Abstracts tagged "Autoimmunity"

Abstract Number: 2726 • 2014 ACR/ARHP Annual Meeting
CD28null T Cells from Polymyositis Patients Are Cytotoxic to Autologous Muscle Cells in Vitro Via Perforin-Dependent Mechanisms
Jayesh Pandya¹, Paulius Venalis¹, Lubna Al-Khalili², Mohammad Shahadat Hossain¹, Ingrid E. Lundberg¹, Vivianne Malmström¹ and Andreas E. R. Fasth¹, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Division of Industrial Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden
Background/Purpose: Inflammatory infiltrates of muscles in polymyositis are dominated by CD4+CD28null and CD8+CD28null T cells. In contrast to conventional CD28+ T cells, these cells…
Abstract Number: 2252 • 2014 ACR/ARHP Annual Meeting
Autoimmune Thyroid Disease Is Associated with a Higher Frequency of Spinal Degenerative Disc Disease
Asha Shrestha¹, Hillel Cohen² and Clement Tagoe¹, ¹Rheumatology, Albert Einstein College of Medicine, Bronx, NY, Bronx, NY, ²Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, Bronx, NY
Background/Purpose: Autoimmune thyroid disease (AITD) has been linked to a number of rheumatic syndromes including arthritis and generalized pain. Although AITD has been associated with…
Abstract Number: 2182 • 2014 ACR/ARHP Annual Meeting
Investigating the Roles of Factor H-Related Proteins in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases
Alexandra Antonioli¹, Brandon Renner², Joshua Thurman³, V. Michael Holers⁴ and Jonathan Hannan⁴, ¹Department of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Renal Division, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose Complement plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) wherein inappropriate activation of complement leads to substantial tissue damage, especially…
Abstract Number: 1733 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Effects of Dietary Non-Digestible Oligosaccharides in T Cell-Mediated Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen², Anita Hartog³, Birgitte Walgreen⁴, Liduine van den Bersselaar¹, Monique M. Helsen¹, Paul Vos³, Johan Garssen^3,5, Linette Willemsen⁵, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdollahi-Roodsaz⁶, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Nutricia Research, Utrecht, Netherlands, ⁴Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Accumulating evidence indicates the relevance of intestinal microbiota in shaping the immune response and supports its contribution to the development of autoimmune diseases. Prebiotic…
Abstract Number: 1032 • 2014 ACR/ARHP Annual Meeting
Neutralization of IL-17 Ameliorated Kidney Pathology Associated with Immune-Complex Mediated Autoimmune Glomerulonephritis
Partha Biswas¹, Kritika Ramani², Kelly Maers³, Anna Huppler⁴ and Sarah L. Gaffen⁵, ¹Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Dept of Medicine, University of Pittsburgh, Pittsburgh, PA, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsurgh, PA, ⁵Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Immune complex mediated autoimmune glomerulonephritis (AGN) is an often-fatal clinical manifestation of systemic lupus erythematosus. In recent years, pro-inflammatory cytokines in the nephritic kidney…
Abstract Number: 995 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients Have Alterations in Inherently Autoreactive 9G4+ B-Cell Subpopulations in Peripheral Blood
Rita A. Moura^1,2, Maria J. Leandro³, Venkat Reddy¹, João E. Fonseca^2,4 and Geraldine Cambridge³, ¹Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ³Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal
Background/Purpose B-cells utilizing the VH-region immunoglobulin gene VH4-34 produce natural autoreactive antibodies. The rat monoclonal antibody 9G4 recognizes B-cells with VH4-34-encoded B-cell receptors (9G4+ B-cells)…
Abstract Number: 756 • 2014 ACR/ARHP Annual Meeting
Nucleosome, a Basic Repeating Unit of Chromatin, in Patients with Systemic Sclerosis: Possible Association with Immunological Abnormalities Via Abnormal Activation of T and B Cells
Ayumi Yoshizaki¹, Yoshihide Asano², Takashi Taniguchi¹, Ryosuke Saigusa¹, Kouki Nakamura¹, Takashi Yamashita¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Yohei Ichimura¹, Zenshiro Tamaki¹, Miki Miyazaki¹ and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose Nucleosome is the basic repeating units of chromatin. Each nucleosome is composed of an inner core of histones H3 and H4 and an outer…
Abstract Number: 658 • 2014 ACR/ARHP Annual Meeting
17β Estradiol Regulates VCAM-1 Expression during Glomerulonephritis
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose The immunomodulating roles of estrogens are not completely understood. Although 17β estradiol (E2) has been shown to promote systemic autoimmunity, it has also been…
Abstract Number: 2725 • 2013 ACR/ARHP Annual Meeting
Regulation Of Aberrant CD4 T Cell Activation By Suppressor Of Cytokine Signaling-1 (SOCS1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Tenisha Wilson¹, Cristina Armbruster², Simone Bedoya², Howard M. Johnson², Westley H. Reeves³, Yi Li⁴, Ying Yi Zheng⁵, Laurence Morel⁶ and Joseph Larkin III², ¹Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL, ²Microbiology and Cell Science, University of Florida, Gainesville, FL, ³Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁴Medicine, University of Florida, Gainesville, FL, ⁵Pathology, University of Florida, Gainesville, FL, ⁶Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, mediated by aberrantly activated CD4 T cells. Notably, suppressor of cytokine signaling-1 (SOCS1) regulates CD4 T…
Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Stephanie M. Stanford¹, William B. Kiosses², Amanda M. Campbell³, Michael F. Maestre³, David L. Boyle⁴, Gary S. Firestein⁴ and Nunzio Bottini³, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
Abstract Number: 1656 • 2013 ACR/ARHP Annual Meeting
Interferon Type I and T Helper 17: A Dangerous Liaison In Primary Sjögren’s Syndrome?
Zana Brkic¹, Sandra M.J. Paulissen², Cornelia G. van Helden-Meeuwsen³, Naomi I. Maria³, Odilia B.J. Corneth⁴, Nadine Davelaar⁵, Jan Piet van Hamburg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Martin van Hagen³, Erik Lubberts⁶ and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome…
Abstract Number: 1374 • 2013 ACR/ARHP Annual Meeting
NR1D1 Is a New Suppressor of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Invasion
Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune disease. Arthritis severity and joint damage predict clinical outcome and the risk for disability in…
Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
Abstract Number: 634 • 2013 ACR/ARHP Annual Meeting
IL-21/IL-21R Interaction On Lymphocyte Subsets From Lupus Patients
Vinh Nguyen¹, Horea Rus², Cosmin Tegla² and Violeta Rus³, ¹Medicine, University of Maryland School of Medicine, Baltimore, MD, ²Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ³Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD
Background/Purpose: We have previously shown that IL-21 promotes autoimmunity in a mouse model of lupus through both CD4 and B cell intrinsic mechanisms. Recent studies…
Abstract Number: 565 • 2013 ACR/ARHP Annual Meeting
Differential Efficacy Of Human Mesenchymal Stem Cells On Disease In Murine Lupus Based On Source Of Origin
Erin Collins¹, Fei Gu², Osama S. Naga¹, Phil Ruiz³ and Gary S. Gilkeson⁴, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology,Medical University of South Carolina, Charleston, SC, ³Pathology, University of Miami, Miami, FL, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that targets multiple organ systems. Current treatment options for SLE often cause non-specific immune suppression,…

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