ACR Meeting Abstracts

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Abstracts tagged "Behcet’s syndrome"

  • Abstract Number: 3041 • 2015 ACR/ARHP Annual Meeting

    Long Term Biological Therapy in Uveitis Refractory Due to Behçet’s Disease. Multicenter Study of 165 Patients. 

    Montserrat Santos-Gómez1, Vanesa Calvo-Río1, Ricardo Blanco1, Emma Beltran2, Juan Sánchez Bursón Sr.3, Marina Mesquida4, Alfredo Adan4, M. Victoria Hernández5, F.Javier López-Longo6, Marisa Hernandez Grafella7, Elia Valls Pascual8, Lucía Martinez-Costa9, Agusti Sellas-Fernandez10, Miguel Cordero11, Manuel Díaz-Llopis12, Roberto Gallego13, Jose L. García Serrano14, JL Callejas Rubio15, Norberto Ortego-Centeno16, Jose M Herreras17, Alejandro Fonollosa18, Angel M. Garcia-Aparicio19, Olga Maiz Alonso20, Ana Blanco21, Ignacio Torre22, Cruz Fernández- Espartero23, Vega Jovani24, Diana Peiteado25, David Diaz Valle26, Esperanza Pato26, Juan Cruz27, Carlos Férnandez Cid28, Elena Aurrecoechea29, Miriam García-Arias30, Miguel Angel Caracuel-Ruiz31, Carlos Alberto Montilla Morales32, Antonio Atanes-Sandoval33, Félix Francisco34, Santos Insua35, Senen González-Suárez36, Amalia Sánchez-Andrade37, Fernando Gamero38, Luis Francisco Linares39, Fredeswinda Romero40, A. Javier García-González41, Raquel Almodóvar González42, Enrique Minguez43, Carmen Carrasco Cubero44, Alejandro Olivé45, Julio Vázquez46, Oscar Ruiz Moreno47, Fernando Jiménez-Zorzo48, Javier Manero48, Santiago MuÑoz Fernandez49, Cristina Fernández-Carballido50, Esteban Rubio Romero51, Fred Antón Pagés52, Javier Toyos-Saenz de Miera53, Myriam Gandía54, Carmen Gonzalez-Vela55, Enrique Raya56, Natalia Palmou1, Leyre Riancho-Zarrabeitia1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 3Rheumatology, Hospital de Valme., Sevilla, Spain, 4Ophthalmology, Hospital Clinic, Barcelona, Spain, 5Arthritis Unit, Rheumatology, Hospital Clinic, Barcelona, Spain, 6Hospital Gregorio Marañón, Madrid, Spain, 7Ophthalmology., Hospital General Universitario de Valencia, Valencia, Spain, 8Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, 9Ophthalmology, Hospital Universitario Dr Peset, Valencia, Spain, 10Rheumatology, Hospital Universitario Valle Hebron, Barcelona, Spain, 11Ophthalmology, Hospital de León, León, Spain, 12Hospital Universitario La Fe, Valencia, Spain, 13Ophthalmology, Hospital Universitario La Fe, Valencia, Spain, 14Ophthalmology, Hospital Universitario San Cecilio, Granada, Spain, 15Hospital Universitario San Cecilio, Granada, Spain, 16Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, 17Ophthalmology, Hospital Universitario, IOBA, Valladolid, Spain, 18Ophtalmology, Hospital de Cruces, Bilbao, Spain, 19Rheumatology, Hospital Virgen de la Salud, Toledo, Spain, 20Rheumatology, Donostia University Hospital, Donostia, Spain, 21Ophthalmology, Donostia University Hospital, Donostia, Spain, 22Rheumatology, Hospital de Basurto, Bilbao, Spain, 23Rheumatology, Hospital La Zarzuela, Madrid, Spain, 24Rheumatology, Hospital General de Alicante, Alicante, Spain, 25Rheumatology, Hospital La Paz, Madrid, Spain, 26Hospital Clínico San Carlos, Madrid, Spain, 27Rheumatology, Hospital de Pontevedra, Pontevedra, Spain, 28Ophthalmology, Hospital de Pontevedra, Pontevedra, Spain, 29Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, 30Rheumatology, Hospital La Princesa, Madrid, Spain, 31Plaza Cruz Roja, 1, Hospital Reina Sofia, Córdoba, Spain, 32Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain, 33Rheumatology, Complejo Hospitalario Universitario de La Coruña, La Coruña, Spain, 34Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain, 35Rheumatology, Hospital Universitario Santiago de Compostela, La Coruña, Spain, 36Rheumatology, Hospital de Cabueñes, Gijón, Spain, 37Hospital Lucus Augusti, Lugo, Spain, 38Rheumatology, Hospital San Pedro Alcántara, Cáceres, Spain, 39Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain, 40Section for Autoimmune Diseases, Rheumatology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 41Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 42Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain, 43Ophthalmology., Hospital Clínico de Zaragoza, Zaragoza, Spain, 44Rheumatology, Hospital de Mérida, Mérida, Spain, 45Hospital Germans Trias i Pujol, Badalona, Spain, 46Rheumatology., Hospital de Ferrol, La Coruña, Spain, 47Ophthalmology and Rheumatology., Hospital Miguel Servet, Zaragoza, Spain, 48Ophthalmology and Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, 49Rheumatology, Hospital Infanta Sofía, Madrid, Spain, 50Rheumatology, Hospital General Universitario de Elda, Elda (Alicante), Spain, 51Rheumatology Department,, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 52Rheumatology, Hospital de Palencia, Palencia, Spain, 53Rheumatology, Hospital Virgen de la Macarena, Seville, Spain, 54Department of Autoimmune Diseases, IDIBAPS, Hospital Clínic, Barcelona, Spain, 55Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 56Rheumatology, Hospital Universitario San Cecilio, Granada, Spain

    Background/Purpose: Conventional management of uveitis due to Behçet’s disease (UBD) consists on conventional immunosuppressive drugs. However, UBD is often refractory requiring more intensive therapy.Our aim was…
  • Abstract Number: 3042 • 2015 ACR/ARHP Annual Meeting

    Tocilizumab in Refractory Uveitis Associated with Behçet’s Disease. Multicenter Study of 7 Patients. 

    Montserrat Santos-Gómez1, Vanesa Calvo-Río1, Ricardo Blanco1, Emma Beltran2, Antonio Atanes-Sandoval3, Enar Pons4, Javier Loricera1, Carmen Gonzalez-Vela5, Leyre Riancho-Zarrabeitia1, Natalia Palmou1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 3Rheumatology, Complejo Hospitalario Universitario de La Coruña, La Coruña, Spain, 4Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 5Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose: Treatment recommended in severe and/or refractory uveitis of Behçet disease is anti-TNF-α therapy, usually infliximab (IFX) or adalimumab (ADA) (Levy-Clarke et al Ophthalmology 2014;121:785-796).…
  • Abstract Number: 3043 • 2015 ACR/ARHP Annual Meeting

    IL-17 Expression By Lymphocytes Is Higher in Behcet’s Disease Compared to Takayasu Arteritis

    Ali Ugur Unal1, Rabia Deniz2, Aysin Tulunay Virlan3, Filiz Ture Ozdemir3, Imren Aydin Tatli3, Gulsen Ozen1, Fatma Alibaz-Oner4, Gonca Mumcu5, Tulin Ergun6 and Haner Direskeneli1, 1Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Marmara University Faculty of Medicine, Istanbul, Turkey, 3Department of Immunology, Marmara University Faculty of Medicine, Istanbul, Turkey, 4Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 5Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 6Dermatology, Marmara University Faculty of Medicine, Dermatology, Istanbul, Turkey

    Background/Purpose: Interleukin-17 (IL-17) has been associated with the pathogenesis of  various inflammatory diseases. The aim of our study was to investigate the expression of Th17-related…
  • Abstract Number: 3044 • 2015 ACR/ARHP Annual Meeting

    Microparticles (MPs) Derived from Cell Plasma Membranes Are Increased in Behcet’s Syndrome (BS) and a Low Ratio of Tissue Factor Pathway Inhibitor Positive Mps to Tissue Factor Positive Mps (TFPI/TF) Is Associated with Thrombosis

    Emon Khan1, Nicola Ambrose1, Miles Stanford2, Michael A. Laffan3 and Dorian O. Haskard4, 1Department of Vascular Sciences, National Heart and Lung Institute, Imperial College, London, United Kingdom, 2Ophthalmology, Guy's and St. Thomas' Hospital, London, United Kingdom, 3Department of Haemostasis and Thrombosis, Imperial College, London, United Kingdom, 4Rheumatology, Imperial College, London, United Kingdom

    Background/Purpose: Thrombosis occurs in around 20% of Behçet's Syndrome (BS) patients and causes substantial morbidity.  There is a clear need for better biomarkers of thrombotic…
  • Abstract Number: 3045 • 2015 ACR/ARHP Annual Meeting

    Anti-Alpha-Enolase Antibodies in Behçet’s Disease: A Marker of Articular Disease Activity?

    Leandro L. Prado, Celio R. Gonçalves, Vilma S. T. Viana, Eloisa Bonfá and Carla G.S. Saad, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Diagnosis of Behçet´s disease (BD) is challenging because is based solely on clinical features. Articular involvement in this disease may mimic other diagnosis such…
  • Abstract Number: 204 • 2015 ACR/ARHP Annual Meeting

    Histone Methylation Profiling in Peripheral White Blood Cells As a Candidate Biomarker for Behcet’s Disease

    Yoshimi Aizaki1,2, Yasuto Araki1,2, Kojiro Sato1, Yuji Akiyama1 and Toshihide Mimura1,2, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Behcet’s disease (BD) is a chronic recurrent, multisystem inflammatory disorder. The phenotypic characteristics include oral aphtha, genital ulcers, uveitis and skin lesions. No specific…
  • Abstract Number: 3046 • 2015 ACR/ARHP Annual Meeting

    Venous Disease-Specific Quality-of-Life Is Impaired in Patients with Vascular Behcet’s Disease

    Fatma Alibaz-Oner1, Belgin Aldag2, Mustafa Aldag3, Ali Ugur Unal4, Tayfur Toptas5, Tülin Ergun6 and Haner Direskeneli4, 1Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 3Dr.Siyami Ersek Cardiovascular Surgery Hospital,, Istanbul, Turkey, 4Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 5Hematology, Marmara University, Istanbul, Turkey, 6Dermatology, Marmara University Faculty of Medicine, Dermatology, Istanbul, Turkey

    Background/Purpose: Vascular involvement is seen in up to 40% of the patients with Behcet's disease (BD), with lower extremity deep vein thrombosis (DVT) as the most…
  • Abstract Number: 1247 • 2015 ACR/ARHP Annual Meeting

    Methylation Analysis of HLA-B Locus in Familial Behçet Syndrome

    Eda Tahir Turanli1, Pelinsu Koprulu2, Serdal Ugurlu3, Hasan Yazici4 and Emire Seyahi3, 1Molecular Biology and Genetics Department, Istanbul Technical University, Istanbul, Turkey, 2Molecular Biology Genetics and Biotechnology Program, Istanbul Technical University, Istanbul, Turkey, 3Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, 4Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: Our focus has been on the potential role of the epigenetic processes, mainly of the methylation, on the development of Beh�et syndrome (BS) using…
  • Abstract Number: 3049 • 2015 ACR/ARHP Annual Meeting

    Cognitive Dysfunction in Chronic Progressive Neuro-Behçet’s Disease: Comparative Study of the Brainstem and Hippocampus Region Using Brain Magnetic Resonance Imaging

    Hirotoshi Kikuchi1, Kurumi Asako1, Maki Takayama1, Shoko Iga1, Yoshitaka Kimura1, Hajime Kono1 and Shunsei Hirohata2, 1Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan

    Background/Purpose: Central nervous system involvement is one of the most serious complications in Behçet's disease (BD). This condition is referred to as neuro-Behçet's disease (NB)…
  • Abstract Number: 1370 • 2015 ACR/ARHP Annual Meeting

    CD40/CD40L Pathway Is Associated with Increased Oxidative Burst and Neutrophil Extracellular Traps Release in Behcet´s Disease

    Sandro F. Perazzio1,2, Paulo Vitor Soeiro Pereira3, Alexandre W.S. Souza4, Antonio Condino-Neto3 and Luis Eduardo C. Andrade5, 1Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, 2Fleury Medicine and Health, Sao Paulo, Brazil, 3Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, 4Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 5Immunology Division, Fleury Medicine and Health, São Paulo, Brazil

    Background/Purpose: Previous studies suggested that unknown plasma factors increase oxidative burst in Behçet’s disease (BD), but little is known about neutrophil extracellular traps (NET) formation.…
  • Abstract Number: 3052 • 2015 ACR/ARHP Annual Meeting

    Budd-Chiari Syndrome in Behçet’s Disease:a Retrospective Multicenter Study

    Lutfi Akyol1, Bahtiyar Toz2, Ozun Bayndır3, Orhan Zengin4, Dondu Uskudar Cansu5, Murat Yigit6, Gozde Yildirim Cetin7, Ahmet Omma8, Abdulsamet Erden9, Orhan Kucuksahin10, Senol Kobak11, Osman Cure1, Ali Ugur Unal12, Ayten Yazici13, Metin Ozgen1, Ali Sahin14, Emel Gonullu15, Suleyman Serdar Koca16, Burak Erer2, Ahmet Gul17, Kenan Aksu3, Gokhan Keser18, Ahmet Mesut Onat4, Bunyamin Kisacik4, Timucin Kasifoglu5, Ayse Cefle19, Umut Kalyoncu9 and Mehmet Sayarlioglu1, 1Department of Internal Medicine Division of Rheumatology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey, 2Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 3İnternal Medicine Division of Rheumatology, Ege University Medical Faculty, Izmir, Turkey, 4İnternal Medicine Division of Rheumatology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey, 5İnternal Medicine Division of Rheumatology, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, 6İnternal Medicine Division of Rheumatology, Pamukkale University, Faculty of Medicine, Denizli, Turkey, 7Rheumatology, Kahramanmaras University School of Medicine, Kahramanmaras, Turkey, 8Department of Internal Medicine, Rheumatology Division, Ankara Numune Hospital, Ankara, Turkey, 9Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 10Rheumatology, Yildirim Beyazit University School of Medicine, Ankara, Turkey, 11Rheumatology, Sifa University, Izmir, Turkey, 12Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 13Rheumatology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey, 14Department of Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey, 15Rheumatology, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, 16İnternal Medicine Division of Rheumatology, Firat University, Faculty of Medicine, Elazig, Turkey, 17Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 18Rheumatology, Ege University Medical Faculty, Izmir, Turkey, 19İnternal Medicine Division of Rheumatology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey

    Background/Purpose: Budd-Chiari syndrome (BCS), or hepatic venous outflow obstruction, is a rare and serious complication of Behçet's disease (BD). The aim of this study was…
  • Abstract Number: 1389 • 2015 ACR/ARHP Annual Meeting

    A Meta-Analysis of the Prevalence of the Ocular Manifestations in All Inflammatory Rheumatic Diseases

    Jacqueline Hayworth1 and Janet E. Pope2, 1Medicine, University of Western Ontario and U of Toronto, Toronto, ON, Canada, 2University of Western Ontario, London, ON, Canada

    Background/Purpose: Many inflammatory rheumatic diseases (IRD) are associated with ocular involvement. The prevalence of these complications is not fully known.  This meta-analysis was performed to…
  • Abstract Number: 3054 • 2015 ACR/ARHP Annual Meeting

    Takayasu’s Arteritis Associated with Behçet’s Syndrome: A Case Series of 8 Patients

    Sinem Nihal Esatoglu1, Emire Seyahi2, Serdal Ugurlu2, Gulen Hatemi2, Melike Melikoglu2, Vedat Hamuryudan3 and Sebahattin Yurdakul1, 1Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, 2Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, 3Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: Takayasu's arteritis (TA) and Behçet's syndrome (BS) are both systemic vasculitis of an unknown etiology, each with unique involvement pattern. TA affects aorta and…
  • Abstract Number: 3034 • 2015 ACR/ARHP Annual Meeting

    A Comparative Metabolomic Evaluation of Behcet’s Disease with Arthritis and Seronegative Arthritis Using Synovial Fluid

    Joong Kyong Ahn1, Sooah Kim2, Jungyeon Kim2, Jiwon Hwang3, Hyungjin Kim4, Hyemin Jeong5, Yeong Hee Eun6, Chan Hong Jeon7, Jaejoon Lee5, Eun-Mi Koh5, Kyoung Heon Kim2 and Hoon-Suk Cha8, 1Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Department of Biotechnology, Korea University Graduate School, Seoul, South Korea, 3Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 4Department of medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 5Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 6Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 7Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, 8Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose: Behcet’s disease (BD) is a chronic, complex systemic vasculitis of unknown etiology characterized by orogenital ulcers, uveitis, and arthritis. Arthritis and arthralgias in BD…
  • Abstract Number: 3224 • 2015 ACR/ARHP Annual Meeting

    Salivary IL-1 Alpha and IL-1 Beta Levels Are Associated with Oral Mucosal Activity in Behcet’s Disease

    Nilufer Alpay Kanitez1, Bahtiyar Toz1, Feyza Berktas1, Sertan Ergun2, Meltem Koray2, Nuray Gurel Polat3, Burak Erer1 and Ahmet Gül1, 1Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Department of Oral Medicine, Istanbul University, Faculty of Dentistry, Istanbul, Turkey, 3Department of Microbiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: Recurrent oral aphthous ulcers are the common manifestation of the Behçet's disease (BD), and they are indistinguishable from ulcers of recurrent aphthous stomatitis (RAS).…
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