Abstracts tagged "autoimmune diseases"

Abstract Number: 2934 • 2016 ACR/ARHP Annual Meeting
Clinical Assessment of the Monoclonal Anitbody, PRX003, a Potential Novel Treatment for Th17-Mediated Inflammatory Disease
Gene G. Kinney¹, Kenneth Flanagan¹, Michael Skov¹, Ronald Goldblum², Sue Griffith³, Robin M. Barbour¹, Wagner Zago¹, Ted Yednock¹, Martin Koller¹ and Dan Ness¹, ¹Prothena Biosciences Inc, South San Francisco, CA, ²Carlsbad Pharmaceutical Consulting, Inc., Carlsbad, CA, ³ClinPharma Services, Inc, San Diego, CA
Background/Purpose: Melanoma cell adhesion molecule (MCAM; CD146) is expressed on the surface of Th17 cells, which have the capacity to produce IL-17 and a multitude…
Abstract Number: 764 • 2016 ACR/ARHP Annual Meeting
Atacicept: Integrated Safety Profile from Phase II Randomized Placebo-Controlled Studies in Autoimmune Diseases
Patricia Fraser, Wai Chin and Amy Kao, EMD Serono, Billerica, MA
Background/Purpose: Atacicept, a recombinant fusion protein, targets both BLyS (B lymphocyte stimulator) and APRIL (a proliferation-inducing ligand), B cell activating factors involved in the pathogenesis…
Abstract Number: 1008 • 2016 ACR/ARHP Annual Meeting
Advantageous Effect of an Endogenous Retroviral Envelope Protein in Systemic Lupus Erythematosus with Ex Vivo and In Vivo Anti-Inflammatory Potential
Anne Troldborg^1,2, Magdalena Janina Laska³, Ellen-Margrethe Hauge^4,5, Shervin Bahrami⁶ and Kristian Stengaard-Pedersen^7,8, ¹clinical medicine, Aarhus University, Aarhus, Denmark, ²Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Dept. of Anatomy, Aarhus University, Aarhus, Denmark, ⁵Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁶Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁷Clinical medicine, Aarhus University, Aarhus, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Human Endogenous Retroviruses (HERVs) are remnants of retroviral infections in the human germline. Most, but not all, HERV genes have become inactive by accumulation…
Abstract Number: 1029 • 2016 ACR/ARHP Annual Meeting
Functional Genetics of PTPN2 in Rheumatoid Arthritis: Haploinsufficiency of PTPN2 Promotes Severity of Th17-Cell Mediated Autoimmune Arthritis
Mattias N. D. Svensson^1,2, Karen M. Doody¹, Cristiano Sacchetti^1,2, Dennis J. Wu¹, Gisen Kim³, Annelie Hellvard⁴, Brith Bergum⁴, Piotr Mydel⁴, Mitchell Kronenberg³, Michel L. Tremblay⁵ and Nunzio Bottini^1,2, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Department of Medicine, University of California, San Diego, La Jolla, CA, ³Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁵Goodman Cancer Centre, McGill University, Montréal, QC, Canada
Background/Purpose: Genome-wide association studies have linked polymorphisms in the PTPN2 locus to rheumatoid arthritis (RA). PTPN2 encodes the tyrosine phosphatase TC-PTP, an important regulator of…
Abstract Number: 1224 • 2015 ACR/ARHP Annual Meeting
Infection Rate in HIV Patients Who Received TNF-a Inhibitor Therapy for Concomitant Autoimmune Diseases
Sintawat Wangsiricharoen¹, Colin Ligon², Ahmad Dehrab³, Lydia Gedmintas⁴, Marisa Tungsiripat⁵, Clifton Bingham⁶, Carlos J. Lozada⁷ and Leonard H. Calabrese⁸, ¹Chiang Mai University, Chiang Mai, Thailand, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology, University of Miami Jackson Memorial Hospital, Miami, FL, ⁴Rheumatology, Brigham's Women's Hospital, Boston, MA, ⁵Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH, ⁶Johns Hopkins University, Baltimore, MD, ⁷University of Miami Miller School of Medicine, Miami, FL, ⁸Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Few HIV-infected patients have been treated with tumor necrosis factor (TNF)-α inhibitor therapy for autoimmune diseases refractory to conventional therapies. Evidence supporting the safety…
Abstract Number: 1356 • 2015 ACR/ARHP Annual Meeting
Autoimmune Manifestations in Hepatitis C: A Single-Centered Experience
Azza Ali¹, Reshma Khan¹, Kirthi Lilley², Paul Naylor², Rajaie Namas¹ and Malini Venkatram¹, ¹Rheumatology, Wayne State University, Detroit, MI, ²Gastroenterology, Wayne State University, Detroit, MI
Background/Purpose: Hepatitis C infection (HCV) is a leading cause of chronic liver disease. It is associated with a plethora of autoimmune manifestations including clinical, serological…
Abstract Number: 1416 • 2015 ACR/ARHP Annual Meeting
Postoperative Complications Rate in Orthopaedic Surgery Performed in Rheumatic Patients in Use of Biologic Agents
Clarissa Queiroz Pimentel¹, Luiz Eduardo de Paula¹, Ana Paula Luppino-Assad², Gilberto Luis Camanho³, Eloisa Bonfá⁴ and Marco Antonio Gonçalves Pontes Filho¹, ¹Division of Rheumatology, University of São Paulo Medical School, São Paulo, Brazil, ²Division of Rheumatology, University of São Paulo, sao paulo, Brazil, ³Division of Orthopedics, University of São Paulo Medical School, São Paulo, Brazil, ⁴Rheumatology, University of São Paulo, São Paulo, Brazil, Sao Paulo, Brazil
Background/Purpose: Biologic agents have been associated with an increased risk of infection, thrombosis and delayed wound healing. However, there is no definitive consensus on suspension…
Abstract Number: 1512 • 2015 ACR/ARHP Annual Meeting
Incidence of Co-Morbid Autoimmune Diseases in Patients with Rheumatoid Arthritis
TA Simon¹, H Kawabata¹, JM Esdaile², V Moorthy³ and S Suissa⁴, ¹Bristol-Myers Squibb, Hopewell, NJ, ²Arthritis Research Canada, Vancouver, BC, Canada, ³Mu Sigma, Northbrook, IL, ⁴McGill University, Montreal, QC, Canada
Background/Purpose: Rheumatoid arthritis (RA) is one of more than 80 different types of autoimmune diseases, many of which, including RA, share common pathogenic mechanisms, resulting…
Abstract Number: 1762 • 2015 ACR/ARHP Annual Meeting
Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model
Toshiki Eri¹, Kimito Kawahata², Ei Bannai¹, Takeyuki Kanzaki³, Lisa Akahira¹, Kazuya Michishita¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ³Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan
Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
Abstract Number: 1937 • 2015 ACR/ARHP Annual Meeting
Dalazatide (ShK-186), a First-in-Class Blocker of Kv1.3 Potassium Channel on Effector Memory T Cells: Safety, Tolerability and Proof of Concept of Immunomodulation in Patients with Active Plaque Psoriasis
Ernesto J. Munoz-Elias¹, David Peckham¹, Kayla Norton¹, Judilyn Duculan², Inna Cueto², Xuan Li³, James Qin⁴, Kurt Lustig⁵, Eric Tarcha¹, Jared Odegard⁴, James G. Krueger² and Shawn P. Iadonato¹, ¹Kineta Inc, Seattle, WA, ²Rockefeller University, New York, NY, ³Rockefeller University, New York, WA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁵Kineta Inc., Seattle, WA
Background/Purpose: Effector memory T cells of both CD4 and CD8 lineages are key drivers of autoimmunity and are pathogenic in several autoimmune diseases including psoriasis,…
Abstract Number: 1947 • 2015 ACR/ARHP Annual Meeting
Hypermethylation of Treg-Specific Demethylated Regions in the Ikaros Transcription Factor Family Members, Helios and Eos, in Rheumatoid Arthritis Tregs
Alla Skapenko¹, Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe¹ and Hendrik Schulze-Koops¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Foxp3 is the signature transcription factor of regulatory T cells (Tregs) and facilitates many of the characteristic functions of Tregs. Members of the Ikaros…
Abstract Number: 2101 • 2015 ACR/ARHP Annual Meeting
HLA Associations in Mothers of Children with Cardiac Manifestations of Neonatal Lupus
Hannah C. Ainsworth¹, Carl D. Langefeld¹, Miranda C. Marion², Nathalie Costedoat-Chalumeau³, Antonio Brucato⁴, Jill P. Buyon⁵ and Robert M. Clancy⁵, ¹Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University Health Sciences, Winston-Salem, NC, ³Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁴Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁵Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Cardiac manifestations of neonatal lupus, comprising atrioventricular conduction defects and cardiomyopathy, occur in fetuses exposed to anti-Ro/SSA antibodies, and carry substantial mortality. There is…
Abstract Number: 2125 • 2015 ACR/ARHP Annual Meeting
Rheumatic and Non-Rheumatic Autoimmune Diseases in SLE Offspring
Julie Couture¹, Sasha Bernatsky², Susan Scott³, Christian A. Pineau² and Evelyne Vinet², ¹McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Autoimmune diseases (AID) have familial aggregation and frequently share a common genetic predisposition. Only few small uncontrolled studies have evaluated the risk of AID…
Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting
Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE
Hanna Kim¹, Yin Liu², Adriana Almeida de Jesus¹, Robert Wesley³, Yan Huang¹, Gina A. Montealegre Sanchez¹, Dawn C. Chapelle¹, Wanxia L. Tsai⁴, Massimo G. Gadina⁴, Frederick W. Miller⁵, Sarfaraz Hasni⁶, Adeline Vanderver⁷, Lisa G Rider⁵ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ²Scientific Review Branch, NIAMS, NIH, Bethesda, MD, ³Clinical Center, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁵Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁷Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis…
Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting
Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements
Rebecca Baum¹, Shruti Sharma¹, Ann Marshak-Rothstein¹, Katherine A. Fitzgerald¹ and Ellen M. Gravallese², ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…

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