ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 845 • 2014 ACR/ARHP Annual Meeting

    The Risk of Cancer with Tumor Necrosis Factor Inhibitors in Patients Concomitantly Exposed to Non-Biological Immunosuppressants Differs According to the Indication

    Layla Saliba1, Guillaume Moulis2, Malak Aboutaam3, Grégory Pugnet2, Vanessa Rousseau1, Leila Chebane1, Nadine Petitpain4, Bernadette Baldin5, Jean-Louis Montastruc1 and Haleh Bagheri1, 1Toulouse University Hospital, Clinical Pharmacology Department, University of Toulouse, Toulouse, France, 2Toulouse University Hospital, Department of Internal Medicine, University of Toulouse, INSERM UMR 1027, Toulouse, France, 3Reims University Hospital, Pharmacovigilance Regional Center, Reims, France, 4Nancy University Hospital, Pharmacovigilance Regional Center, Nancy, France, 5Nice University Hospital, Pharmacovigilance Regional Center, Nice, France

    Background/Purpose: The risk of cancer with TNF-a inhibitor (TNFi) in patients concomitantly exposed to non-biological immunosuppressants (NBIS) is highly debated in RA, AS and psoriasis/PsA.…
  • Abstract Number: 525 • 2014 ACR/ARHP Annual Meeting

    The Genetic Basis of Sjögren’s Syndrome (SS) Clinical Manifestations from Genome-Wide Association Analysis of Subphenotype Extremes in an International Cohort

    Lindsey A. Criswell1, Kimberly E. Taylor2,3, Quenna Wong4, David M. Levine4, Caitlin McHugh4, Cathy Laurie4, Kimberly Doheny5, Mi Y. Lam6, Alan N. Baer7, Stephen Challacombe8, Yi Dong9, Hector Lanfranchi10, Morten Schiødt11, M. Srinivasan12, Susumu Sugai13, Hisanori Umehara14, Frederick B. Vivino15, Zhao Yan16, Stephen Shiboski17, Troy Daniels18, John S. Greenspan6, Caroline H. Shiboski6 and Sjögren's Syndrome Collaborative Clinical Alliance (SICCA)19, 1Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 2Medicine, University of California San Francisco, San Francisco, CA, 3University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 4University of Washington, Biostatistics, Seattle, WA, 5Center for Inherited Disease Research, Baltimore, MD, 6Orofacial Sciences, University of California San Francisco, San Francisco, CA, 7Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 8Kings College London, London, United Kingdom, 9Dept of Rheumatology, Peking Univ Med Coll Hospital, East City Beijing, China, 10University of Buenos Aires, Buenos Aires, Argentina, 11Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark, 12Aravind Eye Hospital, Madurai, India, 13Kanazawa Medical University, Ishikawa, Japan, 14Internal Medicine, Division of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan, 15Medicine, Penn Presbyt Med Ctr, Philadelphia, PA, 16Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, 17Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, 18Orofacial Sciences, Box 0422, University of California San Francisco, San Francisco, CA, 19University of California San Francisco, San Francisco, CA

    Background/Purpose Our goal is to define the contribution of genetic factors to two hallmark manifestations of SS, keratoconjunctivitis sicca (KCS) and focal lymphocytic sialadenitis (FLS),…
  • Abstract Number: 1612 • 2013 ACR/ARHP Annual Meeting

    Rituximab For Treatment Of Refractory Auto-Immune Hepatitis

    Chadi Rakieh1, Edward M. Vital2, Paul Emery3 and Michael Martin1, 1Rheumatology, Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom, 2Section of Musculoskeletal Disease, Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom, 3Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom

    Background/Purpose: Auto-immune hepatitis (AIH), also known as lupoid hepatitis, is a chronic progressive disease of unknown aetiology. First-line therapy consists of corticosteroids alone or in…
  • Abstract Number: 1046 • 2013 ACR/ARHP Annual Meeting

    Comparison Of The Incidence Of Influenza Like Illness In Pregnant Women With Rheumatoid Arthritis and Women Without Rheumatoid Arthritis Who Receive An Influenza Vaccination

    Yunjun Luo1, Diana L. Johnson2, Ronghui Xu3 and Christina D. Chambers1, 1Pediatrics, University of California, San Diego, La Jolla, CA, 2University of California San Diego Department of Pediatrics, La Jolla, CA, 3Family and Preventive Medicine, University of California, San Diego, La Jolla, CA

    Background/Purpose: Influenza infection poses significant risk to pregnant women, therefore it is recommended that all pregnant women be vaccinated. However, it is unknown whether the…
  • Abstract Number: 848 • 2013 ACR/ARHP Annual Meeting

    Human Papillomavirus Vaccine Uptake Among Children and Young Adults With Autoimmune Diseases

    Candace H. Feldman1, Linda T. Hiraki2, Joyce Lii3 and Seoyoung C. Kim4, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 3Department of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 4Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Autoimmune diseases such as lupus and inflammatory bowel disease are associated with increased rates of human papillomavirus (HPV), the most common sexually transmitted disease…
  • Abstract Number: L17 • 2013 ACR/ARHP Annual Meeting

    Safety and Immunogenicity of Inactivated Varicella-Zoster Virus Vaccine in Adults with Autoimmune Disease

    Lawrence McAdam1, Michael Eberhardson2, William Grainger3, Kim Papp4, Stephen Hall5, Tina Sterling6, Jon Stek6, Lei Pang6, Yanli Zhao6, Ivan Chan6, Richard Haupt6, Janie Parrino6 and Jeffrey Silber6, 1Advanced Rheumatology, Infusion and Clinical Research Center, Thousand Oaks, CA, 2Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Neurological Physicians of Arizona, Gilbert, AZ, 4K. Papp Clinical Research,, Waterloo, ON, Canada, 5Emeritus Research, Malvern, Australia, 6Merck & Co., Inc., Whitehouse Station, NJ

    Background/Purpose: Patients with autoimmune diseases are often immunocompromised, resulting in higher incidence of HZ than in immunocompetent individuals with significant morbidity and occasional mortality from…
  • Abstract Number: 154 • 2013 ACR/ARHP Annual Meeting

    Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina

    Paula S. Ramos1, Nathan Titus2, Satria Sajuthi3, Jasmin Divers3, Yiqi Huang4, Uma Nayak5, Wei-Min Chen5, Kelly J. Hunt6, Diane L. Kamen7, Gary S. Gilkeson7, Jyotika K. Fernandes8, Ida J. Spruill8, W. Timothy Garvey9, Michèle M. Sale4 and Carl D. Langefeld3, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 4Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 5Public Health Sciences, University of Virginia, Charlottesville, VA, 6Public Health Sciences, Medical University of South Carolina, Charleston, SC, 7Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 8Medical University of South Carolina, Charleston, SC, 9Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Most autoimmune diseases (ADs) are more prevalent in specific ethnic groups. We hypothesize that one reason for the ethnic disparity may be an effect…
  • Abstract Number: 2655 • 2013 ACR/ARHP Annual Meeting

    Therapeutic Effect Of β2GPI and Its Synthetic derivative  Loaded Tolerogenic Dendritic Cells In Experimental Antiphospholipid Syndrome, Is Associated With miRNA 23b, 142-3p and 221 Expression and Tregs Upregulation

    Miri Blank1, Silvia S. Pierangeli2, Honorio Torres-Aguilar3 and Yehuda Shoenfeld4, 1Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Ramat Gan, Israel, 2Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, 3National Center for Blood Transfusion, Mexico City, Mexico, 4Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel

    Background/Purpose: The importance of beta-glycoprotein I (beta2GPI)-specific CD4+ T cells in the development of pathogenic processes in patients with antiphospholipid syndrome (APS) and APS mice…
  • Abstract Number: 2555 • 2013 ACR/ARHP Annual Meeting

    Development and Validation Of a Questionnaire To Screen For The Presence Of Autoimmune Disease

    Alan Boroway1, Aileen M. Davis2, Carolina Landolt-Marticorena1 and Joan E. Wither3, 1Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 2Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 31E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose:   Healthy family members of patients with systemic autoimmune rheumatic diseases (SARDs) are at higher risk of developing autoimmune disease than the general population. …
  • Abstract Number: 2044 • 2013 ACR/ARHP Annual Meeting

    Birth Outcomes In Childbearing Women Treated With Thiopurines: A Meta-Analysis

    Zeinab F. Saleh1, Raveendhara R. Bannuru2, William F. Harvey2 and Timothy E. McAlindon3, 1Adult Rheumatology, Tufts Medical Center, Boston, MA, 2Rheumatology, Tufts Medical Center, Boston, MA, 3Division of Rheumatology, Tufts Medical Center, Boston, MA

     Background/Purpose: The thiopurines azathioprine (AZA) and 6-mercaptopurine (6-MP) are effective treatments for many rheumatic and autoimmune conditions. These medications have a category D classification from…
  • Abstract Number: 1914 • 2013 ACR/ARHP Annual Meeting

    Patient and Physician Perspectives On Family Planning and Pregnancy Issues In Systemic Inflammatory Diseases: Mind The Gap!

    Megan E. B. Clowse1, Eliza Chakravarty2, Daphnee S. Pushparajah3, Sarah Mertens3 and Caroline Gordon4, 1Duke University Medical Center, Durham, NC, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3UCB Pharma, Brussels, Belgium, 4School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Autoimmune and inflammatory diseases often affect women of reproductive age and can impact pregnancy outcomes. This patient (pt) group has important concerns about family…
  • Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting

    Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis

    Paulina Chalan1, Bart-Jan Kroesen2, Kornelis S.M. van der Geest1, Minke G. Huitema1, Wayel H. Abdulahad3, Elisabeth Brouwer1 and Annemieke M.H. Boots4, 1Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…
  • Abstract Number: 2503 • 2012 ACR/ARHP Annual Meeting

    CD8+Foxp3-CD103+ Regulatory T Cells Generated Ex Vivo with TGF-β Suppress Autoimmunity Through IL-10-Dependet Mechanism

    Ya Liu1, An-Ping Xu2, David A. Horwitz3 and Song G. Zheng4, 1Medicine, USC Keck School of Medicine, Los Angeles, CA, 2Kidney disease and rheumatology, 2nd Affiliated Hospital of Sun Yat-sen University, 3Medicine-Rheumatology-Immun, Keck School of Medicine of USC, Los Angeles, CA, 4Medicine, Keck School of Medicine of USC, Los Angeles, CA

    Background/Purpose: TGF-β is crucial for induction of CD4+Foxp3+ Tregs and maintenance of immunologic tolerance. It is, however, unclear if TGF-β also induces the similar CD8+…
  • Abstract Number: 660 • 2012 ACR/ARHP Annual Meeting

    Abnormal Neutrophil Development in Human Systemic Lupus Erythematosus

    Namrata Singh1, Mariana J. Kaplan2, Philip L. Cohen3 and Michael F. Denny3, 1Internal Medicine, Temple University, Philadelphia, PA, 2Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, 3Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose: Recent research has increased the appreciation of the contributions of neutrophils to systemic lupus erythematosus (SLE).  An abnormal circulating pool of granulocytes has been…
  • Abstract Number: 2327 • 2012 ACR/ARHP Annual Meeting

    CGEN-15001, a Novel Negative Costimulatory Fusion Protein Is Effective in the Collagen-Induced Arthritis Mouse Model of Rheumatoid Arthritis

    Iris Hecht1, Kay McNamee2, Ilan Vaknin3, Anat Oren3, Joseph R. Podojil4, Galit Rotman3, Eyal Neria3, Stephen D. Miller4 and Richard O. Williams2, 1R&D, Compugen Ltd., Tel Aviv, Israel, 2Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, 3Compugen Ltd., Tel Aviv, Israel, 4Microbiology-Immunology, Northwestern University, Chicago, IL

    Background/Purpose: CGEN-15001 is a recombinant Fc fusion protein consisting of the extracellular domain of CGEN-15001T, a protein predicted to be a member of the B7/CD28…
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