Abstracts tagged "B cells"

Abstract Number: 17 • 2018 ACR/ARHP Annual Meeting
Kappa-Deleting Recombination Excision Circles (KREC) in B Cells and Serum B Cell Activating Factor (BAFF): Possible Aids in Predicting Juvenile Dermatomyositis Response to Rituximab
Amer khojah^1,2, Victoria Hans³, Wilfredo Marin⁴, Gabrielle A. Morgan⁴ and Lauren M. Pachman^5,6,7, ¹Division of Pediatric Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ²Division of Pediatric Allergy Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ³Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁵Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁶Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL
Background/Purpose: Rituximab is used for the treatment of juvenile dermatomyositis (JDM) with variable success. Some of this variability is presumed to be related to the…
Abstract Number: 714 • 2018 ACR/ARHP Annual Meeting
A Predictive Clinical-Immunological Index for Infections Unveils Novel Innate and Adaptive Immunity Abnormalities As Key Risk Factors for Infections in a Cohort of Patients with Systemic Lupus Erythematosus
Diana Gómez-Martín^1,2, Jiram Torres-Ruíz³, Nancy R Mejía-Domínguez⁴, Guillermo Juárez-Vega⁵, Javier Merayo-Chalico³, Ana Barrera-Vargas³ and Jorge Alcocer-Varela¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico, ³Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico, ⁴Bioinformatics, Biostatistics and Computational Biology Unit, Red de Apoyo a la Investigación. Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México, Mexico, Mexico, ⁵Flow Cytometry Unit, Red de Apoyo a la Investigación. Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México, Mexico, Mexico
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have multiple innate and adaptive immune response abnormalities. It is unknown whether they play a key role in…
Abstract Number: 2743 • 2018 ACR/ARHP Annual Meeting
Favorable Efficacy of Rituximab in ANCA-Associated Vasculitis Patients with Excessive B Cell Differentiation
Yusuke Miyazaki¹, Shingo Nakayamada¹, Satoshi Kubo¹, Kazuhisa Nakano¹, Shigeru Iwata², Shunsuke Fukuyo³, Akio Kawabe⁴ and Yoshiya Tanaka⁵, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Japan, Fukuoka, Japan, ⁴University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan, ⁵University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: B cell depletion by rituximab (RTX)is effective treatment for ANCA-associated vasculitis (AAV). However, the phenotype of peripheral B cells and the selection criteria for…
Abstract Number: 18 • 2018 ACR/ARHP Annual Meeting
Cytoplasmic FOXO1 Identifies Novel Disease-Activity Associated B Cell Subsets in SLE
Molly Hritzo¹ and Amit Golding², ¹Microbiology and Molecular Immunology, University of Maryland School of Medicine, Baltimore, MD, ²10 South Pine Street, Baltimore VA/VAMHCS AND University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: A key integrator of external stimuli in lymphocytes, Forkhead box protein O1 (FOXO1) is a highly attractive factor to study in SLE because it…
Abstract Number: 972 • 2018 ACR/ARHP Annual Meeting
An Anti-CD28 Domain Antibody, Lulizumab, in Systemic Lupus Erythematosus: Results of a Phase II Study
Joan T. Merrill¹, Diane E. Shevell², Dominique Duchesne², Miroslawa Nowak², Sudeep Kundu², Ihab G. Girgis², Yanhua Sarah Hu², Steven G. Nadler³, Subhashis Banerjee² and John Throup², ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Bristol-Myers Squibb, Princeton, NJ, ³Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: The T cell costimulatory molecule, CD28, is critical for the activation of pathogenic T cells in autoimmune diseases.1,2 An anti-CD28 domain antagonist antibody, lulizumab…
Abstract Number: 2791 • 2018 ACR/ARHP Annual Meeting
Characterization of Monoclonal Anti-PAD4 Autoantibodies from Rheumatoid Arthritis Patients: Functional Implications for Citrullination and Disease Progression
Alejandro Gomez, Sarah Kongpachith, Nithya Lingampalli, Cecilia Cisar and William H. Robinson, Department of Medicine, Stanford University, Stanford, CA
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are present in two-thirds of patients with rheumatoid arthritis (RA), and target proteins that have been post-translationally modified by the…
Abstract Number: 19 • 2018 ACR/ARHP Annual Meeting
Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis
Philip J. Titcombe^1,2, Natalie Sippl³, Monika Hansson⁴, Lena Israelsson³, Khaled Amara³, Timothy B. Niewold⁵, Lars Klareskog², Vivianne Malmström² and Daniel L. Mueller⁶, ¹The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ²Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Colton Center for Autoimmunity, New York University, New York, NY, ⁶Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) have proven highly useful as biomarkers in rheumatoid arthritis (RA) and appear to be important to disease pathogenesis. Nevertheless, the…
Abstract Number: 1082 • 2018 ACR/ARHP Annual Meeting
Peripheral Blood CD11c+ CD21- Age-Associated B Cells (ABCs) in Human Systemic Lupus Erythematosus Are Associated with Innate Type III Interferon and Disease Activity
Jennifer L. Barnas, Lin Gao, Mary O'Connell, Jennifer Albrecht, Nida Meednu, R. John Looney and Jennifer Anolik, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an interferon-stimulated gene (ISG) signature typically attributed to interferon (IFN)-α. However, ISGs can be induced by other…
Abstract Number: 2795 • 2018 ACR/ARHP Annual Meeting
IL-23 Acts through IL-23R+ Tfh cells to Promote Pathogenic IgG Autoantibody Formation in Lupus
Huixian Hong¹, Qi Wu², PingAr Yang², Bao Luo³, Jun Li⁴, Hao Li⁵, Daniel Cua⁶, Hui-Chen Hsu² and John D. Mountz⁷, ¹University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ³DIvision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ⁵Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶Discovery Research, Merck Research Laboratory, Palo Alto, CA, ⁷University of Alabama at Birmingham, Devision of Clinical Immunology and Rheumatology; University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL
Background/Purpose: IL-23 is currently a target for several forms of autoimmune diseases, yet its role in promoting pathogenic autoantibody development is less clear. IL-23 was…
Abstract Number: 20 • 2018 ACR/ARHP Annual Meeting
Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren’s Syndrome and Systemic Lupus Erythematosus
Felice Rivellese^1,2, Daniele Mauro¹, Mattia Congia³, Elena Pontarini¹, Peter Schafer⁴, Michele Bombardieri^1,2, Costantino Pitzalis^1,5 and Myles J. Lewis^1,2, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, ²Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, United Kingdom, London, United Kingdom, ³Rheumatology and Rheumatology Unit, University Clinic and AOU of Cagliari, Cagliari, Italy, Cagliari, Italy, ⁴Celgene Corporation, Summit, NJ, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: Polymorphisms of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which are essential for the maturation, differentiation and survival of B cells, have been…
Abstract Number: 1083 • 2018 ACR/ARHP Annual Meeting
Changes of Innate Lymphoid Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Its Correlations with Clinical Markers
Hui Chu, Xiaomei Li, zhen Tan, ruolan Wu, Xiangpei Li, xuan Fang, xu Zhen and Guosheng Wang, The first affiliated hospital of university of Science and Technology of China, Hefei, China
Background/Purpose: Innate Lymphoid Cells (ILCs) are a novel group of innate immune cells, according to the cytokine profile, they were divided into three major subsets:…
Abstract Number: 2796 • 2018 ACR/ARHP Annual Meeting
Sex-Based Differences Control ABC Function in Swef-Deficient Mice
Michela Manni¹, Danny Flores-Castro², Chao Ye², Edd Ricker¹, Sanjay Gupta³, Yurii Chinenov⁴, Tania Pannellini² and Alessandra B. Pernis⁵, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Age-associated B cells (ABCs) are a novel B cell subset, which expands with age in non-autoimmune mice but accumulates prematurely in autoimmune-prone strains. ABCs…
Abstract Number: 21 • 2018 ACR/ARHP Annual Meeting
Elevated EPSTI1 Promote B Cells Hyperactivation through NF-Kb Signaling in Patients with Sjögren ’s Syndrome
Jin-Lei Sun¹, Zhi-Lei Chen², Chao-Feng Lian³, Ti-Hong Shao², Hao-Ze Zhang², Hua Chen³ and Feng-Chun Zhang², ¹Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China, ³Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Sjogren's syndrome (SS) is a common systemic autoimmune disease characterized with aberrant B cells activation. B cells play a key role in the pathogenesis…
Abstract Number: 1092 • 2018 ACR/ARHP Annual Meeting
Immune Complex-Driven Neutrophil Activation and BAFF Production Promote B Cell Activation and Autoantibody Production in Human SLE
Andrew Vasconcellos¹, John Marken¹, Sladjana Skopelja-Gardner¹, Christian Lood² and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: The production of anti-nuclear auto-antibodies (Ab) and the formation of immune complexes (IC) are hallmarks of Systemic Lupus Erythematosus (SLE). Enhanced neutrophil (PMN) activation…
Abstract Number: 2800 • 2018 ACR/ARHP Annual Meeting
Adenosine 2a Receptor Signals Act to Limit Autoimmune Arthritis By Inhibiting Pathogenic Germinal Center T Follicular Helper (GC-Tfh) Cells
Shirdi Schmiel and Daniel L. Mueller, Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: CD4 germinal center (GC)-T follicular helper (Tfh) cells are important in the pathogenesis of autoimmune arthritis. Previous studies have shown that adenosine 2a receptor…

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