ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 1308 • 2012 ACR/ARHP Annual Meeting

    Opportunistic Infections in Patients with Rheumatoid Arthritis Treated with Rituximab : Data From the Autoimmunity and Rituximab Registry

    Jacques-Eric Gottenberg1, Philippe Ravaud2, Thomas Bardin3, Patrice Cacoub4, Alain G. Cantagrel5, Bernard Combe6, Maxime Dougados7, Rene-Marc Flipo8, Bertrand Godeau9, Loic Guillevin10, Xavier X. Le Loet11, Eric Hachulla12, Thierry Schaeverbeke13, Jean Sibilia14, Isabelle Pane15, Gabriel Baron16 and Xavier Mariette17, 1Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 3Rheumatology, Hôpital Lariboisière, Paris, France, 4Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 5Rheumatology, Place du Docteur Baylac, Toulouse, France, 6Rheumatology, Hopital Lapeyronie, Montpellier, France, 7Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 8Rheumatology, Hopital R Salengro CHRU, Lille, France, 9Internal Medicine, University of Paris, AP-HP, Hôpital Mondor Créteil, Creteil, France, 10Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 11Rheumatology Department, CHU de ROUEN, Rouen, France, 12Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, 13Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, 14Rheumatology, CHU Hautepierre, Strasbourg, France, 15Hotel Dieu University Hospital Paris, Hotel Dieu University Hospital Paris, Paris, France, 16Epidemiology, Strasbourg, France, 17Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France

    Background/Purpose: Therapy  with biological agents may be associated with opportunistic infections (OIs). Data on the occurrence of OIs in patients with RA treated with rituximab…
  • Abstract Number: 2682 • 2012 ACR/ARHP Annual Meeting

    Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Systemic Lupus Erythematosus

    Tomohiro Koga1, Kunihiro Ichinose2, Masayuki Mizui3, José C. Crispín4 and George C. Tsokos4, 1Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA

    Background/Purpose: T cells from patients with SLE exhibit abnormal signaling upon TCR engagement and have an altered gene expression profile. Accordingly, the regulation of several transcription factors…
  • Abstract Number: 1079 • 2012 ACR/ARHP Annual Meeting

    Polyclonal CD4+Foxp3+ treg Cells Induce TGFb-Dependent Tolerogenic Dendritic Cells That Suppress Murine Lupus-Like Syndrome

    Qin Lan1 and Song G. Zheng2, 1Medicine, University of Southern California, Los Angeles, CA, 2Medicine, Keck School of Medicine of USC, Los Angeles, CA

    Background/Purpose: Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are…
  • Abstract Number: 936 • 2012 ACR/ARHP Annual Meeting

    Autoimmune Diseases: Declining Mortality Between 1999 and 2008 However Continuing to be a Leading Cause of Death in Children-A 10-Year Retrospective Review

    Eric Y. Yen1 and Deborah K. McCurdy2, 1Pediatrics/Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, 2Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA

    Background/Purpose: Autoimmune diseases are chronic illnesses that cause significant and chronic disability in children and may lead to death. Using mortality data from 1995, Walsh…
  • Abstract Number: 729 • 2012 ACR/ARHP Annual Meeting

    Apolipoprotein L1 Risk Variants Underlie Racial Disparities in Lupus Nephritis-Induced End-Stage Renal Disease

    Robert P. Kimberly1, Barry I. Freedman2, Carl D. Langfeld3, Devin Absher4, Kelly K. Andringa1, Daniel Birmingham5, Elizabeth E. Brown6, Mary E. Comeau7, Karen H. Costenbader8, Lindsey A. Criswell9, Jeffrey C. Edberg10, John B. Harley11, Judith A. James12, Diane L. Kamen13, Joan T. Merrill14, Timothy B. Niewold15, Neha Patel16, Michelle Petri17, Rosalind Ramsey-Goldman18, Jane E. Salmon19, Mark Segal20, Kathy Moser Sivils12, Betty P. Tsao21, Bruce A. Julian1 and Lupus Nephritis-ESRD Consortium22, 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Biostatistics, Wake Forest University Health Sciences, Winston-Salem, NC, 4HudsonAlpha Institute for Biotechnology, Huntsville, AL, 5Medicine, Ohio State University Medical Center, Columbus, OH, 6University of Alabama at Birmingham, Birmingham, AL, 7Wake Forest University Health Sciences, Winston-Salem, NC, 8Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 9Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, 10Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 11Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Oklahoma Medical Research Foundation, Oklahoma City, OK, 13Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, 14Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 16Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, 17Johns Hopkins University School of Medicine, Baltimore, MD, 18Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 19Rheumatology, Hospital for Special Surgery, New York, NY, 20Medicine/Nephrology, University of Florida, Gainesville, FL, 21Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, 22Medicine, Birmingham, AL

    Background/Purpose: The G1 and G2 coding variants in the apolipoprotein L1 gene (APOL1;  G1: a compound missense allele (glycine-342/methionine-384) and G2: an in-frame deletion (deletion…
  • Abstract Number: 671 • 2012 ACR/ARHP Annual Meeting

    Differences in the SLE Clinical Phenotype by Age of Diagnosis

    T. Clark Powell1, Elizabeth E. Brown on behalf of PROFILE2, Gerald McGwin Jr.3, Luis M. Vila4, Yesenia C. Santiago-Casas4, Michelle Petri5, Rosalind Ramsey-Goldman6, John D. Reveille7, Sergio Duran8, Sergio M.A. Toloza9, Robin L. Brey10, Agustin Escalante11, Randy Q. Cron12, Robert P. Kimberly on behalf of PROFILE investigators13 and Graciela S. Alarcon14, 1Medicine, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 4Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 5Johns Hopkins University School of Medicine, Baltimore, MD, 6Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 7Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, 8UIECD, Guadalajara, Mexico, Guadalajara, Mexico, 9Medicine, Hospital San Juan Bautista, Catamarca, Argentina, 10Medicine/Neurology, UTHSCSA, San Antonio, TX, 11Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 12Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 13Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 14Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the presence of antinuclear autoantibodies, complement activation and the formation and…
  • Abstract Number: 678 • 2012 ACR/ARHP Annual Meeting

    Estrogen Modulation of ZAS3 Is Mediated Through Estrogen Receptor α: An Underlying Mechanism of Gender-Bias in Systemic Lupus Erythematosus?

    Nicholas Young1, Alexandra Friedman2, Lai-Chu Wu2 and Wael N. Jarjour3, 1Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, 2Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Global population data has indicated that post-pubertal females have decreased rates of infectious diseases when compared to male counterparts and preadolescent or postmenopausal females. …
  • Abstract Number: 2503 • 2012 ACR/ARHP Annual Meeting

    CD8+Foxp3-CD103+ Regulatory T Cells Generated Ex Vivo with TGF-β Suppress Autoimmunity Through IL-10-Dependet Mechanism

    Ya Liu1, An-Ping Xu2, David A. Horwitz3 and Song G. Zheng4, 1Medicine, USC Keck School of Medicine, Los Angeles, CA, 2Kidney disease and rheumatology, 2nd Affiliated Hospital of Sun Yat-sen University, 3Medicine-Rheumatology-Immun, Keck School of Medicine of USC, Los Angeles, CA, 4Medicine, Keck School of Medicine of USC, Los Angeles, CA

    Background/Purpose: TGF-β is crucial for induction of CD4+Foxp3+ Tregs and maintenance of immunologic tolerance. It is, however, unclear if TGF-β also induces the similar CD8+…
  • Abstract Number: 660 • 2012 ACR/ARHP Annual Meeting

    Abnormal Neutrophil Development in Human Systemic Lupus Erythematosus

    Namrata Singh1, Mariana J. Kaplan2, Philip L. Cohen3 and Michael F. Denny3, 1Internal Medicine, Temple University, Philadelphia, PA, 2Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, 3Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose: Recent research has increased the appreciation of the contributions of neutrophils to systemic lupus erythematosus (SLE).  An abnormal circulating pool of granulocytes has been…
  • Abstract Number: 2327 • 2012 ACR/ARHP Annual Meeting

    CGEN-15001, a Novel Negative Costimulatory Fusion Protein Is Effective in the Collagen-Induced Arthritis Mouse Model of Rheumatoid Arthritis

    Iris Hecht1, Kay McNamee2, Ilan Vaknin3, Anat Oren3, Joseph R. Podojil4, Galit Rotman3, Eyal Neria3, Stephen D. Miller4 and Richard O. Williams2, 1R&D, Compugen Ltd., Tel Aviv, Israel, 2Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, 3Compugen Ltd., Tel Aviv, Israel, 4Microbiology-Immunology, Northwestern University, Chicago, IL

    Background/Purpose: CGEN-15001 is a recombinant Fc fusion protein consisting of the extracellular domain of CGEN-15001T, a protein predicted to be a member of the B7/CD28…
  • Abstract Number: 518 • 2012 ACR/ARHP Annual Meeting

    Spontaneous Sialadenitis Like Sjögren’s Syndrome in Orphan Nuclear Receptor γt (RORγt) Transgenic Mice

    Mana Iizuka1, Hiroto Tsuboi1, Hiromitsu Asashima1, Yuya Kondo1, Satoru Takahashi2, Isao Matsumoto1 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: The nuclear receptors retinoic-acid-receptor-related orphan receptors gt (RORγt) is required for the generation of Th17 cells expressing the proinflammatory cytokine IL-17. Th17 cells expressing…
  • Abstract Number: 2268 • 2012 ACR/ARHP Annual Meeting

    Hyperacetylation of Histone H4 in Systemic Lupus Erythematosus

    Yiu Tak Leung1, Lihua Shi2, Kelly Maurer2, Li Song2, Zhe Zhang3, Michelle Petri4 and Kathleen E. Sullivan2, 1Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, 3Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, 4Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease and is characterized by multi-systemic chronic inflammation. Epigenetic processes, such as posttranslational histone modifications, can…
  • Abstract Number: 482 • 2012 ACR/ARHP Annual Meeting

    B-Lymphocyte Count Is Not Associated with an Increased Risk of Infection in Patients Treated with Rituximab for Auto-Immune Diseases

    Ilias Lazarou1, Axel Finckh2, Lara Fischer3, Camillo Ribi3, Joerg Seebach3 and Pierre A. Guerne2, 1University Hospitals of Geneva, Geneva, Switzerland, 2Rheumatology, University Hospitals of Geneva, Geneva, Switzerland, 3Immunology, University Hospitals of Geneva, Geneva, Switzerland

    Background/Purpose: B-Lymphocyte (B-Ly) depletion therapy with the monoclonal anti-CD20 antibody rituximab (RTX) is widely used in a variety of autoimmune (AI) diseases. The risk of…
  • Abstract Number: 2271 • 2012 ACR/ARHP Annual Meeting

    Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes

    Olof Berggren1, Andrei Alexsson2, Gunnar V. Alm3, Ann-Christine Syvänen4, Lars Rönnblom2 and Maija-Leena Eloranta2, 1Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 2Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, 3Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, 4Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden

    Background/Purpose: Many autoimmune diseases, e.g. systemic lupus erythematosus (SLE), have an activated type I interferon (IFN) system and about 40 SLE susceptibility loci, many within…
  • Abstract Number: 440 • 2012 ACR/ARHP Annual Meeting

    Effects of Fetal Microchimerisms On Disease Onset and Severity in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Marianne Kekow1, Sara Fill Malfertheiner2, Maria Barleben1, Susanne Drynda3, Joern Kekow3 and Thomas Brune1, 1Univ of Magdeburg, Children's Hospital, Magdeburg, Germany, 2Univ of Magdeburg, Department of Obstetrics and Gynecology, Magdeburg, Germany, 3Clinic of Rheumatology, Univ of Magdeburg, Vogelsang-Gommern, Germany

    Background/Purpose: The major source of naturally acquired microchimerisms (MC) is the transplacental traffic of fetal cells between a mother and the fetus during pregnancy. Fetal…
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