ACR Meeting Abstracts

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Abstracts tagged "Behçet’s Syndrome"

  • Abstract Number: 0801 • ACR Convergence 2023

    LncRNA PIGL-217 Regulates Th17 Differentiation by Targeting miR-5008-5p and Suppressing FoxO1 in Behçet’s Disease

    Zhimian Wang, Xin Yu, Hua Chen and Wenjie Zheng, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Dysregulated Th17 cells are implicated in Behçet's disease (BD). However, the underlying mechanism remains unclear. Here we aim to elucidate the mechanism of forkhead…
  • Abstract Number: 2519 • ACR Convergence 2023

    A Phase II Clinical Study to Investigate the Efficacy and Safety of Hemay005 Tablets in Patients with Active Behçet`sDisease

    Charles Jones1, Zhanguo Li2, Zhuoli Zhang3, Jian Wu4, Guixiu Shi5, Wenjie Zheng6, Jianping Tang7, Xiaobing Wang8, Lie Dai9, Lin Chen10, Yasong Li11, Ling Wu12, Yongfu Wang13, Shengyun Liu14, Yao Ke15, Jin Lin16, Zhenchun Zhang17, Jiankang Hu18, Wantai Dang19, Songlou Yin20, Xin Tang21, Mingfei Zhu22, Jinfeng Lin22, Richard Jones22, Weiguo Wan23 and xianjun Hu22, 1Hemay Pharmaceuticals, Tianjin, China, 2Peking University Health Science Center, Department of Rheumatology and Immunology, People's Hospital, Beijing, China, 3Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 4Suzhou University Affiliated First Hospital, Suzhou, China, 5the First Affiliated Hospital of Xiamen University, Xiamen, China, 6Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 7Shanghai Tongji Hospital, Shanghai, China, 8The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 9Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 10Jilin Provincial People's Hospital, Changchun, China, 1111Zhejiang Provincial People's Hospital, Hangzhou, China, 12University of Hong Kong Shenzhen Hospital, Shenzhen, China, 13The First Affiliated Hospital of Baotou Medical College, Baotou, China, 14The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 15Jiangsu Provincial People's Hospital, Nanjing, China, 16The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 17Linyi People's Hospital, Linyi, China, 18Pingxiang People’s Hospital, PingXiang, China, 19The First Affiliated Hospital of Chengdu Medical College, Chengdu, China, 20Xuzhou Medical University Affiliated Hospital, Xuzhou, China, 21Bestudy (Shanghai) Medical Technology Co., Ltd, Shanghai, China, 22Clinical Department, Tianjin Hemay Pharmaceutical Co., Ltd., Tianjin, China, 23Huashan Hospital Affiliated to Fudan University, Shanghai, China

    Background/Purpose: Behçet's disease (BD) is a chronic and recurrent vascular inflammatory disease with major manifestations including oral ulcers, genital ulcers, skin damage and ophthalmitis, and…
  • Abstract Number: 1126 • ACR Convergence 2023

    Identification of Clinical Phenotypes in Behçet’s Disease Using a Cluster Analysis

    Ana Serrano-Combarro1, Jose Luis Martin-Varillas2, Raul Fernandez-Ramon3, Lara Sanchez-Bilbao4, Carmen Alvarez Reguera3, ELENA Aurrecoechea5 and Ricardo Blanco6, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain, 2Hospital de Laredo, Laredo, Spain, 3Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Spain, 5HOSPITAL SIERRALLANA, Cantabria, Spain, 6Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Behcet's disease (BD) is a variable-vessel vasculitis with a high variability of clinical manifestations. The objective of our study was to identify clinical phenotypes…
  • Abstract Number: 127 • 2023 Pediatric Rheumatology Symposium

    What’s in a Name? A20 Protein Expression in an in Vitro Model of A20 Haploinsufficiency

    Patricia Pontes Aires1, DANIELA GERENT PETRY PIOTTO1, Andre Cunha1, Sandro Perazzio2 and Maria Teresa Terreri3, 1Universidade Federal de São Paulo, São Paulo, Brazil, 2Universidade de So Paulo; Fleury Laboratories, São Paulo, Brazil, 3UNIFESP, São Paulo, Brazil

    Background/Purpose: Tumor necrosis factor alpha (TNF-alpha) induced protein 3 gene, or TNFAIP3, encodes the A20 protein, an important regulator of the NF-κB pathway. Since its…
  • Abstract Number: 1563 • ACR Convergence 2022

    Common Femoral Vein Wall Thickness Measurement as a Diagnostic Test in Incomplete Behçet’s Disease

    Fatma Alibaz-Oner1, seda kutluğ ağaçkıran2, Rabia Ergelen3, Fatma Temiz3, efe Soydemir3, Tulin Ergun4 and Haner Direskeneli5, 1Marmara University, Rheumatology, Istanbul, Turkey, 2Marmara University School of Medicine, Division of Rheumatology, Istanbul, Turkey, 3Marmara University, School of Medicine, Departmant of Internal Medicine, Istanbul, Turkey, 4Marmara University, School of Medicine, Department of Dermatology, Istanbul, Turkey, 5Marmara University, Rheumatology, Istanbul, Istanbul, Turkey

    Background/Purpose: Diagnosing Behçet's Disease (BD) can be a clinical challenge in patients presenting with limited organ manifestations, especially with single major organ involvement. We reported…
  • Abstract Number: 1564 • ACR Convergence 2022

    Anti-TNF versus Anti-IL6 Receptor Antagonist Therapy in Severe Ocular Involvement in Behçet’s Disease

    Nuria Barroso-García1, Belén Atienza-Mateo2, Ivan Ferraz Amaro3, Diana Prieto-Peña2, Ana De Vicente-Delmás4, Ricardo Blanco5 and Miguel Ángel González-Gay6, 1Hospital Universitario Puerta del Mar, Cádiz, Spain, Cádiz, Spain, 2Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 4Hospital General Santa María del Puerto, Cádiz, Spain, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 6Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: To evaluate the efficacy of anti-TNF or anti-IL6 treatment in severe and refractory ocular involvement in patients with refractory cystoid macular edema (CME) due…
  • Abstract Number: 1565 • ACR Convergence 2022

    Dissection of Ocular and Peripheral Blood Immune Phenotypes Suggests Preferential Transmigration of CD16+ Monocytes to Effector Sites in Behçet’s Disease

    Yesim Ozguler1, Ziyan Lin2, Ann Cavers3, gulen Hatemi4, Olivier Manches5 and Johannes Nowatzky3, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 2NYU Grossman School of Medicine, NYU Langone Applied Informatics Laboratories, New York, NY, 3NYU Grossman School of Medicine, New York, NY, 4Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 5Recherche et Développement, Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes Etablissement Français du Sang Auvergne-Rhône-Alpes, Grenoble, France

    Background/Purpose: Cellular immunity of Behçet's Disease (BD) remains poorly understood. Previous work has provided clues pointing to most innate and adaptive immune cell types in…
  • Abstract Number: 1566 • ACR Convergence 2022

    Outcome of Vascular Involvement of Behçet Syndrome Treated with Infliximab: A Retrospective Cohort Study

    gulen Hatemi1, Nur Beyza Tukek2, Sinem Nihal Esatoglu1, Yesim Ozguler3, Sitki Safa Taflan2, Melike Melikoglu1, Serdal Ugurlu4, Izzet Fresko1, Zekayi Kutlubay5, Sebahattin Yurdakul1, Hasan Yazici6 and Vedat Hamuryudan7, 1Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 4Istanbul University-Cerrahpaşa, Istanbul, Turkey, 5Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul, Turkey, 6Letter to Editor Rheumatology, Istanbul, Turkey, 7Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey

    Background/Purpose: Vascular involvement is an important cause of morbidity and mortality in patients with Behçet syndrome (BS). We aimed to survey the efficacy and safety…
  • Abstract Number: 0695 • ACR Convergence 2022

    Epidemiology of Behçet’s Disease in Northern Spain

    Carmen Alvarez Reguera1, guillermo Suárez-Amorin1, Rosalía Demetrio-Pablo1, Raúl fernández-ramón1, Alba Herrero-Morant2, Lara Sánchez-Bilbao1, David Martínez-López1, José Luis Martín-Varillas3, Santos Castañeda4, Miguel Ángel González-Gay5 and Ricardo Blanco6, 1Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, Ontinyent, Spain, 3Hospital de Laredo, Laredo, Cantabria, Spain, 4Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 5Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 6Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: The prevalence of Behçet’s disease (BD) has a considerable geographical and temporal variability. Data regarding epidemiology in Spain are limited. Our study aimed to…
  • Abstract Number: 1567 • ACR Convergence 2022

    Refractory Macular Edema Due to Behçet’s Disease. Multicenter Comparative Study of Adalimumab and Certolizumab Pegol

    José Luis Martín-Varillas1, Lara Sánchez-Bilbao2, Vanesa Calvo Río3, Alf Adán4, Inés Hernanz Rodríguez4, Miguel Cordero Coma5, David Díaz Valle6, Patricia Fanlo7, Juan Ramón de Dios8, A. Garcia-Aparicio9, Sergio Rodriguez Montero10, Vega Jovani Casano11, Patricia Moya Alvarado12, eva Peña Sainz-Pardo13, José Luis Hernández2 and Ricardo Blanco14, 1Hospital de Laredo, Laredo, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Valdecilla Hospital, Santander, Spain, 4H. Clinic, Barcelona, Spain, 5Hospital de León, León, Spain, 6Hospital Clínico San Carlos, Madrid, Spain, 7Complejo Hospitalario de Navarra, Navarra, Spain, 8Hospital de Araba, Araba, Spain, 9Hospital Universitario de Toledo, Toledo, Spain, 10Virgen de Valme University Hospital, Sevilla, Spain, 11National Health system, Alicante, Spain, 12Hospital Parc Tauli, Barcelona, Spain, 13Hospital Universitario 12 de Octubre, Madrid, Spain, 14Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Cystoid Macular Edema (CME) is the leading cause of blindness in non-infectious uveitis. Behçet's disease (BD) is one of the diseases most frequently associated…
  • Abstract Number: 1041 • ACR Convergence 2022

    Tofacitinib in Refractory Uveitis – an Observational Study

    Nikhil Gupta1 and Deepankur Mahajan2, 1Centre for Arthritis and Rheumatological diseases in Delhi, New Delhi, India, 2Mahajan Eye Centre, New Delhi, India

    Background/Purpose: To evaluate the effect of generic tofacitinib in refractory uveitis patients.Methods: It was a prospective observational study of 23 patients of refractory anterior uveitis.…
  • Abstract Number: 1701 • ACR Convergence 2022

    High TNFAIP3-Transfected Cell Activity: An In Vitro Model for Phagocyte Study of Monogenic Behçet’s Disease Pathophysiology

    Patricia Pontes Aires1, André Cunha1, DANIELA GERENT PETRY PIOTTO1, Maria Teresa Terreri2 and Sandro Perazzio1, 1Universidade Federal de São Paulo, São Paulo, Brazil, 2Universidad Federal São Paulo, São Paulo, Brazil

    Background/Purpose: A20 haploinsufficiency (A20HA), an important monogenic etiology of Behçet's disease (BD), is caused by loss-of-function mutations in TNFAIP3. Although monocytes play an important role…
  • Abstract Number: 1237 • ACR Convergence 2022

    Assessment of Common Femoral Vein Intima-Media Thickness by Ultrasound in Behçet’s Disease: Comparative Study of Patients with or Without Vascular Involvement in a National Referral Center

    Diana Prieto-Peña1, Alfonso del Peral-Fanjul2, Belén Atienza-Mateo1, Veronica Pulito-Cueto1, Miguel Ángel González-Gay3 and Ricardo Blanco4, 1Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain, Spain, 3Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 4Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Clinical vascular involvement is present in up to 40% of patients with Behçet’s disease (BD). Increased venous wall thickness assessed with ultrasound (US) has…
  • Abstract Number: 1837 • ACR Convergence 2022

    Eales Disease and Vogt-Koyanagi-Harada Syndrome: Not Everything Is Anterior Uveitis in Rheumatology

    Sonia Pastor Navarro1, Olga Compán Fernández1, Marta Ibáñez Martínez1, Belén Miguel Ibáñez1, Mireia Molina Pérez2, Ángel Beltrán Mazo2, Olga Martínez González1, Carlos Montilla Morales1, Ana Isabel Turrión Nieves1, Susana Gómez Castro3 and Cristina Hidalgo Calleja1, 1Hospital Universitario de Salamanca, Salamanca, Spain, 2Hospital Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, 3Hospital Universitario Salamanca, Salamanca, Spain

    Background/Purpose: Ocular inflammatory involvement for being closely related to systemic autoimmune diseases is monitored and treated in our rheumatology visits. The most frequently studied by…
  • Abstract Number: 1251 • ACR Convergence 2022

    Venous Halo Sign Detected with Superb Microvascular Imaging in Behçet Syndrome

    Yasemin Kayadibi1, Yesim Ozguler2, Melike Melikoglu3, Sinem Nihal Esatoglu3, Ahmet Ustundag1, Ugur Kimyon4, Ayse Kalyoncu Ucar1, Ibrahim Adaletli1 and gulen Hatemi3, 1Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Radiology, Istanbul, Turkey, 2Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 3Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 4Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Department of Internal Medicine, Istanbul, Turkey

    Background/Purpose: Superb microvascular imaging (SMI) is a novel technique that provides a more sensitive assessment of small vessels compared to color Doppler US (CDUS), by…
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