ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 584

Factors Associated with the “Bamboo Spine” Phenotype – Data from the Comospa Study

Koei Oh1, Anna Molto2, Corinne Miceli-Richard3, Soksay Singvongsa4, Adrien Etcheto4 and Maxime Dougados4, 1Departmen of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France, 2Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, 3Department of Rheumatolgy, Paris Descartes University, Hôpital Cochin, Paris, France, 4Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: axial spondyloarthritis, cross-sectional studies, epidemiologic methods and multicenter study

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 5, 2017

Session Title: Spondyloarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The factors associated with “Bamboo spine” occurrence, i.e. the most severe axial phenotype of SpA patients, have been poorly assessed to date. The aim of this study was to clarify the factors associated with the severe type of AS “Bamboo spine” by investigating associations with various demographics, clinical and functional outcomes.

Methods: 275 patients with Bamboo spine enrolled by ASAS-COMOSPA study (Cross-sectional international study involving 22 countries and including 3984 SpA patients fulfilling the ASAS SpA criteria) were included in the analysis. Demographic, Clinical, and biological characteristics were compared between Bamboo-spine and non-Bamboo spine patients. Variables with significant difference in univariate analyses were used as dependent variables in multivariable and logistic regression. A logistic regression was used for the analysis to clarify the parameters associated with the Bamboo spine phenotype. Independent variables with a p value less than 0.2 in univariate linear/logistic regression analysis were tested in multivariate regression models. Odds ratio (ORs) with 95% CIs were calculated.

Results: Results of the univariate analysis are provided in the table. Multivariate analysis showed that Bamboo spine phenotype was independently associated with NSAIDs intake from first symptom (OR 4.29; 95% CI 1.45-12.71 P<0.02), male gender (OR 4.09; 95% CI 2.37-7.05; P<0.02), HLA-B27 positivity (OR 2.26; 95% CI 1.34-3.83; P<0.02), increased CRP (OR 1.76; 95% CI 1.20-2.60; P<0.02), osteoporosis (OR 1.52; 95% CI 0.99-2.34; P=0.05), with only a trend for smoking (OR 1.38, 95% CI 0.97-1.98; P=0.07).

Conclusion: The results of this study confirm parameters that have been previously associated with axial structural severity (longer disease duration, uveitis, smoking, HLA-B27 and male gender). NSAIDs have been reported to have a potential protective effect on the structural progression of the disease. Nevertheless, in this cross sectional study, NSAIDs intake from the first symptoms was associated with the Bamboo spine phenotype, suggesting that severe axial involvement leads to a sustained NSAIDs intake for pain relief. This also suggest that patients evolving to a bamboo spine phenotype have not been under-exposed to NSAIDs treatment and/or that NSAIDs sustained exposure is not sufficient to protect from Bamboo spine phenotype.


Disclosure: K. Oh, None; A. Molto, None; C. Miceli-Richard, None; S. Singvongsa, None; A. Etcheto, None; M. Dougados, None.

To cite this abstract in AMA style:

Oh K, Molto A, Miceli-Richard C, Singvongsa S, Etcheto A, Dougados M. Factors Associated with the “Bamboo Spine” Phenotype – Data from the Comospa Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/factors-associated-with-the-bamboo-spine-phenotype-data-from-the-comospa-study/. Accessed January 27, 2023.
  • Tweet
  • Email
  • Print

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/factors-associated-with-the-bamboo-spine-phenotype-data-from-the-comospa-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences