Abstracts tagged "Biologic agents"

Abstract Number: 484 • 2013 ACR/ARHP Annual Meeting
Response To Biologic Disease-Modifying Anti-Rheumatic Drugs After Discontinuation Of Anti-Tumor Necrosis Factor Alpha Agents In Rheumatoid Arthritis Patients
Eric Elkin¹, Max I. Hamburger², Tripthi Kamath³, Sarika Ogale³, Adam Turpcu³, Jae Oh⁴, Kristin King⁴, Monarch Shah¹ and Martin J. Bergman⁵, ¹ICON Clinical Research, San Francisco, CA, ²Rheumatology Associates, Melville, NY, ³Genentech, South San Francisco, CA, ⁴ICON Late Phase and Outcomes Research, San Francisco, CA, ⁵Taylor Hospital, Ridley Park, PA
Background/Purpose: Rheumatoid arthritis (RA) patients who have failed an anti-TNF agent as their first biologic agent have the option of switching to a second aTNF…
Abstract Number: 2165 • 2013 ACR/ARHP Annual Meeting
Efficacy and Safety Of Biologic Agents In Patients With Poly-Articular Juvenile Idiopathic Arthritis: Network Meta-Analysis Of Randomized Controlled Withdrawal Trials
Gil Amarilyo¹, Simon Tarp², Ivan Foeldvari³, Neta Cohen⁴, Tracy D. Pope⁵, Jennifer M.P. Woo⁶, Robin Christensen² and Daniel Furst⁵, ¹Dana-Dwek Children's hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ³Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ⁴Dana-Duek Children's hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁵David Geffen School of Medicine, University of California, Los Angeles, CA, ⁶Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Although various biologic agents (BAs) are in use for polyarticular juvenile idiopathic arthritis (pJIA), a combined meta-analytic summary comparing the efficacy and safety among…
Abstract Number: 1444 • 2013 ACR/ARHP Annual Meeting
Immunogenicity Induced By Tumor Necrosis Factor Antagonists In Chronic Inflammatory Arthropathies: Retrospective Study In Clinical Practice Conditions
Jose Inciarte-Mundo¹, Maria Victoria Hernández², Sonia Cabrera¹, Virginia Ruiz-Esquide³, Julio Ramirez¹, Juan D. Cañete², Jordi Yague⁴ and Raimon Sanmarti¹, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, ³Rheumatology, Hospital Clinic, Barcelona, Spain, ⁴Hospital Clínic / IDIBAPS, Barcelona, Spain
Background/Purpose: Biological therapy has proved efficacious in various chronic inflammatory arthropathies but, in practice, clinical efficacy is reduced in some patients, suggesting drug-induced immunogenicity as…
Abstract Number: 491 • 2013 ACR/ARHP Annual Meeting
Infection Risk Among Patients Receiving Concurrent Denosumab and Biologic Or Non-Biologic DMARD Therapy: An Analysis Of The Consortium Of Rheumatology Researchers Of North America (CORRONA) Registry
Vance J. Bray¹, Adam W. Bagley², Sterling G. West³, Carol J. Etzel⁴, Joel M. Kremer⁵ and Jason R. Kolfenbach⁶, ¹Denver Arthritis Clinic, Denver, CO, ²Internal Medicine, University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Department of Epidemiology, UT MD Anderson, Houston, TX, ⁵Medicine, Albany Medical College and the Center for Rheumatology, Albany, NY, ⁶Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: RANKL is a cytokine member of the tumor necrosis family that mediates osteoclastic bone resorption. Denosumab prevents RANKL from activating RANK on the cell…
Abstract Number: 2169 • 2013 ACR/ARHP Annual Meeting
Short Term Efficacy Of Biologic Agents In Patients With Systemic Juvenile Idiopathic Arthritis: Network Meta-Analysis Of Randomized Trials
Simon Tarp¹, Gil Amarilyo², Ivan Foeldvari³, Neta Cohen⁴, Tracy D. Pope⁵, Jennifer M.P. Woo⁶, Robin Christensen¹ and Daniel Furst⁵, ¹Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ²Dana-Dwek Children's hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ³Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ⁴Dana-Duek Children's hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁵David Geffen School of Medicine, University of California, Los Angeles, CA, ⁶Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is a severe subtype of JIA, which includes systemic features such as fever, rash, elevated inflammatory markers along with…
Abstract Number: 1451 • 2013 ACR/ARHP Annual Meeting
Comparison Of Clinical Characteristics Of Patients With Rheumatoid Arthritis Receiving Their First Biologic and Biologic-Naïve Patients Considered Biologic-Suitable In The United States
Siva Narayanan¹, Yao Lu², Richard Hutchings² and Amanda Baskett², ¹Evidence Generation, Value and Access Center, Ipsos Healthcare, Columbia, MD, ²Ipsos Healthcare, London, United Kingdom
Background/Purpose: Data on clinical status of biologic-naïve Rheumatoid Arthritis (RA) patients who are considered suitable for biologic therapy (by their physicians) is lacking. We assessed…
Abstract Number: 462 • 2013 ACR/ARHP Annual Meeting
Reduced Response To Biologic Treatments in Rheumatoid Arthritis Patients Affected By Arterial Hypertension
Marco Antivalle¹, Michel Chevallard², Michele Battellino², Alberto Batticciotto³, Maria Chiara Ditto², Alessandra Mutti¹, Federica Rigamonti⁴, Valentina Varisco², Sara Bongiovanni², Fabiola Atzeni⁵ and Piercarlo Sarzi-Puttini⁶, ¹Rheumatology, L. Sacco University Hospital, Milano, Italy, ²Rheumatology, Rheumatology Unit, L. Sacco University Hospital, Milano, Italy, ³Rheumatology, Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ⁴Rheumatology Unit, L. Sacco University Hospital, Milano, Italy, ⁵Rheumatology, Rheumatology Unit, L. Sacco University Hospital, MiIano, Italy, ⁶Rheumatology Unit, L. Sacco University Hospital, Milan, Italy
Background/Purpose: Several reports show that the presence of comorbidities negatively influences both functional status (1) and quality of life (2) in rheumatoid arthritis (RA). No…
Abstract Number: 2056 • 2013 ACR/ARHP Annual Meeting
Use Of Biologics In Polymyositis and Dermatomyositis – A National Register Study
John Svensson¹, Anna Tjärnlund², Balsam Hanna³, Sara Magnusson Bucher⁴, Johan Askling⁵, Ingrid E. Lundberg⁶ and Maryam Dastmalchi⁷, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Stockholm, Sweden, ³Rheumatology Unit, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁴Rheumatology unit, Örebro University Hospital, Örebro, Sweden, ⁵Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Biologics have been used off-label in treatment of refractory polymyositis (PM) and dermatomyositis (DM). In this study we aimed to describe the use of…
Abstract Number: 1419 • 2013 ACR/ARHP Annual Meeting
Mode Of Action Change Not Necessary After Failing The First Tumornecrosisfactor Inhibitor: Preliminary Results Of a Randomized Controlled Trial
Sofie H.M. Manders¹, Wietske Kievit², Herman L.M. Brus³, Hein J. Bernelot Moens⁴, Andre Hartkamp⁵, Reinhard Bos⁶, Elisabeth Brouwer⁷, Henk Visser⁸, Harald E. Vonkeman⁹, Rene Westhovens¹⁰, Mart A.F.J. van de Laar¹¹ and Piet LCM Van Riel¹, ¹Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Rheumatology and DREAM registry, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³TweeSteden Ziekenhuis, Tilburg, Netherlands, ⁴Ziekenhuisgroep Twente, Almelo, Netherlands, ⁵Reumatology, Jeroen Bosch Hospital, 's-Hertogenbosch, Netherlands, ⁶Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ⁷Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁸Rheumatology, Rijnstate, Arnhem, Netherlands, ⁹Medisch Spectrum Twente & University of Twente, Enschede, Netherlands, ¹⁰Rheumatology, University Hospital KU Leuven, Leuven, Belgium, ¹¹Rheumatology, Medisch Spectrum Twente & University of Twente, Enschede, Netherlands
Background/Purpose: The best treatment option after a patient has failed a first TNFi is still unknown. Therefore the objective of this randomized open label study…
Abstract Number: 448 • 2013 ACR/ARHP Annual Meeting
Effectiveness Of Tocilizumab In Monotherapy and In Combination With Different Synthetic Dmards: A Registry-Based Comparison Study
Cem Gabay¹, Myriam Riek², Merete Lund Hetland³, Ulrik Tarp⁴, K. Pavelka⁵, Matija Tomsic⁶, Helena Canhao⁷, Katerina Chatzidionysiou⁸, R.F. van Vollenhoven⁹, Galina Lukina¹⁰, E. Nasonov¹¹, Dan C. Nordström¹², Elisabeth Lie¹³, Ioan Ancuta¹⁴, Estibaliz Loza Santamaria¹⁵, Piet Van Riel¹⁶ and Tore K. Kvien¹³, ¹Rheumatology, Geneva University Hospitals, Geneva, Switzerland, ²SCQM Registry, Zurich, Switzerland, ³DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁵Department of Clinical and Experimental Rheumatology, Charles University, Prague, Czech Republic, ⁶Department of Rheumatology, University Medical Centre Ljubjana, Ljubljana, Slovenia, ⁷Rheumatology Research Unit, Rheumatology Research Unit, on behalf of the Rheumatic Diseases Portuguese Register, Instituto de Medicina Molecular, Rheumatology Research Unit, Rheumatology Research Unit, on behalf of the Rheumatic Diseases Portuguese Register, Lisbon, Portugal, ⁸Dept of Medicine, Unit for Clinical Research Therapy. Inflammatory Diseases (ClinTrid), Karolinska Institute, Stockholm, Sweden, ⁹Karolinska Institute, Stockholm, Sweden, ¹⁰ARBITER, Institute of Rheumatology, Moscow, Russia, ¹¹Institute of Rheumatology, Moscow, Russia, ¹²ROB-FIN, Helsinki University Central Hospital, Helsinki, Finland, ¹³Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ¹⁴“Dr. I. Cantacuzino” Hospital, Bucharest, Romania, ¹⁵Instituto de salud Musculoesqueletica, Madrid, Spain, ¹⁶Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Tocilizumab (TCZ) is efficacious in monotherapy and in combination with methotrexate (MTX) or other DMARDs. However, longitudinal data from large registry populations are missing.…
Abstract Number: 2036 • 2013 ACR/ARHP Annual Meeting
Biologic Therapy For Relapsing Polychondritis: Old and New Efficacy Indices
Mattia Baldini¹, Patrizia Aiello¹, Mirta Tiraboschi¹, Maria Grazia Sabbadini² and Elena Baldissera¹, ¹Internal Medicine and Clinical Immunology, Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milano, Italy, ²Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milano, Italy
Background/Purpose: The inflammatory milieu in affected tissues from Relapsing Polychondritis (RP) is rich in TNF-α, IL-1-β and IL-6. Cytokine-targeted biologic therapies has therefore been proposed…
Abstract Number: 1420 • 2013 ACR/ARHP Annual Meeting
Induction Therapy With Adalimumab On Top Of An Aggressive Treat-To-Target Strategy With Methotrexate and Intraarticular Corticosteroid Reduces Radiographic Erosive Progression In Early Rheumatoid Arthritis, Even After Withdrawal Of Adalimumab. Results Of a 2-Year Trial (OPERA)
Kim Hørslev-Petersen¹, Lykke Midtbøll Ørnbjerg², Merete Lund Hetland³, Peter Junker⁴, Jan Pødenphant⁵, Torkell Ellingsen⁶, Palle Ahlqvist⁷, Hanne M. Lindegaard⁸, Asta Linauskas⁹, Annette Schlemmer¹⁰, Mette Y. Dam¹¹, Ib Hansen¹², Tine Lottenburger⁷, Anette Jørgensen¹³, Sophine B. Krintel¹⁴, Johnny Raun¹⁵, Christian G. Ammitzbøll¹¹, Julia Johansen¹⁴, Mikkel Østergaard¹⁶ and Kristian Stengaard-Pedersen¹¹, ¹Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, ²Copenhagen Center for Arthritis Reasearch, Center for Rheumatology and Spine diseases, Glostrup Hospital, Copenhagen, Denmark, ³DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, ⁴University of Southern Denmark, Odense, Denmark, ⁵Copenhagen University at Gentofte, Hellerup, Denmark, ⁶Silkeborg Regional Hospital, Silkeborg, Denmark, ⁷University of Southern Denmark, Vejle, Denmark, ⁸Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁹Vendsyssel Hospital, Hjørring, Denmark, ¹⁰Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ¹¹Arhus University Hospital, Aarhus, Denmark, ¹²Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ¹³Rheumatology, Arhus University Hospital, Aarhus, Denmark, ¹⁴Copenhagen University and Glostrup Hospital, Copenhagen, Denmark, ¹⁵University of Southern Denmark, Graasten, Denmark, ¹⁶Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: In a randomized double-blind, placebo-controlled 2-year investigator-initiated trial of patients with early rheumatoid arthritis¹ (RA) we aimed to investigate if additional adalimumab (ADA) for…
Abstract Number: 453 • 2013 ACR/ARHP Annual Meeting
Impact Of Inadequate Adherence On Clinical Outcomes: Results From The Biologics In Rheumatoid Arthritis Genetics and Genomics Study Syndicate Cohort
James Bluett¹, Catharine Morgan¹, Layla Thurston², Darren Plant¹, Ann W. Morgan³, Anthony G. Wilson⁴, John Isaacs⁵, Kimme L. Hyrich¹, Lis Cordingley¹ and Anne Barton¹, ¹Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ²Manchester Medical School, The University of Manchester, Manchester, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ⁵National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom
Background/Purpose: Biologic therapy has revolutionised patient prognosis in rheumatoid arthritis (RA). In the UK, continuing biologic therapy requires a sustained response as determined by the…
Abstract Number: 2841 • 2013 ACR/ARHP Annual Meeting
Inflammation and Structural Progression In The Sacroiliac Joints Of Patients With Axial Spa Treated With Adalimumab Or Placebo As Assessed By The Berlin and The Spondyloarthritis Research Consortium Of Canada MRI Methods
Susanne Juhl Pedersen¹, Denis Poddubnyy², Inge Juul Sørensen³, Anne Gitte Loft⁴, Jens Skjødt Hindrup⁵, Gorm Thamsborg⁶, Karsten Asmussen⁷, Elka Kluger⁸, Jesper Nørregaard⁹, Torben Grube Christensen¹⁰, Anne G. Jurik¹¹, J.M. Møller¹², Thomas Skjødt¹³, Dorrit Mikkelsen¹⁴ and Mikkel Østergaard¹⁵, ¹Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Department of Rheumatology, Hvidovre Hospital, Copenhagen, Denmark, ⁴Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, ⁵Dep. of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁶Dep. of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ⁷Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ⁸King Christian 10th Rheumatism Hospital at Gråsten, Graasten, Denmark, ⁹Dep of Rheumatology, Hørsholm Hospital, Hørsholm, Denmark, ¹⁰MD, Slagelse, Denmark, ¹¹Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, ¹²Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, ¹³Dep. of Radiology, Vejle Hospital, Vejle, Denmark, ¹⁴Dep. of Radiology, Aabenraa Hospital, Aabenraa, Denmark, ¹⁵Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: To investigate changes in inflammation and structural progression in the sacroiliac joints (SIJs) in patients with axial spondyloarthritis (SpA) during treatment with adalimumab and…
Abstract Number: 2013 • 2013 ACR/ARHP Annual Meeting
Biologic Therapy In Refractory Uveitis Of Sarcoidosis. Multicenter Study Of 16 Patients
Javier Loricera¹, Vanesa Calvo-Río², Ricardo Blanco³, Marina Mesquida⁴, Alfredo M. Adan⁴, JM Herreras⁵, A Aparicio⁶, MJ Moreno Ramos⁷, MJ Moreno Martínez⁷, LF Linares Ferrando⁷, M Hernández Martínez⁸, D Peitado-Lopez⁹, Miguel Cordero-Coma¹⁰, Jl García Serrano¹¹, Norberto Ortego¹¹, O Maíz¹², A Blanco¹³, Juan Sánchez-Bursón¹⁴, S González-Suárez¹⁵, Alejandro Fonollosa¹⁶, Montserrat Santos-Gómez², F. Ortiz-Sanjuán¹ and Miguel Angel González-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Hospital Marques de Valdecilla, Santander, Spain, ⁴Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, ⁵Hospital Universitario, IOBA. Valladolid, Valladolid, Spain, ⁶Rheumatology., Hospital de Toledo., Toledo, Spain, ⁷Rheumatology, Hospital Clínico Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, ⁸Ophthalmology, Hospital Clínico Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, ⁹Rheumatology, Hospital Universitario La Paz Madrid, Madrid, Spain, ¹⁰Ophthalmology, Hospital de León. Spain, León, Spain, ¹¹Hospital San Cecilio. Granada, Granada, Spain, ¹²Rheumatology, Hospital Donosti San Sebastian, San Sebastián, Spain, ¹³Ophthalmology., Hospital Donosti San Sebastian, San Sebastián, Spain, ¹⁴Hospital de Valme. Sevilla, Sevilla, Spain, ¹⁵Rheumatology., Hospital Cabueñes, Gijón, Gijón, Spain, ¹⁶Ophtalmology Service, Hospital de Cruces. Bilbao, Bilbao, Spain
Background/Purpose: Uveitis related to sarcoidosis is a potentially severe complication. Corticosteroids are the first line of treatment. In refractory cases or in those with unacceptable…

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