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Abstracts tagged "Biologic agents"

  • Abstract Number: 453 • 2013 ACR/ARHP Annual Meeting

    Impact Of Inadequate Adherence On Clinical Outcomes: Results From The Biologics In Rheumatoid Arthritis Genetics and Genomics Study Syndicate Cohort

    James Bluett1, Catharine Morgan1, Layla Thurston2, Darren Plant1, Ann W. Morgan3, Anthony G. Wilson4, John Isaacs5, Kimme L. Hyrich1, Lis Cordingley1 and Anne Barton1, 1Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 2Manchester Medical School, The University of Manchester, Manchester, United Kingdom, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, 5National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom

    Background/Purpose: Biologic therapy has revolutionised patient prognosis in rheumatoid arthritis (RA). In the UK, continuing biologic therapy requires a sustained response as determined by the…
  • Abstract Number: 2841 • 2013 ACR/ARHP Annual Meeting

    Inflammation and Structural Progression In The Sacroiliac Joints Of Patients With Axial Spa Treated With Adalimumab Or Placebo As Assessed By The Berlin and The Spondyloarthritis Research Consortium Of Canada MRI Methods

    Susanne Juhl Pedersen1, Denis Poddubnyy2, Inge Juul Sørensen3, Anne Gitte Loft4, Jens Skjødt Hindrup5, Gorm Thamsborg6, Karsten Asmussen7, Elka Kluger8, Jesper Nørregaard9, Torben Grube Christensen10, Anne G. Jurik11, J.M. Møller12, Thomas Skjødt13, Dorrit Mikkelsen14 and Mikkel Østergaard15, 1Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Department of Rheumatology, Hvidovre Hospital, Copenhagen, Denmark, 4Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, 5Dep. of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, 6Dep. of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, 7Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, 8King Christian 10th Rheumatism Hospital at Gråsten, Graasten, Denmark, 9Dep of Rheumatology, Hørsholm Hospital, Hørsholm, Denmark, 10MD, Slagelse, Denmark, 11Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, 12Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, 13Dep. of Radiology, Vejle Hospital, Vejle, Denmark, 14Dep. of Radiology, Aabenraa Hospital, Aabenraa, Denmark, 15Copenhagen University Hospital Glostrup, Copenhagen, Denmark

    Background/Purpose: To investigate changes in inflammation and structural progression in the sacroiliac joints (SIJs) in patients with axial spondyloarthritis (SpA) during treatment with adalimumab and…
  • Abstract Number: 2013 • 2013 ACR/ARHP Annual Meeting

    Biologic Therapy In Refractory Uveitis Of Sarcoidosis. Multicenter Study Of 16 Patients

    Javier Loricera1, Vanesa Calvo-Río2, Ricardo Blanco3, Marina Mesquida4, Alfredo M. Adan4, JM Herreras5, A Aparicio6, MJ Moreno Ramos7, MJ Moreno Martínez7, LF Linares Ferrando7, M Hernández Martínez8, D Peitado-Lopez9, Miguel Cordero-Coma10, Jl García Serrano11, Norberto Ortego11, O Maíz12, A Blanco13, Juan Sánchez-Bursón14, S González-Suárez15, Alejandro Fonollosa16, Montserrat Santos-Gómez2, F. Ortiz-Sanjuán1 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Marques de Valdecilla, Santander, Spain, 4Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, 5Hospital Universitario, IOBA. Valladolid, Valladolid, Spain, 6Rheumatology., Hospital de Toledo., Toledo, Spain, 7Rheumatology, Hospital Clínico Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 8Ophthalmology, Hospital Clínico Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 9Rheumatology, Hospital Universitario La Paz Madrid, Madrid, Spain, 10Ophthalmology, Hospital de León. Spain, León, Spain, 11Hospital San Cecilio. Granada, Granada, Spain, 12Rheumatology, Hospital Donosti San Sebastian, San Sebastián, Spain, 13Ophthalmology., Hospital Donosti San Sebastian, San Sebastián, Spain, 14Hospital de Valme. Sevilla, Sevilla, Spain, 15Rheumatology., Hospital Cabueñes, Gijón, Gijón, Spain, 16Ophtalmology Service, Hospital de Cruces. Bilbao, Bilbao, Spain

    Background/Purpose: Uveitis related to sarcoidosis is a potentially severe complication. Corticosteroids are the first line of treatment. In refractory cases or in those with unacceptable…
  • Abstract Number: 1425 • 2013 ACR/ARHP Annual Meeting

    Discontinuation Of Tumor Necrosis Factor Inhibitors In Rheumatoid Arthritis Patients In Low Disease Activity: Persistent Benefits

    Arthur Kavanaugh1, Susan J. Lee2,3, Daniel H. Solomon4, Jeffrey D. Greenberg5, Joel M. Kremer6, Lilian Soto7, Carol J. Etzel8,9 and George W. Reed10, 1University of California, San Diego, La Jolla, CA, 2University of California San Diego, La Jolla, CA, 3San Diego Veterans Affairs Medical Center, San Diego, CA, 4Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, 5NYU Hospital for Joint Diseases, New York, NY, 6Center for Rheumatology, Albany Medical College, Albany, NY, 7University of California San Diego, San Diego, CA, 8Department of Epidemiology, UT MD Anderson, Houston, TX, 9PO Box 786, Corrona, LLC., Southborough, MA, 10Corrona, LLC., Southborough, MA

    Background/Purpose: A key question is whether biologic agents can be stopped but clinical benefit maintained for rheumatoid arthritis (RA) patients (pts) in remission or low…
  • Abstract Number: 432 • 2013 ACR/ARHP Annual Meeting

    Use Of Rituximab As Second Line Biologic Agent Compared With Adalimumab, Etanercept and Infliximab In Patients With Rheumatoid Arthritis. a Report From The Rhumadata® Clinical Database and Registry

    Louis Bessette1, Denis Choquette2, Diane Sauvageau3, Boulos Haraoui4, Jean Pierre Pelletier2, Jean-Pierre Raynauld3, Edith Villeneuve3 and Louis Coupal2, 1Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, 2Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 3Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, 4Rhumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada

    Background/Purpose: The order of use of biologic agents after failing a TNF inhibitor is still a question for debate. Phase III trial data in TNF-IR…
  • Abstract Number: 2691 • 2013 ACR/ARHP Annual Meeting

    Results Of The Strass Trial Regarding Impact Of Progressive Spacing Of Tnf-Blocker Injections In Rheumatoid Arthritis Patients In Das28 Remission: Is There a Difference Between Drugs – Adalimumab and Etanercept – Or Their Mode Of Use – Monotherapy Or Combination?

    Bruno Fautrel1, Thao Pham2, Jacques Morel3, Toni Alfaiate4, Emmanuelle Dernis5, Philippe Gaudin6, Olivier Brocq7, Elisabeth Solau-Gervais8, Jean-Marie Berthelot9, Jean-Charles Balblanc10, Xavier Mariette11 and Florence Tubach12, 1Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France, 2Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, 3Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, 4Biostatistics, Bichat Hospital, AP-HP, Paris, France, 5Le Mans Hospital, Le Mans, France, 6Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, 7Hospital of Princesse Grâce de Monaco, Monaco, France, 8Rheumatology, University Hospital of Poitiers, Poitiers, France, 9Rheumatology Unit, Nantes University Hospital, Nantes, France, 10Rheumatology, Centre Hospitalier Général de Belfort, Belfort, France, 11Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, 12INSERM, Universite Paris Diderot, Paris, France

    Background/Purpose: The STRASS trial was an 18-month randomized controlled trial, conducted in established RA patients in DAS28 remission with etanercept (ETA) or adalimumab (ADA), comparing…
  • Abstract Number: 2028 • 2013 ACR/ARHP Annual Meeting

    Efficacy and Safety Of Biologic Agents In Adult-Onset Still’s Disease: A Long-Term Follow-Up Of 19 Patients At a Single Referral Center

    Giulio Cavalli1,2, Stefano Franchini1, Alvise Berti1, Corrado Campochiaro1, Barbara Guglielmi1, Maria Grazia Sabbadini1, Elena Baldissera3 and Lorenzo Dagna4,5, 1Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, 2San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milano, Italy, 4Vita-Salute San Raffaele University, Milan, Italy, 5Medicine and Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy

    Background/Purpose: No data comparing the long-term outcome of Adult-Onset Still’s Disease (AOSD) patients treated with different biological drugs is currently available. We evaluated the efficacy…
  • Abstract Number: 1415 • 2013 ACR/ARHP Annual Meeting

    Safety and Effectiveness Of Abatacept In 3985 Japanese Patients With Rheumatoid Arthritis; Japan All-Cases Post-Marketing Surveillance

    Takao Koike1, Masayoshi Harigai2, Naoki Ishiguro3, Shigeko Inokuma4, Junnosuke Ryu5, Syuji Takei6, Tsutomu Takeuchi7, Y. Tanaka8, Masahiko Watanabe9 and Hisashi Yamanaka10, 1Rheumatology, NTT Sapporo Medical Center, Sapporo, Japan, 2Dept of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan, 3Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 4Department of Allergy and Rheumatology diseases, Japanese Red Cross Medical Center, Tokyo, Japan, 5Nihon University School of Medicine, Tokyo, Japan, 6School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, 7Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 8University of Occupational and Environmental Health, Kitakyushu, Japan, 9Bristol-Myers K.K, Tokyo, Japan, 10Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: A large-scale post-marketing surveillance (PMS) has been implemented to evaluate the safety and effectiveness on the use of intravenous abatacept (ABT) in Japanese patients…
  • Abstract Number: 411 • 2013 ACR/ARHP Annual Meeting

    Differential Effects of biologics On The Removal Of Amyloid Deposition Between The Kidney and Gastric Tract Of Amyloid A Amyloidosis Patients With Rheumatoid Arthritis

    Hiroshi Uda1, Tamaki Harada2, Ayumi Matsumoto3, Aya Mizumoto2, Toshirou Takama2 and Osamu Saiki1, 1Rheumatology, Higashiosaka City General Hospital, Higashiosaka, Japan, 2Nephrology, Higashiosaka City General Hospital, Higashiosaka, Japan, 3Higashiosaka City General Hospital, Higashiosaka, Japan

    Background/Purpose: Several biologics therapy reportedly regress gastric amyloid deposition in amyloid A (AA) amyloidosis patients with rheumatoid arthritis (RA), but it is uncertain whether the…
  • Abstract Number: 2484 • 2013 ACR/ARHP Annual Meeting

    Immunogenicity Of TNFα Blockers In Patients With Psoriatic Arthritis

    Michael Zisapel Zisapel1, Noa Madar-Balakirsi2, Hagit Padova3, Irena Wigler4, Daphna Paran5, Uri Arad4, Dan Caspi6 and Ori Elkayam7, 1Rheumatology, Tel Aviv Medical Centet, Tel Aviv, Israel, 2Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel, 3Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 4Department of Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 5Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv university, Tel Aviv, Israel, 6Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel- Aviv, Israel

    Background/Purpose: TNFα blockers have been shown to produce immunogenecity in patients with rheumatoid arthritis, spondyloarthrritis and inflammatory bowel diseases. Data on the induction of anti-drug…
  • Abstract Number: 1942 • 2013 ACR/ARHP Annual Meeting

    Ultrasound Shows Tenosynovitis to be Frequently Present  as Well As Sensitive to Change in RA Patients On Biologic Medication

    Hilde B. Hammer, Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Ultrasound (US) (grey scale (GS) and power Doppler (PD)) is a sensitive tool for examination of tenosynovitis in patients with rheumatoid arthritis (RA). The…
  • Abstract Number: 1379 • 2013 ACR/ARHP Annual Meeting

    Differential Effects Of TNF Inhibitors, Anti-IL-6 Receptor Antibody and CTLA4-Ig On Human Monocytes

    Toshihiro Tono1, Yoshiyuki Arinuma2, Tatsuo Nagai3, Sumiaki Tanaka2 and Shunsei Hirohata2, 1Int Med/Rheumatol & Infec Dis, Kitasato University school of medicine, sagamihara, Japan, 2Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, 3Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Biological agents inhibiting proinflammatory cytokines, especially IL-6 and TNFa, have brought a great impact in the treatment of rheumatoid arthritis (RA). In addition, CTLA4-Ig…
  • Abstract Number: 415 • 2013 ACR/ARHP Annual Meeting

    Stability Of Carotid Intima Media Thickness and No Plaque Formation In Inflammatory Arthritis Patients On Biologics Over One Year

    Stephanie O. Keeling1, Asvina Bissonauth2, Jeff Odenbach2, Quazi Ibrahim3 and Michael Sean McMurtry4, 1Division of Rheumatology, Department of Medicine, University of Alberta, Canada, Edmonton, AB, Canada, 2Medicine, University of Alberta, Edmonton, AB, Canada, 3Medicine, EPICORE, Edmonton, AB, Canada, 4Cardiology, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Carotid intima media (cIMT) measurement is a validated surrogate measure of cardiovascular (CV) disease. Our aim was to evaluate baseline and follow-up cIMTs in…
  • Abstract Number: 2391 • 2013 ACR/ARHP Annual Meeting

    Pathogenic Pro-Inflammatory Cytokine Production Induced By Synovial Fluid From RA Patients Is Related To Levels Of Endogenous TLR4 Ligands and Is Blocked By a Novel Therapeutic Anti-Human TLR4 Monoclonal Antibody, NI-0101

    Limin Shang1, Greg Elson1, Jeremy Sokolove2, Iain B. McInnes3, James Reilly4, Eric Hatterer1, Marie Kosco-Vilbois5, Walter Ferlin5, Emmanuel Monnet5 and Cristina de Min6, 1NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, 2VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 3Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom, 4University of Glasgow, Glasgow, United Kingdom, 5NovImmune S.A., Geneva, Switzerland, 6Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland

    Background/Purpose: Deregulation of Toll-Like Receptor 4 (TLR4) signaling is thought to play a role in the pathogenesis of certain autoimmune diseases. In rheumatoid arthritis (RA),…
  • Abstract Number: 1750 • 2013 ACR/ARHP Annual Meeting

    Short and Long-Term Biological Therapy In Refractory Uveitis Of Behcet’s Syndrome. Multicenter Study Of 124 Patients

    Francisco Ortiz-Sanjuan1, Vanesa Calvo-Río2, Ricardo Blanco3, Emma Beltrán4, Juan Sánchez-Bursón5, Marina Mesquida6, Alfredo M. Adan6, M Hernandez Grafella7, E Valls Pascual8, L Martínez-Costa9, Agustí Sellas-Fernàndez10, Miguel Cordero-Coma11, Manuel Diaz-llopis12, David Salom12, Jl García Serrano13, Norberto Ortego13, JM Herreras14, Alejandro Fonollosa15, A Aparicio16, O Maíz17, A Blanco18, I Torre19, Cruz Fernández-Espartero20, V Jovani21, D Peitado-Lopez22, Esperanza Pato23, J Cruz24, J. Carlos Fernandez-Cid25, E. Aurrecoechea26, M García27, M Caracuel28, Carlos Montilla29, A Atanes30, F Francisco31, S Insua32, S González-Suárez33, A Sánchez-Andrade34, F Gamero35, Luis Linares36, F Romero-Bueno37, AJ García González38, Raquel Almodovar39, E Minguez40, C Carrasco Cubero41, Alejandro Olive Marques42, J Vázquez43, O Ruiz Moreno44, F Jimenez-Zorzo44, J Manero44, Javier Loricera1 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Marques de Valdecilla, Santander, Spain, 4Rheumatology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, 5Hospital de Valme. Sevilla, Sevilla, Spain, 6Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, 7Ophthalmology, Hospital General Universitario, Valencia, Valencia, Spain, 8Rheumatology, Hospital Peset Valencia, Valencia, Spain, 9Ophthalmology, Hospital Peset Valencia, Valencia, Spain, 10Rheumatology, Hospital Val d´Hebron. Barcelona, Barcelona, Spain, 11Departament of Ophthalmology, Hospital de León, León, Spain, 12Department of Ophthalmology, Hospital Universitario La Fe de Valencia, Valencia, Spain, 13Hospital San Cecilio. Granada, Granada, Spain, 14Hospital Universitario, IOBA. Valladolid, Valladolid, Spain, 15Ophtalmology Service, Hospital de Cruces. Bilbao, Bilbao, Spain, 16Rheumatology., Hospital de Toledo., Toledo, Spain, 17Rheumatology, Hospital Donosti San Sebastian, San Sebastián, Spain, 18Ophthalmology., Hospital Donosti San Sebastian, San Sebastián, Spain, 19Rheumatology., Hospital Basurto. Bilbao, Bilbao, Spain, 20Servicio de Reumatología, Hospital Universitario de Móstoles, Madrid, Spain, 21Rheumatology., Hospital General de Alicante., Alicante, Spain, 22Rheumatology, Hospital Universitario La Paz Madrid, Madrid, Spain, 23Rheumatology, Hospital Clínico San Carlos. Madrid, Madrid, Spain, 24Rheumatology, Hospital de Pontevedra, Pontevedra, Spain, 25Departament of Ophthalmology, Hospital de Pontevedra, Pontevedra, Spain, 26Hospital Sierrallana. Torrelavega, Torrelavega, Spain, 27Rheumatology., Hospital La Princesa. Madrid, Madrid, Spain, 28Rheumatology., Hospital de Córdoba., Córdoba, Spain, 29Unit Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain, 30Rheumatology., HUCA La Coruña., A Coruña, Spain, 31Rheumatology., Hospital Doctor Negrín Canarias., Canarias, Spain, 32Rheumatology., Hospital Universitario Santiago de Compostela, Santiago de Compostela, Spain, 33Rheumatology., Hospital Cabueñes, Gijón, Gijón, Spain, 34Rheumatology., Hospital Lucus Augusti Lugo, Lugo, Spain, 35Rheumatology., Hospital San Pedro Alcantara Caceres, Caceres, Spain, 36Rheumatology, Hospital Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 37Rheumatology., Fundación Jimenez Díaz. Madrid, Madrid, Spain, 38Rheumatology., Hospital 12 de Octubre. Madrid, Madrid, Spain, 39Rheumatology Unit, Hospital Universitario Fundación Alcorcón. Madrid, Alcorcon. Madrid, Spain, 40Ophthalmology, Hospital Clínico de Zaragoza, Zaragoza, Spain, 41Rheumatology., Hospital de Mérida, Mérida, Spain, 42Hospital Germans Trias i Pujol. Badalona, Barcelona, Spain, 43Rheumatology, Hospital de Ferrol. A Coruña, A Coruña, Spain, 44Hospital Universitario Miguel Servet. Zaragoza, Zaragoza, Spain

    Background/Purpose: To evaluate short and long-term response to biological therapy in uveitis associated to Behçet´s syndrome refractory to standard systemic treatment. Methods: Multicenter study of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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