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Abstracts tagged "Biologic drugs"

  • Abstract Number: 635 • 2016 ACR/ARHP Annual Meeting

    Factors Associated to Lack of Adherence to Subcutaneous Biological Medications in Patients with Rheumatoid Arthritis from Spain. Arco Study

    Jaime Calvo-Alen1, Indalecio Monteagudo2, Georgina Salvador Alarcón3, Enrique Raya Álvarez4, Loreto Carmona5, Luis Cea-Calvo6 and Carlos Marras Fernandez-Cid7, 1Rheumatology, Txagorritxu Hospital, Araba, Vitoria, Vitoria, Spain, 2Rheumatology Unit, HGU Gregorio Marañón, Madrid, Madrid, Spain, 3Rheumatology, HU Mutua de Terrassa, Barcelona, Terrassa, Spain, 4Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 5Instituto de Salud Musculoesquelética, Madrid, Spain, 6Medical Affairs Department, Merck Sharp & Dohme, Madrid, Spain, 7Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain

    Background/Purpose: To investigate the variables associated to lack of adherence to subcutaneous (SC) biological drug in patients with rheumatoid arthritis (RA) after 1 year of…
  • Abstract Number: 2540 • 2016 ACR/ARHP Annual Meeting

    The Longitudinal Impact of Biologic Use on Disability within a RA Registry

    N A Shadick1, Nicole Gerlanc2, M Frits1, Bradley S. Stolshek3, Brenna Brady2, Christine Iannaccone4, David Collier5, Jing Cui6, Alex Mutebi7 and Michael Weinblatt4, 1Brigham and Women's Hospital, Boston, MA, 2Health Analytics, LLC, Columbia, MD, 3Amgen, Thousand Oaks, CA, 4Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Amgen Inc., Thousand Oaks, CA, 6Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Global Health Economics, Amgen, Thousand Oaks, CA

    Background/Purpose: Biologics have become the standard of care for treating moderate to severe rheumatoid arthritis (RA) in patients with an inadequate response to small molecule…
  • Abstract Number: 636 • 2016 ACR/ARHP Annual Meeting

    Prospective, Intervention, Multicenter Study of Utility of Biologic Drug Monitoring with Respect to the Efficacy and Cost of Adalimumab Tapering in Patients with Rheumatic Diseases (34-week descriptive data)

    Iñigo Gorostiza1, Eduardo Úcar Angulo2, Catalina Gómez Arango2, Clara Eugenia Perez3, Juan Ramon De Dios4, Belen Alvarez4, Ana Ruibal Escribano4,5, Claudia Stoye4, Margarida Vasques4, Joaquin Belzunegui Otano6, Antonio Escobar7, Ziortza Trancho8, Ainhoa Ruiz del Agua9, Lorena Del Rio9, Antonio Martínez9 and Daniel Nagore9, 1Research Department, Hospital Universitario de Basurto, Bilbao, Spain, 2Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, 3Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain, 4Rheumatology, Hospital Universitario de Araba, Vitoria, Spain, 5Rheumatology, Hospital Universitario de Araba, Vittoria, Spain, 6Donostia University Hospital, San Sebastian, Spain, 7Unidad de Investigación, Red de Investigación en Servicios de Salud en enfermedades crónicas (REDISSEC), Hospital Universitario de Basurto, Bilbao, Spain, 8Unidad de Investigación, Hospital Universitario de Basurto, Bilbao, Spain, 9R&D, Progenika-Grifols, Derio, Spain

    Background/Purpose:  Adalimumab (ADL) dose tapering based on clinical assessment is a usual practice especially in patients who have achieved clinical remission. The primary aim of…
  • Abstract Number: 2551 • 2016 ACR/ARHP Annual Meeting

    Impact of Multmorbidity on Disability and Disease Activity over Time in Patients with RA Taking Biologics: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

    Jennifer Humphreys1, Kath Watson2, Mark Lunt2,3, Deborah P.M. Symmons2,4,5, Kimme L. Hyrich2,4,6 and the BSRBR-RA, 1Manchester Academic Health Science Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 3Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 4Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, 5NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 6Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom

    Background/Purpose:   Multimorbidity is increasingly prevalent in western populations and has the potential to influence disease specific outcomes.  Rheumatoid arthritis (RA) is a chronic inflammatory…
  • Abstract Number: 949 • 2016 ACR/ARHP Annual Meeting

    Comparison of Treatment Response, Remission Rate and Drug Adherence in Polyarticular Juvenile Idiopathic Arthritis Patients Treated with Etanercept, Adalimumab or Tocilizumab

    Gerd Horneff1,2, Ariane Klein3, Kirsten Minden4,5, Hans-Iko Huppertz6, Frank Weller-Heinemann7, Jasmin B. Kuemmerle-Deschner8, Johannes Peter Haas9 and Toni Hospach10, 1Asklepios Klinik Zentrum für Allgemeine Paediatrie und Neonatologie, Sankt Augustin, Germany, 2Department of Pediatrics, Centre of Pediatric Rheumatology, Sankt Augustin, Germany, 3Center of Pediatrics and Neonatology, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, 4Epidemiology, Charite, DRFZ, Berlin, Germany, 5Children’s University Hospital Charite/German Rheumatism Research Centre Berlin, Berlin, Germany, 6Klinikum Bremen-Mitte, Prof.-Hess-Kinderklinik, Bremen, Germany, 7Prof.-Hess-Kinderklinik, Bremen,, Berlin, Germany, 8Universitätsklinikum Tübingen, Klinik fuer Kinder- und Jugendmedizin, Tübingen, Germany, 9German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, 10Pediatrics, Olgahospital, Klinikum Stuttgart, Stuttgard, Germany

    Background/Purpose:  Treatment response, remission rates and compliance in polyarticular JIA patients treated with adalimumab(ADA), etanercept(ETA), or tocilizumab(TCZ) were analyzed in clinical practice. Methods:  Data from the German BIKER…
  • Abstract Number: 2617 • 2016 ACR/ARHP Annual Meeting

    Economic Burden of Non-Responders to Biologic DMARD Treatments in Rheumatoid Arthritis

    Vibeke Strand1, Namita Tundia2, Yan Song3, Dendy Macaulay4 and Mahesh Fuldeore5, 1School of Medicine, Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 2AbbVie, Inc., North Chicago, IL, 3Analysis Group, Inc., Boston, MA, 4Analysis Group, Inc., New York, NY, 5AbbVie, Inc, North Chicago, IL

    Background/Purpose: Biologic agents are effective in treating patients with rheumatoid arthritis (RA); however, some patients either fail to respond or lose response over time. This…
  • Abstract Number: 950 • 2016 ACR/ARHP Annual Meeting

    Flares after Withdrawal of Biotherapies in JIA: Clinical and  Laboratory Correlates of Remission Duration

    Gabriele Simonini1, Erika Scoccimarro1, Irene Pontikaki2, Giovanna Ferrara3, Teresa Giani1, Andrea Taddio3, Pier Luigi Meroni4 and Rolando Cimaz1, 1Pediatric Rheumatology Unit, Anna Meyer Children's Hospital-University of Florence, Firenze, Italy, 2Rheumatology Department, Gaetano Pini Institute, University of Milan, Milano, Italy, 3Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", University of Trieste, Trieste, Italy, 4Rheumatology Department, University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy

    Background/Purpose: Information regarding the history of patients with JIA after systemic treatment withdrawal would be helpful in driving the choice of duration therapy. While some…
  • Abstract Number: 2650 • 2016 ACR/ARHP Annual Meeting

    Prediction of Inhibition of Radiographic Progression By Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis Despite Disease-Modifying Anti-Rheumatic Drug Treatment: Results of a Global, Phase 3 Trial

    George Karpouzas1, Tsutomu Takeuchi2, Carter Thorne3, Shihong Sheng4, Xiaoming Li4, Ravi Rao5, Kaiyin Fei4 and Benjamin Hsu4, 1Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, 3University of Toronto and Southlake Regional Health Centre, Toronto, ON, Canada, 4Janssen Research & Development, LLC, Spring House, PA, 5GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose:  In the SIRROUND-D study, sirukumab, a human anti–IL-6 cytokine monoclonal antibody, significantly reduced radiographic progression after 52 wks of treatment vs placebo in patients…
  • Abstract Number: 951 • 2016 ACR/ARHP Annual Meeting

    A Nationwide Non-Medical Switch from Originator to Biosimilar Infliximab in Patients with Inflammatory Arthritis. Eleven Months’ Clinical Outcomes from the Danbio Registry

    Bente Glintborg1, Inge Juul Sørensen2, Dorte Vendelbo Jensen2, Niels Steen Krogh3, Anne Gitte Loft4, Jakob Espesen2, Jimmi Olsen2, Oliver Hendricks5, Jolanta Grydehøj2, Inger Marie Jensen Hansen2, Michael Veedfald Sørensen2, Stavros Chrysidis2, Birgitte Lange Andersen2, Natalia Manilo2, Mette Klarlund2, Lis Smedegaard Andersen2, Henrik Nordin2, Salome Kristensen2, Jesper Nørregaard2 and Merete Lund Hetland1, 1Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, 2The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 3ZiteLab ApS, Copenhagen, Denmark, 4Departments of Rheumatology at Vejle and Aarhus Hospitals, Vejle and Aarhus, Denmark, 5Dep. of Rheumatology, King Christians Hospital for Rheumatic Diseases, Copenhagen, Denmark

    Background/Purpose: According to national guidelines issued in May 2015, a non-medical switch from originator infliximab (IFX) (Remicade) to biosimilar Remsima was conducted in all Danish…
  • Abstract Number: 2655 • 2016 ACR/ARHP Annual Meeting

    Prevalence and Risk Factors of Reactivation of Resolved Hepatitis B Virus in Rheumatoid Arthritis Patients Treated with Biological Disease-Modifying Anti-Rheumatic Drugs

    Toshiyuki Watanabe1, Shinji Fukaya2 and Kazumasa Akikawa2, 13rd Department of Internal Medicine, Hokkaido P.W.F.A.C Obihiro-Kosei General Hospital, Obihiro, Japan, 23rd Department of Internal medicine, Hokkaido P.W.F.A.C Obihiro-Kosei General Hospital, Obihiro, Japan

    Background/Purpose:  Reactivation of hepatitis B virus (HBV) is one of the most serious complications in rheumatoid arthritis (RA) patients treated with biological disease-modifying anti-rheumatic drugs…
  • Abstract Number: 1004 • 2016 ACR/ARHP Annual Meeting

    Herpes Zoster Virus Infection in Patients Treated with Biological Therapies (BIOBADASAR)

    Juan Pablo Pirola1, Soledad Retamozo2, Diego Baenas3, Alejandro Alvarellos4, Francisco Caeiro5, María Celina De La Vega6, Gustavo Casado7, Gimena Gomez8, Javier Roberti6, Osvaldo Luis Cerda9, Maria de los Angeles Gallardo10, Ana Quinteros11, Ida Exeni12, Juan Manuel Bande13, Pablo Astesana14, Analia Alvarez15, Amelia Granel16, Alejandra Peluzzon17, Ana Capuccio18, Romina Nieto19, Rossana Quintana20, Eduardo Mussano21, Santiago Scarafia22, Carolina Costi23, Mercedes De La Sota24, Monica Patricia Diaz25, Edson Javier Velozo26, Santiago Aguero27, Cristina Battagliotti28, Sidney Soares de Souza29, Emilia Cavillon30, Analia Bohr31, Andrea Smichowski32, Alejandro Benitez33, Daniela Vidal34, Dora Pereira35, Liliana Martinez36, Luis Somma37, Marta Zalazar38, Pablo Finucci Curi39, Leandro Carlevaris40, Guillermo Berbotto41 and Veronica Saurit1, 1Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 2Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, 3Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 4Rheumatology, Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, 5Reumatología, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 6SAR, CABA, Argentina, 7Sociedad Argentina de Reumatologia, CABA, Argentina, 8Section of Rheumatology an, SAR, CABA, Argentina, 9IREP, CABA, Argentina, 10Hospital Italiano de Buenos Aires, CABA, Argentina, 11Centro Integral Reumatológico, Tucuman, Argentina, 12Sanatorio Parque, Córdoba, Argentina, 13Hospital Tornú, CABA, Argentina, 14Sanatorio Allende, Cordoba, Argentina, 15Hospital Penna, Bahía Blanca, Argentina, 16Centro Platense de Reumatología, La Plata, Argentina, 17Hospital Clínica José de San Martín, CABA, Argentina, 18Hospital Cesar Milstein, CABA, Argentina, 19Hospital Provincial, Rosario, Argentina, 20Sanatorio Parque, Rosario, Argentina, 21Córdoba, Hospital Nacional de Clínicas, Córdoba, Argentina, 22Hospital Bernardino Rivadavia, CABA, Argentina, 23Hospital San Martín, LaPlata, Argentina, 24Consultorios, Bahia Blanca, Argentina, 25Hospital Zonal Bariloche, Bariloche, Argentina, 26Rheumatology, Sanatorio Adventista del Plata, Entre Rios, Argentina, 27Sanatorio Pasteur, Catamarca, Argentina, 28Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, 29Ramallo 1851, REUMAR, CABA, Argentina, 30Consultorio, Cordoba, Argentina, 31Hospital de Rehabilitación Rocca, CABA, Argentina, 32Atención Integral de Reumatología, CABA, Argentina, 33CEIM, CABA, Argentina, 34Hospital de Niños de Córdoba, Córdoba, Argentina, 35Centro Raquis, Buenos Aires, Argentina, 36Hospital Fernandez, CABA, Argentina, 37SOMMA, Buenos Aires, Argentina, 38Hospital Pirovano, CABA, Argentina, 39Centro Médico Mitre, Entre Rios, Argentina, 40IARI, CABA, Argentina, 41Sanatorio Británico, Rosario, Argentina

    Background/Purpose: Biologic therapies (bDMARDs) have improved the treatment of rheumatic diseases; however, the risk of herpes zoster (HZ) virus infection or reactivation in patients treated…
  • Abstract Number: 3013 • 2016 ACR/ARHP Annual Meeting

    Dose Reduction or Discontinuation of Biological Therapy in Patients with Rheumatoid Arthritis in Remission –  1-Year Results of a Guideline-Directed Longitudinal Cohort Study

    Cecilie Heegaard Brahe1, Simon Krabbe2, Mikkel Østergaard3, Henrik Rogind4, Hanne Slott Jensen3, Annette Hansen5, Jesper Nørregaard6, Søren Jacobsen7, Lene Terslev8, Tuan K. Huynh9, Dorte Vendelbo Jensen5, Natalia Manilo10, Karsten Heller Asmussen11, Per Brown-Frandsen7, Mikael Boesen12, Zoreh Rastiemadabadi13, Daniel Glinatsi14, Lone Morsel-Carlsen15, Jakob M. Møller16, Niels Steen Krogh17 and Merete Lund Hetland3,18, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Glostrup, Denmark, 2Center for Rheumatology and Spine diseases, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Glostrup, Denmark, 3Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 4Center for Rheumatology and Spine Diseases, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 5DANBIO, On behalf of Depts of Rheumatology, North, South, Central, Zealand and Capital Region, Copenhagen, Denmark, 6Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 7Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 8Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, 9Department of Rheumatology, Copenhagen University Hospital at Nordsjælland, Denmark, Hillerød, Denmark, 10The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 11Department of Rheumatology, Copenhagen University Hospital at Frederiksberg-Bispebjerg, Denmark, Frederiksberg, Denmark, 12Frederiksberg Hospital, Parker Institute, Frederiksberg, Denmark, 13Department of Radiology, Frederiksberg Hospital, Frederiksberg, Denmark, 14Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Glostrup, Denmark, 15Department of Radiology, Rigshospitalet, Copenhagen, Denmark, 16Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark, 17Zitelab, Frederiksberg, Denmark, 18Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark

    Background/Purpose: Dose tapering in patients in remission has previously proven promising in randomized controlled trials. However, systematic implementation in clinical practice is lacking. A new…
  • Abstract Number: 1045 • 2016 ACR/ARHP Annual Meeting

    2016 Update of the ASAS-EULAR Management Recommendations for Axial Spondyloarthritis

    Désirée van der Heijde1, Sofia Ramiro2, Robert Landewé3, Xenofon Baraliakos4, Filip van Den Bosch5, Alexandre Sepriano2, Andrea Regel6, John D. Reveille7 and Jürgen Braun6, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 4Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 5Rheumatology, Ghent University Hospital, Ghent, Belgium, 6Rheumazentrum Ruhrgebiet, Herne, Germany, 7Rheumatology, University of Texas-McGovern Medical School, Houston, TX

    Background/Purpose: In 2010 the latest ASAS-EULAR recommendations for AS and the ASAS recommendations for the use of TNF-inhibitors (TNFi) have been published. Since then new…
  • Abstract Number: 3219 • 2016 ACR/ARHP Annual Meeting

    Altered microRNA Expression Pattern in Synovial and Blood Neutrophils in Rheumatoid Arthritis Reveals the Pathogenic Profile of These Cells. Effect of Biological Therapies

    Nuria Barbarroja1, Ivan Arias de la Rosa1, Carlos Perez-Sanchez1, Yolanda Jiménez-Gómez1, Maria Carmen Abalos-Aguilera2, Miguel Angel Caracuel-Ruiz3, Jerusalem Calvo-Gutierrez1, Rafaela Ortega-Castro1, Eduardo Collantes-Estévez1, Alejandro Escudero-Contreras1, Chary Lopez-Pedrera1 and Patricia Ruiz-Limon2, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain

    Background/Purpose:  MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression, regulating inflammation, degradation of extracellular matrix and invasive behavior of the…
  • Abstract Number: 1207 • 2016 ACR/ARHP Annual Meeting

    Design of a Multiplex Serum Proteome Assay to Monitor Biologic Drug Response in Rheumatoid Arthritis Patients

    Niamh Callan1, Aisha Butt1, Stephen R. Pennington2, Cathy McGeough3, Philip Gardiner4, Gary Wright5, Tony Bjourson3 and David S. Gibson6, 1Proteome Research Centre, Conway Institute, University College Dublin, Dublin, Ireland, 2Proteome Research Centre, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, 3Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom, 4Rheumatology, Altnagelvin Hospital, Londonderry, United Kingdom, 5Rheumatology, Musgrave Park Hospital, BELFAST, United Kingdom, 6Inflammatory Disease Research Group, Northern ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom

    Background/Purpose: Biologic drugs have revolutionised the treatment of Rheumatoid Arthritis (RA), however these therapies are expensive and exhibit a high non–response rate (30%). Currently there…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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