ACR Meeting Abstracts

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Abstracts tagged "B cells"

  • Abstract Number: 2814 • 2019 ACR/ARP Annual Meeting

    Methionine Commits Immunometabolism and Epigenetic Regulation of BACH2 Loci in B Cells, Resulting in Biases Toward Plasmablast Differentiation in the Pathogenesis of SLE

    Mingzeng Zhang1, Shigeru Iwata 1, Maiko Hajime 1, Naoaki Ohkubo 1, Yasuyuki Todoroki 2, Hiroko Miyata 2, Jie Fan 2, Shingo Nakayamada 1, Kaoru Yamagata 1 and Yoshiya Tanaka 3, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, 2The First Department of Internal Medicine, University of Occupational & Environmental Health Kitakyushu, Japan, Kitakyushu, Japan, 3University of Occupational and Environmental Health Japan, Kitakyushu, Japan

    Background/Purpose: Amino acids play an important role in various metabolic processes. However, the role of amino acid metabolism in the regulation of human B cell…
  • Abstract Number: 2815 • 2019 ACR/ARP Annual Meeting

    Lower IL-4R in IgD+ Naïve B Cells Is a Pre-disposing Factor for Development of T-bet+ DN2 B Cells in Systemic Lupus Erythematosus

    John Mountz1, Min Gao 2, Qi Wu 3, PingAr Yang 2, Alex Essman 4, Oluwagbemiga Ojo 4, Shanrun Liu 2, Jake Chen 2, Iñaki Sanz 5, W. Winn Chatham 2 and Hui-Chen Hsu 2, 1University of Alabama at Birmingham and Birmingham VAMC, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, 3University of Alabama at Birmingham, Birmingham, AL, 4Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, 5Emory University, ATLANTA, GA

    Background/Purpose: Studies to date have primarily focused on stimulators that are overexpressed and activate B cells in SLE subjects.  Factors that can maintain B cells…
  • Abstract Number: 2819 • 2019 ACR/ARP Annual Meeting

    The Transcription Factor MAF Controls the Ability of T Peripheral Helper (Tph) Cells to Help B Cells

    Alexandra Bocharnikov1, Vanessa Wacleche 1, Ye Cao 1 and Deepak Rao 2, 1Brigham and Women's Hospital, Boston, 2Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Pathologic T cell-B cell interactions are hallmark features of many autoimmune diseases. PD-1hi CXCR5- T peripheral helper (Tph) cells are B cell-helper T cells…
  • Abstract Number: 3 • 2018 ACR/ARHP Annual Meeting

    Interferon-Alpha Disrupts DNA-Specific B Cell Tolerance in 3H9 Mice

    Dario Ferri1, Yuriy Baglaenko2, Ariana Karanxha1, Kieran Manion1, Carolina Grajales1 and Joan E. Wither1, 1Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Biomedical Informatics, Brigham Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: A central mediator of Systemic Lupus Erythematosus (SLE) pathogenesis is interferon-alpha (IFNα), which is elevated in the serum of SLE patients. IFNα has been…
  • Abstract Number: 27 • 2018 ACR/ARHP Annual Meeting

    Top-Down Proteomics Coupled with Antibody Sequencing from Single B Cells Reveals a Monoclonal Anti-Sm Clone Present in the Serum of an SLE Patient over Three Years

    Zhe Wang1, Jennifer Muther2, Judith A. James3, Si Wu1 and Kenneth Smith2, 1Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Proteomics is becoming an increasingly powerful tool to study autoantibodies. Current bottom-up approaches are yielding a plethora of knowledge about public clonotypes and clonal…
  • Abstract Number: 1895 • 2018 ACR/ARHP Annual Meeting

    Marked Immune Cell Subset Changes in Refractory Lupus Patients in a Phase I Trial of Allogenic Mesenchymal Stem Cells

    Caroline Wallace Fugle1, Chungwen Wei2, Ignacio Sanz2, Zihai Li1, Chrystal Paulos1, Megan Wyatt1, Diane L. Kamen3 and Gary S. Gilkeson4, 1MUSC, Charleston, SC, 2Emory University School of Medicine, Atlanta, GA, 3Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 4Department of Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Reports of positive effects of allogenic mesenchymal stem cells (MSCs) in treating refractory lupus, from a single center in China, led us to investigate…
  • Abstract Number: 6 • 2018 ACR/ARHP Annual Meeting

    Ro52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production

    Margarita Ivanchenko1, Susanna Brauner2, Gudny Ella Thorlacius1, Aurélie Ambrosi1 and Marie Wahren-Herlenius1, 1Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Neuroimmunology Unit, Department of Clinical Neurosciences, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, Solna, Sweden

    Background/Purpose: Systemic rheumatic diseases are characterized by abnormal B cell activation with autoantibody production and hypergammaglobulinemia. The autoantigen Ro52/SSA, also denoted TRIM21, is a major…
  • Abstract Number: 29 • 2018 ACR/ARHP Annual Meeting

    CD70-Mediated CD27 Downregulation Contributed to Regulatory B10 Cell Impairment in Rheumatoid Arthritis

    Lianjie Shi1, Fanlei Hu2, Rong Mu3 and Zhan-Guo Li4, 1Peking University International Hospital, Beijing, China, 2Peking University People's Hospital, Beijing, China, 3Peking University People‘s Hospital, Beijing, China, 4Peking University People’s Hospital, Beijing, China

    Background/Purpose: Impaired function of regulatory B10 cells has been shown in autoimmune diseases. However, the underlying mechanism is still obscure. In the present study, we…
  • Abstract Number: 2024 • 2018 ACR/ARHP Annual Meeting

    Comparison of B and T Cell Subsets, Cytokine Expression and Synovial Pathology in Down’s Arthritis (DA) and Juvenile Idiopathic Arthritis (JIA)

    Charlene Foley1, Achilleas Floudas2, Mary Canavan2, Monika Biniecka2, Emma-Jane MacDermott3, Orla G Killeen3, Ronan Mullan4 and Ursula Fearon5, 1Our Lady's Children's Hospital Crumlin, National Centre for Paediatric Rheumatology, Dublin, Ireland, 2Trinity Biomedical Sciences Institute, Dublin, Ireland, 3National Centre for Paediatric Rheumatology, Dublin, Ireland, 4Rheumatology, Tallaght Hospital, Dublin, Ireland, 5Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Background/Purpose: Down syndrome (DS) is a common chromosomal disorder associated with a range of medical & immune abnormalities e.g. increased susceptibility to infections & a…
  • Abstract Number: 7 • 2018 ACR/ARHP Annual Meeting

    RNA Sequencing Detection of Gene Dysregulation in B Cells Sorted from Salivary Gland Tissue and from Peripheral Blood Reveals New Pathways Involved in Primary Sjögren’s Syndrome Pathophysiology

    Elodie Rivière1,2, Nicolas Tchitchek1, Gaetane Nocturne1,3, Juliette Pascaud1, Saida Boudaoud1, Alice Thai4, Normand Allaire4, Bernd Jagla5, Michael Mingueneau4 and Xavier Mariette1,3, 1Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, 2Arthritis Fondation Courtin, Paris, France, 3Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 4Immunology Research, Biogen, Cambridge, MA, 5Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique C3IB, Institut Pasteur, Paris, France

    Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic auto-immune disorder characterized by lymphocytic infiltrates and destruction of the salivary glands. Chronic B cell activation, the…
  • Abstract Number: 30 • 2018 ACR/ARHP Annual Meeting

    CD21lo Cells Are Increased in Patients with Systemic Sclerosis and May be Associated with Interstitial Lung Disease

    Erin Wilfong1, Katherine Vowell2, Leslie Crofford3 and Peggy Kendall1, 1Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, TN, 2Division of Rheumatology and Immunology, Vanderbilt University, Nashville, TN, 3Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Systemic sclerosis (SSc) is a severe systemic disease characterized by fibrosis of the skin and visceral organs.  While the exact pathogenesis of SSc is…
  • Abstract Number: 2050 • 2018 ACR/ARHP Annual Meeting

    B and T Cell Phenotypes of First Degree Relatives of RA Patients in an Indigenous North American Cohort

    Stacy Tanner1, Christine Zhang2, Irene Smolik3, Aaron Marshall2 and Hani El-Gabalawy4, 1Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 2Immunology, University of Manitoba, Winnipeg, MB, Canada, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: First degree relatives (FDR) of patients with RA are known to have approximately 4 times increased risk of developing RA and prevalence of RA…
  • Abstract Number: 8 • 2018 ACR/ARHP Annual Meeting

    Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

    Yan Wang1, Katy A. Lloyd2, Sunithi Gunasekera3, Camilla Eriksson3, Daniel Ramsköld2, Karin Lundberg4, Per-Johan Jakobsson1, Ulf Göransson3, Vivianne Malmström1 and Caroline Grönwall5, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 3Division of Pharmacognosy, Dept. of Medicinal Chemistry, Uppsala University, Uppsala, Sweden, 4Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 5Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The immunological hallmark of rheumatoid arthritis (RA) is autoreactivity to citrullinated proteins and rheumatoid factor activity. Hence, the adaptive immune system and B cells…
  • Abstract Number: 41 • 2018 ACR/ARHP Annual Meeting

    TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Improves Bone Strength in Mouse Model for Rheumatoid Arthritis

    Ryuusuke Kaneko, Fumihito Hosoi, Satoru Iguchi, Hiroaki Hayashi, Yohei Yoshiga, Yoshinori Nakachi, Daichi Akasaka, Kenji Tanaka, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan

    Background/Purpose: The erosions of bone and cartilage are a cardinal feature of rheumatoid arthritis (RA) and associated with disease severity and poor functional outcome. Although…
  • Abstract Number: 2055 • 2018 ACR/ARHP Annual Meeting

    Laser Capture Microdissection to Interrogate B Cells in RA Synovial Tissue

    Javier Rangel-Moreno1, Nida Meednu2, Andrew McDavid3, Linda Callahan4, V. Kaye Thomas4, Jennifer Albrecht2, Edward F. DiCarlo5, Dana Orange6, Susan M. Goodman6, Laura T. Donlin7 and Jennifer Anolik2, 1Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, 4University of Rochester Medical Center, Rochester, NY, 5Laboratory Medicine, Hospital for Special Surgery, New York, NY, 6Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: Rheumatoid arthritis is an autoimmune disease characterized by immune cell infiltration in synovial tissue and progressive bone damage. B cells are abundant in the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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