Abstracts tagged "axial spondyloarthritis"

Abstract Number: 675 • 2016 ACR/ARHP Annual Meeting
Association Between Structural Lesions in the Sacroiliac Joints and Spinal Inflammatory Lesions in Patients with Non-Radiographic Axial Spondyloarthritis
Maxime Dougados¹, Robert G Lambert², Stephanie Wichuk³, Jean-Claude Becker⁴, Jack F Bukowski⁵, Heather Jones⁶, Lisa Marshall⁶, Annette Szumski⁷ and Walter Maksymowych³, ¹Rheumatology, Paris Descartes University, Paris, France, ²Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Becker Clinical Research Consulting, New York, NY, ⁵Clinical Affairs, Pfizer, Collegeville, PA, ⁶Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ⁷inVentiv Health, Princeton, NJ
Background/Purpose: The relevance of structural lesions in non-radiographic axial SpA (nr-axSpA) is unclear, particularly without signs of MRI inflammation. In a post hoc analysis we…
Abstract Number: 2740 • 2016 ACR/ARHP Annual Meeting
Cam Type Femoroacetabular Impingement Morphology Is More Frequent in Patients with Axial Spondyloarthritis
Servet Akar¹, Ozgur Tosun², Dilek Solmaz³, Gokay Karaca², Aliye Tosun⁴, Mustafa Ozman⁵ and Fatih Esat Topal⁶, ¹Department of Rheumatology, İzmir Katip Çelebi University, School of Medicine, İzmir, Turkey, İzmir, Turkey, ²Radiology, Izmir Katip Celebi University School of Medicine, izmir, Turkey, ³Rheumatology, Izmir Katip Celebi University School of Medicine, izmir, Turkey, ⁴physical therapy and rehabilitation, Izmir Katip Celebi University School of Medicine, izmir, Turkey, ⁵Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ⁶Emergency Medicine, Izmir Katip Celebi University School of Medicine, Izmir, Turkey
Background/Purpose: Femoroacetabular impingement (FAI) is characterized by early pathologic contact of the proximal femur with the acetabulum. Pincer impingement is the acetabular cause of FAI.Whereas…
Abstract Number: 713 • 2015 ACR/ARHP Annual Meeting
Clinical and Imaging Efficacy of Etanercept in Early Non-Radiographic Axial Spondyloarthritis: 104-Week Treatment Results
Maxime Dougados¹, Désirée van der Heijde², Joachim Sieper³, Juergen Braun⁴, Gustavo Citera⁵, Filip van Den Bosch^6,7, Ronald Pedersen⁸, Randi Bonin⁹, Heather Jones¹⁰, Lisa Marshall¹⁰, Sameer Kotak¹¹, Isabelle Logeart¹², Bonnie Vlahos¹³, Jack F Bukowski⁹ and Walter Maksymowych¹⁴, ¹Rheumatology Department, Hôpital Cochin, Paris, France, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, ⁴Rheumazentrum Ruhrgebiet, Herne, Germany, ⁵Rheumatology, Consultorios Reumatológicos Pampa, Buenos Aires, Argentina, ⁶Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁷Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁸Department of Biostatistics, Pfizer, Collegeville, PA, ⁹Clinical Affairs, Pfizer, Collegeville, PA, ¹⁰Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ¹¹Global Health and Value, Pfizer, New York, NY, ¹²Medical Affairs, Pfizer, France, Paris, France, ¹³GIPB - Clinical Sciences, Pfizer, Collegeville, PA, ¹⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: In the multiphase, randomized, placebo (PBO)-controlled EMBARK study (ClinicalTrials.gov identifier: NCT01258738), clinical signs/symptoms and MRI-measured inflammation were evaluated in patients with early, active non-radiographic…
Abstract Number: 714 • 2015 ACR/ARHP Annual Meeting
Baseline MRI and CRP As Predictors of Response to Etanercept in the Management of Patients with Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
Matthew A. Brown¹, Paul A. Bird², Philip C. Robinson³, Philip J. Mease⁴, Filip van Den Bosch⁵, Christine Surian⁶, Zirke Wiid⁶, Heather Jones⁷, Annette Szumski⁸ and Lisa Marshall⁷, ¹Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ²University of New South Wales, Sydney, Australia, ³University of Queensland & Royal Brisbane and Women's Hospital, Brisbane, Australia, ⁴Rheumatology Research, Swedish Medical Center, Seattle, WA, ⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁶Pfizer Australia, Sydney, Australia, ⁷Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ⁸Department of Biostatistics, Pfizer, Collegeville, PA
Background/Purpose: Treatment with tumor necrosis factor α (TNFα) inhibitors has been shown to be effective in improving disease activity and functional capacity in patients with…
Abstract Number: 976 • 2015 ACR/ARHP Annual Meeting
The Reason of Discontinuation of a First TNF Inhibitor Affects Drug Retention of a Second Anti-TNF Agent in Axial Spondyloarthritis
Adrian Ciurea¹, Pascale Exer², Ulrich Weber^3,4, Giorgio Tamborrini⁵, Beate Steininger¹, Rudolf O. Kissling⁶, Jürg Bernhard⁷ and Almut Scherer⁸, ¹Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Private rheumatology practice, Basel, Switzerland, ³Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ⁴Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ⁵Department of Rheumatology, University Hospital, Zurich, Switzerland, ⁶Division of Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ⁷Rheumatology and Rehabilitation, Bürgerspital Solothurn, Solothurn, Switzerland, ⁸SCQM Foundation, Zurich, Switzerland
Background/Purpose: Conflicting results have been demonstrated in axial spondyloarthritis (axSpA) with regard to whether effectiveness of a second (2°) TNFi depends on the reason of…
Abstract Number: 1231 • 2015 ACR/ARHP Annual Meeting
The Prevalence of Non-Radiographic Axial Spondyloarthritis Among Patients with Inflammatory Back Pain in Rheumatology Practices
Rubén Burgos-Vargas¹, James Wei², Mahboob U Rahman³, Nurullah Akkoc⁴, Syed A. Haq⁵, Mohammed Hammoudeh⁶, Ehab Mahgoub⁷, Ena Singh⁸, Lyndon Llamado⁹, Khalid Shirazy¹⁰, Sameer Kotak¹¹, Connie Hammond⁷, Ronald Pedersen¹², Qi Shen¹³ and Bonnie Vlahos¹³, ¹Rheumatology, Hospital General de Mexico, Mexico city, Mexico, ²Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan, ³Perelman School of Medicine, University of Pennsylvania, Philadephia, PA, ⁴Department of Rheumatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey, ⁵Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, ⁶Medicine, Hamad Medical Corporation, Doha, Qatar, ⁷Pfizer, Collegeville, PA, ⁸500 Arcola Road, Pfizer, Collegeville, PA, ⁹Pfizer, Makati, Philippines, ¹⁰Pfizer, Dubai, United Arab Emirates, ¹¹Global Health and Value, Pfizer, New York, NY, ¹²Department of Biostatistics, Pfizer, Collegeville, PA, ¹³GIPB - Clinical Sciences, Pfizer, Collegeville, PA
Background/Purpose: The diagnosis of Ankylosing Spondylitis (AS) is delayed by >10 years after the symptoms develop, as by definition the modified NY criteria for classification…
Abstract Number: 1283 • 2015 ACR/ARHP Annual Meeting
The Burden of Non-Radiographic Axial Spondyloarthritis from the Employer Perspective: A Real World European Study
Tim Holbrook¹, Robert Wood¹, Christopher Black², Xiaohan Hu² and Sumesh Kachroo², ¹Adelphi Real World, Macclesfield, United Kingdom, ²CORE, Merck & Co., Inc., Rahway, NJ
Background/Purpose: Non-radiographic axial spondyloarthritis (nr-axSpA) is a burdensome disease to both the patient and the healthcare system, as previous research has indicated. However, the societal…
Abstract Number: 1284 • 2015 ACR/ARHP Annual Meeting
Burden of Illness Associated with Non-Radiographic Axial Spondyloarthritis: A European Real World Database Analysis from the Clinical and Healthcare System Perspective
Tim Holbrook¹, Robert Wood¹, Christopher Black², Xiaohan Hu² and Sumesh Kachroo², ¹Adelphi Real World, Macclesfield, United Kingdom, ²CORE, Merck & Co., Inc., Rahway, NJ
Background/Purpose: Whilst the burden of axial spondyloarthritis (axSpA) is well known, non-radiographic (nr)-axSpa has only recently been identified as a distinct spondyloarthritic indication with its…
Abstract Number: 2025 • 2015 ACR/ARHP Annual Meeting
Modification of Structural Lesions on Magnetic Resonance Imaging By Etanercept: A 12-Week Randomized Placebo-Controlled Trial
Walter Maksymowych¹, Stephanie Wichuk², Maxime Dougados³, Heather Jones⁴, Annette Szumski⁵, Lisa Marshall⁴, Jack F Bukowski⁶ and Robert G Lambert⁷, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology Research Lab, University of Alberta, Edmonton, AB, Canada, ³Rheumatology Department, Hôpital Cochin, Paris, France, ⁴Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ⁵Department of Biostatistics, Pfizer, Collegeville, PA, ⁶Clinical Affairs, Pfizer, Collegeville, PA, ⁷Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Modification of structural lesions by anti-TNF therapy has not been demonstrated in a randomized placebo (PBO)-controlled trial. The Spondyloarthritis Research Consortium of Canada (SPARCC)…
Abstract Number: 2298 • 2015 ACR/ARHP Annual Meeting
Misdiagnosis of Fibromyalgia (FM) As Axial Spondylarthritis (SpA): Lessons from Analysis of 26 Cases
Dongfeng Liang, Jianglin Zhang and Feng Huang, Rheumatology, Chinese PLA General Hospital, Beijing, China
Background/Purpose: Both patients with fibromyalgia (FM) and with axial spondyloarthritis (SpA) are suffering from pain. The patients with axial SpA are mainly manifested as inflammatory…
Abstract Number: 2629 • 2015 ACR/ARHP Annual Meeting
The Most Frequent Fears and Beliefs of 226 Patients with Rheumatoid Arthritis or Spondyloarthritis, Using a Novel Questionnaire
Laure Gossec^1,2, Pierre Chauvin^3,4, Christophe Hudry⁵, Florence Mathoret-Philibert⁶, Maud Poussière⁷, Thibault de Chalus⁸, Francoise Russo-Marie⁹, Jean-Michel Joubert⁸, Alain Saraux¹⁰ and Francis Berenbaum^1,11, ¹Rheumatology Department, Sorbonne Universités, Université Pierre et Marie Curie, Paris, France, ²Rheumatology Department, AP-HP, Hôpital Pitié Salpêtrière, Paris, France, ³Department of Social Epidemiology, Sorbonne Universités, Université Pierre et Marie Curie, Paris, France, ⁴Department of Social Epidemiology, Pierre Louis Institute of Epidemiology and Public Health, Paris, France, ⁵Rheumatology, AP-HP, Hôpital Cochin, Paris, France, ⁶Clinical Psychology Department, AP-HP, Hôpital Cochin, Paris, France, ⁷Independent Researcher, Paris, France, ⁸UCB Pharma, Colombes, France, ⁹Arthritis Foundation Courtin, Neuilly-sur-Seine, France, ¹⁰Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹¹Rheumatology Department, AP-HP, Hôpital Saint-Antoine, Paris, France
Background/Purpose: Patients with chronic inflammatory disorders such as rheumatoid arthritis (RA) or spondyloarthritis (SpA) create personal sets of fears and beliefs related to their disease.…
Abstract Number: 2632 • 2015 ACR/ARHP Annual Meeting
Development and Validation of a Questionnaire Assessing the Fears and Beliefs of Patients Suffering from Chronic Rheumatic Diseases
Laure Gossec^1,2, Alain Saraux³, Christophe Hudry⁴, Florence Mathoret-Philibert⁵, Maud Poussière⁶, Thibault de Chalus⁷, Francoise Russo-Marie⁸, Jean-Michel Joubert⁷, Pierre Chauvin⁹ and Francis Berenbaum^1,10, ¹Rheumatology Department, Sorbonne Universités, Université Pierre et Marie Curie, Paris, France, ²Rheumatology Department, AP-HP, Hôpital Pitié Salpêtrière, Paris, France, ³Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ⁴Rheumatology, AP-HP, Hôpital Cochin, Paris, France, ⁵Clinical Psychology Department, AP-HP, Hôpital Cochin, Paris, France, ⁶Independent Researcher, Paris, France, ⁷UCB Pharma, Colombes, France, ⁸Arthritis Foundation Courtin, Neuilly-sur-Seine, France, ⁹Department of Social Epidemiology, Sorbonne Universités, Université Pierre et Marie Curie, Paris, France, ¹⁰Rheumatology Department, Hôpital Saint-Antoine, Paris, France
Background/Purpose: Questionnaires assessing the beliefs of patients with chronic rheumatic diseases mainly focus on medications.1A validated questionnaire evaluating patients' fears and beliefs towards their disease…
Abstract Number: 346 • 2015 ACR/ARHP Annual Meeting
Autoantibodies to Osteoprotegerin Are Independently Associated with Low Hip Bone Mineral Density and Increased Fractures in Axial Spondyloarthritis
Sizheng Zhao^1,2, Barbara Hauser³, Micaela Visconti³, Philip L. Riches³, Stuart H. Ralston³ and Nicola Goodson^1,2, ¹Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ²Department of Rheumatology, Aintree University Hospital, Liverpool, United Kingdom, ³Centre for Genomic and Experimental Medicine, Western General Hospital, Edinburgh, United Kingdom
Background/Purpose: Axial spondyloarthritis (axSpA) is associated with osteoporosis. However the underlying causes are incompletely understood. Osteoprotegerin (OPG) is a bone protective protein that acts as…
Abstract Number: 2812 • 2015 ACR/ARHP Annual Meeting
Cytokine Secretion By Peripheral Blood Mononuclear Cells in Patients with Axial Spondyloarthritis and the Effect of Thymoquinone on Cytokine Profile
Erkan Kilic¹, Cagri Sakalar², Huriye Aksu³, Mustafa Cakir³, Gamze Kilic¹ and Salih Ozgocmen⁴, ¹Dept. PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ²Genome and Stem Cell Center (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ³Genome and Stem Cell Senter (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ⁴Dept.PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey
Background/Purpose: Axial spondyloarthritis (axSpA) defines a group of chronic inflammatory diseases which includes non-radiographic axSpA (nr-axSpA) who do not have definite sacroiliitis on pelvic X-rays.…
Abstract Number: 663 • 2015 ACR/ARHP Annual Meeting
Mases Correlates Linearly with Disease Activity and Patient Related Outcomes in Patients with Axial Spondyloarthritis within the Scqm Cohort
Ruediger Mueller¹, Toni Kaegi², Nicole Graf³, Johannes von Kempis⁴ and J.J. Luime⁵, ¹Rheumatology, MD, St. Gallen, Switzerland, ²Kantonsspital St. Gallen, St. Gallen, Switzerland, ³graf biostatistics, Winterthur, Switzerland, ⁴Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, ⁵Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands
Background/Purpose: Enthesitis is one of the potential extra-axial manifestations found in patients with spondyloarthritis (SpA). Enthesitis can be quantified using the MASES (Maastrich Ankylosing Spondylitis…

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