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Abstracts tagged "Biologic agents and rheumatoid arthritis (RA)"

  • Abstract Number: 1115 • 2019 ACR/ARP Annual Meeting

    Switching Patterns Among Patients with Chronic Inflammatory Diseases Switching to an Infliximab Biosimilar or Remaining on Originator Infliximab (REMICADE)

    Bruno Emond 1, Kay Sadik 2, Marie-Hélène Lafeuille 1, Willy Wynant 1, Aurélie Côté-Sergent 1, Patrick Lefebvre 1, Kimberly Woodruff 2 and Timothy Fitzgerald3, 1Analysis Group, Inc, Montreal, QC, Canada, 2Janssen Scientific Affairs, LLC, Titusville, NJ, 3Janssen Scientific Affairs, LLC, Horsham, PA

    Background/Purpose: Chronic inflammatory diseases (CIDs) such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), plaque psoriasis (PsO), ankylosing spondylitis (AS), Crohn's disease (CD), and ulcerative colitis…
  • Abstract Number: 609 • 2018 ACR/ARHP Annual Meeting

    Multi-Biologic Usage in Rheumatoid Arthritis Is Not Infrequent in the Routine Practice

    Alper Sari1, Levent Kilic1, Berkan Armagan1, Abdulsamet Erden2, Gozde Yardımcı1, Ali Akdogan2, Omer Karadag2, Sule Apras Bilgen2, Ihsan Ertenli2 and Sedat Kiraz2, 1Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Biologic DMARDs (bDMARDs) have proven efficacy in rheumatoid arthritis (RA) however, some patients inadequately response to multiple bDMARDs.  This study aims to determine the…
  • Abstract Number: 1490 • 2018 ACR/ARHP Annual Meeting

    Effects of Biologic Drugs on Prognosis of Rheumatoid Arthritis Among Patients with Poor Glycated Hemoglobic A1c (HbA1c) Control

    Yusuke Miwa1 and Tsuyoshi Kasama2, 1Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Shinagawa-ku Tokyo, Japan, 2Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Poor control of glycated hemoglobic A1c (HbA1c) worsens prognosis for diabetes mellitus and various complicated diseases. Corticosteroids exacerbate poor HbA1c control. This study, investigated…
  • Abstract Number: 606 • 2016 ACR/ARHP Annual Meeting

    A Randomized, Double Blind, Single Dose Study to Assess the Pharmacokinetics, Safety, and Tolerability of ONS-3010 (Adalimumab, Oncobiologics, Inc.) Compared to Two Reference Products of Humira® (AbbVie) in Healthy Adult Subjects

    Kenneth Bahrt1, Joannes Reijers2, Marlous Dillingh2, Claudia Rehrig1 and Jacobus Burggraaf3, 1Oncobiologics Inc, Cranbury, NJ, 2Centre for Human Drug Research, Leiden, Netherlands, 3Centre for Human Drug Research, Leiden,, Netherlands

    ONS-3010 is being developed as a biosimilar candidate of Humira® (Adalimumab), a full-length recombinant human IgG1 monoclonal antibody specific for TNFα. This study evaluated the b,…
  • Abstract Number: 2244 • 2016 ACR/ARHP Annual Meeting

    Utilization Patterns of Subcutaneously Administered Biologic Medications within a Sample of Rheumatoid Arthritis Patients

    Joseph Tkacz1, Brenna Brady2, Lorie A. Ellis3 and Roxanne Meyer4, 1Health Analytics, Columbia, MD, 2Health Analytics, LLC, Columbia, MD, 3Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Horsham, PA, 4Janssen Scientific Affairs, Horsham, PA

      Background/Purpose:   Adherence to medication is crucial to the maximum therapeutic benefit of biologic treatment. The plethora of currently approved biologic agents makes comparison…
  • Abstract Number: 2249 • 2016 ACR/ARHP Annual Meeting

    Comparison of Discontinuation Rates Among Patients with RA Initiating Biologics

    Sofia Pedro1 and Kaleb Michaud1,2, 1National Data Bank for Rheumatic Diseases, Wichita, KS, 2University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: While difficult to directly compare effectiveness of biologics in observational settings, drug discontinuation can be a useful substitute. We compared the discontinuation rates of…
  • Abstract Number: 428 • 2015 ACR/ARHP Annual Meeting

    Use of Rituximab Compared to Anti-TNF Agents As Second and Third Line Therapy in Patients with Rheumatoid Arthritis: 6-Year Follow-up Report from the Rhumadata® Clinical Database and Registry

    Denis Choquette1, Louis Bessette2, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard3, Diane Sauvageau1, Édith Villeneuve1, Louis Coupal1, Jacques Brown4 and Angèle Turcotte4, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Rhumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 4Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada

    Background/Purpose: The order of use of biologic agents after failing a TNF inhibitor is still a question for debate. Phase III trial data in TNF-IR…
  • Abstract Number: 461 • 2015 ACR/ARHP Annual Meeting

    Etanercept Has a Better Retention Rate at 10 Years Than Adalimumab in Patients with Rheumatoid Arthritis. Results from Rhumadata®: A Real-Life Clinical Database and Registry

    Denis Choquette1, Louis Bessette2, Jacques Brown3, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard4, Diane Sauvageau1, Angèle Turcotte3, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada, 4Rhumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada

    Background/Purpose: Very few studies have compare different agents used in the treatment of rheumatoid arthritis (RA) over the very long term. The majority of them…
  • Abstract Number: 480 • 2015 ACR/ARHP Annual Meeting

    Comparative 10-Year Retention Rates of Adalimumab Used in Mono and Combination Therapy in Rheumatoid Arthritis (RA) Patients from the Rhumadata Clinical Database and Registry

    Denis Choquette1, Louis Bessette2, Jacques Brown3, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard4, Diane Sauvageau1, Angèle Turcotte3, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada, 4Rhumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada

    Background/Purpose: The recent publication of the concerto trial comparing the use of adalimumab in monotherapy versus in association with methotrexate (MTX) at dose varying from…
  • Abstract Number: 585 • 2015 ACR/ARHP Annual Meeting

    Outcomes after Discontinuing Tumor Necrosis Factor Inhibitor in Rheumatoid Arthritis: 2 Years of ‘post-Golimumab’ after Completion of the 5-Year Extension Study in Korea

    Kichul Shin1, Hyun Mi Kwon2, Seong-Wook Kang3, Won Park4, Sung-Hwan Park5,6, Chang-Hee Suh7,8, Hyun Ah Kim9,10, Seung-Geun Lee11, Choong Ki Lee12, Sang-Cheol Bae13, Soo-Kon Lee14 and Yeong Wook Song15, 1Division of Rheumatology, SMG-SNU Boramae Medical Center, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 3Division of Rheumatology, Chungnam National University Hospital, Gwangju, South Korea, 4Division of Rheumatology, Inha University Hospital, Incheon, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 6Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, 7Allergy-Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 8Division of Rheumatology, Ajou University Hospital, Suwon, South Korea, 9Internal Medicine, Hallym Univ Sacred Heart Hosp, Anyang, South Korea, 10Division of Rheumatology, Hanlim University Hospital, Anyang, South Korea, 11Division of Rheumatology, Busan University Hospital, Busan, South Korea, 12Division of Rheumatology, Youngnam National University Hospital, Daegu, South Korea, 13Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 14Division of Rheumatology, Yonsei University College of Medicine, Seoul, South Korea, 15Division of Rheumatology, Department of internal medicine, Seoul National University Hospital, Seoul, South Korea

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) have helped patients achieve remarkable outcomes as in improving synovitis and halting structural damages in severe cases of rheumatoid…
  • Abstract Number: 2526 • 2014 ACR/ARHP Annual Meeting

    Efficacy of Biological Therapies in Rheumatoid Arthritis: Graphical Modeling of DAS28 Components’ Evolution over Time

    G. Avila1, Arnald Alonso1, María América López-Lasanta1, Andrea Pluma-Sanjurjo2, C. Diaz2 and Sara Marsal1, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Rheumatology, University Hospital Vall d'Hebron, Barcelona, Spain

    Background/Purpose The wide use of biological therapies (BTs) has clearly modified the therapeutic approach in rheumatoid arthritis (RA). One of the most commonly used tools…
  • Abstract Number: 2383 • 2014 ACR/ARHP Annual Meeting

    The 12-Years Retention Rate of the First-Line TNF-Inhibitor in the Treatment of Rheumatoid Arthritis: Real-Life Data from a Local Registry

    Ennio Giulio Favalli1, Martina Biggioggero2, Francesca Pregnolato3, Andrea Becciolini2, Alessandra Emiliana Penatti2, Antonio Marchesoni4 and Pier Luigi Meroni2, 1Department of Rheumatology, Gaetano Pini Institute, Milan, Italy, 2Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy, 3Experimental Laboratory of Immunological and Rheumatologic Researches, IRCCS, Istituto Auxologico Italiano, Milan, Italy, 4Rheumatology, Department of Rheumatology, Gaetano Pini Institute, Milan, Italy

    Background/Purpose Data on over-10-years drug survival of TNF inhibitors (TNFi) are still lacking. The aim of the study is to analysed the long-term retention rate…
  • Abstract Number: 1149 • 2014 ACR/ARHP Annual Meeting

    Novel Adherence Measures for Infusible Therapeutic Agents in Rheumatoid Arthritis

    Roxanne Meyer1, Michael Ingham2, Joseph Tkacz3, Brenna Brady3 and Charles Ruetsch4, 1Janssen Scientific Affairs, Horsham, PA, 2850 Ridgeview Drive, Janssen Services, LLC, Horsham, PA, 3Health Analytics, LLC, Columbia, MD, 4Health Analytics LLC, Columbia, MD

    Background/Purpose: Adherence is under consideration for quality reporting in a number of disease states. Published data on adherence of biologics reveal a wide range of…
  • Abstract Number: 2514 • 2014 ACR/ARHP Annual Meeting

    Biological Treatment for Rheumatoid Arthritis (RA): A Fifteen Years Multicentric Overview

    Vittorio Grosso1, Roberto Gorla2, Piercarlo Sarzi-Puttini3, Fabiola Atzeni4, Raffaele Pellerito5, Enrico Fusaro6, Giuseppe Paolazzi7, Pier Andrea Rocchetta8, Ennio Giulio Favalli9, Antonio Marchesoni10 and Roberto Caporali11, 1Division of Rheumatology,, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, 2Reumatologia, Spedali Civili, Brescia, Italy, 3Rheumatology Unit, University Hospital L Sacco, Milano, Italy, 4Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, 5Rheumatology, Ospedale Mauriziano, Turin, Italy, 6Department of Rheumatology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Turin, Italy, 7Rheumatology, Santa Chiara Hospital, Trento, Italy, 8Struttura di Reumatologia A.S.O. «SS.Antonio e Biagio e C.Arrigo», Alessandria, Italy, 9Department of Rheumatology, Gaetano Pini Institute, Milan, Italy, 10Department of Rheumatology, Gaetano Pini Institute, Milano, Italy, 11Rheumatology, Division of Rheumatology, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy

    Background/Purpose During the last fifteen years, the role of biologics in the management of RA, the number of available biologics, and the recommendations of use,…
  • Abstract Number: 2386 • 2013 ACR/ARHP Annual Meeting

    Survival Of Biological Therapy In Rheumatoid Arthritis: 12 Years Follow-Up Cohort

    Zulema Rosales1, Cristina Vadillo1, Leticia León1, Rayma Peña1, Margarita Blanco1, Esperanza Pato2, J.L. Fernández Rueda1, Luis Rodriguez-Rodriguez3, Benjamin Fernández-Gutiérrez1, Lydia Abásolo1 and Juan A. Jover1, 1Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 2Rheumatology, Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, 3Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain

    Background/Purpose: After more than a decade of biological agents (BA) use for the treatment of rheumatoid arthritis (RA), it is necessary a thorough knowledge of…
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