Abstract Number: 152 • 2017 Pediatric Rheumatology Symposium
Characteristics of Patients With Juvenile Idiopathic Arthritis in a US Healthcare Claims Database
Background/Purpose: Abatacept, the first selective co-stimulation modulator approved and used for the treatment of juvenile idiopathic arthritis (JIA), has a mechanism of action that is…Abstract Number: 147 • 2017 Pediatric Rheumatology Symposium
Epigenetic and Transcriptomic Profiling of Primary Juvenile Idiopathic Arthritis Patient Cells: Better Understanding of Disease Pathogenesis
Background/Purpose: For many autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA), the molecular mechanisms remain elusive. JIA can be used as a model to study autoimmune…Abstract Number: 12L • 2016 ACR/ARHP Annual Meeting
Efficacy and Safety of Atacicept in Patients with Systemic Lupus Erythematosus: Results of a 24-Week Randomized, Placebo-Controlled, Phase IIb Study
Background/Purpose: Atacicept targets B-cell stimulating factors BLyS and APRIL. In the APRIL-SLE trial, atacicept 150 mg was associated with reduced SLE flares in post-hoc analyses.1Methods:…Abstract Number: 1179 • 2016 ACR/ARHP Annual Meeting
The Impact of Autoimmune Disease in the Management and Prognosis of Acute Coronary Syndrome
Background/Purpose: Patients with autoimmune diseases (AID) have a high burden of cardiovascular disease leading to premature morbidity and mortality. But it is unclear if it…Abstract Number: 1244 • 2016 ACR/ARHP Annual Meeting
Establishing a Case Report Form (CRF) for Systemic Autoimmune Diseases Studies
Background/Purpose: Systemic autoimmune diseases (SADs) are heterogeneous conditions with peculiar characteristics that share several clinical features. It is suspected that SADs share similar molecular abnormalities,…Abstract Number: 1313 • 2016 ACR/ARHP Annual Meeting
Rheumatologic Diseases in HIV-Infected Patients in the Post-Antiretroviral Therapy Era: The County Experience
Background/Purpose: HIV infection has been associated with a plethora of rheumatologic diseases, however there are only few studies in the US analyzing the frequency of…Abstract Number: 1359 • 2016 ACR/ARHP Annual Meeting
New Markers for Celiac Disease: Anti-Neo-Epitope Human and Microbial Transglutaminases
Background/Purpose: Microbial transglutaminase (mTg) and human tissue Tg (tTg) complexed to gliadin peptides present neo-epitopes. Antibodies against these complexes are called tTg neo-epitope and mTg…Abstract Number: 1428 • 2016 ACR/ARHP Annual Meeting
Patient Attitudes Towards Being Prescribed Biosimilars in Inflammatory Autoimmune Diseases in Germany
Background/Purpose: Our aim is to address the lack of understanding surrounding patient attitudes to being prescribed biosimilars in the real world for Rheumatoid Arthritis (RA),…Abstract Number: 1610 • 2016 ACR/ARHP Annual Meeting
Safety, Tolerability, and Dose-Dependent Inhibition of T-Cell-Dependent Antibody Response with MEDI4920, a Novel, Engineered CD40L Antagonist: Results of a Single-Ascending Dose Study in Healthy Volunteers
Background/Purpose: The CD40L/CD40 co-stimulatory pathway is important for T-cell-dependent antibody production. Previous clinical programs with intact monoclonal antibodies against CD40L have been discontinued due to…Abstract Number: 1912 • 2016 ACR/ARHP Annual Meeting
A New Avenue of Immune Regulation Conferred By Self-Glycerophospholipids Via Mobilization and Migration of Myeloid-Derived Suppressor Cells
Background/Purpose: Lipids function as essential components of biological membranes, as signaling molecules, and as energy storage molecules. Glycerol-based phospholipids, called glycerophospholipids (GPL), are the most…Abstract Number: 2150 • 2016 ACR/ARHP Annual Meeting
Autoimmune Uveitis : Potential Role of Interleukin-22 (IL-22) in Pathogenesis
Background/Purpose: : IL-22 is a member of IL-10 family, with both anti- inflammatory and pro- inflammatory functions, orchestrating the immune and inflammatory response.IL-22 is secreted…Abstract Number: 2175 • 2016 ACR/ARHP Annual Meeting
Comparisons of Patients Prescribed Biosimilars or BIO-Originators for Autoimmune Diseases in Germany
Background/Purpose: To compare the characteristics of patients who receive biosimilars against patients receiving bio-originators. Methods: The Adelphi Biosimilars Programme 2016 is a cross-sectional survey of…Abstract Number: 2428 • 2016 ACR/ARHP Annual Meeting
Autoantibody Diversity in Pediatric Patients Undergoing Evaluation for Autoimmune Encephalitis: A Retrospective Investigation
Background/Purpose: Antibodies directed against N-methyl-D-aspartate type glutamate receptor (NMDAR), voltage-gated potassium channel (VGKC) or glutamic acid decarboxylase (GAD65) are frequently associated with autoimmune encephalitis (AE)…Abstract Number: 2857 • 2016 ACR/ARHP Annual Meeting
Results from a Phase 0 Longitudinal Clinical Trial in Cutaneous Lupus Erythematosus: Analysis of the Type I IFN Signature in the Skin and Blood and Its Relationship with Disease Activity Scores and Autoantibody Profiles
Background/Purpose: Type I IFN (IFN-I)-regulated gene expression is known to be elevated in blood and skin lesions of patients with two different forms of cutaneous…Abstract Number: 2927 • 2016 ACR/ARHP Annual Meeting
Mechanisms Regulating the Loss of Tregs in CD11c-Flip-KO Mice That Contribute to the Spontaneous Development of Inflammatory Arthritis
Background/Purpose: CD11c-Flip-KO (HUPO) mice spontaneously develop inflammatory, erosive arthritis. We previously demonstrated that T regulatory cells (Tregs) were reduced in HUPO mice and that the…
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