Abstracts tagged "Behcet’s syndrome"

Abstract Number: 2370 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Study Identifies Significant Epigenetic Changes Across the Genome and in Multiple HLA Loci in Behcet’s Disease
Haner Direskeneli¹, Patrick S. Coit², Filiz Ture-Ozdemir¹, Fatma Alibaz-Oner¹, Guher Saruhan-Direskeneli³, Matlock A. Jeffries⁴ and Amr H. Sawalha², ¹Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Medicine, University of Oklahoma and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Behcet’s disease (BD) is a systemic vasculitis of poorly understood etiology. Herein, we study the DNA methylome in BD for the first time and…
Abstract Number: 2371 • 2012 ACR/ARHP Annual Meeting
The Unmet Need in Behcet’s Disease: Most Patients Are Not in Complete Remission in the Long-Term Follow-up
Fatma Alibaz-Oner¹, Gonca Mumcu², Gülsen Ozen³, Zeynep Kubilay⁴, Meryem Can¹, Sibel Yýlmaz Oner¹, Tülin Ergun⁵ and Haner Direskeneli¹, ¹Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ²Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, ³Rheumatology, Marmara University School of Medicine., Istanbul, Turkey, ⁴Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey, ⁵Dermatology, Marmara University School of Medicine, Istanbul, Turkey
Background/Purpose: The nature of Behcet’s disease (BD) as a multi-systemic disorder with a remitting-relapsing course is unsufficiently explored. As complete remission should be aimed in…
Abstract Number: 2372 • 2012 ACR/ARHP Annual Meeting
Efficacy of Quantitative Analysis of Brainstem Atrophy On Magnetic Resonance Imaging for Diagnosis of Chronic Progressive Neuro-Behçet’s Disease
Hirotoshi Kikuchi¹, Maki Takayama², Yoshitaka Kimura², Kurumi Asako², Hajime Kono², Yasuo Ono¹ and Shunsei Hirohata³, ¹Department of Microbiology and Immunology, Teikyo University Shool of Medicine, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose : CNS involvement in Behçet's disease, usually called neuro-Behçet's disease (NB), can be classified into acute NB (ANB) and chronic progressive NB (CPNB) based…
Abstract Number: 2373 • 2012 ACR/ARHP Annual Meeting
The Clinical Course of the Acute Deep Vein Thrombosis of the Legs in Behçet’s Syndrome
Yesim Ozguler¹, Melike Melikoglu², Firat Cetinkaya³, Serdal Ugurlu⁴, Emire Seyahi⁵, Koray Tascilar⁶ and Hasan Yazici⁷, ¹Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey, ²Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ³Radiology, Colormed Radiology Center, Istanbul, Turkey, ⁴Rheumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey, ⁵Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁶University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁷Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: 15-50% of patients with Behçet’s syndrome have vascular involvement (BS). Deep vein thrombosis is the most common form with lower extremity deep vein thrombosis…
Abstract Number: 2374 • 2012 ACR/ARHP Annual Meeting
Characteristics, Treatment and Outcome of Gastrointestinal Involvement in Behcet’s Syndrome: Experience in A Dedicated Center
Ibrahim Hatemi¹, Gulen Hatemi², Yusuf Erzin¹, Aykut Ferhat Celik¹ and Hasan Yazici³, ¹Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Gastroenterology, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: Gastrointestinal involvement can be a severe complication resulting in perforation and massive bleeding. Controlled data regarding treatment is lacking and long term prognosis is…
Abstract Number: 2376 • 2012 ACR/ARHP Annual Meeting
Behcet’s Disease: Combination of Pulse Cyclophosphamide, Azathioprine, and Prednisolone for the Treatment of Retinal Vasculitis; Longitudinal Study On 10 Years
Fereydoun Davatchi¹, Farhad Shahram², Bahar Sadeghi Abdollahi², Hormoz Shams², Abdolhadi Nadji², Massoomeh Akhlaghi², Tahereh Faezi² and Farimah Ashofteh², ¹Rheumatology Research Ctr and Department of Rheumatology, Shariati Hospital-Tehran Univ, Tehran, Iran, ²Rheumatology, Behcet's Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Background/Purpose: Ocular lesions of Behcet’s Disease (BD), need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents…
Abstract Number: 1005 • 2012 ACR/ARHP Annual Meeting
The Identification of Pathway Markers in Behcet’s Disease Using Genomewide Association Data From Two Different Populations
Burcu Bakir-Gungor¹, Elaine Remmers², Daniel L. Kastner², Akira Meguro³, Nobuhisa Mizuki⁴, Ahmet Gul⁵ and Osman Ugur Sezerman⁶, ¹Department of Genetics and Bioinformatics, Faculty of Arts and Sciences, Bahcesehir University, Istanbul, Turkey, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁴Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁵Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁶Biological Sciences and Bioengineering, Faculty of Engineering and Natural Sciences, Sabancı University, Istanbul, Turkey
Background/Purpose: Behcet's disease (BD) is a multi-system inflammatory disease, characterized by recurrent exacerbations affecting several organs including orogenital mucosa, eyes and skin. Two recent genome-wide…
Abstract Number: 858 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping, Imputation, and Regression Analysis Identifies Multiple Independent Genetic Susceptibility Loci within the HLA Region in Behcet’s Disease
Travis Hughes¹, Adam Adler², Patrick S. Coit¹, Vuslat Yilmaz³, Kenan Aksu⁴, Nursen Duzgun⁵, Gokhan Keser⁴, Ayse Cefle⁶, Ayten Yazici⁶, Andac Ergen⁷, Erkan Alpsoy⁸, Carlo Salvarani⁹, Bruno Casali¹⁰, Ina Koetter¹¹, Javier Gutierrez-Achury¹², Cisca Wijmenga¹², Haner Direskeneli¹³, Guher Saruhan-Direskeneli¹⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey, ⁴Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, ⁵Ankara University, Ankara, Turkey, ⁶Department of Rheumatology, Kocaeli University, Kocaeli, Turkey, ⁷Okmeydaný Research and Education Hospital, Istanbul, Turkey, ⁸Department of Dermatology, Akdeniz University, Antalya, Turkey, ⁹Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ¹⁰Molecular Biology Laboratory, Arcispedale S. Maria Nuova,, Reggio Emilia, Italy, ¹¹Robert Bosch Krankenhaus, Stuttgart, Germany, ¹²Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ¹³Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ¹⁴Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: The genetic association between HLA-B51 and Behcet’s disease is well established. However, localizing this genetic effect and exploring additional susceptibility loci within the HLA…
Abstract Number: 203 • 2012 ACR/ARHP Annual Meeting
Clinical Course Factors Associated with Outcome of Monoarthritis : A Retrospective Study of 173 Cases
Hyemin Jeong¹, Eun-Jung Park¹, Jiwon Hwang¹, Ji Young Chai², Joong Kyong Ahn³, Eun-Mi Koh⁴ and Hoon-Suk Cha¹, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, ³Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea
Background/Purpose: To evaluate the clinical features and outcomes in patients with monoarthritis and to investigate predictive factors associated with the clinical course in terms of…

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