ACR Meeting Abstracts

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Abstracts tagged "Bioinformatics"

  • Abstract Number: 1982 • ACR Convergence 2022

    Pluripotency Marker PBX1 Predicts Treatment Effect in Rheumatoid Arthritis

    Karin Andersson1, Eric Malmhäll-Bah2, Nina Oparina1, Tao Weiyang3, Malin Erlandsson1, Venkataragavan Chandrasekaran2, Aridaman Pandit3, Sofia Töyrä Silfverswärd4, Maria Bokarewa4 and Rille pullerits4, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 3Center for Translational Immunology, University Medical Center, Utrecht, Netherlands, 4Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: Self-renewal ability, which is important for the adaptive immunity and adequate T cell function, is severely impaired in rheumatoid arthritis (RA). This leads to…
  • Abstract Number: 0668 • ACR Convergence 2022

    Differential Expression of Interferon Related Genes in SLE Patients of Asian and European Ancestries Abstract

    Ian Rector1, Prathyusha Bachali2, Jinoos Yazdany3, Maria Dall'Era4, Amrie Grammer5 and Peter lipsky1, 1AMPEL Biosolutions, Charlottesville, VA, 2AMPEL BioSolutions, Redmond, WA, 3UCSF, San Francisco, CA, 4University of California, Division of Rheumatology, San Francisco, CA, 5AMPEL LLC, Charlottesville, VA

    Background/Purpose: Interferon has been shown to play a role in the pathogenesis of SLE, but insufficient studies have been conducted into the differences in interferon…
  • Abstract Number: 1150 • ACR Convergence 2022

    Spatial Transcriptomics Stratifies Health and Psoriatic Disease Severity by Emergent Cellular Ecosystems

    Rochelle Castillo1, Ikjot Sidhu1, Igor Dolgalev1, Ipsita Subudhi1, Di Yan1, Piotr Konieczny1, Brandon Hsieh1, Tinyi Chu2, Rebecca Haberman1, Shanmugapriya Selvaraj1, Tomoe Shiomi1, Rhina Medina1, Parvathy Vasudevanpillai Girija1, Adriana Heguy1, Cynthia Loomis1, Luis Chiriboga1, Shane Meehan1, Christopher Ritchlin3, Maria de la Luz Garcia-Hernandez4, John Carucci1, Andrea Neimann1, Shruti Naik1 and Jose Scher5, 1NYU Langone Health, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 4University of Rochester, West Henrietta, NY, 5New York University School of Medicine, New York, NY

    Background/Purpose: The skin is recognized as a window into the immunopathogenic mechanisms driving the vast phenotypic spectrum of psoriatic disease.Methods: To better decipher the cellular…
  • Abstract Number: 1990 • ACR Convergence 2022

    Artificial Intelligence Applied to Transcriptomics Profiling of Synovial Tissue Biopsies Accurately Predicts Rheumatoid Arthritis Patients Who Will Respond or Be Refractory to Standard Biological Treatments

    Giorgio CASABURI, Todd Holscher and Ming-Chou Lee, Exagen, Inc., Vista, CA

    Background/Purpose: In recent years, biological therapies have revolutionized treatments of Rheumatoid Arthritis (RA). However, about 40% of RA patients do not respond to given biologics…
  • Abstract Number: 0043 • ACR Convergence 2022

    Non-invasive Tape Strip Gene Expression Profiling of Lesional Juvenile Dermatomyositis Skin Identifies Immunoregulatory Module That Associates with Skin, Muscle and Global Disease Activity

    Jessica Turnier1, Celine Berthier2, Madison McClune2, Sarah Vandenbergen2, Johann Gudjonsson2, Alex Tsoi2 and J. Michelle Kahlenberg2, 1University of Michigan, Saline, MI, 2University of Michigan, Ann Arbor, MI

    Background/Purpose: Skin inflammation in juvenile dermatomyositis (JDM) frequently persists even in the absence of active muscle disease. Tape stripping is a non-invasive skin sampling method…
  • Abstract Number: 0732 • ACR Convergence 2022

    Application of Natural Language Processing to Identify Varicella Zoster Infection in Clinical Notes

    Austin Ho1, Zara Izadi2, Gabriela Schmajuk3, Jinoos Yazdany4, Suzanne Tamang5 and Milena Gianfrancesco6, 1University of California, Berkeley, Berkeley, CA, 2University of California San Francisco, San Francisco, CA, 3UCSF / SFVA, San Francisco, CA, 4UCSF, San Francisco, CA, 5Stanford Center for Population Health Sciences, Redwood City, CA, 6University of California, San Francisco, San Francisco, CA

    Background/Purpose: Varicella zoster virus (VZV) infection can be associated with significant morbidity in immunosuppressed individuals. However, infections of VZV are often documented in unstructured fields…
  • Abstract Number: 1168 • ACR Convergence 2022

    Dermal Fibroblast-derived Exosomes Drive Profibrotic Macrophage Activation in Systemic Sclerosis

    Heetaek Yang1, Rajan Bhandari1, Noelle Kosarek2, Jonathan Garlick3, Michael Whitfield4 and Patricia Pioli1, 1Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Lebanon, NH, 3Tufts University School of Dental Medicine, Boston, MA, 4Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Macrophage (MØ) activation derives from coordination of signals received in local tissue microenvironments. In prior studies, we demonstrated that cocultured MØs and fibroblasts from…
  • Abstract Number: 2019 • ACR Convergence 2022

    Fine Mapping of the Sjögren’s Disease and Systemic Lupus Erythematosus DDX6-CXCR5 Risk Interval Reveals Common SNPs with Functional Significance in Immune and Salivary Gland Cells

    Mandi Wiley1, Bhuwan Khatri1, Kandice Tessneer1, Michelle Joachims1, Anna Stolarczyk1, Anna Nagel1, Astrid Rasmussen1, Professor Simon Bowman2, Lida Radfar3, Roald Omdal4, Marie Wahren-Herlenius5, Blake Warner6, Torsten Witte7, Roland Jonsson8, Maureen Rischmueller9, Patrick Gaffney1, Judith James1, Lars Ronnblom10, Hal Scofield1, Xavier Mariette11, Fai Ng12, Gunnel Nordmark10, Betty Tsao13 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University Hospitals Birmingham, Birmingham, United Kingdom, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Stavanger University, Stavanger, Norway, 5Karolinska Institutet, Stockholm, Sweden, 6National Institutes of Health, Bethesda, MD, 7MH-Hannover, Hannover, Germany, 8University of Bergen, Bergen, Norway, 9RheumatologySA, Adelaide, Australia, 10Uppsala University, Uppsala, Sweden, 11Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 12Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 13Medical University of South Carolina, Charleston, SC

    Background/Purpose: Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) share several characteristics and have similar genome-wide significant associations in the DDX6-CXCR5 locus. Fine mapping of…
  • Abstract Number: 0256 • ACR Convergence 2022

    Patients with ACPA-positive and ACPA-negative Rheumatoid Arthritis Show Different Circulating Auto-antibody Repertoires

    Kevin Cunningham1, Benjamin Hur2, John Davis2 and Jaeyun Sung2, 1University of Minnesota, Rochester, MN, 2Mayo Clinic, Rochester, MN

    Background/Purpose: RA is commonly diagnosed through a serological test for the presence of ACPA, and RA patients who test positive are collectively known as 'ACPA-positive…
  • Abstract Number: 0905 • ACR Convergence 2022

    Predicting Disease Activity in Rheumatoid Arthritis Patients Using Machine Learning: Data from the ACR’s RISE Registry

    Eren-Ajani Tshimanga1, Milena Gianfrancesco2, Stefanos Giampanis3, Jing Li2, Emma Kersey4, Jinoos Yazdany5, Beau Norgeot6, Gabriela Schmajuk7 and Zara Izadi4, 1University of California, Berkeley, Berkeley, CA, 2University of California, San Francisco, San Francisco, CA, 3Anthem, San Francisco, 4University of California San Francisco, San Francisco, CA, 5UCSF, San Francisco, CA, 6Anthem, Oakland, CA, 7UCSF / SFVA, San Francisco, CA

    Background/Purpose: Predicting the trajectory of disease in individuals with RA is difficult, with numerous factors influencing whether a patient may experience higher or lower disease…
  • Abstract Number: 1181 • ACR Convergence 2022

    Hippo Pathway Effectors Promote and Maintain Myofibroblast Differentiation and Endothelial-to-mesenchymal Transition in Systemic Sclerosis

    Feiyang Ma1, Pei-Suen Tsou1, Grace Hile1, John Varga1, J. Michelle Kahlenberg1, Allison Billi1, Johann Gudjonsson1 and Dinesh Khanna2, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix molecules leading to fibrosis of skin and…
  • Abstract Number: 2020 • ACR Convergence 2022

    Autophagy-related Risk Loci in Systemic Lupus Erythematous and Sjögren’s Disease

    Anna Nagel1, Bhuwan Khatri1, Marcin Radziszewski1, Mandi Wiley1, Anna Stolarczyk1, Michelle Joachims1, Kandice Tessneer1, Astrid Rasmussen1, Professor Simon Bowman2, Lida Radfar3, Roald Omdal4, Marie Wahren-Herlenius5, Blake Warner6, Torsten Witte7, Roland Jonsson8, Maureen Rischmueller9, Patrick Gaffney1, Judith James1, Lars Ronnblom10, Hal Scofield1, Xavier Mariette11, Marta Alarcon-Riquelme12, Fai Ng13, Gunnel Nordmark10, Qing Sun14, Kwangwoo Kim15, Sang-Cheol Bae16, Betty Tsao14, A. Darise Farris1 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University Hospitals Birmingham, Birmingham, United Kingdom, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Stavanger University, Stavanger, Norway, 5Karolinska Institutet, Stockholm, Sweden, 6National Institutes of Health, Bethesda, MD, 7MH-Hannover, Hannover, Germany, 8University of Bergen, Bergen, Norway, 9RheumatologySA, Adelaide, Australia, 10Uppsala University, Uppsala, Sweden, 11Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 12Center for Genomics and Oncological Research (GENYO), Granada, Spain, 13Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 14Medical University of South Carolina, Charleston, SC, 15Kyung Hee University, Seoul, Republic of Korea, 16Hanyang University Medical Center, Seoul, Republic of Korea

    Background/Purpose: Dysregulated autophagy is implicated in systemic lupus erythematous (SLE) and Sjögren's disease (SjD), including dysregulated expression of Autophagy-related gene 5 (ATG5) and Autophagy Related…
  • Abstract Number: 0329 • ACR Convergence 2022

    Scoring Personalized Molecular Portraits Identify Systemic Lupus Erythematosus Subtypes and Predict Individualized Drug Responses, Symptomatology and Disease Progression

    Daniel Toro-Domínguez1, Manuel Martinez-Bueno1, Raúl López-Domínguez2, Jordi Martorell-Marugán1, Elena Carnero-Montoro1, Guillermo Barturen1, Daniel W. Goldman3, Michelle Petri3, Pedro Carmona-Sáez2 and Marta Alarcon-Riquelme1, 1Center for Genomics and Oncological Research (GENYO), Granada, Spain, 2University of Granada, Granada, Spain, 3Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Systemic Lupus Erythematosus is a complex autoimmune disease that leads to important worsening of quality of life and mortality. Flares appear unpredictably during the…
  • Abstract Number: 0935 • ACR Convergence 2022

    Targeted Synovial Tissue RNA-Seq Coupled with Artificial Intelligence Accurately Predicts Early Rheumatoid Arthritis Patients Likely to Respond to CsDMARDs, Enriching CsDMARDs Response Rates and Enabling Early Identification of Patients Requiring Subsequent Biological Therapy

    Giorgio CASABURI, Tyler O'Malley, Todd Holscher and Ming-Chou Lee, Exagen, Inc., Vista, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease, affecting the joints with varying severity. RA affects approximately 0.5/1% of adults in the…
  • Abstract Number: 1183 • ACR Convergence 2022

    Functionally Distinct Fibroblast Populations in Systemic Sclerosis Skin Revealed by Explant Tissue Characterization and Single-cell RNAseq

    Kristina Clark1, Alice Cole2, Shiwen Xu1, Voon Ong3, Christopher Buckley4 and Chris Denton1, 1University College London, London, United Kingdom, 2Royal Free Hospital, London, United Kingdom, 3UCL Medical School Royal Free Campus, London, United Kingdom, 4University of Oxford, Oxford, United Kingdom

    Background/Purpose: Traditional studies of skin fibroblasts in SSc focus on the early "migratory" fibroblast population derived from explant culture of skin biopsies. Single-cell RNAseq has…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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