ACR Meeting Abstracts

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Abstracts tagged "Behcet’s syndrome"

  • Abstract Number: 2625 • 2013 ACR/ARHP Annual Meeting

    Biologic Therapy In Refractory Uveitis Of Behcet’s Syndrome: Switching and Dose Modification. Multicenter Study Of 124 Patients

    F. Ortiz-Sanjuán1, Vanesa Calvo-Río2, Ricardo Blanco3, Emma Beltrán4, Juan Sánchez-Bursón5, Marina Mesquida6, Alfredo M. Adan6, M Hernandez Grafella7, E Valls Pascual8, L Martínez-Costa9, A Sellas-Fernàndez10, Miguel Cordero-Coma11, Manuel Diaz-llopis12, David Salom12, Jl García Serrano13, Norberto Ortego13, JM Herreras14, Alejandro Fonollosa15, A Aparicio16, O Maíz17, A Blanco18, I Torre19, Cruz Fernández-Espartero20, V Jovani21, D Peitado-Lopez22, Esperanza Pato23, J Cruz24, J. Carlos Fernandez-Cid25, Elena Aurrecoechea26, M García27, M Caracuel28, Carlos Montilla29, A Atanes30, F Francisco31, S Insua32, S González-Suárez33, A Sánchez-Andrade34, F Gamero35, Luis Linares36, F Romero-Bueno37, J García38, AJ García González39, Raquel Almodovar40, E Minguez41, C Carrasco Cubero42, Alejandro Olivé Marqués43, J Vázquez44, O Ruiz Moreno45, F Jimenez-Zorzo45, J Manero45, Javier Loricera2 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Marques de Valdecilla, Santander, Spain, 4Rheumatology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, 5Hospital de Valme. Sevilla, Sevilla, Spain, 6Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, 7Ophthalmology, Hospital General Universitario, Valencia, Valencia, Spain, 8Rheumatology, Hospital Peset Valencia, Valencia, Spain, 9Ophthalmology, Hospital Peset Valencia, Valencia, Spain, 10Rheumatology, Hospital Val d´Hebron. Barcelona, Barcelona, Spain, 11Departament of Ophthalmology, Hospital de León, León, Spain, 12Department of Ophthalmology, Hospital Universitario La Fe de Valencia, Valencia, Spain, 13Hospital San Cecilio. Granada, Granada, Spain, 14Hospital Universitario, IOBA. Valladolid, Valladolid, Spain, 15Ophtalmology Service, Hospital de Cruces. Bilbao, Baracaldo, Spain, 16Rheumatology., Hospital de Toledo., Toledo, Spain, 17Rheumatology, Hospital Donosti San Sebastian, San Sebastián, Spain, 18Ophthalmology., Hospital Donosti San Sebastian, San Sebastián, Spain, 19Rheumatology., Hospital Basurto. Bilbao, Bilbao, Spain, 20Servicio de Reumatología, Hospital Universitario de Móstoles. Madrid, Madrid, Spain, 21Rheumatology., Hospital General de Alicante., Alicante, Spain, 22Rheumatology, Hospital Universitario La Paz Madrid, Madrid, Spain, 23Rheumatology, Hospital Clínico San Carlos. Madrid, Madrid, Spain, 24Rheumatology, Hospital de Pontevedra, Pontevedra, Spain, 25Departament of Ophthalmology, Hospital de Pontevedra, Pontevedra, Spain, 26Rheumatology, Hospital Sierrallana. Torrelavega, Torrelavega, Spain, 27Rheumatology., Hospital La Princesa. Madrid, Madrid, Spain, 28Rheumatology., Hospital de Córdoba., Córdoba, Spain, 29Rheumatology Service, Hospital Universitario de Salamanca, Salamanca, Spain, 30Rheumatology., HUCA La Coruña., A Coruña, Spain, 31Rheumatology., Hospital Doctor Negrín Canarias., Canarias, Spain, 32Rheumatology., Hospital Universitario Santiago de Compostela, Santiago de Compostela, Spain, 33Rheumatology., Hospital Cabueñes, Gijón, Gijón, Spain, 34Rheumatology., Hospital Lucus Augusti Lugo, Lugo, Spain, 35Rheumatology., Hospital San Pedro Alcantara Caceres, Caceres, Spain, 36Rheumatology, Hospital Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 37Rheumatology., Fundación Jimenez Díaz. Madrid, Madrid, Spain, 38Rheumatology, Hospital 12 de Octubre. Madrid, Madrid, Spain, 39Rheumatology., Hospital 12 de Octubre. Madrid, Madrid, Spain, 40Rheumatology Unit, Hospital Universitario Fundación Alcorcón. Madrid, Alcorcon. Madrid, Spain, 41Ophthalmology, Hospital Clínico de Zaragoza, Zaragoza, Spain, 42Rheumatology., Hospital de Mérida, Mérida, Spain, 43Hospital Germans Trias i Pujol. Badalona, Barcelona, Spain, 44Rheumatology, Hospital de Ferrol. A Coruña, A Coruña, Spain, 45Hospital Universitario Miguel Servet. Zaragoza, Zaragoza, Spain

    Background/Purpose: Several situations can be observed in patients undergoing biologic therapy in uveitis associated to Behçet´s syndrome (BS): a) Patients are switched to another therapy…
  • Abstract Number: 2627 • 2013 ACR/ARHP Annual Meeting

    Prognostic Factors Of Visual Function In The Treatment With Infliximab For Uveitis Of Behçet’s Disease

    Akihiko Nakabayashi1, Toru Hirano2, Yoshihiro Hishitani2, Keisuke Hagihara3, Kei Nakai4, Kouji Nishida4 and Atsushi Kumanogoh2, 1Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, 2Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, 3Department of Kampo Medicine, Osaka University Graduate School of Medicine, Suita, Japan, 4Department of Ophthalmology, Osaka University Graduate School of Medicine, suita, Japan

    Background/Purpose: Infliximab, a chimeric monoclonal antibody against TNF-a, is expected to improve prognosis of visual function in patients with severe and refractory uveitis of Behçet's…
  • Abstract Number: 2628 • 2013 ACR/ARHP Annual Meeting

    Immunogenicity Of Infliximab Modulates Efficacy and Safety In Behcet’s Disease Patients With Uveitis

    Mitsuhiro Takeno1, Kayo Terauchi1, Yohei Kirino1,2, Ryusuke Yoshimi1, Nobuhisa Mizuki2, Etsuko Shibuya3 and Yoshiaki Ishigatsubo2, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Infliximab (IFX) suppresses ocular attacks in Behcet’s disease (BD) with uveitis, resulting in favorable long-term visual prognosis. However, some patients had ocular attacks which…
  • Abstract Number: 2629 • 2013 ACR/ARHP Annual Meeting

    Is Complete Remission a Realistic Target With Current Therapeutic Options in Behçet’s Disease ?

    Fatma Alibaz-Oner1, Gonca Mumcu2, Zeynep Kubilay3, Gülsen Ozen4, Gülce Celik3, Aslı Karadeniz3, Meryem Can5, Sibel Yılmaz Oner1, Nevsun Inanc6, Pamir Atagunduz7, Tülin Ergun8 and Haner Direskeneli1, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 3Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey, 4Rheumatology, Marmara University School of Medicine., Istanbul, Turkey, 5Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 6Marmara University School of Medicine, Istanbul, Turkey, 7Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 8Dermatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: The clinical course of Behcet’s disease (BD) as a multi-systemic disorder with a remitting-relapsing nature is unsufficiently explored. As complete remission should be aimed…
  • Abstract Number: 2631 • 2013 ACR/ARHP Annual Meeting

    Fertility In Behçet’s Syndrome: Structured Interview In A Multidisciplinary Center

    Caner Saygin1, Didem Uzunaslan1, Gulen Hatemi2, Koray Tascilar1 and Hasan Yazici3, 1University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 2Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 3Cerrahpasa Medical Faculty University of Istanbul, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose: Behçet’s Syndrome (BS) follows an active course during the child-bearing years in both men and women. Whether fertility is decreased among the BS patients…
  • Abstract Number: 2632 • 2013 ACR/ARHP Annual Meeting

    Long Term Outcome Of Neuro-Behçet’s Disease

    Nicolas Noel1, Remy Bernard2, Bertrand Wechsler3, Matthieu Resche-Rigon2, Du Boutin4, Jean-Charles Piette5, Aurélie Drier6, Didier Dormont6, Patrice Cacoub4 and David Saadoun7, 1APHP, Hopital Bicêtre, Service de Médecine Interne et Immunologie Clinique, Le Kremlin Bicêtre, France, 2Biostatistics, Hopital Saint-Louis, Paris, France, 3Internal Medecine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 4Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 5Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 6Neuroradiology, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 7DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France

    Background/Purpose: Neurological involvement occurs in 5.3 to up to 59% of patients with Behçet’s disease (BD). Although the clinical and imaging features of neuro-Behçet’s disease…
  • Abstract Number: 2613 • 2013 ACR/ARHP Annual Meeting

    NF-κB Pathway Is Depleted In Phagocytes From Behçet´s Disease Patients Secondarily To Constitutive Phosphorylation Of The p65 Subunit

    Sandro F. Perazzio1,2, Paulo Vitor Soeiro Pereira3, Alexandre W.S. Souza4,5, Antonio Condino-Neto3 and Luis Eduardo C. Andrade6, 1Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 2Fleury Medicine and Health, Sao Paulo, Brazil, 3Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, 4University Medical Center Groningen, Groningen, Netherlands, 5Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 6Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil

    Background/Purpose: : Increased neutrophil activation has been previously shown in Behçet’s disease (BD) patients and it is unclear whether neutrophil activation occurs constitutively or if…
  • Abstract Number: 2385 • 2012 ACR/ARHP Annual Meeting

    Prognostic Impact of HLA-B*51 and HLA–A*26:01 On Ocular Behcet’s Disease

    Jun Won Park1, Eun Ha Kang2, Hye Won Kim1, Chaerin Park3, Hyeong Gon Yu3, Eun Young Lee1, Yun Jong Lee4, Eun Bong Lee1 and Yeong Wook Song5, 1Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 2Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 3Ophthalmology, Seoul National University Hospital, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Rheumatology, Seoul National University, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea

    Background/Purpose: To investigate the prognostic implication of HLA-B*51 and HLA-A*26:01on visual outcome in Korean Behcet’s disease (BD) patients with uveitis. Methods: Seventy-seven Korean BD patients…
  • Abstract Number: 186 • 2012 ACR/ARHP Annual Meeting

    Long-Term Infliximab Therapy in Patients with Behcet’s Disease Is Well Tolerated without Increasing Risk of Serious Infections

    Sho Ueda, Hiroshi Tsukamoto, Yasushi Inoue, Masahiro Ayano, Satomi Hisamoto, Naoko Ueki, Atsushi Tanaka, Shun-ichiro Ohta, Naoyasu Ueda, Yojiro Arinobu, Hiroaki Niiro, Takahiko Horiuchi and Koichi Akashi, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: Infliximab (IFX) is a monoclonal antibody against tumor necrosis factor-a (TNF-a) and is increasingly used in various immune-related diseases including rheumatoid arthritis (RA), ankylosing…
  • Abstract Number: 2394 • 2012 ACR/ARHP Annual Meeting

    Fibromyalgia in Behçet’s Disease Is Associated with Disease Activity

    Meryem Can1, Fatma Alibaz-Öner2, Sibel Yılmaz-Öner3, Birkan İlhan4, Tülin Ergun5, Gonca Mumcu6 and Haner Direskeneli7, 1Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Department of Rheumatology, Marmara University School of Medicine, Turkey, 3Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 4Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey, 5Dermatology, Marmara University, School of Medicine, Istanbul, Turkey, 6Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 7Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Studies on the relationship between Fibromyalgia (FM), a generalized pain disorder with up to 2% prevelance and Behcet’s Disease (BD), a systemic, inflammatory vasculitis,…
  • Abstract Number: 2369 • 2012 ACR/ARHP Annual Meeting

    Aspects of Innate Immunity in Behçet´s Disease: A Model of Autoinflammatory Disease?

    Sandro F. Perazzio1, Paulo Vitor Soeiro Pereira2, Alexandre Wagner S. de Souza3, Antonio Condino-Neto2 and Luis Eduardo C. Andrade4, 1Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 2Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, 3Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 4Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil

    Background/Purpose: Behçet's disease (BD) is a systemic vasculitis of unknown etiopathogenesis. Increased neutrophil activation has been previously shown in BD patients and it is unclear…
  • Abstract Number: 2370 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide DNA Methylation Study Identifies Significant Epigenetic Changes Across the Genome and in Multiple HLA Loci in Behcet’s Disease

    Haner Direskeneli1, Patrick S. Coit2, Filiz Ture-Ozdemir1, Fatma Alibaz-Oner1, Guher Saruhan-Direskeneli3, Matlock A. Jeffries4 and Amr H. Sawalha2, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 4Medicine, University of Oklahoma and Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Behcet’s disease (BD) is a systemic vasculitis of poorly understood etiology. Herein, we study the DNA methylome in BD for the first time and…
  • Abstract Number: 2371 • 2012 ACR/ARHP Annual Meeting

    The Unmet Need in Behcet’s Disease: Most Patients Are Not in Complete Remission in the Long-Term Follow-up

    Fatma Alibaz-Oner1, Gonca Mumcu2, Gülsen Ozen3, Zeynep Kubilay4, Meryem Can1, Sibel Yýlmaz Oner1, Tülin Ergun5 and Haner Direskeneli1, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 3Rheumatology, Marmara University School of Medicine., Istanbul, Turkey, 4Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey, 5Dermatology, Marmara University School of Medicine, Istanbul, Turkey

    Background/Purpose: The nature of Behcet’s disease (BD) as a multi-systemic disorder with a remitting-relapsing course is unsufficiently explored. As complete remission should be aimed in…
  • Abstract Number: 2372 • 2012 ACR/ARHP Annual Meeting

    Efficacy of Quantitative Analysis of Brainstem Atrophy On Magnetic Resonance Imaging for Diagnosis of Chronic Progressive Neuro-Behçet’s Disease

    Hirotoshi Kikuchi1, Maki Takayama2, Yoshitaka Kimura2, Kurumi Asako2, Hajime Kono2, Yasuo Ono1 and Shunsei Hirohata3, 1Department of Microbiology and Immunology, Teikyo University Shool of Medicine, Tokyo, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 3Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose : CNS involvement in Behçet's disease, usually called neuro-Behçet's disease (NB), can be classified into acute NB (ANB) and chronic progressive NB (CPNB) based…
  • Abstract Number: 2373 • 2012 ACR/ARHP Annual Meeting

    The Clinical Course of the Acute Deep Vein Thrombosis of the Legs in Behçet’s Syndrome

    Yesim Ozguler1, Melike Melikoglu2, Firat Cetinkaya3, Serdal Ugurlu4, Emire Seyahi5, Koray Tascilar6 and Hasan Yazici7, 1Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey, 2Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 3Radiology, Colormed Radiology Center, Istanbul, Turkey, 4Rheumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey, 5Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, 6University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 7Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey

    Background/Purpose: 15-50% of patients with Behçet’s syndrome have vascular involvement (BS). Deep vein thrombosis is the most common form with lower extremity deep vein thrombosis…
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