Abstracts tagged "B cells"

Abstract Number: 1895 • 2018 ACR/ARHP Annual Meeting
Marked Immune Cell Subset Changes in Refractory Lupus Patients in a Phase I Trial of Allogenic Mesenchymal Stem Cells
Caroline Wallace Fugle¹, Chungwen Wei², Ignacio Sanz², Zihai Li¹, Chrystal Paulos¹, Megan Wyatt¹, Diane L. Kamen³ and Gary S. Gilkeson⁴, ¹MUSC, Charleston, SC, ²Emory University School of Medicine, Atlanta, GA, ³Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Reports of positive effects of allogenic mesenchymal stem cells (MSCs) in treating refractory lupus, from a single center in China, led us to investigate…
Abstract Number: 6 • 2018 ACR/ARHP Annual Meeting
Ro52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production
Margarita Ivanchenko¹, Susanna Brauner², Gudny Ella Thorlacius¹, Aurélie Ambrosi¹ and Marie Wahren-Herlenius¹, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Neuroimmunology Unit, Department of Clinical Neurosciences, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, Solna, Sweden
Background/Purpose: Systemic rheumatic diseases are characterized by abnormal B cell activation with autoantibody production and hypergammaglobulinemia. The autoantigen Ro52/SSA, also denoted TRIM21, is a major…
Abstract Number: 29 • 2018 ACR/ARHP Annual Meeting
CD70-Mediated CD27 Downregulation Contributed to Regulatory B10 Cell Impairment in Rheumatoid Arthritis
Lianjie Shi¹, Fanlei Hu², Rong Mu³ and Zhan-Guo Li⁴, ¹Peking University International Hospital, Beijing, China, ²Peking University People's Hospital, Beijing, China, ³Peking University People‘s Hospital, Beijing, China, ⁴Peking University People’s Hospital, Beijing, China
Background/Purpose: Impaired function of regulatory B10 cells has been shown in autoimmune diseases. However, the underlying mechanism is still obscure. In the present study, we…
Abstract Number: 2024 • 2018 ACR/ARHP Annual Meeting
Comparison of B and T Cell Subsets, Cytokine Expression and Synovial Pathology in Down’s Arthritis (DA) and Juvenile Idiopathic Arthritis (JIA)
Charlene Foley¹, Achilleas Floudas², Mary Canavan², Monika Biniecka², Emma-Jane MacDermott³, Orla G Killeen³, Ronan Mullan⁴ and Ursula Fearon⁵, ¹Our Lady's Children's Hospital Crumlin, National Centre for Paediatric Rheumatology, Dublin, Ireland, ²Trinity Biomedical Sciences Institute, Dublin, Ireland, ³National Centre for Paediatric Rheumatology, Dublin, Ireland, ⁴Rheumatology, Tallaght Hospital, Dublin, Ireland, ⁵Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland
Background/Purpose: Down syndrome (DS) is a common chromosomal disorder associated with a range of medical & immune abnormalities e.g. increased susceptibility to infections & a…
Abstract Number: 7 • 2018 ACR/ARHP Annual Meeting
RNA Sequencing Detection of Gene Dysregulation in B Cells Sorted from Salivary Gland Tissue and from Peripheral Blood Reveals New Pathways Involved in Primary Sjögren’s Syndrome Pathophysiology
Elodie Rivière^1,2, Nicolas Tchitchek¹, Gaetane Nocturne^1,3, Juliette Pascaud¹, Saida Boudaoud¹, Alice Thai⁴, Normand Allaire⁴, Bernd Jagla⁵, Michael Mingueneau⁴ and Xavier Mariette^1,3, ¹Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ²Arthritis Fondation Courtin, Paris, France, ³Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁴Immunology Research, Biogen, Cambridge, MA, ⁵Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique C3IB, Institut Pasteur, Paris, France
Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic auto-immune disorder characterized by lymphocytic infiltrates and destruction of the salivary glands. Chronic B cell activation, the…
Abstract Number: 30 • 2018 ACR/ARHP Annual Meeting
CD21lo Cells Are Increased in Patients with Systemic Sclerosis and May be Associated with Interstitial Lung Disease
Erin Wilfong¹, Katherine Vowell², Leslie Crofford³ and Peggy Kendall¹, ¹Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, TN, ²Division of Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ³Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Systemic sclerosis (SSc) is a severe systemic disease characterized by fibrosis of the skin and visceral organs. While the exact pathogenesis of SSc is…
Abstract Number: 2050 • 2018 ACR/ARHP Annual Meeting
B and T Cell Phenotypes of First Degree Relatives of RA Patients in an Indigenous North American Cohort
Stacy Tanner¹, Christine Zhang², Irene Smolik³, Aaron Marshall² and Hani El-Gabalawy⁴, ¹Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ²Immunology, University of Manitoba, Winnipeg, MB, Canada, ³Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ⁴University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: First degree relatives (FDR) of patients with RA are known to have approximately 4 times increased risk of developing RA and prevalence of RA…
Abstract Number: 8 • 2018 ACR/ARHP Annual Meeting
Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG
Yan Wang¹, Katy A. Lloyd², Sunithi Gunasekera³, Camilla Eriksson³, Daniel Ramsköld², Karin Lundberg⁴, Per-Johan Jakobsson¹, Ulf Göransson³, Vivianne Malmström¹ and Caroline Grönwall⁵, ¹Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Division of Pharmacognosy, Dept. of Medicinal Chemistry, Uppsala University, Uppsala, Sweden, ⁴Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The immunological hallmark of rheumatoid arthritis (RA) is autoreactivity to citrullinated proteins and rheumatoid factor activity. Hence, the adaptive immune system and B cells…
Abstract Number: 41 • 2018 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Improves Bone Strength in Mouse Model for Rheumatoid Arthritis
Ryuusuke Kaneko, Fumihito Hosoi, Satoru Iguchi, Hiroaki Hayashi, Yohei Yoshiga, Yoshinori Nakachi, Daichi Akasaka, Kenji Tanaka, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan
Background/Purpose: The erosions of bone and cartilage are a cardinal feature of rheumatoid arthritis (RA) and associated with disease severity and poor functional outcome. Although…
Abstract Number: 2055 • 2018 ACR/ARHP Annual Meeting
Laser Capture Microdissection to Interrogate B Cells in RA Synovial Tissue
Javier Rangel-Moreno¹, Nida Meednu², Andrew McDavid³, Linda Callahan⁴, V. Kaye Thomas⁴, Jennifer Albrecht², Edward F. DiCarlo⁵, Dana Orange⁶, Susan M. Goodman⁶, Laura T. Donlin⁷ and Jennifer Anolik², ¹Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, ⁴University of Rochester Medical Center, Rochester, NY, ⁵Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁶Hospital for Special Surgery, New York, NY, ⁷Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Rheumatoid arthritis is an autoimmune disease characterized by immune cell infiltration in synovial tissue and progressive bone damage. B cells are abundant in the…
Abstract Number: 9 • 2018 ACR/ARHP Annual Meeting
Integration of Cytokine Profiles with Distinct B-Cell Functions Reveals a Specific Micro-Environmental Framework in Autoimmune Diseases
Quentin Simon¹, Alexis Grasseau², Bénédicte Rouvière², Laetitia Le Pottier², Divi Cornec³, Maria Orietta Borghi⁴, Rocio Aguilar Quesada⁵, Yves Renaudineau^2,6, Marta Alarcón-Riquelme⁷, Jacques-Olivier Pers¹ and Sophie Hillion^2,6, ¹U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, ²U1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Brest, France, ³Hopital La Cavale Blanche, Brest, France, ⁴University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ⁵Biobanco Del Sistema Sanitario Publico de Andalucía, Sevilla, Spain, ⁶CHU de Brest, Brest, France, ⁷Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain
Background/Purpose: The functional duality of B cells is central to balance immune homeostasis by regulating or promoting the immune response. However, the mechanisms by which…
Abstract Number: 108 • 2018 ACR/ARHP Annual Meeting
Sex-Specific Expression of CXorf21 Provide Molecular Explanation for the Fundamental Difference in Male and Female Immune Response: An Explanation for Female-Bias SLE Pathogenesis
R. Hal Scofield¹, Valerie M Harris², Biji T. Kurien³ and Kristi A. Koelsch⁴, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Okalahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is complex autoimmune disorders characterized by B cell hyperactivity resulting in autoantibody and cytokine production. Approximately 90% of patients are…
Abstract Number: 2077 • 2018 ACR/ARHP Annual Meeting
Pathological Osteogenesis and Inflammation in Experimental Spondyloarthritis Are Associated with Aberrant Type H Blood Vessels and Development of High Endothelial Venules Accompanied By Ectopic Lymphoid Structures in Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg², George Kollias³, Dominique Baeten¹, Leonie van Duivenvoorde¹ and Sander W. Tas², ¹Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Spondyloarthritis (SpA) is characterized by pathological osteogenesis, inflammation and extensive angiogenesis in inflamed tissues. TNF plays a central role in SpA pathology and transgenic…
Abstract Number: 10 • 2018 ACR/ARHP Annual Meeting
Fibroblast like Synoviocytes (FLS) Are Capable of Inducing Phenotypical Changes Including Class Switch Recombination (CSR) in Naive B Cells, but Additional Factors Are Required to Trigger Immunoglobulin Secretion
Dennis Bleck¹, Torsten Lowin², Matthias Schneider³ and Georg Pongratz⁴, ¹Rheumatology Policlinic & Hiller Research Unit, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, ²Department and Hiller Research Center for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, ³Department and Hiller Research Center for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, ⁴Dpt. of Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
Background/Purpose: Rheumatoid Arthritis (RA) is a disease characterized by chronic inflammation of the synovial tissue in joints. It is driven by highly activated B cells.…
Abstract Number: 111 • 2018 ACR/ARHP Annual Meeting
BAFF Inhibition Attenuates Fibrosis in Bleomycin-Induced Scleroderma Model Via Modulating the Regulatory and Effector B-Cell Balance
Takashi Matsushita¹, Tadahiro Kobayashi², Yasuhito Hamaguchi², Minoru Hasegawa³, Manabu Fujimoto⁴ and Kazuhiko Takehara¹, ¹Kanazawa University, Department of Dermatology, Kanazawa, Japan, ²Department of Dermatology, Kanazawa University, Kanazawa, Japan, ³University of Fukui, Department of Dermatology, Fukui, Japan, ⁴University of Tsukuba, Faculty of Medicine, Department of Dermatology, Tsukuba, Japan
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. Over 90% of patients with SSc are positive for autoantibodies. In…

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