Abstracts tagged "Autoimmune Skin Disease"

Abstract Number: 775 • 2019 ACR/ARP Annual Meeting
Cutaneous Gene Expression Signatures in Juvenile Myositis Reveal a Prominent IFN Signature in Lesional Skin
Jessica Turnier¹, Celine Berthier ¹, Lam Tsoi ¹, Lori Lowe ¹, Gabrielle Morgan ², Johann Gudjonsson ¹, Lauren Pachman ² and J. Michelle Kahlenberg ¹, ¹University of Michigan, Ann Arbor, MI, ²Northwestern University, Chicago
Background/Purpose: Skin inflammation can herald systemic disease manifestations and disease chronicity in juvenile myositis (JM), yet we lack an understanding of the pathogenic mechanisms driving…
Abstract Number: 1939 • 2019 ACR/ARP Annual Meeting
Analysis of Discoid Lupus Erythematosus (DLE) Gene Expression Reveals Dysregulation of Pathogenic Pathways Associated with Infiltrating Immune/Inflammatory Cells
Frances Harris¹, Sarah Heuer ², Robert Robl ², Prathyusha Bachali ², Adam Labonte ², Benjamin Chong ³, Michelle Catalina ², Peter Lipsky ² and Amrie Grammer ², ¹RILITE Research Institute, Charlottesville, VA, ²RILITE Research Institute, Charlottesville, ³University of Texas Southwestern, Dallas
Background/Purpose: DLE is a chronic, scarring inflammatory autoimmune disease of the skin. The precise molecular pathways underlying DLE pathogenesis have not been fully delineated. To…
Abstract Number: 99 • 2018 ACR/ARHP Annual Meeting
DC-Hil+ Myeloid-Derived Suppressor Cells Are Elevated in the Peripheral Blood and Lesional Skin of Cutaneous Lupus Patients
Stephanie Florez-Pollack¹, Lin-chiang Tseng¹, Masato Kobayashi¹, Gregory Hosler^1,2, Kiyoshi Ariizumi¹ and Benjamin F. Chong¹, ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Propath, Dallas, TX
Background/Purpose: Myeloid derived suppressor cells (MDSCs) are major T cell suppressors, and their dysfunction has been implicated in the pathophysiology of autoimmune diseases. MDSCs suppress…
Abstract Number: 2040 • 2013 ACR/ARHP Annual Meeting
Pilot Study Of Abatacept In Patients With Refractory Autoimmune Chronic Urticaria
Clifton O. Bingham III¹, Marilyn Towns¹ and Susan J. Bartlett², ¹Rheumatology, Johns Hopkins University, Baltimore, MD, ²Clinical Epidemiology, McGill University, Montreal, QC, Canada
Background/Purpose: Associations between chronic urticaria (CU) with autoantibodies and other autoimmune conditions have implicated T cells in CU initiation and/or propagation. Many patients (pts) have…
Abstract Number: 1935 • 2013 ACR/ARHP Annual Meeting
Validation Of The Cutaneous Dermatomyositis Disease Area and Severity Index: Characterizing Severity and Assessing Responsiveness To Clinical Change
Cynthia O. Anyanwu^1,2, David Fiorentino³, Lorinda Chung⁴, Yanli Wang⁵, Kathleen J. Propert⁶ and Victoria P. Werth^7,8, ¹Department of Dermatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, ²Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, ³Dermatology, Stanford University School of Medicine, Redwood City, CA, ⁴Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ⁵Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ⁶Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ⁷Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA, ⁸Department of Dermatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Translational research and clinical trials necessitate validated outcome measures to reliably assess disease progression and treatment efficacy. The Cutaneous Dermatomyositis Disease Area and Severity…