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Abstracts tagged "axial spondyloarthritis"

  • Abstract Number: 2133 • 2018 ACR/ARHP Annual Meeting

    Comparative Disease Burden of Patients with Rheumatoid Arthritis, Psoriatic Arthritis, and Axial Spondyloarthritis: Data from the Corrona Rheumatoid Arthritis and Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registries

    Philip J. Mease1, Mei Liu2, Sabrina Rebello3, Hyungjoo Kang2, Yujin Park4 and Jeffrey Greenberg2,5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Waltham, MA, 3Corrona, LLC, Southborough, MA, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5New York University School of Medicine, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) are 3 common inflammatory rheumatic diseases that can lead to deformities and joint destruction;…
  • Abstract Number: 893 • 2018 ACR/ARHP Annual Meeting

    Identification of Axial Spondyloarthritis Patients in a Large Dataset: The Development and Validation of Novel Methods

    Rebecca S. Overbury1, Shaobo Pei2, Gopi Penmetsa2, Grant W. Cannon2, Daniel O. Clegg3, Brian Sauer4 and Jessica Walsh5, 1Internal Medicine, Divison of Rheumatology, University of Utah Medical Center, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT, 3Division of Rheumatology, University of Utah Medical Center, Salt Lake City, UT, 4Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 5Rheumatology, Salt Lake City Veterans Affairs, Salt Lake City, UT

    Background/Purpose: Big data research in axial spondyloarthritis (axSpA) is limited by a lack of adequate methods for identifying axSpA patients, since there are no billing…
  • Abstract Number: 2537 • 2018 ACR/ARHP Annual Meeting

    Benefit Study: Results of Interim Analysis of a Pan-European Observational Study to Evaluate Real-World Effectiveness of SB4 Following Transition from Originator Etanercept (ETN) in Patients with Rheumatoid Arthritis (RA) or Axial Spondyloarthritis (AxSpA)

    Klaus Krüger1, Carlo Selmi2,3, Alain Cantagrel4, Miguel A. Abad5, Ulrich Freudensprung6, Mourad Farouk Rezk6 and Janet Addison7, 1Medical Centre of Rheumatology, Munich, Germany, 2Rheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Rozzano (MI), Italy, 3BIOMETRA Department, University of Milan, Milan, Italy, 4Center of Rheumatology of CHU, Toulouse, France, 5FEA Reumatología, Hospital Virgen del Puerto, Cáceres, Spain, 6Biogen International GmbH, Zug, Switzerland, 7Biogen Idec, Maidenhead, United Kingdom

    Background/Purpose: SB4, a biosimilar to the reference ETN, received EU marketing authorisation in January 2016, based on the totality of evidence from pre-clinical and clinical…
  • Abstract Number: 644 • 2017 ACR/ARHP Annual Meeting

    Association of Osteonectin, Osteopontin and Osteocalcin with Inflammation and Cardiovascular Risk in Patients with Axial Spondyloarthritis

    Fernanda Genre1, Javier Rueda-Gotor2, Juan Irure-Ventura3, Sara Remuzgo-Martínez1, Alfonso Corrales1, Begoña Ubilla1, Veronica Mijares1, Carlos Fernández-Díaz1, Virginia Portilla1, Ricardo Blanco1, Javier Llorca4, J. Gonzalo Ocejo-Vinyals3, Raquel López-Mejías1 and Miguel Angel González-Gay5, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 5Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain

    Background/Purpose: A higher incidence of cardiovascular (CV) risk factors and atherosclerosis has been reported in axial spondyloarthritis (axSpA) patients1. Since axSpA (particularly AS) is an…
  • Abstract Number: 2516 • 2017 ACR/ARHP Annual Meeting

    Trabecular Bone Score As an Assessment Tool to Identify the Risk of Osteoporosis in Axial Spondyloarthritis: A Case-Control Study

    Kwi Young Kang, Internal Medicine, Catholic University of Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: The trabecular bone score (TBS) is a novel tool used to evaluate bone microarchitecture. It is a textural index that evaluates pixel gray-level variations…
  • Abstract Number: 1315 • 2017 ACR/ARHP Annual Meeting

    Influence of Rheumatoid Arthritis and Axial Spondyloarthritis on Pregnancy Complications, Pregnancy Outcome and Delivery Mode

    Frauke Förger1, Stephanie van den Brandt2, Astrid Zbinden3, Monika Ostensen3 and Peter M. Villiger3, 1Inselspital, University of Bern, Bern, Switzerland, 2Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, Netherlands, 3Rheumatology, Immunology and Allergology, Inselspital, University of Bern, Bern, Switzerland

    Background/Purpose: To analyze pregnancy complications, pregnancy outcome and delivery mode in patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA).Methods: Patients with RA and axSpA…
  • Abstract Number: 2521 • 2017 ACR/ARHP Annual Meeting

    Metabolic Syndrome Is Associated with Active Disease in Psoriatic Arthritis and May Contribute to Development of Syndesmophytes

    Pervin Sanci1, Gokce Kenar2, Berrin Zengin2, Sadettin Uslu3, Aydan Koken3, Handan Yarkan3, Gerçek Can3, Merih Birlik3 and Fatos Onen2, 1Internal Medicine, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 2Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, 3Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey

    Background/Purpose: An increased prevalence of metabolic syndrome (MetS) has been reported in psoriatic arthritis (PsA) suggesting an association between the inflammation and MetS. The aim…
  • Abstract Number: 1503 • 2017 ACR/ARHP Annual Meeting

    The Prevalence of Axial Spondyloarthritis in Israel

    Sara Borok Lev-Ran1, Hagit Sarvagyl-Maman2, Victoria Furer3, Sara Pel4, Iddo Drukman5, Gideon Flusser5 and Ori Elkayam6, 1Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine,Tel Aviv University, Tel AViv, Israel, 2Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel-aviv, Israel, 3Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 4Rheumatology, Sourasky Medical Center, Tel Aviv, Israel, 5Radiology, Tel Aviv Medical Center, Tel Aviv, Israel, 6Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Background/Purpose: The concept of axial Spondyloarthritis (SpA) as defined by the ASAS criteria is relatively new. While the prevalence of Ankylosing spondylitis is around 0.5%,…
  • Abstract Number: 2803 • 2017 ACR/ARHP Annual Meeting

    Predictors of Remission Maintenance up to Week 68 and Successful Therapy Discontinuation in Patients with Non-Radiographic Axial Spondyloarthritis Who Achieved Sustained Remission on 28-Week Open-Label Adalimumab Treatment

    Joachim Sieper1, Robert B.M. Landewé2, Marina N. Magrey3, Jaclyn K. Anderson4, Sheng Zhong4, Xin Wang4 and Apinya Lertratanakul4, 1Charité Universitätsmedizin Berlin, Berlin, Germany, 2University of Amsterdam, Amsterdam, Netherlands, 3Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH, 4AbbVie Inc., North Chicago, IL

    Background/Purpose:  Sustained remission is an important treatment goal in patients (pts) with non-radiographic axial SpA (nr-axSpA). Factors predicting successful remission maintenance are unknown. We sought…
  • Abstract Number: 1507 • 2017 ACR/ARHP Annual Meeting

    Comparison of the Clinical and Imaging Arms of the Assessment of Spondyloarthritis International Society Classification Criteria and Parameters of Objective Inflammation in Patients with Non-Radiographic Axial Spondyloarthritis

    Robert B.M. Landewé1, Joachim Sieper2, Atul A. Deodhar3, Helena Marzo-Ortega4, Robert G. Lambert5, Mei Li6, Xin Wang6 and Jaclyn K. Anderson6, 1University of Amsterdam, Amsterdam, Netherlands, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Oregon Health & Science University, Portland, OR, 4NIHR LBRC, Leeds Teaching Hospitals Trust and LIRMM, University of Leeds, Leeds, United Kingdom, 5University of Alberta, Edmonton, AB, Canada, 6AbbVie Inc., North Chicago, IL

    Background/Purpose: Assessment of SpondyloArthritis international Society (ASAS) recommendations for use of TNF inhibitors (TNFi) in axial SpA include active disease and a positive expert opinion,…
  • Abstract Number: 1513 • 2017 ACR/ARHP Annual Meeting

    Clinical Characteristics and Peripheral Joint Involvement at the Time of Diagnosis of Non-Radiographic Axial Spondyloarthritis Patients in the United States and Europe

    Atul A. Deodhar1, Theresa Hunter2, David Sandoval Calderon3, Steve Lobosco4, Rachel Moon4 and Gary Milligan5, 1Oregon Health & Science University, Portland, OR, 2Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Indianapolis, IN, 3Eli Lilly and Company, Indianapolis, IN, 4Adelphi Real World, Macclesfield, United Kingdom, 5Adelphi Real World, Macclesfield,, United Kingdom

    Background/Purpose: Timely identification of nr-axSpA may lead to earlier intervention to reduce symptoms, improve function, and reduce disease burden. The purpose of this study was…
  • Abstract Number: 1515 • 2017 ACR/ARHP Annual Meeting

    Improvements in Enthesitis Scores with Certolizumab Pegol Treatment in Males and Females with Active Axial Spondyloarthritis Are Maintained to Week 204

    Maxime Dougados1, Philip J Mease2, Joachim Sieper3, Peter C. Taylor4, Natasha de Peyrecave5, Tommi Nurminen6 and Jürgen Braun7, 1Rheumatology Department, Paris-Descartes University and Cochin Hospital, Paris, France, 2Swedish Medical Center and University of Washington, Seattle, WA, 3Charité University Hospital, Berlin, Germany, 4Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal, Sciences, Kennedy Institute of Rheumatology, University of Oxford,, Oxford, United Kingdom, 5UCB Pharma, Slough, United Kingdom, 6UCB Pharma, Monheim, Germany, 7Rheumazentrum Ruhrgebiet, Herne, Germany

    Background/Purpose: Axial spondyloarthritis (axSpA), characterized by spinal inflammation, is also associated with extra-spinal manifestations including inflammation of the entheses (enthesitis). Enthesitis is equally prevalent throughout…
  • Abstract Number: 1566 • 2017 ACR/ARHP Annual Meeting

    Elevated IL-1 Expression Levels in Mesenchymal Stem Cells Derived from Spondyloarthitis Patients Might be Linked to Increased Osteoblast Mineralization

    Gerlinde Layh-Schmitt1, Breanna Nguyen1, Emily Lazowick1, Stephen R. Brooks2 and Robert Colbert1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2NIAMS/NIH, Biodata Mining & Discovery, Bethesda, MD

    Background/Purpose:  Axial spondyloarthritis (AxSpA) is an immune–mediated inflammatory disease involving the spine and sacroiliac joint. AxSpA is characterized by vertebral trabecular bone loss and progressive…
  • Abstract Number: 1573 • 2017 ACR/ARHP Annual Meeting

    In Vivo Phosphorylation of p38 in Monocytes Is Enhanced in Patients with Axial Spondyloarthritis (axSpA) at the Time of Diagnosis

    Antti Kuuliala1,2, Krista Kuuliala1,3, Riitta Koivuniemi2,4, Mari Hämäläinen5, Eeva Moilanen6, Hannu Kautiainen7, Heikki Repo1,3 and Marjatta Leirisalo-Repo2,4, 1Bacteriology and Immunology, University of Helsinki, Helsinki, Finland, 2Rheumatology, Helsinki University Hospital, Helsinki, Finland, 3Helsinki University Hospital, Helsinki, Finland, 4Rheumatology, University of Helsinki, Helsinki, Finland, 5The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 6The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland, Tampere, Finland, 7Unit of Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Background/Purpose: Host response to microbes is considered to contribute to the pathogenesis to axSpA and other HLA-B27 associated diseases. The p38 MAP kinase pathway plays…
  • Abstract Number: 1787 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Patients with Non-Radiographic Axial Spondyloarthritis

    Robert B.M. Landewé1, Joachim Sieper2, Philip J Mease3, Robert D Inman4, Xin Wang5, Mei Li5, Aileen L. Pangan5 and Jaclyn K. Anderson5, 1University of Amsterdam, Amsterdam, Netherlands, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Swedish Medical Center and University of Washington, Seattle, WA, 4Department of Immunology, University of Toronto, Toronto, ON, Canada, 5AbbVie Inc., North Chicago, IL

    Background/Purpose: It is not known whether TNF blockers can be stopped in non-radiographic (nr-axSpA) patients who are in remission. In ABILITY-1, adalimumab (ADA) significantly improved…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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