Abstracts tagged "autoimmune diseases"

Abstract Number: 518 • 2012 ACR/ARHP Annual Meeting
Spontaneous Sialadenitis Like Sjögren’s Syndrome in Orphan Nuclear Receptor γt (RORγt) Transgenic Mice
Mana Iizuka¹, Hiroto Tsuboi¹, Hiromitsu Asashima¹, Yuya Kondo¹, Satoru Takahashi², Isao Matsumoto¹ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: The nuclear receptors retinoic-acid-receptor-related orphan receptors gt (RORγt) is required for the generation of Th17 cells expressing the proinflammatory cytokine IL-17. Th17 cells expressing…
Abstract Number: 2268 • 2012 ACR/ARHP Annual Meeting
Hyperacetylation of Histone H4 in Systemic Lupus Erythematosus
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song², Zhe Zhang³, Michelle Petri⁴ and Kathleen E. Sullivan², ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease and is characterized by multi-systemic chronic inflammation. Epigenetic processes, such as posttranslational histone modifications, can…
Abstract Number: 482 • 2012 ACR/ARHP Annual Meeting
B-Lymphocyte Count Is Not Associated with an Increased Risk of Infection in Patients Treated with Rituximab for Auto-Immune Diseases
Ilias Lazarou¹, Axel Finckh², Lara Fischer³, Camillo Ribi³, Joerg Seebach³ and Pierre A. Guerne², ¹University Hospitals of Geneva, Geneva, Switzerland, ²Rheumatology, University Hospitals of Geneva, Geneva, Switzerland, ³Immunology, University Hospitals of Geneva, Geneva, Switzerland
Background/Purpose: B-Lymphocyte (B-Ly) depletion therapy with the monoclonal anti-CD20 antibody rituximab (RTX) is widely used in a variety of autoimmune (AI) diseases. The risk of…
Abstract Number: 2271 • 2012 ACR/ARHP Annual Meeting
Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes
Olof Berggren¹, Andrei Alexsson², Gunnar V. Alm³, Ann-Christine Syvänen⁴, Lars Rönnblom² and Maija-Leena Eloranta², ¹Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ³Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, ⁴Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden
Background/Purpose: Many autoimmune diseases, e.g. systemic lupus erythematosus (SLE), have an activated type I interferon (IFN) system and about 40 SLE susceptibility loci, many within…
Abstract Number: 440 • 2012 ACR/ARHP Annual Meeting
Effects of Fetal Microchimerisms On Disease Onset and Severity in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Marianne Kekow¹, Sara Fill Malfertheiner², Maria Barleben¹, Susanne Drynda³, Joern Kekow³ and Thomas Brune¹, ¹Univ of Magdeburg, Children's Hospital, Magdeburg, Germany, ²Univ of Magdeburg, Department of Obstetrics and Gynecology, Magdeburg, Germany, ³Clinic of Rheumatology, Univ of Magdeburg, Vogelsang-Gommern, Germany
Background/Purpose: The major source of naturally acquired microchimerisms (MC) is the transplacental traffic of fetal cells between a mother and the fetus during pregnancy. Fetal…
Abstract Number: 1929 • 2012 ACR/ARHP Annual Meeting
Pernicious Anemia and Vitamin B-12 Deficiency in Autoimmune Disease: Neglecting the Feet Will Lead You Astray
Michael R. Lovy, Desert Oasis Healthcare, Palm Springs, CA
Background/Purpose: The occurrence of multiple autoimmune disorders in individual patients is commonly observed. Rarely, this is explained by recently recognized genetically based autoimmune polyendocrine syndromes.…
Abstract Number: 338 • 2012 ACR/ARHP Annual Meeting
The Potent Phosphoinositide-3-Kinase-(δ,γ) Inhibitor IPI-145 Is Active in Preclinical Models of Arthritis and Well Tolerated in Healthy Adult Subjects
James R. Porter¹, Janid Ali², Jonathan P. DiNitto², Joi Dunbar², Kerrie Faia², Jennifer Hoyt², Brianne Leary², Alice R. Lim², Christian Martin², Charlotte McKee², Patrick O'Hearn², Melissa Pink², Jennifer Proctor², John Soglia², Bonnie Tillotson², Kerry White², David G. Winkler² and Vito J. Palombella², ¹Product Development, Infinity Pharmaceuticals, Inc., Cambridge, MA, ²Infinity Pharmaceuticals, Inc., Cambridge, MA
Background/Purpose: Phosphoinositide-3-kinases (PI3K) play pivotal roles in cell signaling and regulate a variety of cellular functions. PI3K-δ and PI3K-γ isoforms are necessary for adaptive and…
Abstract Number: 1820 • 2012 ACR/ARHP Annual Meeting
Human Papillomavirus Vaccine [Types 6, 11, 16, 18] (Gardasil^®) and Autoimmune Disorders: Safety Assessment Using the Pharmacoepidemiologic General Research Extension System
Lamiae Grimaldi-Bensouda¹, Michel Rossignol², Elodie Aubrun¹, Pamela Leighton³, Didier Guillemot⁴, Alfred Mahr⁵, Jacques Benichou⁶, Paul-Henri Lambert⁷, Bertrand Godeau⁸ and Lucien Abenhaim⁹, ¹LA-SER, Paris, France, ²LA-SER, Centre for Risk Research, Montreal, Canada, ³LA-SER Europe Ltd., London, United Kingdom, ⁴Institut Pasteur (PhEMI)/ INSERM U657 & Université Paris-Ile de France Ouest, Paris, France, ⁵Internal Medicine, Hospital Saint-Louis, Paris, France, ⁶INSERM U657 Pharmacoepidemiology and evaluation of the impact of health products on human health, France, and Department of Biostatistics, University Hospital of Rouen, Rouen, France, Rouen, France, ⁷Centre of Vaccinology & neonatal immunology, University of Geneva, Geneva, Switzerland, ⁸Internal Medicine, University of Paris, AP-HP, Hôpital Mondor Créteil, Creteil, France, ⁹LA-SER Europe Ltd, London, United Kingdom
Background/Purpose: This study investigated whether the human papillomavirus (HPV) vaccine [types 6, 11, 16, 18] is associated with a modified risk of autoimmune disorders (AIDs).…
Abstract Number: 341 • 2012 ACR/ARHP Annual Meeting
Oral Administration of a Novel Small Molecule BET Bromodomain Inhibitor, RVX-297, Reduces Disease Severity in a Rat Collagen-Induced Arthritis Model
R. Jahagirdar¹, S. Attwell¹, E.M. Gesner¹, K.G. McLure¹, H.C. Hansen¹, J. Chen², J. Wu¹, K. Norek¹, N. Shenoy², G.S. Wagner¹ and P. R. Young¹, ¹Resverlogix Corporation, Calgary, AB, Canada, ²Aravasc Inc., Sunnyvale, CA
Background/Purpose: BET (Bromodomain and Extra-Terminal) proteins have recently emerged as a key epigenetic regulator of genes at the transcriptional level and inhibition of their binding…
Abstract Number: 1671 • 2012 ACR/ARHP Annual Meeting
Characterization of Jo-1 Autoantibodies in Patients with Inflammatory Myopathy and Interstitial Lung Disease
Kyle P. Chiang¹, Varun Gauba¹, Darin Lee¹, Minh-Ha T. Do¹, Jie J. Zhou², Feng Wang², Ying Buechler¹, Leslie Nangle¹, Zhiwen Xu², John Mendlein¹, Melissa Ashlock¹ and Jeffrey M. Greve¹, ¹aTyr Pharma, San Diego, CA, ²Scripps Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong
Background/Purpose: Anti-Jo-1 autoantibodies (Jo-1 Abs), directed against histidine tRNA synthetase (HisRS1), are detected in a high proportion of patients with both autoimmune inflammatory myopathy (IM)…
Abstract Number: 196 • 2012 ACR/ARHP Annual Meeting
Sarcoidosis in Northern New England. Clinical Characteristics and Predictive Factors for More Aggressive Therapy
Alireza Meysami¹, Kevin F. Spratt² and Christopher M. Burns³, ¹Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ²Department of Orthopaedic Surgery, Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Dartmouth Medical School, Lebanon, NH
· Background/Purpose: Sarcoidosis is characterized by a variable clinical presentation. DMARDs and biologics have been used for resistant and/or organ-threatening disease. We analyzed the cases…
Abstract Number: 1627 • 2012 ACR/ARHP Annual Meeting
New Insights Into the Presentation and the Management of Hepatitis B Reactivation in Patients with Autoimmune Diseases and Inflammatory Arthritis
Nina Droz¹, Laurent Gilardin², Patrice Cacoub Sr.³, Francis Berenbaum⁴, Daniel Wendling⁵, Bertrand Godeau⁶, Anne-Marie Piette⁷, Emmanuelle Dernis⁸, Mikael Ebbo⁹, Bruno Fautrel¹⁰, Arsène Meikinian¹¹, Aude Rigolet¹², Sophie Rivière¹³, Stanislas Pol¹⁴, Loic Guillevin¹⁵, Luc Mouthon¹⁶ and Benjamin Terrier¹⁷, ¹Internal Medicine, Cochin Hospital, Paris, France, ²Internal Medicine, Saint Antoine Hospital, Paris, France, ³Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France, ⁴Rheumatology, AP-HP, St Antoine Hospital, Paris, France, ⁵Service de Rhumatologie, Minjoz University Hospital, Besancon, France, ⁶Internal Medicine, University of Paris, AP-HP, Hôpital Mondor Créteil, Creteil, France, ⁷Internal Medicine, Foch Hospital, Suresnes, France, ⁸Centre Hospitalier, Le Mans, France, ⁹Internal Medicine, Conception Hospital, Marseille, France, ¹⁰Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, ¹¹Internal Medicine, Jean Verdier Hospital, Bondy, France, ¹²Internal Medicine I & II, Pitie-Salpetriere Hospital, APHP, UPMC Paris VI, Paris, France, ¹³Internal Medicine, Lapeyronie, Montpellier, France, ¹⁴Hepatology, Cochin Hospital, Paris, France, ¹⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ¹⁶Internal Medicine, Hopital Cochin, Paris, France, ¹⁷Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: In patients with autoimmune diseases and inflammatory arthritis, immunosuppressive therapy may trigger Hepatitis B virus (HBV) reactivation, leading to significant morbidity and mortality. Objective.…
Abstract Number: 200 • 2012 ACR/ARHP Annual Meeting
Rheumatic Manifestations and Connective Tissue Diseases in Autoimmune Hepatitis of the Child and the Adult
Federico Zazzetti¹, Nora C. Fernandez², Javier Benavidez², Luis A. Colombato³, Graciela R. Rodriguez⁴, Graciela Nardi⁵, Carolina Bru Morón⁶, Oscar L. Rillo⁷, Nelo A. Quadrini⁸, Stella M. Garay⁹, Mariana Fabi⁹, Teresita Gonzalez¹⁰ and Juan C. Barreira¹¹, ¹Rheumatology, Buenos Aires Hospital Britanico, Buenos Aires, Argentina, ²Hepatology, Buenos Aires British Hospital, Buenos Aires, Argentina, ³Gastroenterology, Buenos Aires British Hospital, Buenos Aires, Argentina, ⁴Rheumatology, Hospital Dr. Ignacio Pirovano, Buenos Aires, Argentina, ⁵Gastroenterology, Hospital Dr. Ignacio Pirovano, Buenos Aires, Argentina, ⁶Rheumatology, Hospital Dr. Enrique Tornú, Buenos Aires, Argentina, ⁷Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ⁸Gastroenterology, Hospital Dr. Enrique Tornú, Buenos Aires, Argentina, ⁹Rheumatology, Hospital IAEP Sor María Ludovica, La Plata, Argentina, ¹⁰Hepatology, Hospital IAEP Sor María Ludovica, La Plata, Argentina, ¹¹Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina
Background/Purpose: Autoimmune hepatitis (AIH) is a progressive fibrosing inflammatory disease of the liver of unknown etiology, leading to cirrhosis. Its course is usually fluctuating and…
Abstract Number: 1388 • 2012 ACR/ARHP Annual Meeting
Diagnostic Accuracy of Anti-dsDNA Antibodies in Unselected Patients with Recent Onset of Rheumatic Symptoms
Michele Compagno¹, Søren Jacobsen², Ole Petter Rekvig³, Lennart Truedsson⁴, Niels H. H. Heegaard⁵, Johannes C. Nossent⁶, Andreas Jönsen¹, Rasmus Sleimann Jacobsen⁷, Gro Østli Eilertsen⁶, Gunnar K. Sturfelt⁸ and Anders Bengtsson¹, ¹Department of clinical sciences - Rheumatology, Lund University, Lund, Sweden, ²Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ³Department of Biochemistry and Medical Biology, University Hospital, Tromsø, Norway, ⁴Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, ⁵Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁶Dept of Rheumatology, University of Tromsø, Tromso, Norway, ⁷Department of Infectious Diseases and Rheumatology, Section 4242, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ⁸Department of Rheumatology, University Hospital Lund, Lund, Sweden
Background/Purpose: Anti-dsDNA antibodies are widely used in diagnostic settings when SLE is suspected. Crithidia Luciliae Immunofluorescence Test (CLIFT) and Enzyme Linked ImmunoSorbent Assay (ELISA) are…
Abstract Number: 100 • 2012 ACR/ARHP Annual Meeting
Further Evidence On Biased Cancer Risk Estimation in Studies Comparing A Subpopulation to the General Population
Koray Tascilar¹ and Hasan Yazici², ¹University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: We had previously proposed a selection bias in studies estimating cancer risk in patients with rheumatoid arthritis (RA) stemming from the comparison of a…

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