Abstracts tagged "Big data"

Abstract Number: 876 • 2017 ACR/ARHP Annual Meeting
Epidemiologic Subsets Drive a Differentiated Clinical and Immunological Presentation of Primary Sjögren Syndrome: Analysis of 9302 Patients from the Big Data International Sjögren Cohort
Soledad Retamozo^1,2,3, Pilar Brito-Zerón^3,4, Margit Zeher⁵, Kathy L. Sivils⁶, Raphaele Seror⁷, Thomas Mandl⁸, Xiaomei Li⁹, Chiara Baldini¹⁰, Jacques-Eric Gottenberg¹¹, Debashish Danda¹², Roberta Priori¹³, Luca Quartuccio¹⁴, Gabriela Hernandez-Molina¹⁵, Aike A. Kruize¹⁶, Seung-Ki Kwok¹⁷, Marie Wahren-Herlenius¹⁸, Sonja Praprotnik¹⁹, Damien Sene²⁰, Roberto Gerli²¹, Roser Solans²², Yasunori Suzuki²³, David A. Isenberg²⁴, Maureen Rischmueller²⁵, Gunnel Nordmark²⁶, Guadalupe Fraile²⁷, Piotr Wiland²⁸, Hendrika Bootsma²⁹, Takashi Nakamura³⁰, Valeria Valim³¹, Roberto Giacomelli³², Valérie Devauchelle-Pensec³³, Benedikt Hofauer³⁴, Michele Bombardieri³⁵, Virginia Fernandes Moça Trevisani³⁶, Daniel S. Hammenfors³⁷, Steven E. Carsons³⁸, Sandra Gofinet Pasoto³⁹, Jacques Morel⁴⁰, Tamer Gheita⁴¹, Fabiola Atzeni⁴², Cristina F. Vollenweider⁴³, Belchin Kostov⁴⁴, Xavier Mariette⁴⁵ and Manuel Ramos-Casals⁴⁶, ¹Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, ²Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, ³Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, ⁴Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, ⁵Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, ⁶Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, ⁸Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, ⁹Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, China, Hefei, Anhui, China, ¹⁰Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ¹¹Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France, Strasbourg, France, ¹²Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, ¹³UO Complessa Reumatologia, Policlinico Umberto I Università Sapienza di Roma, Rome, Italy, ¹⁴Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, ¹⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición SZ, mexico city, Mexico, ¹⁶Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁷[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ¹⁸Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ¹⁹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²⁰Service de Médecine Interne 2, Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, 2, Paris, France, Paris, France, ²¹University and Azienda Ospedaliera of Perugia, Perugia, Italy, ²²Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, ²³Division of Rheumatology, Kanazawa University Graduate School of Medicine, Ishikawa, Japan, Kanazawa, Japan, ²⁴Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²⁵Rheumatology, The Queen Elizabeth Hospital, South Australia, Adelaide, Australia, ²⁶Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²⁷Autoimmune Diseases Department, Hospital Ramón y Cajal, Madrid, Spain, ²⁸Department and Clinic of Rheumatology and Internal Medicine, Medical University, Wroclaw, Poland, ²⁹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³⁰Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan, ³¹Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, ³²University of L'Aquila, L'Aquila, Italy, ³³Department of Rheumatology, Brest University Hospital, Brest, France, ³⁴Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, München, Germany, München, Germany, ³⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK, London, United Kingdom, ³⁶UNIFESP, Sao Paulo, Brazil, San Paulo, Brazil, ³⁷Department of Rheumatology, Haukeland University Hospital, University of Bergen, Bergen, Norway, ³⁸NYU Winthrop University Hospital, Department of Medicine, Mineola, NY, ³⁹Internal Medicine, Division of Rheumatology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, ⁴⁰Department of Rheumatology, Teaching hospital and University of Montpellier, France, Montpellier, France, ⁴¹Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ⁴²Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, ⁴³Rheumatology, German Hospital, Buenos Aires, Argentina, Buenos Aires, Argentina, ⁴⁴Primary Care Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Primary Care Centre Les Corts, CAPSBE, Barcelona, Spain, ⁴⁵Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ⁴⁶Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain
Background/Purpose: To analyse whether epidemiologic factors (such as gender or age at diagnosis of the disease) are associated with particular disease expressions and define some…
Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting
Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing
Aleksander Lenert¹ and David W. Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
Abstract Number: 672 • 2016 ACR/ARHP Annual Meeting
Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)
Pilar Brito-Zerón^1,2, Soledad Retamozo³, Margit Zeher⁴, Astrid Rasmussen⁵, Raphaele Seror⁶, Elke Theander⁷, Xiaomei Li⁸, Chiara Baldini⁹, Jacques-Eric Gottenberg¹⁰, Debashish Danda¹¹, Luca Quartuccio¹², Roberta Priori^13,14, Gabriela Hernandez-Molina¹⁵, Aike A. Kruize¹⁶, Valeria Valim¹⁷, Marika Kvarnström¹⁸, Damien Sene¹⁹, Roberto Gerli²⁰, Sonja Praprotnik²¹, David A. Isenberg²², Roser Solans²³, Maureen Rischmueller²⁴, Seung-Ki Kwok²⁵, Gunnel Nordmark²⁶, Yasunori Suzuki²⁷, Roberto Giacomelli²⁸, Valerie Devauchelle²⁹, Michele Bombardieri³⁰, Benedikt Hofauer³¹, Hendrika Bootsma³², Johan G. Brun³³, Guadalupe Fraile³⁴, Steven E. Carsons³⁵, Tamer Gheita³⁶, Jacques Morel³⁷, Cristina F. Vollenweider³⁸, Fabiola Atzeni³⁹, Nihan Acar-Denizli⁴⁰, Ildike-Fanny Horvath⁴, Kathy Sivils⁵, Thomas Mandl⁴¹, Pulukool Sandhya¹¹, Salvatore De Vita⁴², Jorge Sánchez-Guerrero⁴³, Eefje van der Heijden¹⁶, Virginia Moça Trevisano⁴⁴, Marie Wahren-Herlenius¹⁸, Xavier Mariette⁶, Manuel Ramos-Casals^1,45,46 and EULAR-SS Task Force Big Data Consortium (ASSES, GEAS-SEMI, EULAR), ¹Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ²Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, ³Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, ⁴Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, ⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ⁶Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, ⁷Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Malmö, Sweden, ⁸Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, China, Hefei, Anhui, China, ⁹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ¹⁰Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France, Strasbourg, France, ¹¹Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, ¹²Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, ¹³Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ¹⁴Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ¹⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, ¹⁶Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Utrecht, Netherlands, ¹⁷Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, ¹⁸Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ¹⁹Service de Médecine Interne 2, Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, 2, Paris, France, Paris, France, ²⁰Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Italy, Perugia, Italy, ²¹Department of Rheumatology, University Medical Centre Ljubljana, Slovenia, Ljubljana, Slovenia, ²²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ²³Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, ²⁴Department of Rheumatology, School of Medicine, The University of Western Australia, Crawley, Australia, Crawley, Australia, ²⁵Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea, ²⁶Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ²⁷Division of Rheumatology, Kanazawa University Graduate School of Medicine, Ishikawa, Japan, Kanazawa, Japan, ²⁸Clinical Unit of Rheumatology, University of l'Aquila, School of Medicine, L'Aquila, Italy, L'Aquila, Italy, ²⁹Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ³⁰Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, QMUL, UK, London, United Kingdom, ³¹Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, München, Germany, München, Germany, ³²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands, ³³Department of Clinical Science, University of Bergen. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, Bergen, Norway, ³⁴Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, ³⁵Division of Rheumatology, Allergy and Immunology Winthrop-University Hospital, Stony Brook University School of Medicine, NY, USA, Mineola, NY, ³⁶Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ³⁷Department of Rheumatology, Teaching hospital and University of Montpellier, France, Montpellier, France, ³⁸Rheumatology, German Hospital, Buenos Aires, Argentina, Buenos Aires, Argentina, ³⁹IRCCS Galeazzi Orthopedic Institute, Milan, Italy, Milan, Italy, ⁴⁰Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Turkey, Istabul, Turkey, ⁴¹Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Rheumatology, Malmö, Sweden, Malmö, Sweden, ⁴²Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital "Santa Maria della Misericordia", Udine, Italy, Udine, Italy, ⁴³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico, ⁴⁴Federal University of São Paulo, Sao Paulo, Brazil, San Paulo, Brazil, ⁴⁵Sjögren Syndrome Research Group (AGAUR), Barcelona, Spain, ⁴⁶Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain
Background/Purpose: To analyse the influence of geolocation (North-to-South gradient) on the clinical presentation of primary Sjögren syndrome (SjS) at diagnosis. Methods: The Big Data Sjögren…
Abstract Number: 807 • 2016 ACR/ARHP Annual Meeting
A Novel Multi-Network Approach Reveals Tissue-Specific Cellular Modulators of Fibrosis in Systemic Sclerosis, Pulmonary Fibrosis and Pulmonary Arterial Hypertension
Jaclyn N. Taroni¹, Casey S. Greene², Tammara A. Wood³, Romy B. Christmann⁴, Harrison W. Farber⁵, Robert A. Lafyatis⁶, Christopher Denton⁷, Monique Hinchcliff⁸, Patricia A. Pioli⁹, Michael L. Whitfield¹⁰ and J. Matthew Mahoney¹¹, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Division of Rheumatology, Boston University Medical School, Boston, MA, ⁵Pulmonary Center, Boston University Medical Center, Boston, MA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁰Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹¹Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT
Background/Purpose: Systemic sclerosis (SSc) is characterized by multi-organ involvement and clinical heterogeneity. “Big data” approaches have yielded powerful tools to infer tissue-specific pathobiology. Large amounts of…
Abstract Number: 1217 • 2015 ACR/ARHP Annual Meeting
Phenome-Wide Association Study of Novel Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis
Katherine Liao¹, Jeffrey A. Sparks¹, Boris Hejblum², I-Hsin Kuo¹, Jing Cui¹, Lauren J. Lahey³, Andrew Cagan⁴, Vivian Gainer⁴, Weidong Liu⁵, Tony Cai⁶, Jeremy Sokolove⁷ and Tianxi Cai², ¹Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA, ²Biostatistics, Harvard School of Public Health, Boston, MA, ³Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, ⁴Research Computing, Partners HealthCare, Charlestown, MA, ⁵Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China, ⁶Statistics, University of Pennsylvania, Philadelphia, PA, ⁷Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA
Background/Purpose: RA patients develop autoantibodies against a spectrum of antigens. However, the clinical significance of these autoantibodies after RA diagnosis is unclear. The Phenome-Wide Association…
Abstract Number: 2316 • 2014 ACR/ARHP Annual Meeting
Adherence to Denosumab in a Large Healthcare System
Robert A. Overman¹, Julie C. Lauffenburger², Margaret L. Gourlay³ and Chad L. Deal⁴, ¹Eshelman School of Pharmacy - Division of Pharmaceutical Policy and Outcomes, University of North Carolina, Chapel Hill, NC, ²Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, ³Family Medicine, University of North Carolina, Chapel Hill, NC, ⁴Dept of Rheum & Imm Dis /A 50, Cleveland Clinic, Cleveland, OH
Background/Purpose: Oral bisphosphonates adherence has been reported as less than 50% at one year. Adherence to denosumab has been reported to be higher than alendronate…
Abstract Number: 2263 • 2014 ACR/ARHP Annual Meeting
Continued Zoledronic Acid Use in a Large Healthcare System
Robert A. Overman¹, Julie C. Lauffenburger², Margaret L. Gourlay³ and Chad L. Deal⁴, ¹Eshelman School of Pharmacy - Division of Pharmaceutical Policy and Outcomes, University of North Carolina, Chapel Hill, NC, ²Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, ³Family Medicine, University of North Carolina, Chapel Hill, NC, ⁴Dept of Rheum & Imm Dis /A 50, Cleveland Clinic, Cleveland, OH
Background/Purpose: Oral bisphosphonates adherence has been reported as less than 50% at one year. With patients frequently having refill gaps greater than 30 days. Zoledronic…

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