ACR Meeting Abstracts

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Abstracts tagged "BAFF"

  • Abstract Number: L19 • 2019 ACR/ARP Annual Meeting

    Ianalumab (VAY736), a Dual Mode of Action Biologic Combining BAFF Receptor Inhibition with B Cell Depletion, for Treatment of Primary Sjögren’s Syndrome: Results of an International Randomized, Placebo Controlled Dose Range Finding Study in 190 Patients

    Simon Bowman1, Robert Fox 2, Thomas Dörner 3, Xavier Mariette 4, Athena Papas 5, Thomas Grader-Beck 6, Benjamin A. Fisher 7, Filipe Barcelos 8, Salvatore De Vita 9, Hendrik Schulze-Koops 10, Robert J. Moots 11, Guido Junge 12, Janice Woznicki 13, Monika Sopala 12, Wen-Lin Luo 13 and Wolfgang Hueber 12, 1University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 2Scripps Memorial Hospital and Research Institute, La Jolla, California, 3Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, 5Tufts School of Dental Medicine, Massachusetts, 6Johns Hopkins University, Baltimore, 7University Hospitals Birmingham NHS Foundation Trust, Birmingham Biomedical Research Centre, Birmingham, United Kingdom, 8Nova Medical School, Hospital Cuf Descobertas, Instituto Português de Reumatologia,, Lisbon, Portugal, 9Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, 10Department of Rheumatology/Clinical Immunology, Ludwig-Maximilians-University Munich, Munich, Germany, 11Institute of Ageing and Chronic Disease, Liverpool, United Kingdom, 12Novartis Pharma AG, basel, Switzerland, 13Novartis Pharmaceuticals Corporation, New Jersey

    Background/Purpose: Primary Sjogren’s syndrome (pSS) is a multi-organ autoimmune disease primarily affecting excretory glands and characterized by B-cell hyperactivity. No approved systemic treatments are available.…
  • Abstract Number: 412 • 2019 ACR/ARP Annual Meeting

    Elevated Serum BAFF Levels in Patients with Dermatomyositis: Association with Interstitial Lung Disease

    Takashi Matsushita1, Tadahiro Kobayashi 1, Miyu Kano 1, Yasuhito Hamaguchi 1 and Kazuhiko Takehara 2, 1Kanazawa University, Kanazawa, Japan, 2Department of Dermatology, Kanazawa University, Kanazawa, Japan

    Background/Purpose: Patients with dermatomyositis (DM) frequently have myositis-specific autoantibodies (MSAs), which are closely associated with different clinical features. Patients with anti-aminoacyl-tRNA synthetase (ARS) antibody (Ab)…
  • Abstract Number: 2287 • 2019 ACR/ARP Annual Meeting

    Combined First-Trimester Serum BAFF and sFlt-1 Levels as an Early Biomarker of Spontaneous Abortion

    Hindi Stohl 1, Ning Yu 2 and William Stohl2, 1Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, 2University of Southern California Keck School of Medicine, Los Angeles, CA

    Background/Purpose: Immunologic, angiogenic, and anti-angiogenic factors have been associated with spontaneous abortion (SAB), yet early identification of those pregnant women who ultimately undergo SAB remains…
  • Abstract Number: 17 • 2018 ACR/ARHP Annual Meeting

    Kappa-Deleting Recombination Excision Circles (KREC) in B Cells and Serum B Cell Activating Factor (BAFF): Possible Aids in Predicting Juvenile Dermatomyositis Response to Rituximab

    Amer khojah1,2, Victoria Hans3, Wilfredo Marin4, Gabrielle A. Morgan4 and Lauren M. Pachman5,6,7, 1Division of Pediatric Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Division of Pediatric Allergy Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 4Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 5Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 6Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 7Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL

    Background/Purpose: Rituximab is used for the treatment of juvenile dermatomyositis (JDM) with variable success. Some of this variability is presumed to be related to the…
  • Abstract Number: 111 • 2018 ACR/ARHP Annual Meeting

    BAFF Inhibition Attenuates Fibrosis in Bleomycin-Induced Scleroderma Model Via Modulating the Regulatory and Effector B-Cell Balance

    Takashi Matsushita1, Tadahiro Kobayashi2, Yasuhito Hamaguchi2, Minoru Hasegawa3, Manabu Fujimoto4 and Kazuhiko Takehara1, 1Kanazawa University, Department of Dermatology, Kanazawa, Japan, 2Department of Dermatology, Kanazawa University, Kanazawa, Japan, 3University of Fukui, Department of Dermatology, Fukui, Japan, 4University of Tsukuba, Faculty of Medicine, Department of Dermatology, Tsukuba, Japan

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. Over 90% of patients with SSc are positive for autoantibodies. In…
  • Abstract Number: 1092 • 2018 ACR/ARHP Annual Meeting

    Immune Complex-Driven Neutrophil Activation and BAFF Production Promote B Cell Activation and Autoantibody Production in Human SLE

    Andrew Vasconcellos1, John Marken1, Sladjana Skopelja-Gardner1, Christian Lood2 and Natalia V. Giltiay1, 1Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 2Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA

    Background/Purpose: The production of anti-nuclear auto-antibodies (Ab) and the formation of immune complexes (IC) are hallmarks of Systemic Lupus Erythematosus (SLE). Enhanced neutrophil (PMN) activation…
  • Abstract Number: 1765 • 2018 ACR/ARHP Annual Meeting

    Cerebrospinal Fluid Biomarker of Disease Activity: Significance in ANCA-Related Hypertrophic Pachymeningitis

    Yasuhiro Shimojima1, Dai Kishida2 and Yoshiki Sekijima2, 1Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan, 2Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan

    Background/Purpose: Hypertrophic pachymeningitis (HP), which becomes the cause of chronic headache, seizure, and cranial neuropathy, is an inflammatory disorder demonstrating focal and diffuse thickening of…
  • Abstract Number: 1837 • 2017 ACR/ARHP Annual Meeting

    Development of Murine SLE in the Absence of BAFF

    William Stohl1, Ning Yu1, Samantha Chalmers2, Chaim Putterman3 and Chaim O. Jacob1, 1Division of Rheumatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, 2Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 3Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY

    Background/Purpose:  BAFF is a vital survival and differentiation factor for B cells. In human SLE, clinical efficacy with any of 4 different BAFF antagonists is…
  • Abstract Number: 20 • 2017 ACR/ARHP Annual Meeting

    Low Molecular Weight BAFF Receptor Antagonists Restrain Infiltration of B Cells into Organs of Autoimmune Model Mice By Suppressing B Cell Activation

    Keiko Yoshimoto1, Noriyasu Seki2, Katsuya Suzuki3, Kunio Sugahara4 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 23) Research Unit/Immunology & Inflammation, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 3Division of Rheumatology, Department of Internal Medicine, Keio University School of Medcine, Tokyo, Japan, 4Research Unit/Immunology & Inflammation, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan

    Background/Purpose: We have reported that soluble BAFF (sBAFF) robustly increased IL-6 production by peripheral monocytes of patients with primary Sjögren’s syndrome (pSS) and that the…
  • Abstract Number: 576 • 2017 ACR/ARHP Annual Meeting

    Immunosignature-Based Diagnosis and Prediction of Therapeutic Response Enables Retrospective Patient Stratification in a Phase IIa Clinical Trial for VAY736 in Primary Sjögren’s Syndrome

    Robert Gerwien1, Theodore M. Tarasow2, Jonathan Melnick2, Anna Lei3, Arvind Kinhikar4, Julie Doucet5, Remi Kazma5, Paul Maguire4, Irina Koroleva6, Giulio Macchiarella4, Alexandre Avrameas5, Marie-Anne Valentin5, Stephen Oliver5 and Alessandra Vitaliti5, 1HealthTell, Inc, san ramon, CA, 2HealthTell, Inc., San Ramon, CA, 3Health Tell, San Ramon, CA, 4Novartis, Cambridge, MA, 5Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, 6Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA

    Background/Purpose: Although patient stratification can improve the success rate of clinical trials, efforts to apply this strategy to autoimmune studies such as Sjögren’s syndrome are…
  • Abstract Number: 875 • 2017 ACR/ARHP Annual Meeting

    Serum Autoantibody Profiling of Primary Sjoegren’s Syndrome Patients Reveals Novel Biomarkers Associated with the Disease, Disease Activity, and Clinical Response to VAY736

    Petra Budde1, Julie Doucet2, Hans-Dieter Zucht1, Remi Kazma2, Paul Maguire2, Alexandre Avrameas2, Marie-Anne Valentin2, Stephen Oliver2, Peter Schulz-Knappe1 and Alessandra Vitaliti2, 1Protagen AG, Dortmund, Germany, 2Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland

    Background/Purpose: Overexpression of B cell activating factor (BAFF) in salivary glands contributes to the pathogenesis of primary Sjögren’s syndrome (pSS) by promoting autoantibody (AAB) production.…
  • Abstract Number: 888 • 2017 ACR/ARHP Annual Meeting

    Phase 3 Trial Results with Blisibimod, a Selective Inhibitor of B-Cell Activating Factor, in Subjects with Moderate-to-Severe Systemic Lupus Erythematosus

    Joan T. Merrill1, Renee S. Martin2, William Shanahan2, Morton Scheinberg3, Kenneth C. Kalunian4 and David Wofsy5, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Anthera, Hayward, CA, 3Department of Immunology, Center for Clinical Immunology, Sao Paulo SP, Brazil, 4Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 5Rheumatology, UCSF, San Francisco, CA

    Background/Purpose: The Phase 3 CHABLIS-SC1 trial (NCT01395745) evaluated blisibimod, an inhibitor of B-cell activating factor (BAFF), in SLE. Prior SLE trials suggested that treatments are…
  • Abstract Number: 1463 • 2017 ACR/ARHP Annual Meeting

    Interaction between Methotrexate and BAFF for Preventing Immunization Against TNF-α Inhibitors By Increasing Adenosine and Regulatory B-Cell Subsets

    Samuel Bitoun1, Gaetane Nocturne2, Bineta Ly3, Juliette Pascaud4, Alain Pruvost5 and X Mariette6, 1INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicëtre, France, 2INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 3INSERM U1184, Paris Sud University, Kremlin Bicetre, France, 4U1184 IMVA, Université Paris Sud, Le Kremlin-Bicêtre Cedex, France, 5CEA - DRF/iBiTec-S - LabEx LERMIT - MetaboHUB-Paris, Gif sur Yvette, France, 6INSERM U1184, Université Paris-Sud, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France

    Background/Purpose: TNFα inhibitors (TNFi) can be immunogenic in patients with autoimmune diseases. B-cell activating factor transgenic mice (BAFFtg) are a model of autoimmune disease since…
  • Abstract Number: 1667 • 2017 ACR/ARHP Annual Meeting

    Increased Levels of BAFF in SLE Patients Correlates with Neutrophil Activation and Autoantibody Production

    Andrew Vasconcellos1, John Marken1, Ting Wang1,2, Christian Lood3 and Natalia V. Giltiay1, 1Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 2Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, 3Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil (PMN) activation and neutrophil extracellular trap (NET) formation are implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE), particularly in the acceleration of…
  • Abstract Number: 1823 • 2017 ACR/ARHP Annual Meeting

    Methotrexate Requires High Serum BAFF Levels to Prevent Immunization Against TNF-α Inhibitors

    Samuel Bitoun1, Pierre Dönnes2, Aline Doublet3, Kimberly Florence4, Agnes Hincelin-Mery5, Gaetane Nocturne6, Mattieu Allez7, N Ruperto8, Marc Pallardy9 and Xavier Mariette10, 1INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicëtre, France, 2SciCross AB, Skövde, Sweden, 3Department of Rheumatology, Kremlin-Bicêtre hospital INSERM U1184, Le Kremlin Bicêtre, France, 4Immunogenicity and Clinical Immunology, GlaxoSmithKline, King of Prussia, PA, 5Sanofi, Chilly-Mazarin, France, 6INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 7Department of Gastroenterology, Hopital Saint-Louis, APHP, Paris, France, 8PRINTO Coordinating Centre, Genoa, Italy, 9Inflammation, Chimiokines et Immunopathologie, INSERM UMR 996, Faculté de Pharmacie, Chatenay Mallabry, France, 10Université Paris Sud, Paris, France

    Background/Purpose: Immunization against TNF Inhibitors (TNFi) is observed in 30-50% of patients with inflammatory rheumatic diseases. With most TNFi, anti-drug antibodies (ADA) lead to rapid…
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