Abstracts tagged "Biologic agents"

Abstract Number: 491 • 2014 ACR/ARHP Annual Meeting
Do Patients with Congestive Heart Failure Treated with Biologics for RA Have a Lower Risk of Fatal Outcome of Serious Infections?
Anja Strangfeld¹, Adrian Richter¹, Yvette Meissner¹, Matthias Schneider², Michael Zaenker³, Wolfgang Ochs⁴, Thomas Klopsch⁵, Angela Zink⁶ and Joachim Listing¹, ¹German Rheumatism Research Center, Berlin, Germany, ²Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ³Immanuel Klinikum Bernau, Rheumatology Center Northern Brandenburg, Bernau, Germany, ⁴Rheumatologist in private practice, Bayreuth, Germany, ⁵Rheumatologist in private practice, Neubrandenburg, Germany, ⁶German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany
Background/Purpose: Patients with multimorbid conditions are at high risk of developing serious infections (SI) and of premature mortality. TNF inhibitors increase the infection risk (1)…
Abstract Number: 2511 • 2014 ACR/ARHP Annual Meeting
Predictors of Discontinuation of Biologic DMARD Therapy Due to Remission in Patients with Rheumatoid Arthritis in a National Registry
Jose A Gomez-Puerta^1,2, M. Victoria Hernández¹, Fernando Sanchez-Alonso³, Kazuki Yoshida^2,4, Raimon Sanmarti¹, Daniel H Solomon², Juan J Gomez-Reino⁵ and On behalf of BIOBADASER 2.0 study group³, ¹Arthritis Unit, Department of Rheumatology, Hospital Clinic, Barcelona, Barcelona, Spain, ²Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, Boston, MA, ³Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, ⁴Department of Rheumatology, Kameda Medical Center, Kamogawa, Japan, Kamogawa, Japan, ⁵Hospital Clinico Universitario at the Universidad de Santiago de Compostela, Santiago, Spain
Background/Purpose: Remission is considered an achievable goal for many patients under biologic therapies. However, currently there is limited information about predictors of discontinuation of biologic…
Abstract Number: 1881 • 2014 ACR/ARHP Annual Meeting
Patients Who Fail Biologics Are More Likely to Have Concomitant Fibromyalgia
Robert S. Katz¹ and Jessica L. Polyak², ¹Rush Medical College, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: One area not assessed by studies to evaluate the efficacy of new medications in patients with inflammatory arthritis is whether the patient may have…
Abstract Number: 490 • 2014 ACR/ARHP Annual Meeting
A Randomised Controlled Trial Evaluating the Effect of Humira upon Endothelial Function in ACPA Positive Rheumatoid Arthritis â€“ an Interim Analysis
Stephen Oakley^1,2,3, Niloofar Esmaili⁴, Gabor Major⁴, David Mathers^4,5, Siva Ratnarajah⁶, John van der Kallen⁵, Mark Collins⁶, Marc Toh⁶ and John Glass⁴, ¹Dept of Rheumatology, Newcastle Bone & Joint Institute, Newcastle, Australia, ²School of Medicine & Public Health, University of Newcastle, Newcastle, Australia, ³Clinical Trials Unit, Hunter Medical Research Institute, Newcastle, Australia, ⁴Rheumatology, Newcastle Bone & Joint Institute, Newcastle, Australia, ⁵Rheumatology, Georgetown Arthritis Centre, Newcastle, Australia, ⁶Rheumatology, Private Practice, Newcastle, Australia
Background/Purpose Rheumatoid arthritis (RA) is associated with elevated cardiovascular (CV) risk not explained by traditional risk factors. Increased CV risk may develop prior to the…
Abstract Number: 2478 • 2014 ACR/ARHP Annual Meeting
Analysis of the Clinical Sustained Response after Retreatment with a Lower Dose of Rituximab in Patients with Chronic Inflammatory Arthropathies
M. Victoria Hernández¹, Andrea Cuervo¹, Sonia Cabrera¹, Jose Inciarte-Mundo¹, Julio Ramirez¹, Virginia Ruiz-Esquide¹, Juan D. Cañete² and Raimon Sanmarti¹, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clinic, Barcelona, Spain
Background/Purpose: The dosage of rituximab (RTX) approved for the treatment of active rheumatoid arthritis (RA) is two intravenous (iv.) 1 g infusions, separated by two…
Abstract Number: 1842 • 2014 ACR/ARHP Annual Meeting
High Rates of Failure after Biological DMARD Discontinuation While in Remission in a Japanese Multi-Center Registry
Kazuki Yoshida^1,2, Mitsumasa Kishimoto³, Helga Radner^1,4, Kazuo Matsui⁵, Masato Okada⁶, Yukihiko Saeki⁷, Daniel H. Solomon¹ and Shigeto Tohma⁸, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Department of Rheumatology, Kameda Medical Center, Kamogawa City, Japan, ³Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ⁴Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ⁵Department of Rheumatology, Kameda Medical Center, Kamogawa, Japan, ⁶Division of Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, ⁷Department of Clinical Research, Osaka-Minami Medical Center, Osaka, Japan, ⁸Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
Background/Purpose: Since the introduction of biological disease-modifying antirheumatic drugs (bDMARDs) and tight control strategies, remission has become a more feasible treatment target for an increasing…
Abstract Number: 478 • 2014 ACR/ARHP Annual Meeting
Adverse Events and Infections in Patients with Rheumatoid Arthritis Treated with Conventional Drugs or Biologic Agents: A Real World Study
Christos E. Lampropoulos¹, Philippos Orfanos², Vasiliki-Kalliopi Bournia³, Theofilos P. Karatsourakis⁴, Clio P. Mavragani⁵, Dimitrios Pikazis⁴, Menelaos N. Manoussakis⁶, Athanasios G. Tzioufas⁴, Haralampos M. Moutsopoulos⁷ and Panayiotis G. Vlachoyiannopoulos³, ¹Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ²Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece, ³First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ⁴Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ⁵Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ⁶Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece, ⁷Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease with joint destruction and permanent disability. Biologic agents (BAs) offer a better outcome when disease is…
Abstract Number: 2691 • 2013 ACR/ARHP Annual Meeting
Results Of The Strass Trial Regarding Impact Of Progressive Spacing Of Tnf-Blocker Injections In Rheumatoid Arthritis Patients In Das28 Remission: Is There a Difference Between Drugs – Adalimumab and Etanercept – Or Their Mode Of Use – Monotherapy Or Combination?
Bruno Fautrel¹, Thao Pham², Jacques Morel³, Toni Alfaiate⁴, Emmanuelle Dernis⁵, Philippe Gaudin⁶, Olivier Brocq⁷, Elisabeth Solau-Gervais⁸, Jean-Marie Berthelot⁹, Jean-Charles Balblanc¹⁰, Xavier Mariette¹¹ and Florence Tubach¹², ¹Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France, ²Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ³Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ⁴Biostatistics, Bichat Hospital, AP-HP, Paris, France, ⁵Le Mans Hospital, Le Mans, France, ⁶Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, ⁷Hospital of Princesse Grâce de Monaco, Monaco, France, ⁸Rheumatology, University Hospital of Poitiers, Poitiers, France, ⁹Rheumatology Unit, Nantes University Hospital, Nantes, France, ¹⁰Rheumatology, Centre Hospitalier Général de Belfort, Belfort, France, ¹¹Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ¹²INSERM, Universite Paris Diderot, Paris, France
Background/Purpose: The STRASS trial was an 18-month randomized controlled trial, conducted in established RA patients in DAS28 remission with etanercept (ETA) or adalimumab (ADA), comparing…
Abstract Number: 2028 • 2013 ACR/ARHP Annual Meeting
Efficacy and Safety Of Biologic Agents In Adult-Onset Still’s Disease: A Long-Term Follow-Up Of 19 Patients At a Single Referral Center
Giulio Cavalli^1,2, Stefano Franchini¹, Alvise Berti¹, Corrado Campochiaro¹, Barbara Guglielmi¹, Maria Grazia Sabbadini¹, Elena Baldissera³ and Lorenzo Dagna^4,5, ¹Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, ²San Raffaele Scientific Institute, Milan, Italy, ³Vita-Salute San Raffaele University, Milano, Italy, ⁴Vita-Salute San Raffaele University, Milan, Italy, ⁵Medicine and Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy
Background/Purpose: No data comparing the long-term outcome of Adult-Onset Still’s Disease (AOSD) patients treated with different biological drugs is currently available. We evaluated the efficacy…
Abstract Number: 1415 • 2013 ACR/ARHP Annual Meeting
Safety and Effectiveness Of Abatacept In 3985 Japanese Patients With Rheumatoid Arthritis; Japan All-Cases Post-Marketing Surveillance
Takao Koike¹, Masayoshi Harigai², Naoki Ishiguro³, Shigeko Inokuma⁴, Junnosuke Ryu⁵, Syuji Takei⁶, Tsutomu Takeuchi⁷, Y. Tanaka⁸, Masahiko Watanabe⁹ and Hisashi Yamanaka¹⁰, ¹Rheumatology, NTT Sapporo Medical Center, Sapporo, Japan, ²Dept of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan, ³Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁴Department of Allergy and Rheumatology diseases, Japanese Red Cross Medical Center, Tokyo, Japan, ⁵Nihon University School of Medicine, Tokyo, Japan, ⁶School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ⁷Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁸University of Occupational and Environmental Health, Kitakyushu, Japan, ⁹Bristol-Myers K.K, Tokyo, Japan, ¹⁰Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: A large-scale post-marketing surveillance (PMS) has been implemented to evaluate the safety and effectiveness on the use of intravenous abatacept (ABT) in Japanese patients…
Abstract Number: 411 • 2013 ACR/ARHP Annual Meeting
Differential Effects of biologics On The Removal Of Amyloid Deposition Between The Kidney and Gastric Tract Of Amyloid A Amyloidosis Patients With Rheumatoid Arthritis
Hiroshi Uda¹, Tamaki Harada², Ayumi Matsumoto³, Aya Mizumoto², Toshirou Takama² and Osamu Saiki¹, ¹Rheumatology, Higashiosaka City General Hospital, Higashiosaka, Japan, ²Nephrology, Higashiosaka City General Hospital, Higashiosaka, Japan, ³Higashiosaka City General Hospital, Higashiosaka, Japan
Background/Purpose: Several biologics therapy reportedly regress gastric amyloid deposition in amyloid A (AA) amyloidosis patients with rheumatoid arthritis (RA), but it is uncertain whether the…
Abstract Number: 2484 • 2013 ACR/ARHP Annual Meeting
Immunogenicity Of TNFα Blockers In Patients With Psoriatic Arthritis
Michael Zisapel Zisapel¹, Noa Madar-Balakirsi², Hagit Padova³, Irena Wigler⁴, Daphna Paran⁵, Uri Arad⁴, Dan Caspi⁶ and Ori Elkayam⁷, ¹Rheumatology, Tel Aviv Medical Centet, Tel Aviv, Israel, ²Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel, ³Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Department of Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁵Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv university, Tel Aviv, Israel, ⁶Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel- Aviv, Israel
Background/Purpose: TNFα blockers have been shown to produce immunogenecity in patients with rheumatoid arthritis, spondyloarthrritis and inflammatory bowel diseases. Data on the induction of anti-drug…
Abstract Number: 1942 • 2013 ACR/ARHP Annual Meeting
Ultrasound Shows Tenosynovitis to be Frequently Present as Well As Sensitive to Change in RA Patients On Biologic Medication
Hilde B. Hammer, Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Ultrasound (US) (grey scale (GS) and power Doppler (PD)) is a sensitive tool for examination of tenosynovitis in patients with rheumatoid arthritis (RA). The…
Abstract Number: 1379 • 2013 ACR/ARHP Annual Meeting
Differential Effects Of TNF Inhibitors, Anti-IL-6 Receptor Antibody and CTLA4-Ig On Human Monocytes
Toshihiro Tono¹, Yoshiyuki Arinuma², Tatsuo Nagai³, Sumiaki Tanaka² and Shunsei Hirohata², ¹Int Med/Rheumatol & Infec Dis, Kitasato University school of medicine, sagamihara, Japan, ²Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ³Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Biological agents inhibiting proinflammatory cytokines, especially IL-6 and TNFa, have brought a great impact in the treatment of rheumatoid arthritis (RA). In addition, CTLA4-Ig…
Abstract Number: 415 • 2013 ACR/ARHP Annual Meeting
Stability Of Carotid Intima Media Thickness and No Plaque Formation In Inflammatory Arthritis Patients On Biologics Over One Year
Stephanie O. Keeling¹, Asvina Bissonauth², Jeff Odenbach², Quazi Ibrahim³ and Michael Sean McMurtry⁴, ¹Division of Rheumatology, Department of Medicine, University of Alberta, Canada, Edmonton, AB, Canada, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³Medicine, EPICORE, Edmonton, AB, Canada, ⁴Cardiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Carotid intima media (cIMT) measurement is a validated surrogate measure of cardiovascular (CV) disease. Our aim was to evaluate baseline and follow-up cIMTs in…

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