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Abstracts tagged "Behcet’s syndrome"

  • Abstract Number: 1753 • 2013 ACR/ARHP Annual Meeting

    An Outcome Survey Of 40 Patients With Budd-Chiari Syndrome Due To BEHÇET’S Syndrome Followed By A Single Center

    Emire Seyahi1, SerdaL Ugurlu2, Erkan Caglar3, Fatih Kantarci4, Abdullah Sonsuz5, Sebahattin Yurdakul2 and Hasan Yazici2, 1Division of Rheumatology,Department of Medicine,Cerrahpasa Medical Faculty, University of Istanbul, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Division of Gastroenterology, Department of Internal Medicine, Bakirkoy Research and Training Hospital, Istanbul, Turkey, 4Department of Radiology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 5Division of Gastroenterology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: Budd-Chiari syndrome is a rare complication of BS with a frequency of < 1 %, and carries a high mortality rate. In a previous…
  • Abstract Number: 2621 • 2013 ACR/ARHP Annual Meeting

    Venous Claudication Is A Severe and Frequent Symptom In BEHCET’S Syndrome

    SerdaL Ugurlu1, Emire Seyahi1, Veysel Oktay2, Zerrin Yigit2, Serdar Kucukoglu2 and Hasan Yazici1, 1Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Department of Cardiology, Cardiology Institute, University of Istanbul, Istanbul, Turkey

    Background/Purpose: In a previous cross-sectional questionnaire survey, we had shown that intermittent claudication was significantly more common among BS patients when compared to healthy controls,…
  • Abstract Number: 1703 • 2013 ACR/ARHP Annual Meeting

    High Density Genotyping Of Immune-Related Disease Genes Identifies 7 New Susceptibility Loci For Behçet’s Disease

    Masaki Takeuchi1,2, Nobuhisa Mizuki2, Akira Meguro2, Michael J. Ombrello3, Colleen Satorius4, Yohei Kirino2, Tatsukata Kawagoe2, Duran Ustek5, Ilknur Tugal-tutkun6, Emire Seyahi7, Yilmaz Ozyazgan7, Shigeaki Ohno8, Atsuhisa Ueda2, Yoshiaki Ishigatsubo2, Ahmet Gül6,9, Daniel L. Kastner4 and Elaine Remmers4, 1Medical Genetics Branch, Inflammation Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 2Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3Translational Genetics and Genomics Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 5Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, 6Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 7Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, 8Hokkaido University Graduate School of Medicine, Hokkaido, Japan, 9Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: Genome-wide association studies have revealed susceptibility genes for many genetically complex diseases. The Immunochip is a custom array with 196,524 markers in 186 loci…
  • Abstract Number: 2622 • 2013 ACR/ARHP Annual Meeting

    Comparison Of Different Methods Of Skin Pathergy Test In Patients With Behçet’s Syndrome

    Aysegul Lacin1, Cigdem Atan Uzun1, Zafer Gunendi2 and Feride Gogus1, 1Physical Medicine and Rehabilitation, Division of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, 2Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Skin pathergy test (SPT) has a diagnostic value in Behçet’s syndrome (BS). There are different descriptions of the test which may effect its positivity rate.…
  • Abstract Number: 1165 • 2013 ACR/ARHP Annual Meeting

    Systems Approach To The Study Of the Microbiome and Inflammatory Pathways In Oral Ulcer Tissue From Patients With Active Behςet’s Syndrome (BS)

    Cailin Sibley1, Gulen Hatemi2, Yusuf Yazici3, Yin Liu4, Steve Brooks5, Hasan Yazici6 and Raphaela Goldbach-Mansky7, 1Office of the Clinical Director, NIH / NIAMS, Bethesda, MD, 2Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 4Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, 5NIAMS/NIH, Bethesda, MD, 6Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 7Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose: Behcet's syndrome (BS) exhibits features of both innate and acquired immunity.   Oral ulceration is the cardinal lesion which usually precedes other manifestations.  Despite the…
  • Abstract Number: 2623 • 2013 ACR/ARHP Annual Meeting

    A CT Evaluation Of Pulmonary and Cardiac Lesions In BEHÇET’S Syndrome Patients Without Pulmonary Symptoms

    Emire Seyahi1, Deniz Cebi Olgun2, SerdaL Ugurlu1, Idil Hanci3, Reona Takahashi4 and Hasan Yazici1, 1Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Department of Radiology,, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Department of Neurology, Krankrenhaus Nordwest, Frankfurt am Main, Frankfurt, Germany, 4Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose:  In Behçet’s syndrome (BS) patients with symptomatic pulmonary artery involvement (PAI) varying and multiple pulmonary parenchymal and cardiac lesions can be seen in thorax CT…
  • Abstract Number: 893 • 2013 ACR/ARHP Annual Meeting

    Association Between Human Leukocyte Antigen-B’s Amino Acid Variation and Disease-Susceptibility To Takayasu’s Arteritis

    Hajime Yoshifuji1, Chikashi Terao2, Kosaku Murakami3, Daisuke Kawabata3, Koichiro Ohmura1, Takao Fujii4, Yasushi Kawaguchi5, Hisashi Yamanaka5 and Tsuneyo Mimori1, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Center for Genomic Medicine, Kyoto University, Kyoto, Japan, 3Dept of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: HLA-B52 and HLA-B51 are frequently seen in Asian population and are almost identical except two amino acid residues(the 63rd and 67th), but HLA-B52 is…
  • Abstract Number: 2376 • 2012 ACR/ARHP Annual Meeting

    Behcet’s Disease: Combination of Pulse Cyclophosphamide, Azathioprine, and Prednisolone for the Treatment of Retinal Vasculitis; Longitudinal Study On 10 Years

    Fereydoun Davatchi1, Farhad Shahram2, Bahar Sadeghi Abdollahi2, Hormoz Shams2, Abdolhadi Nadji2, Massoomeh Akhlaghi2, Tahereh Faezi2 and Farimah Ashofteh2, 1Rheumatology Research Ctr and Department of Rheumatology, Shariati Hospital-Tehran Univ, Tehran, Iran, 2Rheumatology, Behcet's Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Background/Purpose: Ocular lesions of Behcet’s Disease (BD), need aggressive treatment to prevent severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents…
  • Abstract Number: 1005 • 2012 ACR/ARHP Annual Meeting

    The Identification of Pathway Markers in Behcet’s Disease Using Genomewide Association Data From Two Different Populations

    Burcu Bakir-Gungor1, Elaine Remmers2, Daniel L. Kastner2, Akira Meguro3, Nobuhisa Mizuki4, Ahmet Gul5 and Osman Ugur Sezerman6, 1Department of Genetics and Bioinformatics, Faculty of Arts and Sciences, Bahcesehir University, Istanbul, Turkey, 2Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 3Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 4Yokohama City University Graduate School of Medicine, Yokohama, Japan, 5Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 6Biological Sciences and Bioengineering, Faculty of Engineering and Natural Sciences, Sabancı University, Istanbul, Turkey

    Background/Purpose: Behcet's disease (BD) is a multi-system inflammatory disease, characterized by recurrent exacerbations affecting several organs including orogenital mucosa, eyes and skin. Two recent genome-wide…
  • Abstract Number: 858 • 2012 ACR/ARHP Annual Meeting

    Dense Genotyping, Imputation, and Regression Analysis Identifies Multiple Independent Genetic Susceptibility Loci within the HLA Region in Behcet’s Disease

    Travis Hughes1, Adam Adler2, Patrick S. Coit1, Vuslat Yilmaz3, Kenan Aksu4, Nursen Duzgun5, Gokhan Keser4, Ayse Cefle6, Ayten Yazici6, Andac Ergen7, Erkan Alpsoy8, Carlo Salvarani9, Bruno Casali10, Ina Koetter11, Javier Gutierrez-Achury12, Cisca Wijmenga12, Haner Direskeneli13, Guher Saruhan-Direskeneli14 and Amr H. Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey, 4Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, 5Ankara University, Ankara, Turkey, 6Department of Rheumatology, Kocaeli University, Kocaeli, Turkey, 7Okmeydaný Research and Education Hospital, Istanbul, Turkey, 8Department of Dermatology, Akdeniz University, Antalya, Turkey, 9Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 10Molecular Biology Laboratory, Arcispedale S. Maria Nuova,, Reggio Emilia, Italy, 11Robert Bosch Krankenhaus, Stuttgart, Germany, 12Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, 13Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 14Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: The genetic association between HLA-B51 and Behcet’s disease is well established. However, localizing this genetic effect and exploring additional susceptibility loci within the HLA…
  • Abstract Number: 203 • 2012 ACR/ARHP Annual Meeting

    Clinical Course Factors Associated with Outcome of Monoarthritis : A Retrospective Study of 173 Cases

    Hyemin Jeong1, Eun-Jung Park1, Jiwon Hwang1, Ji Young Chai2, Joong Kyong Ahn3, Eun-Mi Koh4 and Hoon-Suk Cha1, 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, 3Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 4Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea

    Background/Purpose: To evaluate the clinical features and outcomes in patients with monoarthritis and to investigate predictive factors associated with the clinical course in terms of…
  • Abstract Number: 181 • 2012 ACR/ARHP Annual Meeting

    Thiopurine S-Methyltransferase Levels in Patients with Behçet’s Disease

    Hakan Emmungil1, Melike Kalfa2, Raika Durusoy3, Figen Yargucu Zihni2, Gokhan Keser4 and Kenan Aksu2, 1Rheumatology, Mersin State Hospital, Mersin, Turkey, 2Dept. of Internal Medicine, Division of Rheumatology, Ege University, Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, 3Department of Public Health, Ege University, Department of Public Health, Ege University, Izmir, Turkey, 4Dept. of Internal Medicine, Division of Rheumatology, Ege University School of Medicine, Izmir, Turkey

    Background/Purpose: Azathioprine (AZA) is an immunosuppressive agent which is widely used not only for the treatment of Behcet’s disease (BD), but also for the treatment…
  • Abstract Number: 183 • 2012 ACR/ARHP Annual Meeting

    A Strong Association Between HLA-A*26 and Behçet’s Syndrome in Japanese Patients: From Two-Center Cohort Study of Behçet’s Syndrome

    Tatsuo Kobayashi1, Mitsumasa Kishimoto2, Kazuki Yoshida1, Yuri Ohara3, Hiroto Nakano1, Masahiro Minoda1, Hideto Oshikawa1 and Kazuo Matsui1, 1Rheumatology, Kameda Medical Center, Kamogawa City, Chiba, Japan, 2Division of Allergy and Rheumatology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan, 3Allergy and Rheumatology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan

    Background/Purpose: An association between Behçet’s Syndrome (BS) and HLA-B*51 is widely reported among many different ethnic groups. Recently, a few reports from Taiwan, Greece and…
  • Abstract Number: 184 • 2012 ACR/ARHP Annual Meeting

    The Retrospective Review of 39 Intestinal Behcet’s Disease Focusing On the Requirement for the Immunosuppresive Drugs Other Than Corticosteroid

    Yoshitaka Kimura1, Kurumi Asako2, Hirotoshi Kikuchi2, Akiteru Takeuchi3 and Hajime Kono2, 1Department of Internal Medicine, Teikyo University school of medecine, Tokyo, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 36-7-8 Arakawa, Tokyo, Japan

    Background/Purpose: To examine the demography, clinical characteristics, features of intestinal lesions, treatment, and prognosis in patients with the intestinal Behcet’s disease currently followed at a…
  • Abstract Number: 185 • 2012 ACR/ARHP Annual Meeting

    Long-Term Efficacy and Safety of Tumour Necrosis Factor Antagonists for Patients with Behçet’s Disease with Uveitis As Main Involvement

    M. Victoria Hernández1, Marina Mesquida2, Gerard Espinosa3, Victor Llorens2, Laura Pelegrin2, Juan D. Cañete4, Ricard Cervera5, Alfredo M. Adan2 and Raimon Sanmarti1, 1Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 2Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, 3Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Spain, 4Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, 5Autoimmune Diseases, Hospital Clínic of Barcelona, Barcelona, Spain

    Background/Purpose: To assess the long-term efficacy and safety of tumour necrosis factor (TNF) antagonists (infliximab [IFX], adalimumab [ADA] and golimumab) for the treatment of patients…
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