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Abstracts tagged "belimumab and B cell targeting"

  • Abstract Number: 941 • ACR/ARP Annual Meeting 2019

    Treatment of Lupus Nephritis with anti-CD20 Followed by Anti-BAFF: Impact on B Cell Reconstitution, B Cell Subsets, and Autoreactivity

    Yemil Atisha Fregoso1, Susan Malkiel 2, Kristina Harris 3, Sai Kanaparthi 3, Margie Byron 4, Linna Ding 5, Dawn Smilek 6, David Wofsy 7, Maria Dall'Era 8, Cynthia Aranow 1 and Betty Diamond 9, 1Feinstein Institute for Medical Research, Manhasset, NY, 2Feinstein Institute for Medical Research, Manhasset, 3Immune Tolerance Network, Bethesda, 4Rho Federal Systems, Inc., Chapel Hill, NC, 5National Institute of Allergy and Infectious Diseases, Bethesda, MD, 6Immune Tolerance Network, San Francisco, CA, 7UCSF, San Francisco, 8University of California, San Francisco, San Francisco, CA, 9Feinstein Institutes for Medical Research, Manhasset

    Background/Purpose: Despite the relevance of B cells in lupus, two clinical trials of anti-CD20 failed to meet primary endpoints in patients with lupus and lupus…

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