ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 0577 • ACR Convergence 2025

    Persistence and Effectiveness Across PsA Patient Subgroups with Guselkumab and IL-17 Inhibitors: 6-Month Results of the PsABIOnd Observational Study

    Laure Gossec1, Mohamed Sharaf2, Xenofon Baraliakos3, mitsumasa kishimoto4, Ruben Queiro5, Ennio Lubrano6, Emmanouil Rampakakis7, László Köleséri8, Karissa Lozenski9, Enrique R. Soriano10, Proton Rahman11, Frank Behrens12 and Stefan Siebert13, 1Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 2Janssen - Johnson & Johnson, Dubai, United Arab Emirates, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 4Kyorin University School of Medicine, Tokyo, Japan, 5Hospital Universitario Central de Asturias, Oviedo. Asturias, Spain, 6Department of Medicine, Università deglia Studi del Molise, CAMPOBASSO, Italy, 7JSS Medical Research, Montréal, QC, Canada, 8IQVIA, Budapest, Hungary, 9Johnson & Johnson, Horsham, PA, 10Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires and University Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 11Division of Rheumatology, Craig L. Dobbin Genetics Research Centre, Discipline of Medicine, Memorial University of Newfoundland, St. John's, Canada, 12Goethe-University & Fraunhofer ITMP, Frankfurt, Germany, 13University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Randomized controlled trials have demonstrated the efficacy of IL-23 inhibitors (i) and IL-17i in PsA; however, real-world data on their effectiveness in heterogeneous patient…
  • Abstract Number: 0780 • ACR Convergence 2025

    Baseline Pharmacodynamic Markers and Response to Emapalumab in Children and Adults with Macrophage Activation Syndrome (MAS) in Still’s Disease: Results from a Pooled Analysis of Two Prospective Trials

    Edward Behrens1, Sebastiaan Vastert2, Jordi anton3, Pierre Quartier4, Bruno Fautrel5, Paul Brogan6, Melissa Elder7, Francesca Minoia8, Pavla Dolezalova9, Robert Biesen10, Masaki Shimizu11, Uwe Ullmann12, Adnan Mahmood13, Andrew Danquah12, Elena Burillo12, Marco Petrimpol12, Steve Mallett14, Brian Jamieson15, Alexiei GROM16 and Fabrizio De Benedetti17, 1CHOP, West Chester, PA, 2University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 3Hospital Sant Joan de Düu. Universitat de Barcelona, Barcelona, Spain, 4Hôpital Necker-Enfants Malades, Paris, France, 5Sorbonne Université - APHP, Department of Rheumatology, Hôpital Pitié-Salpêtrière, Inserm UMRS 1136-5, PARIS, France, Paris, France, 6Great Ormond Street Hospital for Children NHS Foundation Trust and University College London Great Ormond Street Institute of Child Health, London, United Kingdom, 7College of Medicine and Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of Florida, GAINESVILLE, FL, 8Pediatric Immuno-Rheumatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, 9Paediatric Rheumatology and Autoinflammatory Diseases Unit, General University Hospital, Prague, Czech Republic, 10Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany, 11Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 12Sobi, Basel, Switzerland, 13Sobi, Stockholm, Sweden, 14Sobi, Stock, Sweden, 15Sobi Inc., Morrisville, NC, 16Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, 17Bambino Gesu Children's Hospital, Rome, Rome, Italy

    Background/Purpose: MAS is a life-threatening complication of Still’s disease, characterized by IFNg-driven macrophage activation and systemic hyperinflammation. Chemokine C-X-C motif ligand 9 (CXCL9) is released…
  • Abstract Number: 0475 • ACR Convergence 2025

    Drug Discontinuation in Inflammatory Arthritis Following Mandatory Non-Medical Switching from Originator to Biosimilar in Quebec, Canada

    Cristiano Moura1, Luck Lukusa2, Denis Choquette3, Gilles Boire4, Nathalie Carrier5, Autumn Neville2 and Sasha Bernatsky6, 1Research Institute of the McGill University Health Center, Montréal, Canada, 2Research Institute of the McGill University Health Centre, Montreal, Canada, 3Institut de Rhumatologie de Montréal, Saint-Donat-de-Montcalm, Canada, 4Retired, Sherbrooke, QC, Canada, 5Centre integré universitaire de santé et de services sociaux de l’Estrie – Centre hospitalier universitaire de Sherbrooke (CIUSSS de l’Estrie-CHUS), Sherbrooke, Canada, 6Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: In April 2022, the Canadian province of Quebec introduced a mandatory non-medical switch to biosimilars for persons on bio-originators to manage healthcare costs. Our…
  • Abstract Number: 0014 • ACR Convergence 2025

    NKX019, an allogeneic off-the-shelf CD19 targeting CAR-NK cell therapy, induces deep CD19+ B cell depletion in hematological malignancy and models of autoimmune disease

    Mira Tohmé, Meriam Vejiga, Wendy Yu, Emily Kang, Katharine Yu, Jessica Sood, Ivan Chan, Kyle Hansen, David Shook and Phung Gip, Nkarta, South San Francisco, CA

    Background/Purpose: Autologous CAR T-cell therapies have remarkable clinical activity in autoimmune disease (AD) via B-cell targeting, with many patients achieving durable, drug-free remission. However, safety…
  • Abstract Number: 2610 • ACR Convergence 2025

    Imaging remission in aortitis associated with giant cell arteritis. Multicenter study with tocilizumab in monotherapy and combined therapy

    Adrian Martin-Gutierrez1, Javier Loricera2, Diana Prieto-Peña3, Vicente Aldasoro Cáceres4, Olga Maiz5, Eugenio de Miguel6, Eva Galíndez Agirregoikoa7, Ivan Ferraz Amaro8, Santos Castañeda9 and Ricardo Blanco10, 1Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain., Renedo de Piélagos, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander , Spain, Santander, Spain, 3Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain., Santander, Spain, 4Hospital Universitario de Navarra, Pamplona, Spain, 5Hospital Universitario de Donosti, Donostia, Spain, 6Hospital Universitario La Paz, Madrid, Spain, 7BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 8Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 9Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 10Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain

    Background/Purpose: Aortitis is a frequent and potential severe complication of giant cell arteritis (GCA)(GCA-aortitis). Tocilizumab (TCZ) was approved for the treatment of GCA, but its…
  • Abstract Number: 2450 • ACR Convergence 2025

    Spanish Real-World Ambispective Multicenter Registry of Anifrolumab in Systemic Lupus Erythematosus: Efficacy and Safety at 3- and 6-Month Follow-Up (ANIFRO-Reu Study)

    Irene Carrión-Barberà1, Tarek Salman Montes2, Laura Triginer3, Judit Font-Urgelles4, Anne Riveros frutos5, Sandra Garrote Corral6, Maria Garcia-Villanueva7, Carlos de Frías Polo8, María Galindo-Izquierdo9, Berta Magallares10, Andrea Hernández-martín11, Jorge Juan Fragío Gil12, Sebastián Sandoval Moreno13, Consuelo Ramos Giraldez14, Josefina Cortés-Hernández15, Elvira Díez García16, Clara Moriano17, Paloma Vela Casasempere18, M.Pilar Bernabeu Gonzalvez19, Irene Altabás-González20, Samuel Hernández-Baldizón21, Leyre Riancho22, Inmaculada Ros Vilamajo21, Carlos Marras Fernández-Cid23, Maria Piqueras García24, Angel Garcia-Aparicio25, marta Garijo Bufort26, José Gomez-Puerta27, Beatriz Frade Sosa28, Silvia García Cirera29, Vicenç Torrente-Segarra30, Luis Sala31, Concepción Fito-Manteca32, Natividad del Val del amo33, Julia Martínez Barrio34, Jose Rosas Gómez de Salazar35, Sergi Heredia36, ana Urruticoechea-Arana37, Anahy Maria Brandy38, Maria Esther Uriarte39, José María Pego-Reigosa40 and Iñigo Rúa-Figueroa41, 1Department of Rheumatology. Hospital del Mar, Barcelona, Spain, 2Hospital del Mar/Parc de Salut Mar-IMIM, Barcelona, Spain, 3Hospital del Mar, Barcelona, Spain, 4Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 5Hospital Germans Trias i Pujol, Barcelona, Spain, 6Hospital Ramón y Cajal, Madrid, 7Hospital Ramón y Cajal, Madrid, Spain, 8Hospital Universitario 12 de octubre, Madrid, Spain, 9Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, Madrid, Madrid, Spain, 10Hospital de Sant Pau, Bareclona, 11Hospital Universitario de Gran Canaria Dr Negrín, Las palmas, Spain, 12Hospital General Universitario, Valencia, Spain, 13Hospital Universitario Vall d’Hebron, Barcelona, Spain, 14Hospital Universitario Virgen de Valme, Servicio de Reumatología, Seville, Spain, 15Hospital Universitari Vall d’Hebron-Universitat Autónoma de Barcelona, Barcelona, Spain, 16Complejo Asistencial Universitario de León, León, Spain, 17Hospital León, LEON, Castilla y Leon, Spain, 18Hospital General Universitario Alicante, Alicante, Comunidad Valenciana, Spain, 19Rheumatology Department, Dr. Balmis General University Hospital, Alicante, Spain., Alicante, Spain, 20Complejo Hospitalario de Vigo, Vigo, Spain, 21Hospital Son Llàtzer, Palma de Mallorca, Spain, 22Hospital de Sierrallana, Torrelavega, 23Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 24Servicio Murciano de Salud, Murcia, Spain, 25Hospital Universitario de Toledo, Toledo, Spain, 26Rheumatology Department, Hospital de Sagunto, Spain, Valencia, Spain, 27Rheumatology Department, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 28Hospital Clinic de Barcelona, Barcelona, Catalonia, Spain, 29Consorci Coporació Sanitaria Parc Taulí, Sabadell, Spain, 30Hospital Comarcal Alt Penedés Garraf, Vilafranca del Penedès, Spain, 31Hospital Universitario de Torrejón, Madrid, Spain, 32Rheumatology. Hospital Universitario de Navarra., Pamplona, Navarra, Spain, 33Complejo Universitario de Navarra, Navarra, Spain, 34Department of Rheumatology, Hospital Gregorio Marañón, Madrid, Spain, Madrid, Madrid, Spain, 35Hospital Marina Baixa, PALMA DE MALLORCA, Spain, 36Hospital Moisès Broggi, Barcelona, Spain, 37Rheumatology Division. Hospital Universitario Son Espases, Palma de Mallorca, Spain, 38Hospital Germans Trias i Pujol, Badalona, Spain, 39Hospital Universitario Donostia, San Sebastian, Spain, 40Department of Rheumatology, University Hospital of Vigo, Vigo, Spain; IRIDIS Group (Investigation in Rheumatology and Immune-Diseases), Galicia Sur Health Research Institute, Vigo, Spain, 41Hospital de Gran Canaria Doctor Negrin, Las Palmas GC, Spain

    Background/Purpose: Anifrolumab is a biologic recently approved for systemic lupus erythematosus (SLE), with efficacy shown in trials, but data from real-world practice remain limited. The…
  • Abstract Number: 2287 • ACR Convergence 2025

    Interpretable Ensemble Machine Learning Explaining Nonadherence and the Risk of Nonpersistence of Targeted Disease-Modifying Antirheumatic Agents in Older Adults with Rheumatoid Arthritis

    yinan huang1 and Sandeep Agarwal2, 1Department of Pharmacy Administration, University of Mississippi, Oxford, MS, US, MS, 2Baylor College of Medicine, Houston

    Background/Purpose: Interpretable machine learning (ML) method can identify factors associated with biological or targeted synthetic disease modifying antirheumatic drugs (b/tsDMARDs) nonadherence and nonpersistence for rheumatoid…
  • Abstract Number: 1921 • ACR Convergence 2025

    Re-escalation of Treatment in Older Adults with Rheumatoid Arthritis After Anti-TNF Therapy De-escalation

    Jiha Lee1, Jonathan Martindale2, Una Makris3 and Julie Bynum2, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, 3UT Southwestern Medical Center and Dallas VA, Dallas, TX

    Background/Purpose: Older adults with rheumatoid arthritis (RA) treated with biologic disease-modifying antirheumatic drugs (bDMARDs), including anti-TNFs, are at an increased risk of adverse effects. Current…
  • Abstract Number: 1545 • ACR Convergence 2025

    Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: Interim Analysis of a Phase 3 Randomized Placebo-controlled Study

    Susan Manzi1, Ian Bruce2, Eric Morand3, Richard Furie4, Yoshiya Tanaka5, Patricia Puzio6, Emon Khan7, Jenny Wissmar8, Michael Song9 and Catharina Lindholm10, 1Lupus Center of Excellence, Autoimmunity Institute, Allegheny Health Network, Pittsburgh, PA, 2Centre for Public Health, Faculty of Medicine, Health and Life Sciences, Queen's University, Belfast, Manchester, United Kingdom, 3Centre for Inflammatory Diseases, Monash University and Monash Health, Melbourne, Victoria, Australia, 4Division of Rheumatology, Northwell Health, Great Neck, NY, 5University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 6BioPharmaceuticals R&D, AstraZeneca US, Gaithersburg, MD, 7BioPharmaceuticals R&D, Late Respiratory and Immunology, AstraZeneca, Academy House, Cambridge, United Kingdom, 8BioPharmaceuticals R&D, Late-Stage Development, Respiratory & Immunology, AstraZeneca, Gothenburg, Sweden, 9BioPharmaceuticals R&D, Late Clinical Development Immunology, AstraZeneca, Boston, MA, 10BioPharmaceuticals R&D, Late Clinical Development Immunology, AstraZeneca, Gothenburg, Sweden

    Background/Purpose: Intravenous (IV) anifrolumab (300 mg, every 4 weeks [Q4W]) is an approved biologic add-on therapy for moderate to severe SLE;1 a subcutaneous (SC) formulation…
  • Abstract Number: 1439 • ACR Convergence 2025

    Bimekizumab in Psoriatic Arthritis. A real-world prospective study. Comparison of its efficacy in bDMARD-naive and IL-17A-experienced patients

    Vassiliki Poulia1, Eleni Sampatakaki2, Dimitrios Katsifis-Nezis3, Maria Pappa3, Evangelia Mole4, Sousana Gazi4, Elpida Skouvaklidou5, Nikolaos Kougkas5, Maria Polyzou6, Loukia Koutsogeorgopoulou6, Ioannis Xynogalas7, Anastasios Karamanakos7, Konstantinos D Vassilakis1, Evangelos Papadimitriou8, Charalampos Papagoras8, Gerasimos Evangelatos9, Nafsika Gerolymatou10, Paraskevi V Voulgari10 and George E Fragoulis1, 1First Department of Propedeutic and Internal Medicine, Joint Academic Rheumatology program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 2Joint Academic Rheumatology Program, Attikon University Hospital, National and Kapodistrian University of Athens, School of Medicine, 4th Department of Internal Medicine, Athens, Greece, Athens, Attiki, Greece, 3Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 4Rheumatology department, KAT General Hospital of Attica, Athens, Attiki, Greece, 54th Department of Internal Medicine, Aristotle University, Thessaloniki, Thessaloniki, Greece, 6Department of Pathophysiology, Joint Academic Rheumatology program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 7Department of Rheumatology, Evangelismos General Hospital, Athens, Attiki, Greece, 8First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Evros, Greece, 9Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Attiki, Greece, 10Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Ioannina, Greece

    Background/Purpose: Bimekizumab, a dual IL-17 A and F blocker, has recently been added in the therapeutic rheumatologist’s armamentarium of PsA, but real-world evidence is lacking.…
  • Abstract Number: 1282 • ACR Convergence 2025

    Real-world use of belimumab in childhood-onset SLE in Spain: cross-sectional analysis from a multicenter study (JULES registry)

    Alina-Lucica Boteanu1, Clara Udaondo2, Joan Calzada3, Daniel Clemente Garulo4, Juan Carlos Nieto Gonzáles5, Eugenia Enriquez6, inmaculada Calvo Penades7, Lourdes Villalobos8, Belen Sevilla9, Sara Murias10, Berta Magallares11, Ana Capilla12, Jaime Arroyo13, Beatriz Bravo14, Gisela Diez-Cordoves15, Marisol Camacho16, Genaro grana17, Juan Jose Bethencourt18, Pablo Mesa19, Natalia Palmou20, Mireia Lopez Corbeto21, Judith Sanchez22, Maria Isabel Gonzalez23, isabel Patora Granados bautista24, Clara Moriano25, Diego Dios17, Lorena Exposito26, Alicia Garcia27, Laura Martin28, David Fernandez29, Laura Trujillo14, Anahy Maria Brandy30 and CARLOS GUILLEN-ASTETE31, 1H.U. Ramón y Cajal, Madrid, Spain, 2La Paz University Hospital, Madrid, Spain, 3University Hospital Sant Joan de Deu, Barcelona, Spain, 4H.U Niño Jesús, Madrid, Spain, 5H.U Gregorio Marañón, Madrid, Spain, 6Clínica Universidad de Navarra, Madrid, Spain, 7Pediatric Rheumatology Department. HUP La Fe, Valencia, Spain, 8Ramon y Cajal Hospital, MADRID, Spain, 9Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, 10H.U Central de Asturias, Oviedo, Spain, 11Hospital de Sant Pau, Bareclona, 12H.U de La Merced, Sevilla, Spain, 13HOSPITAL UNIVERSITARIO LA PAZ, MADRID, 14H.U Virgen de Las Nieves, Granada, Spain, 15H. R. U. Malaga, Malaga, Spain, 16H.U. Virgen del Rocío, Sevilla, Spain, 17H.U de A Coruña, A Coruña, Spain, 18H.U. Canarias, Canarias, Spain, 19H.U Virgen de la Arrixaca, Murcia, Spain, 20H.U. marques de Valdecilla, Santander, Spain, 21H.U Vall d´Hebron, Barcelona, Spain, 22Pediatric Rheumatology Department, Taulí Hospital Universitari-Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Sabadell (Spain)., Sabadell, Spain, 23H.U. La Fé, Valencia, Spain, 24H.U Toledo, Toledo, Spain, 25Hospital León, LEON, Castilla y Leon, Spain, 26H.U Canarias, Canarias, Spain, 27Rheumatologist, La Laguna, Spain, 28H.R.U Malaga, Malaga, Spain, 29Complejo Hospitalario Universitario de Vigo, Vigo, Galicia, Spain, 30Hospital Germans Trias i Pujol, Badalona, Spain, 31H.U Ramón y Cajal, Madrid, Spain

    Background/Purpose: SLE is a multisystemic autoimmune disease with several manifestations. Childhood-onset SLE (cSLE) has a more severe disease course than adult-onset SLE, with a higher…
  • Abstract Number: 1055 • ACR Convergence 2025

    The Price of Relief: Examining the Role of Insurance in High-Cost Medication Use

    Antara Dattagupta1, Colin Diffie2 and Sana Cheema2, 1Washington University in St. Louis, St. Louis, MO, 2Washington University in St. Louis, St. Louis

    Background/Purpose: High-cost biologic therapies are integral to the management of rheumatoid arthritis (RA), yet access to these agents may be influenced by insurance type, particularly…
  • Abstract Number: 0574 • ACR Convergence 2025

    Bimekizumab 3-Year Efficacy In Patients With Psoriasis And Risk Factors For Progression To Psoriatic Arthritis Or Screening Positive For Psoriatic Arthritis: Long-Term Results From Five Phase 3/3b Trials

    Richard G. Langley1, Joseph F Merola2, Diamant Thaçi3, Emi Nishida4, Bruce Strober5, Richard B. Warren6, José M. López Pinto7, Christina Crater8, Sarah Kavanagh8 and Paolo Gisondi9, 1Dalhousie University, Halifax, NS, Canada, 2Department of Dermatology and Department of Medicine, UT Southwestern Medical Center, Dallas, TX, 3Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany, 4Nagoya City West Medical Center, Nagoya, Japan, 5Department of Dermatology, Yale University, New Haven, and Central Connecticut Dermatology Research, Cromwell, CT, 6Dermatology Centre, Northern Care Alliance, NHS Foundation Trust & Division of Musculoskeletal and Dermatological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 7UCB, Madrid, Spain, 8UCB, Morrisville, NC, 9Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy

    Background/Purpose: Psoriatic arthritis (PsA) affects up to one-third of patients with psoriasis;1 early identification and intervention for patients with psoriasis and risk factors (RFs) for…
  • Abstract Number: 0779 • ACR Convergence 2025

    Interim Results of a Randomized Placebo Controlled Study of IL-1 Inhibitor Goflikicept in Patients With Familial Mediterranean Fever

    Olga Uhanova1, serdal Ugurlu2, Mikhail Kostik3, Tamara Sarkisyan4, Anna Yeghiazaryan4, Lidiya Lysenko5, Vilen Rameev5, Omer Karadag6, Valentina Vardanyan7, Veli Yazisiz8, Tatiana Sotnikova9, Vyacheslav Podsvirov1, Alina Egorova10, Daria Bukhanova10, Sergey Grishin10, Tolga Tuncel11, Mikhail Samsonov10 and Ahmet Gul12, 1Terafarm LLC, Stavropol, Russia, 2Istanbul University-Cerrahpasa, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 3Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 4Center of Medical Genetics and Primary Health Care LTD, Yerevan, Armenia, 5Sechenov’s 1st State Moscow Medical University, Moscow, Russia, 6Division of Rheumatology, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey, 7Ecosense Diagnostic Center, Yerevan, Armenia, 8Akdeniz University, Faculty of Medicine, Antalya, Turkey, 9State Budgetary Institution of Healthcare of Moscow Multispeciality Hospital named after S.P. Botkin of the Moscow City and Sechenov University, Moscow, Russia, 10R-Pharm JSC, Moscow, Russia, 11TRpharm, Istanbul, Turkey, 12Istanbul University, Istanbul Faculty of Medicine, Division of Rheumatology, Istanbul, Istanbul, Turkey

    Background/Purpose: Goflikicept (GFC; RPH-104) is a novel fusion protein inhibiting interleukin-1 (IL-1). This study aimed to investigate its efficacy and safety in IL-1β-driven monogenic autoinflammatory…
  • Abstract Number: 0474 • ACR Convergence 2025

    Real-World Experience of Janus Kinase Inhibitors; Retention and Factors Associated with Discontinuation

    Joseph Nathan1, Bayram Farisogullari2, Nicholas Jones3, Mohammad Ayoub3, James Brown3, Sarah Levy3, James Brader4, Ayse Ersoy4, Blossom Israni4, Mark Lloyd4, Afzal Latheef5, Diane Hill5, Amybel Taylor6, Darshani Arachchige6, Hlaing Chitsu6, Helen Linklater6, Kunal Lather7, Luke Gompels7, Eman Elfar8, Ritu Malaiya8, Pedro Machado9 and Patrick Kiely10, 1St George's Hospital, London, United Kingdom, 2University College London, London, 3Croydon Health Services NHS Trust, Croydon, England, United Kingdom, 4Frimley Health NHS Foundation Trust, Frimley, England, United Kingdom, 5St George's University Hospitals NHS Foundation Trust, London, England, United Kingdom, 6Surrey and Sussex Healthcare NHS Trust, Redhill, England, United Kingdom, 7Somerset NHS Foundation Trust, Taunton, England, United Kingdom, 8Epsom and St Helier University Hospitals NHS Trust, Carshalton, England, United Kingdom, 9Department of Rheumatology, University College London, and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 10St George's University Hospitals NHS Foundation Trust, London, United Kingdom

    Background/Purpose: The use of Janus Kinase inhibitors (JAKi) to treat RA and PsA in a real-world setting has not been well described. Our aim was…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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