ACR Meeting Abstracts

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Abstracts tagged "autophagy"

  • Abstract Number: 1978 • 2019 ACR/ARP Annual Meeting

    HSP90AA1, a Chaperone-mediated Autophagy Mediator, Is a Biomarker of Joint Damage in Osteoarthritis

    Irene Lorenzo-Gomez1, Uxia Nogueira-Recalde 2, Natividad Oreiro 3, Jose antonio Pinto-Tasende 4, Francisco J. Blanco 3 and Beatriz Carames 1, 1Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, 2Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, 3Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 4Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruna, Spain

    Background/Purpose: In osteoarthritis (OA) defects in Autophagy are evident and precede joint damage. Therefore, identifying biomarkers associated with autophagy defects could facilitate the development of…
  • Abstract Number: 2418 • 2019 ACR/ARP Annual Meeting

    Tofacitinib Inhibits Increased Inflammatory Marker Expression in a Human Salivary Cell Line Deficient in Autophagy: A Model of Sjögren’s Syndrome

    María José Barrera 1, Sergio Aguilera2, Patricia Carvajal 3, Isabel Castro 4, Sergio González 5, Claudio Molina 1, Soledad Matus 6, Daniela Jara 3 and María Julieta González 3, 1Facultad de Odontología, Universidad San Sebastián, Santiago, Chile, 2Clínica INDISA, Santiago, Chile, 3ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile, 4Departamento Tecnología Médica, Universidad de Chile, Santiago, Chile, 5Escuela de Odontología, Universidad Mayor, Santiago, Chile, 6Fundación Ciencia & Vida, Santiago, Chile, Santiago, Chile

    Background/Purpose: Sjögren’s syndrome (SS) is an immune-mediated exocrinopathy, where defects in autophagy could contribute to the pathogenesis. Minor labial salivary glands (MLSG) of primary SS…
  • Abstract Number: 890 • 2019 ACR/ARP Annual Meeting

    Adenosine A2A Receptor Signaling Activates FoxO1 and FoxO3 and Promotes Cartilage Autophagy

    Benjamin Friedman1, Carmen Corciulo 2, Cristina Castro-Rivera 2 and Bruce Cronstein 2, 1Department of Medicine, Division of Rheumatology NYUSoM, NYC, 2NYU Langone, New York

    Background/Purpose: Osteoarthritis (OA) is a debilitating and costly condition caused by loss of articular cartilage secondary to chondrocyte dysfunction. Autophagy is a homeostatic pathway that…
  • Abstract Number: 1975 • 2019 ACR/ARP Annual Meeting

    Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment

    Uxia Nogueira-Recalde1, Irene Lorenzo-Gomez 2, Francisco J. Blanco 3, María I. Loza 4, Diego Grassi 5, Valery Shirinsky 6, Ivan Shirinsky 6, martin lotz 7, Paul D. Robbins 8, Eduardo Domínguez 4 and Beatriz Carames 2, 1Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, 2Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, 3Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 4Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain, 5Institute for Interdisciplinary Neuroscience (IINS), Bordeaux, Nouvelle-Aquitaine, France, Bordeaux, France, 6Scientific Research Institute of Clinical immunology, Novosibirsk, Rusia, Novosibirsk, Russia, 7Department of Molecular Medicine. Scripps Research, La Jolla, CA, USA, La Jolla, CA, 8Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN

    Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset.…
  • Abstract Number: 151 • 2018 ACR/ARHP Annual Meeting

    Molecular Mechanisms of Pathogenic T Cell Resilience in Human Arthritis

    Pavanish Kumar1, Jing Yao Leong1, Bhairav Paleja1, Suzan Saidin1, jorg van Loosdregt1, Thaschawee Arkachaisri2, Alessandro Consolaro3, Marco Gattorno4, Alberto Martini5, Gary W Williams6, Ken D Pischel6, Martin Lotz7 and Salvatore Albani8, 1Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, 2KK Women's and Children's Hospital, Singapore, Singapore, 3Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genova, Italy, 4Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genoa, Italy, 5Pediatric Rheumatology International Trial Organization (PRINTO) Coordinating Centre, Genoa, Italy, 6Scripps Clinic, La Jolla,, California, CA, 7Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA, 8Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore

    Background/Purpose: T-cell resilience is critical to the immune pathogenesis of human autoimmune arthritis. Autophagy is essential for memory T cell generation and is associated with…
  • Abstract Number: 781 • 2018 ACR/ARHP Annual Meeting

    Simultaneous Identification of Two Biomarkers in ACTIVE LUPUS Nephritis: Autophagy in Treg CELLS and Prolactin Receptors in B Lymphocytes

    Luis J. Jara-Quezada1, Emma Zurita2, Ana Durán2, Antonio Sanchez3, Reyna Bustamante3, Gabriela Medina4, Miguel A Saavedra5, María Pilar Cruz-Dominguez3, Olga Vera-Lastra6, María Pilar Jiménez-Arellano7, Michel Augusto Martínez-Bencomo3 and Azucena Rodriguez2, 1Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico, Mexico, 2Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico City, Mexico, 3Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico City, Mexico, 4Clinical Research Unit, Hospital de Especialidades Centro Medico La Raza,IMSS, Mexico City, Mexico, 5Novartis Farmaceutica, Calz de Tlaplan 1779, Mexico, Mexico, 6Rheumatology, Instituto Mexicano Seguro Social, Mexico City, Mexico, 7Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico CIty, Mexico

    Background/Purpose: Recent studies suggest that autophagy defects contributes to systemic lupus erythematosus (SLE) pathogenesis. Prolactin (PRL) is associated with active SLE and stimulates the immune…
  • Abstract Number: 1048 • 2018 ACR/ARHP Annual Meeting

    Identification of Novel Molecules with Senolytic and Autophagy Activity As Osteoarthritis Therapeutics

    Uxia Nogueira-Recalde1, Francisco J Blanco1, Maria I. Loza2, Diego Grassi3, Paul Robbins3, Eduardo Dominguez4 and Beatriz Carames1, 1Cartilage Biology Group, Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, 2BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, 3Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, 4BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain

    Background/Purpose: Disease-modifying treatments for Osteoarthritis (OA) are not available. Aging-related features such as failure of homeostasis mechanisms, including autophagy, cause extracellular matrix damage, chondrocyte senescence…
  • Abstract Number: 1057 • 2018 ACR/ARHP Annual Meeting

    Autophagy Promotes Citrullination of Vimentin and Its Interaction with Major Histocompatibility Complex Class II in Synovial Fibroblasts

    Eri Sugawara, Masaru Kato, Yuki Kudo, WenShi Lee, Yuichiro Fujieda, Toshiyuki Bohgaki, Olga Amengual, Kenji Oku, Shinsuke Yasuda and Tatsuya Atsumi, Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Background/Purpose: Citrullinated vimentin (cVIM) is one of the major autoantigens in patients with rheumatoid arthritis (RA), recognized by anti-citrullinated peptide antibodies. Autophagy is a self-cannibalism…
  • Abstract Number: 1353 • 2018 ACR/ARHP Annual Meeting

    Autophagy Marker LC3 Accumulates in Immune-Mediated Necrotizing Myopathy Muscle Fibres

    Margherita Giannini1, Francesco Girolamo2, Anna Lia2, Angela Amati2, Luigi Serlenga2, Dario D'Abbicco3, Marilina Tampoia4, Maria Trojano2 and Florenzo Iannone1, 1D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, Unit of Neurophysiopathology, Policlinico Hospital, University of Bari, BARI, Italy, 3Institute of General Surgery ‘G Marinaccio’ (DETO), Policlinico Hospital, University of Bari, BARI, Italy, 4Laboratory of Clinical Pathology, University Hospital of Bari, BARI, Italy

    Background/Purpose: To investigate the expression of autophagy marker LC3, localization of macrophages and accumulation of misfolded proteins in myofibres of immune-mediated necrotizing myopathy (IMNM) muscle…
  • Abstract Number: 1586 • 2018 ACR/ARHP Annual Meeting

    Expression of JAK Proteins and Autophagy Markers in Sjögren’s Syndrome Patients

    María-José Barrera1,2, Sergio Aguilera3, Isabel Castro2, Patricia Carvajal2, Sergio González4, Claudio Molina1, Ulises Urzua2 and María-Julieta González2, 1Facultad de Odontología, Universidad San Sebastián, Santiago, Chile, 2Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile, 3Reumatologia, Clinica Indisa, Santiago, Chile, 4Facultad de Odontología, Universidad Mayor, Santiago, Chile

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune epitheliitis that mainly affects the salivary and lachrymal glands. The glandular hypofunction has been associated to loss of…
  • Abstract Number: 1817 • 2018 ACR/ARHP Annual Meeting

    MicroRNA-128 Impairs Cartilage Integrity and Deteriorates Osteoarthritis Pathogenesis through Deregulating Chondrocyte Autophagy

    Feng-Sheng Wang1, Wei-Shiung Lian2, Yi-Chih Sun1, Jih-Yang Ko3 and Yu-Shan Chen1, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 3Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose: Autophagy gets rids of unwanted proteins or organelle keeping cells to stay functional upon encountering adverse stresses. While non-coding microRNAs interfere with mRNA targets…
  • Abstract Number: 1998 • 2018 ACR/ARHP Annual Meeting

    Autophagy-Related Molecules Detected in Blood and Cartilage Are Biomarkers of Joint Damage in OA

    Beatriz Carames1, Irene Lorenzo Gomez1, Jose Antonio Pinto Tasende2, Natividad Oreiro Villar2 and Francisco J Blanco1, 1Cartilage Biology Group, Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, 2Clinical Rheumatology Division, Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña, A Coruña, Spain

    Background/Purpose: In osteoarthritis (OA), defects in cellular homeostasis, and in particular in autophagy, are evident and precede joint damage. We have shown that there is…
  • Abstract Number: 2001 • 2018 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor Stimulation Regulates Autophagy in Chondrocytes

    Benjamin Friedman1, Carmen Corciulo2, Cristina Castro3 and Bruce N. Cronstein1, 1Rheumatology, New York University School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis (OA) is a debilitating condition characterized by chondrocyte dysfunction and loss of cartilage. Autophagy, a homeostatic process that occurs in times of cellular…
  • Abstract Number: 1745 • 2017 ACR/ARHP Annual Meeting

    Autophagic Memory in Stress Experienced Human T Cells

    Pavanish Kumar1, Jorg van Loosdregt2, Suzan Saidin1, Bhairav Paleja1 and Salvatore Albani1, 1SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 2Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Autophagy is central to many key immune related pathways, disregulation of which has been associated with rheumatoid arthritis (RA), cancer and neurodegenerative diseases. Autophagy…
  • Abstract Number: 1925 • 2017 ACR/ARHP Annual Meeting

    TGFβ Promotes Fibrosis By MYST1-Dependent Epigenetic Regulation of Autophagy

    Ariella Zehender1, Neng-Yu Lin2, Adrian Stefanica3, Chih-Wei Chen4, Alina Soare5, Thomas Wohlfahrt6, Simon Rauber6, Christina Bergmann7, Andreas Ramming8, Oliver Distler9, Georg Schett10 and Jörg Distler5, 11Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 31Department of Internal Medicine 3 – Rheumatology and Immunology, University of Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 6Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 7Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 8Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 9Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 10Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Autophagy (Atg) is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of Atg has been implicated into the pathogenesis…
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