Abstracts tagged "Autoimmunity"

Abstract Number: 756 • 2014 ACR/ARHP Annual Meeting
Nucleosome, a Basic Repeating Unit of Chromatin, in Patients with Systemic Sclerosis: Possible Association with Immunological Abnormalities Via Abnormal Activation of T and B Cells
Ayumi Yoshizaki¹, Yoshihide Asano², Takashi Taniguchi¹, Ryosuke Saigusa¹, Kouki Nakamura¹, Takashi Yamashita¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Yohei Ichimura¹, Zenshiro Tamaki¹, Miki Miyazaki¹ and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose Nucleosome is the basic repeating units of chromatin. Each nucleosome is composed of an inner core of histones H3 and H4 and an outer…
Abstract Number: 658 • 2014 ACR/ARHP Annual Meeting
17β Estradiol Regulates VCAM-1 Expression during Glomerulonephritis
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose The immunomodulating roles of estrogens are not completely understood. Although 17β estradiol (E2) has been shown to promote systemic autoimmunity, it has also been…
Abstract Number: 659 • 2014 ACR/ARHP Annual Meeting
Breakdown of Tolerance at the Tissue Level in Systemic Autoimmunity: Role of Tissue-Resident Dendritic Cells
Jennifer K. King¹, Rachael Philips¹, Anna Eriksson¹ and Ram Raj Singh^1,2,3,4, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ⁴Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
Background/Purpose Systemic autoimmune diseases such as lupus affect multiple organs including skin and kidneys, usually in a diverse fashion where only certain organs are affected…
Abstract Number: 639 • 2014 ACR/ARHP Annual Meeting
Lack of Response Gene to Complement-32 Impairs Th17 Differentiation and Attenuates Lupus-like Chronic Graft Versus Host Disease
Vinh Nguyen¹, Cosmin Tegla², Cornelia Cudrici³, Tudor Badea⁴, Horea Rus² and Violeta Rus¹, ¹Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ²Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ³Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁴NIH, National Eye Institute, Bethesda, MD
Background/Purpose . Response Gene to Complement (RGC)-32 was cloned and characterized by our group as one of the genes induced by complement activation. It encodes…
Abstract Number: 401 • 2014 ACR/ARHP Annual Meeting
Association of Anti-Thyroid Autoantibodies with Fibromyalgia in Rheumatoid Arthritis
Jowairiyya Ahmad¹, Helena Blumen², Claudene George³, Asha Shrestha⁴ and Clement Tagoe⁵, ¹Geriatrics, Albert Einstein College of Medicine/Montefiore Medical Centre, Bronx, NY, ²Geriatrics, Albert Einstein College of Medicine, Bronx, NY, ³Geriatrics, Albert Einstein College of Medicine/Montefiore Medical centre, Bronx, NY, ⁴Rheumatology, Albert Einstein College of Medicine/Montefiore Medical Centre, Bronx, NY, ⁵Rheumatology, Albert Einsetin College of Medicine/Montefiore Medical Centre, Bronx, NY
Background/Purpose Autoimmune thyroiditis has been linked independently with fibromyalgia and chronic widespread pain. We studied how the presence of autoimmune thyroiditis affects the clinical presentation…
Abstract Number: 340 • 2014 ACR/ARHP Annual Meeting
Role of Beta-Catenin Signaling to Control Dendritic Cell Function in Collagen-Induced Arthritis
Celso Henrique Alves^1,2, Julia L. Ober-Blöbaum³, Inge Brouwers-Haspels^1,2, Patrick S. Asmawidjaja^1,2, Anne-Marie Mus^1,2, Björn E. Clausen³ and Erik Lubberts^2,4, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, ⁴Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and synovial infiltration of immune cells. T-cell priming by activated dendritic cells (DCs)…
Abstract Number: 2726 • 2014 ACR/ARHP Annual Meeting
CD28null T Cells from Polymyositis Patients Are Cytotoxic to Autologous Muscle Cells in Vitro Via Perforin-Dependent Mechanisms
Jayesh Pandya¹, Paulius Venalis¹, Lubna Al-Khalili², Mohammad Shahadat Hossain¹, Ingrid E. Lundberg¹, Vivianne Malmström¹ and Andreas E. R. Fasth¹, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Division of Industrial Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden
Background/Purpose: Inflammatory infiltrates of muscles in polymyositis are dominated by CD4+CD28null and CD8+CD28null T cells. In contrast to conventional CD28+ T cells, these cells…
Abstract Number: 2252 • 2014 ACR/ARHP Annual Meeting
Autoimmune Thyroid Disease Is Associated with a Higher Frequency of Spinal Degenerative Disc Disease
Asha Shrestha¹, Hillel Cohen² and Clement Tagoe¹, ¹Rheumatology, Albert Einstein College of Medicine, Bronx, NY, Bronx, NY, ²Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, Bronx, NY
Background/Purpose: Autoimmune thyroid disease (AITD) has been linked to a number of rheumatic syndromes including arthritis and generalized pain. Although AITD has been associated with…
Abstract Number: 146 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity Locus Cia4 Is An Early Regulator of IL-6, IL-1β, and NFκB activators’ Expression in Pristane-Induced Arthritis
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Cia4 is a quantitative trait locus on rat chromosome 7 that regulates disease severity and joint damage in three models of rheumatoid arthritis including…
Abstract Number: 2823 • 2013 ACR/ARHP Annual Meeting
FLIP Deficiency In Dendritic Cells Promotes Spontaneous Inflammatory and Erosive Arthritis
Qi Quan Huang¹, Harris R. Perlman², Robert Birkett³, Renee E. Koessler¹, Syamal K. Datta⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ⁴Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: FLIP is an anti-apoptotic protein induced by chronic inflammation. In this study a mouse line with FLIP deleted in CD11c+ dendritic cells (DCs), that…
Abstract Number: 2725 • 2013 ACR/ARHP Annual Meeting
Regulation Of Aberrant CD4 T Cell Activation By Suppressor Of Cytokine Signaling-1 (SOCS1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Tenisha Wilson¹, Cristina Armbruster², Simone Bedoya², Howard M. Johnson², Westley H. Reeves³, Yi Li⁴, Ying Yi Zheng⁵, Laurence Morel⁶ and Joseph Larkin III², ¹Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL, ²Microbiology and Cell Science, University of Florida, Gainesville, FL, ³Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁴Medicine, University of Florida, Gainesville, FL, ⁵Pathology, University of Florida, Gainesville, FL, ⁶Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, mediated by aberrantly activated CD4 T cells. Notably, suppressor of cytokine signaling-1 (SOCS1) regulates CD4 T…
Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Stephanie M. Stanford¹, William B. Kiosses², Amanda M. Campbell³, Michael F. Maestre³, David L. Boyle⁴, Gary S. Firestein⁴ and Nunzio Bottini³, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
Abstract Number: 1656 • 2013 ACR/ARHP Annual Meeting
Interferon Type I and T Helper 17: A Dangerous Liaison In Primary Sjögren’s Syndrome?
Zana Brkic¹, Sandra M.J. Paulissen², Cornelia G. van Helden-Meeuwsen³, Naomi I. Maria³, Odilia B.J. Corneth⁴, Nadine Davelaar⁵, Jan Piet van Hamburg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Martin van Hagen³, Erik Lubberts⁶ and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome…
Abstract Number: 1374 • 2013 ACR/ARHP Annual Meeting
NR1D1 Is a New Suppressor of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Invasion
Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune disease. Arthritis severity and joint damage predict clinical outcome and the risk for disability in…
Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…

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