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Abstracts tagged "axial spondyloarthritis"

  • Abstract Number: 2876 • 2015 ACR/ARHP Annual Meeting

    Baseline Demographic and Disease Characteristics Associated with Response to Golimumab in Patients with Active Nonradiographic Axial Spondyloarthritis

    Maxime Dougados1, Gina Bergman2, Walter Maksymowych3, Sean P. Curtis2, Susan Huyck2, Anjela Tzontcheva2 and Joachim Sieper4, 1Paris-Descartes University, Paris, France, 2Merck & Co., Inc., Kenilworth, NJ, 3University of Alberta, Edmonton, AB, Canada, 4University Clinic Benjamin Franklin, Berlin, Germany

    Background/Purpose:  Subgroup analyses can be used to investigate the size and direction of treatment effects across a range of demographic and disease characteristics. The purpose…
  • Abstract Number: 691 • 2015 ACR/ARHP Annual Meeting

    Standards for the Classification of Non-Radiographic Axial Spondyloarthritis: A European Real World Study

    Tim Holbrook1, Robert Wood1, Christopher Black2, Xiaohan Hu2 and Sumesh Kachroo2, 1Adelphi Real World, Macclesfield, United Kingdom, 2CORE, Merck & Co., Inc., Rahway, NJ

    Background/Purpose: Classification of non-radiographic axial spondyloarthritis (nr-axSpA) requires the presence of Assessment of Spondyloarthritis international Society (ASAS) criteria for AxSpA, without radiologic evidence of sacroiliitis…
  • Abstract Number: 2878 • 2015 ACR/ARHP Annual Meeting

    Treating Axial Spondyloarthritis to Target: Influence of the Population Characteristics and Comorbidities in Reaching Ankylosing Spondylitis Disease Activity Score (ASDAS) Inactive Disease in a Cohort of Patients Treated with Tnfalpha Inhibitors Agents

    Sara Monti, Veronica Codullo, Vittorio Grosso, Silvia Breda, Carlomaurizio Montecucco and Roberto Caporali, Division of Rheumatology, University of Pavia, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy

    Background/Purpose: The treat to target strategy (T2T), aiming at inactive disease (ID), has become the recommended approach also in the field of axial-SpA (axSpA) (1). …
  • Abstract Number: 696 • 2015 ACR/ARHP Annual Meeting

    Current and Past Smoking Are Associated with Functional Impairement and Increased Disease Activity in Axial Spondyloarthritis: Systematic Review and Meta-Analysis

    Kristina SCHREIBER1, Thomas Barnetche2, BG Combe3, Jacques Morel1 and Claire I. Daien1, 1Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, 2Rheumatology Department, Pellegrin University Hospital, BORDEAUX, France, 3Lapeyronie, Montpellier, France

    Background/Purpose: The influence of smoking on the development of rheumatoid arthritis, the severity of the disease and the response to treatment is well established. The…
  • Abstract Number: 2885 • 2015 ACR/ARHP Annual Meeting

    Long-Term Effects of Etanercept on Patient-Reported Outcomes in Early Non-Radiographic Axial Spondyloarthritis: 104-Week Results of a Phase III Study

    Filip van Den Bosch1,2, Edit Drescher3, Jan Rosa4, Ronald Pedersen5, Randi Bonin6, Bonnie Vlahos7, Jack F Bukowski6 and Sameer Kotak8, 1Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 2Rheumatology, Ghent University Hospital, Ghent, Belgium, 3Csolnoky Ferenc Hospital, Veszprém, Hungary, 4Mediscan Group, Prague, Czech Republic, 5Department of Biostatistics, Pfizer, Collegeville, PA, 6Clinical Affairs, Pfizer, Collegeville, PA, 7GIPB - Clinical Sciences, Pfizer, Collegeville, PA, 8Global Health and Value, Pfizer, New York, NY

    Background/Purpose: In patients with active, NSAID-resistant, non-radiographic axial spondyloarthritis (nr-axSpA) who participated in the multiphase, randomized, placebo (PBO)-controlled EMBARK study (ClinicalTrials.gov identifier: NCT01258738), health-related quality-of-life…
  • Abstract Number: 697 • 2015 ACR/ARHP Annual Meeting

    Identification Methods for Axial Spondyloarthritis in American Veterans

    Jessica Walsh1, Jianwei Leng2, Brian Breviu3, Daniel Clegg4, Tao He2 and Brian Sauer5, 1Division of Rheumatology, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 2Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 3Department of Internal Medicine, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 4Rheumatology, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 5Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT

    Background/Purpose: Current methods for identifying people with axial spondyloarthritis (AxSpA) in large datasets are inadequate because billing codes for most types of spondyloarthrtis (SpA) do…
  • Abstract Number: 2893 • 2015 ACR/ARHP Annual Meeting

    Quality of Life in Patients with Active Nonradiographic Axial Spondyloarthritis after 16 Weeks of Golimumab Treatment

    Walter Maksymowych1, Sean P. Curtis2, Maxime Dougados3, Gina Bergman2, Susan Huyck2, Anjela Tzontcheva2 and Joachim Sieper4, 1Medicine, University of Alberta, Edmonton, AB, Canada, 2Merck & Co., Inc., Kenilworth, NJ, 3Paris-Descartes University, Paris, France, 4University Clinic Benjamin Franklin, Berlin, Germany

    Background/Purpose:  Chronic inflammation, back pain, and progressive spinal stiffness associated with axial spondyloarthritis (axSpA) can decrease quality of life (QoL). The purpose of this study…
  • Abstract Number: 709 • 2015 ACR/ARHP Annual Meeting

    Progression of Patients with Non-Radiographic Axial Spondyloarthritis to Ankylosing Spondylitis: A Population-Based Cohort Study

    Runsheng Wang1, Sherine Gabriel2 and Michael M. Ward1, 1NIH/NIAMS, Bethesda, MD, 2Division of Rheumatology; Department of Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: The long-term outcome of patients with non-radiographic axial spondyloarthritis (nr-axSpA) is unclear, particularly whether few or most progress to ankylosing spondylitis (AS).  Our objective…
  • Abstract Number: 2938 • 2014 ACR/ARHP Annual Meeting

    A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of Subcutaneous Golimumab in Patients with Active Nonradiographic Axial Spondyloarthritis

    J Sieper1, D van der Heijde2, M Dougados3, Walter P. Maksymowych4, J Boice5, G Bergman5, S Curtis5, A Tzontcheva5, S Huyck5 and HH Weng5, 1University Clinic Benjamin Franklin, Berlin, Germany, 2Leiden University Medical Center, Leiden, Netherlands, 3Paris-Descartes University, Paris, France, 4Department of Medicine, University of Alberta, Alberta, AK, 5Merck & Co., Inc., Whitehouse Station, NJ

    Background/Purpose Axial spondyloarthritis (axSpA), including ankylosing spondylitis and nonradiographic axial SpA (nr-axSpA), is a chronic inflammatory disease marked by back pain and progressive spinal stiffness.…
  • Abstract Number: 589 • 2014 ACR/ARHP Annual Meeting

    Patients with Nr-Axspa Show a Statistically Higher Disease Burden in Clinical Practice Compared with Patients with Radiographic Axial Spa

    Lennart TH Jacobsson1, Tomas Husmark2, Elke Theander3, Kenneth Henriksson4, Katharina Büsch5 and Martin Johansson5, 1Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 2Rheumatology, Falu Hospital, Falun, Sweden, 3Skane University Hospital Malmö, Lund University, Malmö, Sweden, 4Rheumatology city clinic, Stockholm, Sweden, Stockholm, Sweden, 5AbbVie AB, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose The ASAS axial SpA classification criteria was published in 2009 but so far there has been limited research on axial SpA patients in clinical…
  • Abstract Number: 2604 • 2014 ACR/ARHP Annual Meeting

    Ankylosing Spondylitis and Non- Radiographic Axial Spondyloarthritis :      the Same Syndrome or Different Diseases? Analysis from Esperanza Cohort

    Azucena Hernández-Sanz1, Victoria Navarro-Compán2, Cristina Fernández-Carballido3, Carlos Montilla-Morales4, Juan Mulero5 and Eugenio De Miguel6, 1H. Virgen de la Salud, Toledo, Spain, 2Rheumatology, University Hospital La Paz, Madrid, Spain, 3Rheumatology, University General Hospital Elda, Elda (Alicante), Spain, 4H. de Salamanca, Salamanca, Spain, 5Rheumatology, University Hospital Puerta de Hierro, Majadahonda (Madrid), Spain, 6Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain

    Background/Purpose New ASAS criteria for axial spondyloarthritis (axSpA) have two entrances: the imaging and clinical arm (presence of HLA B27). The imaging arm allows classifying patients…
  • Abstract Number: 585 • 2014 ACR/ARHP Annual Meeting

    Optimism Levels Are Moderate and Similar in Patients with Axial Spondyloarthritis and Chronic Low Back Pain, and Are Related to Mental Quality of Life but Not Physical Quality of Life. a Cross Sectional Study of 277 Patients

    Sarah Kreis1,2,3, Anna Molto2,3, Florian Bailly2,3, Sabrina Dadoun2,3, Stephanie Fabre2,3,4, Christophe Hudry2, Franck Zenasni5, Sylvie Rozenberg2,3, Edouard Perthuiset4, Bruno Fautrel2,6 and Laure Gossec2,7, 1Institut de Psychologie, Laboratoire de Psychopathologie et Processus de Santé EA4057, Université Paris Descartes, Boulogne-Billancourt, France, 2Sorbonne Universités, UPMC Univ Paris 06, GRC-08, Institut Pierre Louis d’Epidémiologie et de Santé Publique, paris, France, 3Pitié-Salpêtrière Hospital, AP-HP, Rheumatology department, paris, France, 4Pontoise University Hospital, pontoise, France, 5Institut de Psychologie, Laboratoire de Psychopathologie et Processus de Santé EA4057, Université Paris Descartes, Paris, France, Boulogne-Billancourt, France, 6Rheumatology, Pitie Salpetriere Hospital, Paris, France, 7Rheumatology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France

    Background/Purpose Axial Spondyloarthritis (AxSpA) and chronic low back pain (LBP) are very different chronic rheumatic diseases in terms of physiopathology and prognosis but both have…
  • Abstract Number: 2584 • 2014 ACR/ARHP Annual Meeting

    Smoking Is Not Associated with Response to TNF Blockers in Patients with Axial Spondyloarthritis

    Anna Dellyes1, Pierre Lafforgue1, Vincent Pradel2 and Thao Pham1, 1Rheumatology, APHM, Aix Marseille University, Marseille, France, 2Epidemiology, APHM, Aix Marseille University, Marseille, France

    Background/Purpose Smoking has been reported as associated with increase disease activity, more functional impairment, poorer quality of life and more radiographic damages in patients (pts)…
  • Abstract Number: 581 • 2014 ACR/ARHP Annual Meeting

    Evaluation of the Nonsteroidal Anti-Inflammatory Drug-Sparing Effect of Etanercept in Axial Spondyloarthritis: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

    Maxime Dougados1, Emily Wood2, Bernard Combe3, Corinne Miceli-Richard4, Francis Berenbaum5, Nandan Koppiker6, Arnaud Dubanchet7 and Isabelle Logeart7, 1Université Paris René Descartes and Hôpital Cochin, Paris, France, 2Biostatistics, Quanticate, Hitchin, England, 3Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 4Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, 5Service de Rhumatologie, Saint-Antoine Hospital, Paris, France, 6Pfizer PGRD, Sandwich, United Kingdom, 7Pfizer, Paris, France

    Background/Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line pharmacotherapy in axial spondyloarthritis (axSpA) but are recommended for use at the lowest effective dose for the shortest…
  • Abstract Number: 2581 • 2014 ACR/ARHP Annual Meeting

    Clinically Active Non-Radiographic Axial Spondyloarthritis Patients Who Initially Have a Negative MRI and Normal CRP May Develop a Positive MRI or Elevated CRP at a Later Timepoint

    Xenofon Baraliakos1, Joachim Sieper2, Su Chen3, Aileen L. Pangan3 and Jaclyn K. Anderson3, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3AbbVie Inc., North Chicago, IL

    Background/Purpose: Patients (pts) with non-radiographic axial spondyloarthritis (nr-axSpA) and active disease may have objective evidence of inflammation, either as bone marrow edema (BME) on magnetic…
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