ACR Meeting Abstracts

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Abstracts tagged "Autoimmunity"

  • Abstract Number: 2182 • 2014 ACR/ARHP Annual Meeting

    Investigating the Roles of Factor H-Related Proteins in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases

    Alexandra Antonioli1, Brandon Renner2, Joshua Thurman3, V. Michael Holers4 and Jonathan Hannan4, 1Department of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Renal Division, University of Colorado School of Medicine, Aurora, CO, 4Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose Complement plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) wherein inappropriate activation of complement leads to substantial tissue damage, especially…
  • Abstract Number: 1733 • 2014 ACR/ARHP Annual Meeting

    Immunomodulatory Effects of Dietary Non-Digestible Oligosaccharides in T Cell-Mediated Autoimmune Arthritis

    Rebecca Rogier1, Tom Ederveen2, Anita Hartog3, Birgitte Walgreen4, Liduine van den Bersselaar1, Monique M. Helsen1, Paul Vos3, Johan Garssen3,5, Linette Willemsen5, Wim B. van den Berg1, Marije I. Koenders1 and Shahla Abdollahi-Roodsaz6, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, 3Danone Nutricia Research, Utrecht, Netherlands, 4Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 5Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, 6Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Accumulating evidence indicates the relevance of intestinal microbiota in shaping the immune response and supports its contribution to the development of autoimmune diseases. Prebiotic…
  • Abstract Number: 1032 • 2014 ACR/ARHP Annual Meeting

    Neutralization of IL-17 Ameliorated Kidney Pathology Associated with Immune-Complex Mediated Autoimmune Glomerulonephritis

    Partha Biswas1, Kritika Ramani2, Kelly Maers3, Anna Huppler4 and Sarah L. Gaffen5, 1Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2Dept of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Medicine, University of Pittsburgh, Pittsburgh, PA, 4Medicine, University of Pittsburgh, Pittsurgh, PA, 5Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Immune complex mediated autoimmune glomerulonephritis (AGN) is an often-fatal clinical manifestation of systemic lupus erythematosus.  In recent years, pro-inflammatory cytokines in the nephritic kidney…
  • Abstract Number: 995 • 2014 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients Have Alterations in Inherently Autoreactive 9G4+ B-Cell Subpopulations in Peripheral Blood

    Rita A. Moura1,2, Maria J. Leandro3, Venkat Reddy1, João E. Fonseca2,4 and Geraldine Cambridge3, 1Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, 2Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 3Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 4Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal

    Background/Purpose B-cells utilizing the VH-region immunoglobulin gene VH4-34 produce natural autoreactive antibodies. The rat monoclonal antibody 9G4 recognizes B-cells with VH4-34-encoded B-cell receptors (9G4+ B-cells)…
  • Abstract Number: 756 • 2014 ACR/ARHP Annual Meeting

    Nucleosome, a Basic Repeating Unit of Chromatin, in Patients with Systemic Sclerosis: Possible Association with Immunological Abnormalities Via Abnormal Activation of T and B Cells

    Ayumi Yoshizaki1, Yoshihide Asano2, Takashi Taniguchi1, Ryosuke Saigusa1, Kouki Nakamura1, Takashi Yamashita1, Takehiro Takahashi1, Tetsuo Toyama1, Yohei Ichimura1, Zenshiro Tamaki1, Miki Miyazaki1 and Shinichi Sato1, 1Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Background/Purpose Nucleosome is the basic repeating units of chromatin. Each nucleosome is composed of an inner core of histones H3 and H4 and an outer…
  • Abstract Number: 658 • 2014 ACR/ARHP Annual Meeting

    17β Estradiol Regulates VCAM-1 Expression during Glomerulonephritis

    Neelakshi Jog1 and Roberto Caricchio2, 1Rheumatology, Temple University, Philadelphia, PA, 2Medicine/Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose The immunomodulating roles of estrogens are not completely understood. Although 17β estradiol (E2) has been shown to promote systemic autoimmunity, it has also been…
  • Abstract Number: 659 • 2014 ACR/ARHP Annual Meeting

    Breakdown of Tolerance at the Tissue Level in Systemic Autoimmunity: Role of Tissue-Resident Dendritic Cells

    Jennifer K. King1, Rachael Philips1, Anna Eriksson1 and Ram Raj Singh1,2,3,4, 1Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, 2Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, 3Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 4Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    Background/Purpose Systemic autoimmune diseases such as lupus affect multiple organs including skin and kidneys, usually in a diverse fashion where only certain organs are affected…
  • Abstract Number: 639 • 2014 ACR/ARHP Annual Meeting

    Lack of Response Gene to Complement-32 Impairs Th17 Differentiation and Attenuates Lupus-like Chronic Graft Versus Host Disease

    Vinh Nguyen1, Cosmin Tegla2, Cornelia Cudrici3, Tudor Badea4, Horea Rus2 and Violeta Rus1, 1Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, 2Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, 3Neurology, University of Maryland School of Medicine, Baltimore, MD, 4NIH, National Eye Institute, Bethesda, MD

    Background/Purpose . Response Gene to Complement (RGC)-32 was cloned and characterized by our group as one of the genes induced by complement activation. It encodes…
  • Abstract Number: 1656 • 2013 ACR/ARHP Annual Meeting

    Interferon Type I and T Helper 17: A Dangerous Liaison In Primary Sjögren’s Syndrome?

    Zana Brkic1, Sandra M.J. Paulissen2, Cornelia G. van Helden-Meeuwsen3, Naomi I. Maria3, Odilia B.J. Corneth4, Nadine Davelaar5, Jan Piet van Hamburg5, Paul L. Van Daele3, Virgil A. Dalm1, Martin van Hagen3, Erik Lubberts6 and Marjan A. Versnel1, 1Erasmus Medical Center, Immunology, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, 3Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 4Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 5Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 6Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands

    Background/Purpose: The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome…
  • Abstract Number: 1374 • 2013 ACR/ARHP Annual Meeting

    NR1D1 Is a New Suppressor of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Invasion

    Teresina Laragione1,2 and Percio Gulko1,2, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune disease. Arthritis severity and joint damage predict clinical outcome and the risk for disability in…
  • Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting

    The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts

    Max Brenner1,2, Teresina Laragione1,2 and Percio Gulko1,2, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
  • Abstract Number: 634 • 2013 ACR/ARHP Annual Meeting

    IL-21/IL-21R Interaction On Lymphocyte Subsets From Lupus Patients

    Vinh Nguyen1, Horea Rus2, Cosmin Tegla2 and Violeta Rus3, 1Medicine, University of Maryland School of Medicine, Baltimore, MD, 2Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, 3Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD

    Background/Purpose: We have previously shown that IL-21 promotes autoimmunity in a mouse model of lupus through both CD4 and B cell intrinsic mechanisms. Recent studies…
  • Abstract Number: 565 • 2013 ACR/ARHP Annual Meeting

    Differential Efficacy Of Human Mesenchymal Stem Cells On Disease In Murine Lupus Based On Source Of Origin

    Erin Collins1, Fei Gu2, Osama S. Naga1, Phil Ruiz3 and Gary S. Gilkeson4, 1Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, 2Division of Rheumatology and Immunology,Medical University of South Carolina, Charleston, SC, 3Pathology, University of Miami, Miami, FL, 4Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that targets multiple organ systems.  Current treatment options for SLE often cause non-specific immune suppression,…
  • Abstract Number: 116 • 2013 ACR/ARHP Annual Meeting

    Lack Of Association Between Preclinical Markers For Cardiovascular Disease and Rheumatoid Arthritis-Related Autoimmunity In First-Degree Relatives Without Rheumatoid Arthritis

    Jill M. Norris1, Ryan W. Gan1, Jan M. Hughes-Austin2, Kevin D. Deane3, M. Kristen Demoruelle3, Elaine M. Urbina4, Kerrie Moreau5, Peter K. Gregersen6, Michael H. Weisman7 and V. Michael Holers8, 1Epidemiology, Colorado School of Public Health, Aurora, CO, 2Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4Preventive Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Medicine, University of Colorado School of Medicine, Aurora, CO, 6Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 7Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 8Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by systemic inflammation and immune dysregulation, including the presence of autoantibodies and elevated inflammatory biomarkers in subjects with classifiable…
  • Abstract Number: 146 • 2013 ACR/ARHP Annual Meeting

    The Arthritis Severity Locus Cia4 Is An Early Regulator of IL-6, IL-1β, and NFκB activators’ Expression in Pristane-Induced Arthritis

    Max Brenner1,2, Teresina Laragione1,2 and Percio Gulko1,2, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY

    Background/Purpose: Cia4 is a quantitative trait locus on rat chromosome 7 that regulates disease severity and joint damage in three models of rheumatoid arthritis including…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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