ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 2662 • ACR Convergence 2025

    Target trial emulation of biologic and targeted synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis-associated interstitial lung disease

    Gregory McDermott1, Daniel Solomon2, Jeffrey Sparks3 and Rishi Desai3, 1Brigham and Women's Hospital, Brookline, MA, 2Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: RA-ILD is associated with high mortality, but the optimal treatment approach is unclear. While immunosuppressants may treat inflammatory components of ILD, there are concerns…
  • Abstract Number: 0180 • ACR Convergence 2025

    Digital Transformation in IMID Care: Results from the Implementation of IMIDOC

    JOSE INIESTA-CHAMORRO1, Marta Novella-Navarro2, Diego Benavent3, HELENA BORREL-PAÑOS4, Xabier Michelena Vegas5, Javier Bachiller6, Verónica García García7, ESTHER ESPARTAL4, LETICIA LOJO-OLIVEIRA8, Enrique Calvo-Aranda9, José Rodríguez gago10, Gema Bonilla11, Irene Monjo Henry2, Victoria Navarro-Compan12, Jaime Arroyo10, Eugenio de Miguel2, Mariana Díaz-Almirón13, cARMEN ALEGRE10, ENRIQUE J GÓMEZ14 and Chamaida Plasencia-Rodríguez2, 11Biomedical Engineering and Telemedicine Centre, ETSIT, Center for Biomedical Technology, Universidad Politéctica de Madrid, TELEMEDICINE, MADRID, 2Hospital Universitario La Paz, Madrid, Spain, 3Hospital Universitari de Bellvitge, Madrid, Spain, 44HOSPITAL UNIVERSITARIO VALL D´HEBRON, RHEUMATOLOGY, BARCELONA, Spain,, BARCELONA, 5Hospital Universitari Vall Hebron, Barcelona, Spain, 6Hospital Ramon y Cajal, Madrid, Madrid, Spain, 7Ramón y Cajal University Hospital, MADRID, Spain, 8Hospital Universitario Infanta Leonor, Madrid, Spain, 9Department of Rheumatology, Hospital Universitario Infanta Leonor / Universidad Complutense de Madrid, Madrid, Spain, madrid, 10Hospital Universitario La Paz, MADRID, 11Hospital Universitario La Paz, Rheumatology, Madrid, Madrid, Spain, 12Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, 13LIMA, Advanced Medical Informatics Lab, La Paz Research Institute, IdiPAZ, Madrid, Spain, 141Biomedical Engineering and Telemedicine Centre, ETSIT, Center for Biomedical Technology, Universidad Politéctica de Madrid, TELEMEDICINE, MADRID, Spain,, MADRID

    Background/Purpose: Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are immune-mediated inflammatory diseases (IMIDs) characterized by joint and spinal inflammation, leading to functional impairment. Their management requires…
  • Abstract Number: 0484 • ACR Convergence 2025

    Comparable Efficacy of FK-Tocilizumab and Reference Tocilizumab in Rheumatoid Arthritis Patients With and Without Prior Biologic Exposure

    Ernest Choy1, Marco Gattorno2, Kamila Klama3, Andras Illes4, Peter Baker5, Maria Romanova Michailidi6 and Anna Zubrzycka-Sienkiewicz7, 1Division of Infection and Immunity, CREATE Centre, Cardiff University, Cardiff, United Kingdom, 2IRCCS G. Gaslini, Genova, Genoa, Italy, 3Solumed Clinical Research Center, Poznan, Poland, 4Fresenius Kabi SwissBioSim, Eysin, Switzerland, 5Fresenius Kabi Biopharma, Eysins, Switzerland, 6University of Geneva, Eysins, Switzerland, 7Reumatika - Centrum Reumatologii, Warszawa, Poland

    Background/Purpose: Biosimilars offer comparable efficacy and safety to their originators, thereby improving patient access to affordable treatments. FK-Tocilizumab (FK-toci) is the first tocilizumab biosimilar approved…
  • Abstract Number: 0803 • ACR Convergence 2025

    Improved Efficacy and Safety Outcomes in Patients with SLE Treated with Belimumab (BEL) Versus Immunosuppressants (IS), in Addition to Antimalarials (AM) and Glucocorticoids (GC): A Post Hoc Summary of Five Phase 3 Trials

    Mariele Gatto1, Karen H. Costenbader2, Andreas Schwarting3, Julia Harris4, Ciara O'Shea5, Roger A. Levy6 and Andrea Doria7, 1Academic Rheumatology Centre, Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Turin, Italy, 2Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 3Johannes Gutenberg University Mainz, University Medical Centre, Mainz, Germany, 4GSK, Biostatistics, London, United Kingdom, 5Global Medical Affairs, GSK, Dublin, Ireland, 6GSK, Specialty Care, Global Medical Affairs, Collegeville, PA, 7University of Padova, Padova, Italy

    Background/Purpose: Chronic GC and IS use increases damage accrual and mortality. The 2023 EULAR SLE recommendations support initiation of biologics such as BEL, a human…
  • Abstract Number: 0588 • ACR Convergence 2025

    The effect of biological and targeted synthetic DMARDs on peripheral manifestations in axial spondyloarthritis: a systematic literature review

    Casper Webers1, AUGUSTA ORTOLAN2, Elena Nikiphorou3, Alexandre Sepriano4, Louise Falzon5, Clementina López Medina6, Dafne capelusnik7, Désirée Van Der Heijde8, Anna Molto9 and Sofia Ramiro10, 1Maastricht University Medical Centre, Maastricht, Netherlands, 2Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy, 3King's College London, London, United Kingdom, 4Department of Rheumatology, Leiden University Medical Centre, Portela Loures, Portugal, 5Sheffield Centre for Health and Related Research, University of Sheffield, Sheffield, United Kingdom, 6Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain, 7Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Assistance Publique Hôpitauxde Paris, Paris, France, 10Leiden University Medical Center, Bunde, Netherlands

    Background/Purpose: In axial spondyloarthritis (axSpA), peripheral musculoskeletal manifestations (peripheral arthritis, enthesitis, dactylitis) are common and contribute to the burden of disease. Our objective was to…
  • Abstract Number: 1090 • ACR Convergence 2025

    Quantitative Immunoglobulin Screening Prior to Rituximab Initiation: A Retrospective Cohort Study

    Amelia Khoo and Anokhi Saklecha, Yale University, New Haven, CT

    Background/Purpose: Rituximab, a monoclonal antibody which binds to the CD20 antigen of B cells, is used in the treatment of many rheumatologic conditions. Due to…
  • Abstract Number: 1312 • ACR Convergence 2025

    Evolution of patients with active rheumatoid arthritis: analysis of disease activity trajectories in a tertiary‑care rheumatology department

    Elodie Portier1, Olivier Fogel2, Terkia Medkour3, Sophie Hecquet3 and Jérôme AVOUAC3, 1Rheumatology department, Bicetre hospital, Le Kremlin Bicetre, France, 2AP-HP, Paris, France, 3Rheumatology department, Cochin hospital, Paris, France

    Background/Purpose: The objective of this study was to identify clusters of patients with rheumatoid arthritis (RA) in clinical practice, according to evolution of disease activity…
  • Abstract Number: 1446 • ACR Convergence 2025

    Persistence of Second-line Treatment in Anti-TNF-experienced Axial Spondyloarthritis Patients: Comparing Cycling Anti–TNF vs Switching to a Different Mechanism of Action

    José Miguel Senabre1, Lucia Otero2, Jerusalén Calvo3, Vega Jovaní4, Javier Manero-Ruiz5, Rabadán Elena6, Eugenia Enriquez7, Yanira Pérez8, Alicia Garcia9, Francisca Sivera10, Olga Martínez11, María Colazo Burlato12, Diana Sueiro13, Fernando Sánchez-Alonso14 and Isabel Castrejón Fernández15, 1Hospital Marina Baixa, Villajoyosa/Vila Joiosa, La, Comunidad Valenciana, Spain, 2Spanish Society of Rheumatology, Madrid, Spain, 3IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, 4Hospital General Universitario de Alicante, Reumatología, Alicante, Alicante, Comunidad Valenciana, Spain, 5Hospital Miguel Servet, Zaragoza, Spain, 6Hospital Universitario Príncipe de Asturias, Alcala de Henares, Spain, 7Clínica Universidad de Navarra, Madrid, Spain, 8Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain, 9Rheumatologist, La Laguna, Spain, 10Hospital General Universitario Elda, Elda, Spain, 11Hospital Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, 12Hospital Universitario de Burgos, Burgos, Spain, 13Complexo Hospitalario Universitario de Ourense, Ourense, 14Sociedad Española de Reumatología, Madrid, Spain, 15MD, PhD, Madrid, Madrid, Spain

    Background/Purpose: Failure of a first-line anti-TNF in axial spondyloarthritis (axSpA) is common, and when it occurs, there are no randomized clinical trials (RCTs) comparing the…
  • Abstract Number: 1548 • ACR Convergence 2025

    Anifrolumab In Systemic Lupus Erythematosus. Spanish Multicenter Registry In Clinical Practice

    Vanesa Calvo-Río1, Carmen Secada-Gómez1, Miriam Retuerto Guerrero2, Judit Font-Urgelles3, Ivette Casafont-Solé3, Adrián Mayo-Juanatey4, Juan José Alegre-Sancho5, DALIFER FREITES6, Cristina Hormigos Martin7, Noemí Garrido8, GUILLERMO GONZALEZ ARRIBAS9, Juan Roberto Miguelez Sanchez10, Andrea García-Valle11, Marta Ibañez12, Fernando Lozano Morillo13, Ángel García Manzanares14, Sebastián Sandoval-Moreno15, Josefina Cortés-Hernández16, Deseada Palma-Sanchez17, LETICIA LOJO-OLIVEIRA18, Evelin Cervantes19, Paz Collado Ramos20, cristina arciniega Larios21, Luis Sala22, Eztizen Labrador-Sánchez23, Cilia Peralta-Ginés24, Nahia Plaza-Aulestia25, Irati Urionaguena Onaindia26, Miguel Medina Malone27, Jose Rosas Gómez de Salazar28, Montserrat Corteguera29, Laura Cebrian30, Fred Anton Pages31, Jose Ramón Lamua-Riazuelo32, María Dolores Fábregas Canales33, María José Alados Hernández34, Marta Garijo Bufort35, Anna Pamies36, Luis Sarabia37, Rodrigo Aguirre-del-Pino38, José Ángel Cabezas Lefler39, alvaro seijas38, Carmen Carrasco-Cubero40, Ana López-Cerón Cofiño41, Vera Ortiz-Santamaria42, Santos Castañeda43, Maria Laino44, Carmen Ordás Calvo45, Celia arconada46, ana Urruticoechea-Arana47, Blanca Garcia-Magallon48, Ana Valeria Acosta Alfaro49, Samuel Leal Rodriguez50, Marina Salido Olivares7, Patricia Lavilla Villar51, Anahy Maria Brandy3, Inmaculada Ros Vilamajo52, Alvaro García Martos53, Berta Magallares54, Guillen Sada Urmeneta55, Cristina Córdoba Martín56, Elena Riera Alonso57, Carmen Bejerano-Herreria58 and Ricardo Blanco,<58, 1Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain, 2Complejo Asistencial Universitario de Leon, Leon, Castilla y Leon, Spain, 3Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 4Hospital Universitario Doctor Peset, Valencia, Comunidad Valenciana, Spain, 5Hospital Universitario Doctor Peset, Valencia, Spain, 6Rheumatology Service, San Carlos Clinical Hospital, Madrid, Madrid, Spain, 7Hospital Clínico San Carlos, Madrid, Spain, 8Hospital Universitario Virgen del Rocío, Sevilla, Andalucia, Spain, 9Facultativo especialista, PALMA DE MALLORCA, Galicia, Spain, 10Department of Rheumatology, Hospital Universtiario de Móstoles, Madrid, Spain, Madrid, Madrid, Spain, 11Rheumatology. Hospital General Río Carrión, Palencia, Castilla y Leon, Spain, 12Hospital Universitario de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain, 13Hospital Central de La Defensa Gómez Ulla, Madrid, Madrid, Spain, 14Hospital Universitario de Torrevieja, Alicante, Spain, 15Hospital Universitario Vall D'Hebron, Barcelona, Spain, 16Hospital Universitari Vall d’Hebron-Universitat Autónoma de Barcelona, Barcelona, Spain, 17Rheumatology. Hospital Rafael Méndez, Lorca, Murcia, Spain, 18Hospital Universitario Infanta Leonor, Madrid, Spain, 19Hospital Provincial de Pontevedra, Pontevedra, Spain, 20Department of Rheumatology, Hospital Universitario Severo Ochoa, Madrid, Spain,, MADRID, Madrid, Spain, 21Hospital de Mérida, Badajoz, Spain, 22Hospital Universitario de Torrejón, Madrid, Spain, 23Hospital General de La Rioja, Logroño, Spain, 24Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 25Hospital Galdakao, Vizcaya, Spain, 26Rheumatology.Hospital Galdakao, Vizcaya, Pais Vasco, Spain, 27Hospital de Calahorra, Calahorra, Spain, 28Hospital Marina Baixa, PALMA DE MALLORCA, Spain, 29Rheumatology. Complejo Asistencial de Ávila, Ávila, Castilla y Leon, Spain, 30Department of Rheumatology, Hospital Universitario Infanta Leonor / Universidad Complutense de Madrid, Madrid, Spain, Madrid, Spain, 31Hospital General de Segovia, Segovia, Spain, 32Hospital Universitario del Henares, Madrid, Spain, 33Hospital de Barbastro, Huesca, Spain, 34Hospital Universitario Puerta del Mar, Cadiz, Spain, 35Hospital de Sagunto, Valencia, Spain, 36Hospital Verge de la Cinta, Tortosa, Tarragona, Spain, 37Complejo Hospitalario de Jaén, Jaén, Spain, 38Hospital Universitario Lucus Augusti, Lugo, Spain, 39Complejo Asistencial de Zamora, Zamora, Spain, 40Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 41Hospital Santa Bárbara, Soria, Spain, 42Hospital General de Granollers, Barcelona, Spain, 43Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 44Hospital Universitario de Navarra, Pamplona, Spain, 45Hospital Universitario de Cabueñes, Gijón, Spain, 46Hospital universitario de Getafe, Getafe, Madrid, Spain, 47Rheumatology Division. Hospital Universitario Son Espases, Palma de Mallorca, Spain, 48Rheumatology, Hospital Universitario Puerta de Hierro, Madrid, Spain, 49Hospital Universitario Infanta Sofia; Universidad Europea de Madrid; FIIB HUIS-HUHEN, Madrid, Spain, 50Hospital Universitario La Fe, Valencia, Valencia, Spain, 51Hospital General de Villalba, Collado Villalba, Madrid, Spain, 52Hospital Son Llàtzer, Palma de Mallorca, Spain, 53Hospital del Tajo, Aranjuez, Madrid, Spain, 54Hospital de Sant Pau, Barcelona, Spain, 55Rheumatology, Hospital Reina Sofía, Tudela, Spain, 56Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Tenerife, Spain, 57Hospital Universitari Mùtua Terrassa, Terrassa, Spain, 58Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain.

    Background/Purpose: Anifrolumab (ANI) is a human monoclonal antibody that binds to the type I interferon receptor subunit 1 (IFNAR1). ANI was approved by Spanish authorities…
  • Abstract Number: 1992 • ACR Convergence 2025

    Tolerance of Methotrexate Coadministered with Pegloticase in Patients with Uncontrolled Gout: Findings from MIRROR RCT

    Vinicius Domingues1, Alexis Woods2, Xiaoqing Yang3, Brian Lamoreaux4 and Michael Weinblatt5, 1Rheumatology, Allergy, Asthma & Arthritis Center, Daytona beach, FL, 2Amgen, Detroit, MI, 3Amgen, Seattle, WA, 4Amgen, Inc., Deerfield, IL, 5Brigham and Women's Hospital/ Harvard Medical School, Waban, MA

    Background/Purpose: Methotrexate (MTX) coadministered with pegloticase attenuates anti-drug antibody formation, leading to higher response rates and markedly reduced infusion reaction risk compared with pegloticase +…
  • Abstract Number: 2299 • ACR Convergence 2025

    Real-world clinical effectiveness of rituximab rescue therapy in patients with progressive interstitial lung disease associated with primary sjögren’s syndrome

    Paula Estrada-Alarcón1, Delia Reina2, JUAN JOSE ALEGRE SANCHO3, Montserrat Roig Kim4, martí Aguilar-Coll5, Laia De Daniel Bisbe4, Aina Fabregat5, Monica Cubells5 and Javier Narváez6, 1Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 2Complex Hospitalari Universitari Moisès Broggi, Barcelona, Spain, 3Department of rheumatology. Hospital Universitario Doctor Peset, Valencia, Spain, 4Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, 5Hospital Universitari de Bellvitge, Barcelona, Spain, 6Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose: To evaluate the real-world, long-term effectiveness of rituximab (RTX) as rescue therapy in patients with primary Sjögren’s syndrome-associated interstitial lung disease (pSS-ILD).Methods: Multicentre observational…
  • Abstract Number: 2453 • ACR Convergence 2025

    Belimumab Is Associated with Lower Risk of Progression to LN Compared with Standard of Care in Patients with SLE

    Maral DerSarkissian1, Yan Chen1, Ariel Chao1, Shumin Rui1, Bronwyn Moore2, Karen Worley3, Daniel Moldaver4, Jeffrey J. Ellis3 and Aarat M Patel5, 1Analysis Group, Los Angeles, CA, 2Analysis Group, Montreal, QC, Canada, 3GSK, Global Real-World Evidence & Health Outcomes Research, Collegeville, PA, 4GSK, Global Real-World Evidence & Health Outcomes Research, Toronto, ON, Canada, 5GSK, US Medical Affairs, Durham, NC

    Background/Purpose: LN develops in ~40% of patients with SLE and is associated with increased risk of morbidity, including end-stage kidney disease, and mortality. Belimumab, a…
  • Abstract Number: 2669 • ACR Convergence 2025

    RESET-Myositis: Clinical Trial Evaluating Rese-cel (Resecabtagene Autoleucel), A Fully Human, Autologous 4-1BB CD19-CAR T Cell Therapy in Idiopathic Inflammatory Myopathies

    Erin Wilfong1, Tahseen Mozaffar2, Elie Naddaf3, Nizar Chahin4, Huifang Lu5, Iazsmin Bauer Ventura6, Courtney Little7, Carl diCasoli7, Claire Miller8, Jenell Volkov7, Daniel Nunez7, Thomas Furmanak7, Jason Stadanlick7, Larissa Ishikawa7, Zachary Vorndran7, Alexandra Ellis7, Jazmean Williams7, Steve Flanagan7, Quynh Lam8, Fatemeh Hadi-Nezhad8, Raj Tummala8, Samik Basu7 and David Chang9, 1Vanderbilt University Medical Center, Nashville, TN, USA, Nashville, TN, 2University of California, irvine, Orange, CA, 3Mayo Clinic, Rochester, MN, 4Oregon Health & Science University, Portland, 5UT MD Anderson Cancer Center, Houston, TX, 6University of Chicago, Chicago, IL, 7Cabaletta Bio, Philadelphia, PA, 8Cabaletta Bio, Philadelphia, 9Cabaletta Bio, Bryn Mawr, PA

    Background/Purpose: The goals of treatment for idiopathic inflammatory myopathy (IIM) are to eliminate or reduce inflammation, restore muscle performance, reduce morbidity, and improve a patient’s…
  • Abstract Number: 0194 • ACR Convergence 2025

    Evaluation of a Home-based Therapeutics Service: Feasibility, Patient and Caregiver Experience, and Cost

    Xiaohui Xin, Andrea Low, Sow Ling Yee, Miao Miao Liu, Christina Tan, Daphne Ng and Siaw Ing Yeo, Singapore General Hospital, Singapore, Singapore

    Background/Purpose: The home-based therapeutics service (HTS) by a community nurse is part of an ongoing larger initiative—Community Therapeutics Programme (CTP)—spearheaded by the Rheumatology and Immunology…
  • Abstract Number: 0485 • ACR Convergence 2025

    Multicenter study on the use of Upadacitinib: Results in RA patients previously treated with Baricitinib

    Guillermo Gonzalez Mozo de Rosales1, Luis Maria Lopez-Dominguez2, Nerea Alcorta-Lorenzo3, oihane ibarguengoitia Barrena4, David Montero5, Ana Ruibal Escribano6, estibaliz barastay Alberdi7, Jesus Alejandro Valero Jaimes8, Libe Ibarrola9, Paula Garcia Escudero10, Marta Lopez I Gomez11, Eva Galindez Aguirregoicoa12 and Maria Luz Garcia Vivar13, 1Basurto University Hospital, Bilbao, Spain, 2Rheumatology Department, Donostia University Hospital., San Sebastián, Pais Vasco, Spain, 3Rheumatology Department, Donostia University Hospital., San Sebastian, Spain, 4Galdakao-Usansolo University Hospital, GALDAKAO, Spain, 5Galdakao-Usansolo University Hospital, Bilbao, Spain, 6Urduliz Hospital, Urduliz, Pais Vasco, Spain, 7Urduliz Hospital, Urduliz, Spain, 8Hospital Bidasoa, Irán, Spain, 9Galdakao-Usansolo University Hospital, Galdakao, 10H.U.Araba, Vitoria, 11Araba University Hospital, Vitoria, Pais Vasco, Spain, 12Basurto University Hospital, Bilbao, Pais Vasco, Spain, 13Basurto Hospital, Bilbao, Spain

    Background/Purpose: Rheumathoid Arthritis (RA) is a chronic inflammatory disease that affects the musculoskeletal system. Early and effective treatment is important to improve the quality of…
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All abstracts accepted to PRYSM are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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