Abstracts tagged "autoimmune diseases"

Abstract Number: 2848 • 2014 ACR/ARHP Annual Meeting
T-Cell Signaling Defects Can be Corrected By Manipulating ‘TCR Signal Fine-Tuning Molecules’ That Are Altered Due to Increased Ubiquitination in Systemic Autoimmune Disease
Julia Pinkhasov¹ and Ram Raj Singh^1,2,3,4, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ⁴Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
Background/Purpose . T-cell selection in the thymus is primarily determined by the avidity of T cell receptor (TCR) for self-ligand-MHC. Since this process is dependent…
Abstract Number: 2779 • 2014 ACR/ARHP Annual Meeting
Systemic Inflammatory and Autoimmune Manifestations Associated with Myelodysplastic Syndrome: A French Multicenter Retrospective Study
Arsene Mekinian¹, Eric Grignano¹, Thorsten Braun², Olivier Decaux³, Eric Liozon⁴, Nathalie Costedoat-Chalumeau⁵, Jean Emmanuel Kahn⁶, Mohamed Hamidou⁷, Geraldine Falgarone⁸, Olivier Lortholary⁹, Sophie Park¹⁰, Zahir Amoura¹¹, A. Mathian¹², Bruno Gombert¹³, Christian Rose¹⁴, Xavier Puechal¹⁵, David Launay¹⁶, Guillaume Denis¹⁷, Bertrand Lioger¹⁸, Anne Laure Buchdaul¹⁹, Sophie georgin Lavialle²⁰, Francois Montestruc²¹, Mohammed Omouri²², Julien Rossignol²³, Jean Marc Ziza²⁴, Pascal Cathebras²⁵, Serge Madaule²⁶, Benoit de Wazières²⁷, Nathalie Morel¹⁵, Sebastien Trouillet²⁸, Loic Raffray²⁹, Yoland Schoindre³⁰, Eric Toussirot³¹, jean Charles Piette³², Claude Gardin², Lionel Ades³³, Pierre Fenaux³³ and Olivier Fain³⁴, ¹Internal Medicine, DHUi2B Saint Antoine Hospital, paris, France, ²Haematology department Avicenne Hospital, bobigny, France, ³Department of Internal Medicine, Rennes University Hospital, Rennes, France, ⁴INTERNAL MEDICINE, DIJON, France, ⁵Internal Medicine, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁶Internal medicine Hopital Foch, PARIS, France, ⁷CHU Hôtel Dieu, Nantes, Nantes, France, ⁸Rheumatology department Avicenne Hospital INSERM 1125, bobigny, France, ⁹Service de maladies infectieuses, Hôpital Necker-Enfants malades, AP-HP, Paris, France, ¹⁰Haematology Department, Grenoble University Hospital, grenoble, France, ¹¹Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ¹²Internal Medecine Department, Pitie-Salpetriere Hospital, Paris, France, ¹³Internal Medicine, La Rochelle hospital, La Rochelle, France, ¹⁴haematology, lille, France, ¹⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹⁶Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹⁷Internal Medicine, Rochefoucault hospital, Rochefoucault, France, ¹⁸INTERNAL MEDICINE, tours, France, ¹⁹Internal Medicine, Douai hospital, Douai, France, ²⁰Internal Medicine Department Tenon Hospital, paris, France, ²¹exystat, PARis, France, ²²Rheumatology Department Romilly Hospital, romilly, France, ²³haematology, paris, France, ²⁴Hopital Croix-Saint-Simon, Paris Cedex 20, France, ²⁵Internal Medicine, University Hospital St Etienne, St Etienne, France, ²⁶Medecine interne, Chg, Albi, France, ²⁷Department of Internal Medicine and Gerontology, Hôpital Universitaire Carémeau, Nîmes, France, Nimes, France, ²⁸INTERNAL MEDICINE, aurillac, France, ²⁹INTERNAL MEDICINE, bordeaux, France, ³⁰DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, PARIS, France, ³¹Clinical Investigation Centre Biotheraoy CIC 1431, Rheumatology Department, Univesity Hospital, besancon, France, ³²INTERNAL MEDICINE, PARIS, France, ³³Haematology department Saint Louis Hospital, paris, France, ³⁴Hôpital Saint Antoine, DHU i2B, Service de Médecine Interne, paris, France
Background/Purpose: To describe characteristics, treatment and outcome of patients with systemic inflammatory or autoimmune diseases (SAID) and myelodysplastic syndrome (MDS).Methods: For this retrospective study, a…
Abstract Number: 2359 • 2014 ACR/ARHP Annual Meeting
CGEN-15001, a Novel Immunomodulatory Fusion Protein of the B7 Family Induces Immune Tolerance and Shows Efficacy in Mouse Models of Rheumatoid Arthritis and Psoriasis
Iris Hecht¹, Kay McNamee², Aviad Keren³, Joseph R. Podojil⁴, Ilan Vaknin¹, Anat Oren¹, Galit Rotman¹, Eyal Neria¹, Stephen D. Miller⁴, Amos Gilhar³ and Richard O. Williams², ¹Compugen Ltd., Tel Aviv, Israel, ²Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, ³Technion Institute of Technology, Haifa, Israel, ⁴Microbiology-Immunology, Northwestern University, Chicago, IL
Background/Purpose CGEN-15001 is an Fc-fusion protein consisting of the extracellular domain of a novel B7-like protein, discovered based on shared family characteristics. CGEN-15001 inhibits T…
Abstract Number: 2201 • 2014 ACR/ARHP Annual Meeting
Haematological Complications in Rheumatic Diseases: Not Only Lymphomas
Elena Elefante¹, Chiara Baldini¹, Alice Parma¹, Elisa Cioffi², Francesco Ferro¹, Roberta Vagelli², Martina Rousseau³, Rosaria Talarico², Sara Galimberti³ and Stefano Bombardieri², ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Rheumatology Unit, Pisa, Italy, ³Hematology Unit, Pisa, Italy
Background/Purpose Several immunological abnormalities have been reported among patients affected by myelodisplastic syndrome (MDS). On the other hand, a relatively limited number of studies have…
Abstract Number: 2190 • 2014 ACR/ARHP Annual Meeting
Features of Interstitial Lung Disease Associated with Connective Tissue Disease in a Spanish Southwest Cohort
Adela Gallego Flores¹, Carmen Carrasco Cubero², Raul Veroz Gonzalez¹, Luz Maria Mellado Narciso¹, Tamara Libertad Rodriguez Araya¹, Juan Jose Aznar Sánchez¹ and Eugenio Chamizo Carmona¹, ¹Rheumatology, Hospital de Mérida, Mérida, Spain, ²Rheumatology, Hospital de Merida, Mérida, Spain
Background/Purpose Diffuse interstitial lung disease (ILD) can be associated with connective tissue diseases (CTD), and can increase morbidity and mortality significantly. The predominant patterns of…
Abstract Number: 2182 • 2014 ACR/ARHP Annual Meeting
Investigating the Roles of Factor H-Related Proteins in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases
Alexandra Antonioli¹, Brandon Renner², Joshua Thurman³, V. Michael Holers⁴ and Jonathan Hannan⁴, ¹Department of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Renal Division, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose Complement plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) wherein inappropriate activation of complement leads to substantial tissue damage, especially…
Abstract Number: 2167 • 2014 ACR/ARHP Annual Meeting
Snapin Is Critical for Cathepsin D Activation and the Normal Lysosomal Function
Bo Shi¹, Qi Quan Huang², Robert Birkett², Renee E. Koessler¹, Andrea Dorfleutner¹, Christian Stehlik¹ and Richard M. Pope¹, ¹Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Our recent data indicates that Snapin, a SNAP associated protein, is critical for maintaining healthy autophagy and monocytes to macrophage (MFs) differentiation which requires…
Abstract Number: 2555 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Questionnaire To Screen For The Presence Of Autoimmune Disease
Alan Boroway¹, Aileen M. Davis², Carolina Landolt-Marticorena¹ and Joan E. Wither³, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Healthy family members of patients with systemic autoimmune rheumatic diseases (SARDs) are at higher risk of developing autoimmune disease than the general population. …
Abstract Number: 2044 • 2013 ACR/ARHP Annual Meeting
Birth Outcomes In Childbearing Women Treated With Thiopurines: A Meta-Analysis
Zeinab F. Saleh¹, Raveendhara R. Bannuru², William F. Harvey² and Timothy E. McAlindon³, ¹Adult Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: The thiopurines azathioprine (AZA) and 6-mercaptopurine (6-MP) are effective treatments for many rheumatic and autoimmune conditions. These medications have a category D classification from…
Abstract Number: 1914 • 2013 ACR/ARHP Annual Meeting
Patient and Physician Perspectives On Family Planning and Pregnancy Issues In Systemic Inflammatory Diseases: Mind The Gap!
Megan E. B. Clowse¹, Eliza Chakravarty², Daphnee S. Pushparajah³, Sarah Mertens³ and Caroline Gordon⁴, ¹Duke University Medical Center, Durham, NC, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³UCB Pharma, Brussels, Belgium, ⁴School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Autoimmune and inflammatory diseases often affect women of reproductive age and can impact pregnancy outcomes. This patient (pt) group has important concerns about family…
Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting
Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis
Paulina Chalan¹, Bart-Jan Kroesen², Kornelis S.M. van der Geest¹, Minke G. Huitema¹, Wayel H. Abdulahad³, Elisabeth Brouwer¹ and Annemieke M.H. Boots⁴, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…
Abstract Number: 1612 • 2013 ACR/ARHP Annual Meeting
Rituximab For Treatment Of Refractory Auto-Immune Hepatitis
Chadi Rakieh¹, Edward M. Vital², Paul Emery³ and Michael Martin¹, ¹Rheumatology, Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom, ²Section of Musculoskeletal Disease, Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom, ³Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom
Background/Purpose: Auto-immune hepatitis (AIH), also known as lupoid hepatitis, is a chronic progressive disease of unknown aetiology. First-line therapy consists of corticosteroids alone or in…
Abstract Number: 1046 • 2013 ACR/ARHP Annual Meeting
Comparison Of The Incidence Of Influenza Like Illness In Pregnant Women With Rheumatoid Arthritis and Women Without Rheumatoid Arthritis Who Receive An Influenza Vaccination
Yunjun Luo¹, Diana L. Johnson², Ronghui Xu³ and Christina D. Chambers¹, ¹Pediatrics, University of California, San Diego, La Jolla, CA, ²University of California San Diego Department of Pediatrics, La Jolla, CA, ³Family and Preventive Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Influenza infection poses significant risk to pregnant women, therefore it is recommended that all pregnant women be vaccinated. However, it is unknown whether the…
Abstract Number: 848 • 2013 ACR/ARHP Annual Meeting
Human Papillomavirus Vaccine Uptake Among Children and Young Adults With Autoimmune Diseases
Candace H. Feldman¹, Linda T. Hiraki², Joyce Lii³ and Seoyoung C. Kim⁴, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ³Department of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ⁴Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Autoimmune diseases such as lupus and inflammatory bowel disease are associated with increased rates of human papillomavirus (HPV), the most common sexually transmitted disease…
Abstract Number: L17 • 2013 ACR/ARHP Annual Meeting
Safety and Immunogenicity of Inactivated Varicella-Zoster Virus Vaccine in Adults with Autoimmune Disease
Lawrence McAdam¹, Michael Eberhardson², William Grainger³, Kim Papp⁴, Stephen Hall⁵, Tina Sterling⁶, Jon Stek⁶, Lei Pang⁶, Yanli Zhao⁶, Ivan Chan⁶, Richard Haupt⁶, Janie Parrino⁶ and Jeffrey Silber⁶, ¹Advanced Rheumatology, Infusion and Clinical Research Center, Thousand Oaks, CA, ²Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Neurological Physicians of Arizona, Gilbert, AZ, ⁴K. Papp Clinical Research,, Waterloo, ON, Canada, ⁵Emeritus Research, Malvern, Australia, ⁶Merck & Co., Inc., Whitehouse Station, NJ
Background/Purpose: Patients with autoimmune diseases are often immunocompromised, resulting in higher incidence of HZ than in immunocompetent individuals with significant morbidity and occasional mortality from…

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