Abstract Number: 151 • 2018 ACR/ARHP Annual Meeting
Molecular Mechanisms of Pathogenic T Cell Resilience in Human Arthritis
Background/Purpose: T-cell resilience is critical to the immune pathogenesis of human autoimmune arthritis. Autophagy is essential for memory T cell generation and is associated with…Abstract Number: 781 • 2018 ACR/ARHP Annual Meeting
Simultaneous Identification of Two Biomarkers in ACTIVE LUPUS Nephritis: Autophagy in Treg CELLS and Prolactin Receptors in B Lymphocytes
Background/Purpose: Recent studies suggest that autophagy defects contributes to systemic lupus erythematosus (SLE) pathogenesis. Prolactin (PRL) is associated with active SLE and stimulates the immune…Abstract Number: 1048 • 2018 ACR/ARHP Annual Meeting
Identification of Novel Molecules with Senolytic and Autophagy Activity As Osteoarthritis Therapeutics
Background/Purpose: Disease-modifying treatments for Osteoarthritis (OA) are not available. Aging-related features such as failure of homeostasis mechanisms, including autophagy, cause extracellular matrix damage, chondrocyte senescence…Abstract Number: 1057 • 2018 ACR/ARHP Annual Meeting
Autophagy Promotes Citrullination of Vimentin and Its Interaction with Major Histocompatibility Complex Class II in Synovial Fibroblasts
Background/Purpose: Citrullinated vimentin (cVIM) is one of the major autoantigens in patients with rheumatoid arthritis (RA), recognized by anti-citrullinated peptide antibodies. Autophagy is a self-cannibalism…Abstract Number: 1353 • 2018 ACR/ARHP Annual Meeting
Autophagy Marker LC3 Accumulates in Immune-Mediated Necrotizing Myopathy Muscle Fibres
Background/Purpose: To investigate the expression of autophagy marker LC3, localization of macrophages and accumulation of misfolded proteins in myofibres of immune-mediated necrotizing myopathy (IMNM) muscle…Abstract Number: 1586 • 2018 ACR/ARHP Annual Meeting
Expression of JAK Proteins and Autophagy Markers in Sjögren’s Syndrome Patients
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune epitheliitis that mainly affects the salivary and lachrymal glands. The glandular hypofunction has been associated to loss of…Abstract Number: 1817 • 2018 ACR/ARHP Annual Meeting
MicroRNA-128 Impairs Cartilage Integrity and Deteriorates Osteoarthritis Pathogenesis through Deregulating Chondrocyte Autophagy
Background/Purpose: Autophagy gets rids of unwanted proteins or organelle keeping cells to stay functional upon encountering adverse stresses. While non-coding microRNAs interfere with mRNA targets…Abstract Number: 1998 • 2018 ACR/ARHP Annual Meeting
Autophagy-Related Molecules Detected in Blood and Cartilage Are Biomarkers of Joint Damage in OA
Background/Purpose: In osteoarthritis (OA), defects in cellular homeostasis, and in particular in autophagy, are evident and precede joint damage. We have shown that there is…Abstract Number: 2001 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Stimulation Regulates Autophagy in Chondrocytes
Background/Purpose: Osteoarthritis (OA) is a debilitating condition characterized by chondrocyte dysfunction and loss of cartilage. Autophagy, a homeostatic process that occurs in times of cellular…Abstract Number: 2698 • 2017 ACR/ARHP Annual Meeting
IL-21-mTOR Axis Blocks the Differentiation and Function of SLE Tregs Via Suppression of Autophagy
Background/Purpose: Mechanistic target of rapamycin (mTOR) activation has emerged as a prominent mediator of pro-inflammatory T-cell expansion and regulatory T (Treg) cell depletion in systemic…Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis
Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…Abstract Number: 975 • 2017 ACR/ARHP Annual Meeting
IL-17A Induced Autophagy That the Proliferation of Rheumatoid Arthritis Fibroblast-like Synoviocytes through Down-Regulation of PI3K/AKT/mTOR Signaling Pathway
Background/Purpose: Autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Fibroblast-like synoviocytes (FLS) resistance to…Abstract Number: 1434 • 2017 ACR/ARHP Annual Meeting
COX-2 Inhibitor Contributes Cell Death in Rheumatoid Arthritis Fibroblast-like Synoviocytes Via PI3K/AKT/mTOR Signaling Pathway Triggered By Autophagy
Background/Purpose: Recently, the possibilities that autophagy regulates apoptosis resistance and hyperplasia of fibroblast-like synoviocytes (FLS) were also presented. The aim of this study is to…Abstract Number: 1745 • 2017 ACR/ARHP Annual Meeting
Autophagic Memory in Stress Experienced Human T Cells
Background/Purpose: Autophagy is central to many key immune related pathways, disregulation of which has been associated with rheumatoid arthritis (RA), cancer and neurodegenerative diseases. Autophagy…Abstract Number: 1925 • 2017 ACR/ARHP Annual Meeting
TGFβ Promotes Fibrosis By MYST1-Dependent Epigenetic Regulation of Autophagy
Background/Purpose: Autophagy (Atg) is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of Atg has been implicated into the pathogenesis…
ACR Meeting Abstracts