Capilla12, Jaime Arroyo13, Beatriz Bravo14, Gisela Diez-Cordoves15, Marisol Camacho16, Genaro grana17, Juan Jose Bethencourt18, Pablo Mesa19, Natalia Palmou20, Mireia Lopez Corbeto21, Judith Sanchez22, Maria Isabel Gonzalez23, isabel Patora Granados bautista24, Clara Moriano25, Diego Dios17, Lorena Exposito26, Alicia Garcia27, Laura Martin28, David Fernandez29, Laura Trujillo14, Anahy Maria Brandy30 and CARLOS GUILLEN-ASTETE31, 1H.U. Ramón y Cajal, Madrid, Spain, 2La Paz University Hospital, Madrid, Spain, 3University Hospital Sant Joan de Deu, Barcelona, Spain, 4H.U Niño Jesús, Madrid, Spain, 5H.U Gregorio Marañón, Madrid, Spain, 6Clínica Universidad de Navarra, Madrid, Spain, 7Pediatric Rheumatology Department. HUP La Fe, Valencia, Spain, 8Ramon y Cajal Hospital, MADRID, Spain, 9Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, 10H.U Central de Asturias, Oviedo, Spain, 11Hospital de Sant Pau, Bareclona, 12H.U de La Merced, Sevilla, Spain, 13HOSPITAL UNIVERSITARIO LA PAZ, MADRID, 14H.U Virgen de Las Nieves, Granada, Spain, 15H. R. U. Malaga, Malaga, Spain, 16H.U. Virgen del Rocío, Sevilla, Spain, 17H.U de A Coruña, A Coruña, Spain, 18H.U. Canarias, Canarias, Spain, 19H.U Virgen de la Arrixaca, Murcia, Spain, 20H.U. marques de Valdecilla, Santander, Spain, 21H.U Vall d´Hebron, Barcelona, Spain, 22Pediatric Rheumatology Department, Taulí Hospital Universitari-Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Sabadell (Spain)., Sabadell, Spain, 23H.U. La Fé, Valencia, Spain, 24H.U Toledo, Toledo, Spain, 25Hospital León, LEON, Castilla y Leon, Spain, 26H.U Canarias, Canarias, Spain, 27Rheumatologist, La Laguna, Spain, 28H.R.U Malaga, Malaga, Spain, 29Complejo Hospitalario Universitario de Vigo, Vigo, Galicia, Spain, 30Hospital Germans Trias i Pujol, Badalona, Spain, 31H.U Ramón y Cajal, Madrid, Spain

    Background/Purpose: SLE is a multisystemic autoimmune disease with several manifestations. Childhood-onset SLE (cSLE) has a more severe disease course than adult-onset SLE, with a higher…
  • Abstract Number: 1439 • ACR Convergence 2025

    Bimekizumab in Psoriatic Arthritis. A real-world prospective study. Comparison of its efficacy in bDMARD-naive and IL-17A-experienced patients

    Vassiliki Poulia1, Eleni Sampatakaki2, Dimitrios Katsifis-Nezis3, Maria Pappa3, Evangelia Mole4, Sousana Gazi4, Elpida Skouvaklidou5, Nikolaos Kougkas5, Maria Polyzou6, Loukia Koutsogeorgopoulou6, Ioannis Xynogalas7, Anastasios Karamanakos7, Konstantinos D Vassilakis1, Evangelos Papadimitriou8, Charalampos Papagoras8, Gerasimos Evangelatos9, Nafsika Gerolymatou10, Paraskevi V Voulgari10 and George E Fragoulis1, 1First Department of Propedeutic and Internal Medicine, Joint Academic Rheumatology program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 2Joint Academic Rheumatology Program, Attikon University Hospital, National and Kapodistrian University of Athens, School of Medicine, 4th Department of Internal Medicine, Athens, Greece, Athens, Attiki, Greece, 3Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 4Rheumatology department, KAT General Hospital of Attica, Athens, Attiki, Greece, 54th Department of Internal Medicine, Aristotle University, Thessaloniki, Thessaloniki, Greece, 6Department of Pathophysiology, Joint Academic Rheumatology program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 7Department of Rheumatology, Evangelismos General Hospital, Athens, Attiki, Greece, 8First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Evros, Greece, 9Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Attiki, Greece, 10Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Ioannina, Greece

    Background/Purpose: Bimekizumab, a dual IL-17 A and F blocker, has recently been added in the therapeutic rheumatologist’s armamentarium of PsA, but real-world evidence is lacking.…
  • Abstract Number: 1545 • ACR Convergence 2025

    Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: Interim Analysis of a Phase 3 Randomized Placebo-controlled Study

    Susan Manzi1, Ian Bruce2, Eric Morand3, Richard Furie4, Yoshiya Tanaka5, Patricia Puzio6, Emon Khan7, Jenny Wissmar8, Michael Song9 and Catharina Lindholm10, 1Lupus Center of Excellence, Autoimmunity Institute, Allegheny Health Network, Pittsburgh, PA, 2Centre for Public Health, Faculty of Medicine, Health and Life Sciences, Queen's University, Belfast, Manchester, United Kingdom, 3Centre for Inflammatory Diseases, Monash University and Monash Health, Melbourne, Victoria, Australia, 4Division of Rheumatology, Northwell Health, Great Neck, NY, 5University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 6BioPharmaceuticals R&D, AstraZeneca US, Gaithersburg, MD, 7BioPharmaceuticals R&D, Late Respiratory and Immunology, AstraZeneca, Academy House, Cambridge, United Kingdom, 8BioPharmaceuticals R&D, Late-Stage Development, Respiratory & Immunology, AstraZeneca, Gothenburg, Sweden, 9BioPharmaceuticals R&D, Late Clinical Development Immunology, AstraZeneca, Boston, MA, 10BioPharmaceuticals R&D, Late Clinical Development Immunology, AstraZeneca, Gothenburg, Sweden

    Background/Purpose: Intravenous (IV) anifrolumab (300 mg, every 4 weeks [Q4W]) is an approved biologic add-on therapy for moderate to severe SLE;1 a subcutaneous (SC) formulation…
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All abstracts accepted to PRYSM are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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