Abstracts tagged "B cells"

Abstract Number: 35 • 2017 ACR/ARHP Annual Meeting
B-Cell Subset Differences in Inflammatory Rheumatic Diseases
Joao Lagoas Gomes^1,2, Dario Ligeiro³, Alice Lima³, Cristina Teixeira³, Alexandre Sepriano^4,5, Sofia Ramiro⁶, Carina Lopes⁷, Tiago Costa⁸, Manuela Costa⁸, Jaime Cunha Branco^1,2 and Fernando Pimentel-Santos^1,2, ¹Rheumatology, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal, ²CEDOC, NOVA Medical School, Lisbon, Portugal, ³Centro de Sangue e Transplantação de Lisboa, Instituto Português do Sangue e Transplantação (IPST), I.P, Lisbon, Portugal, ⁴CEDOC, NOVA Medical School, Lisboa, Portugal, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ⁷Hospital de Egas Moniz-CHLO, Lisbon, Portugal, ⁸Rheumatology, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
Background/Purpose: Targeting humoral immunity has been proved effective in several inflammatory rheumatic diseases (IRD). Though clinical trials have shown some efficacy of B-cell depletion in…
Abstract Number: 886 • 2017 ACR/ARHP Annual Meeting
CC-220 Decreases B-Cell Subsets and Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus (SLE) Patients and Is Associated with Skin Improvement: Pharmacodynamic Results from a Phase IIa Proof of Concept Study
Victoria P Werth¹, Richard Furie², Allison Gaudy³, Ying Ye³, Shimon Korish³, Nikolay Delev³, Douglas Hough³, Michael Weiswasser³, Suktae Choi³ and Peter Schafer³, ¹University of Pennsylvania and the VA Medical Center, Philadelphia, PA, ²Northwell Health, Great Neck, NY, ³Celgene Corporation, Summit, NJ
Background/Purpose: CC-220 is a high affinity ligand for cereblon with immunomodulatory properties, currently in development for the treatment of Systemic Lupus Erythematosus as well as…
Abstract Number: 2974 • 2017 ACR/ARHP Annual Meeting
B Cell Binding Autoreactive VH4.34 Antibodies Are Specific to Lupus, Consist of Diverse Isotypes, and Are Associated with High Disease Activity and Lupus Nephritis
Scott Jenks¹, Joseph Marcus², Kevin Cashman¹ and Ignacio Sanz³, ¹Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ²San Antonio Uniformed Services Health Education Consortium, San Antonio, TX, ³Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA
Background/Purpose: SLE is characterized by the dysregulation of humoral immunity including high levels of autoreactive IgG VH4.34 antibodies recognized by the rat anti-human idiotypic antibody…
Abstract Number: 36 • 2017 ACR/ARHP Annual Meeting
GM-CSF-Producing B Cells: A Novel B Cell Subset Involved in the Pathogenesis of Systemic Sclerosis
Kazuhiko Higashioka¹, Yuri Ota¹, Tsuyoshi Nakayama¹, Koji Mishima¹, Masahiro Ayano¹, Yasutaka Kimoto², Hiroki Mitoma¹, Mitsuteru Akahoshi¹, Yojiro Arinobu¹, Koichi Akashi¹, Takahiko Horiuchi³ and Hiroaki Niro⁴, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁴Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: Systemic sclerosis (SSc) is a T helper type 2 (Th2)-driven autoimmune disease characterized by vasculopathy and fibrosis. There are still unmet needs in the…
Abstract Number: 949 • 2017 ACR/ARHP Annual Meeting
Sequence Homology and Immune Reactivity between T Cell Epitopes of Related Gut Microbes and Two Novel Autoantigens Provide a Link between Microbial and Host Immunity in Patients with Rheumatoid Arthritis
Annalisa Pianta¹, Sheila Arvikar², Klemen Strle³, Elise E. Drouin¹, Qi Wang⁴, Catherine E. Costello⁴ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁵Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: It has been proposed that immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity affecting joints in patients with rheumatoid…
Abstract Number: 104 • 2017 Pediatric Rheumatology Symposium
Rituximab Treatment for Chronic Steroid-Dependent Henoch-Schonlein Purpura
Esraa M. A. Eloseily^1,2, Courtney Crayne¹, Melissa L Mannion³, Saji P Azerf⁴, Peter Weiser¹, Timothy Beukelman¹, Matthew L. Stoll¹, Dan Feig⁵, Prescott Atkinson⁶ and Randy Q. Cron¹, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pediatrics, Assiut University, Assiut, Egypt, ³Pediatric rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴School of medicine, Univesity of Alabama at Birmingham,, Birmingham, AL, ⁵Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, AL, ⁶Pediatric Allergy and Immunology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited, but more severe…
Abstract Number: 19 • 2017 Pediatric Rheumatology Symposium
The Lymphocyte Repertoire in Juvenile Dermatomyositis
Kacie Hoyt¹, Edwin Anderson^1,2, Megan L. Curran³, Robert Fuhlbrigge⁴, Luigi Notarangelo⁵, Lauren M. Pachman⁶, Susan Kim⁷ and Lauren Henderson⁸, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Clinical Research Center/Rheumatology, Boston Children's Hospital, Medford, MA, ³Pediatric Rheumatology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴Children's Hospital Colorado, Aurora, CO, ⁵National Institute of Allergy and Infectious Diseases, Bethesda, MD, ⁶Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁷Pediatric Rheumatology, University of California, San francisco School of Medicine, San Francisco, CA, ⁸Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: In adult dermatomyositis (DM), clonal populations of T and B cells with shared variable (V) gene usage have been identified in affected muscle, suggesting…
Abstract Number: 7 • 2017 Pediatric Rheumatology Symposium
Activation of Immature, Transitional B cells by Integrated BCR, TLR and TACI signals promotes systemic autoimmunity in high BAFF settings
Holly Jacobs, Samuel Du, Tanvi Arkatkar and Shaun Jackson, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: B cell activating factor of the TNF family (BAFF, also known as BLyS) promotes B cell survival and activation by binding distinct B cell…
Abstract Number: 655 • 2016 ACR/ARHP Annual Meeting
Comprehensive Immuno-Phenotyping of Follicular Helper T Cells and B Cell Subpopulations in Primary Sjögren’s Syndrome
Nida Meednu¹, Cécile Seifert², Jennifer Barnard³, Madhu Ramaswamy⁴, Jeffrey Riggs⁴, Alex Rosenberg³, Jamie Biear⁵, Gianluca Carlesso⁴, Ralf G. Thiele⁶, Andreea Coca³, Fanny Monneaux², Helene Dumortier², Jacques-Eric Gottenberg^2,7 and Jennifer H. Anolik³, ¹Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²CNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence Medalis, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France, ³University of Rochester Medical Center, Rochester, NY, ⁴MedImmune LLC, Gaithersburg, MD, ⁵Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁶Medicine, University of Rochester Medical Center, Rochester, NY, ⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by immune cell infiltration in the salivary glands resulting in ocular and oral dryness.…
Abstract Number: 1090 • 2016 ACR/ARHP Annual Meeting
CpG-Stimulated B Cells Require Glutaminolysis for Glycolysis, Mitochondrial Respiration, and Cytokine Production
Matthew Cheung¹, Dongyue Huang¹, Doujiao Wu², Edward Pearce³ and Alfred Kim¹, ¹Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ³Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine secretion. A wide variety of stimuli can activate B cells to produce cytokines…
Abstract Number: 2112 • 2016 ACR/ARHP Annual Meeting
Disease-Activity Associated Autoantibodies to Malondialdehyde-Modified Proteins Can be Isolated from Synovial B Cells in RA
Caroline Grönwall¹, Khaled Amara¹, Uta Hardt¹, Lelise Getu², Jeffrey D. Greenberg³, Robert M Clancy³, Vivianne Malmström⁴ and Gregg J. Silverman³, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Malondialdehyde (MDA) is a naturally occurring reactive aldehyde that arises during apoptosis or as a consequence of elevated reactive oxygen species and lipid peroxidation.…
Abstract Number: 3244 • 2016 ACR/ARHP Annual Meeting
Observations of Early and Late B Cell Alterations during Belimumab Treatment in Patients with Systemic Lupus Erythematosus Using Mass Cytometry (CyTOF)
Ioannis Parodis¹, Daniel Ramsköld¹, Petter Brodin², Agneta Zickert¹, Lakshmikanth Tadepally², Yang Chen², Jaromir Mikes², Adnane Achour², Iva Gunnarsson¹ and Vivianne Malmström¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Belimumab is a recombinant monoclonal antibody that inhibits soluble B lymphocyte stimulator (BLyS), also known as BAFF or TNFSF13B, and is approved for treating…
Abstract Number: 660 • 2016 ACR/ARHP Annual Meeting
Expression of the Chemokine Receptor CXCR5 Is Decreased in the Periphery of Patients with Primary Sjogren’s Syndrome
Marie Wahren-Herlenius¹, Lara Adnan Aqrawi¹, Margarita Ivanchenko¹, Albin Björk¹, Jorge Ramírez¹, Marika Kvarnström¹, Janicke Cecilie Liaaen Jensen² and Kathrine Skarstein³, ¹Karolinska Institutet, Stockholm, Sweden, ²University of Oslo, Oslo, Norway, ³University of Bergen, Bergen, Norway
Background/Purpose: CXCR5 is a chemokine receptor expressed on B and T cell subsets, which binds the CXCL13 ligand produced by follicular dendritic cells. It is…
Abstract Number: 1092 • 2016 ACR/ARHP Annual Meeting
Expansion of Age Associated B Cells in Murine Lupus Is Regulated By DEF6 and Its Homologue Swap-70
Michela Manni¹, Sanjay Gupta², Edd Ricker³, Yurii Chinenov⁴, Rolf Jessberger⁵ and Alessandra B. Pernis^2,6,7,8, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Dresden University of Technology, Dresden, Dresden, Germany, ⁶Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ⁷David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁸Department of Medicine, Weill Cornell Medical College, New York, NY
Background/Purpose: Age-associated B cells (ABCs) are a novel B cell subset, which expresses CD11c and preferentially accumulates with age in female mice. Increased expansion of…
Abstract Number: 2116 • 2016 ACR/ARHP Annual Meeting
Cytokines Inhibition Modulates Activation and Homing Receptor of Different Peripheral Memory B Cell Subsets in RA
Zafar Mahmood¹, Marc Schmalzing², Michael Gernert³, Thomas Dörner⁴ and Hans-Peter Tony³, ¹Department of Medicine II, Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, ³Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, ⁴Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: With the advent of B cell targeted therapies the modulation of memory B cells seems to be a prime target. Human peripheral memory B…

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