ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 2182 • 2014 ACR/ARHP Annual Meeting

    Investigating the Roles of Factor H-Related Proteins in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases

    Alexandra Antonioli1, Brandon Renner2, Joshua Thurman3, V. Michael Holers4 and Jonathan Hannan4, 1Department of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Renal Division, University of Colorado School of Medicine, Aurora, CO, 4Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose Complement plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) wherein inappropriate activation of complement leads to substantial tissue damage, especially…
  • Abstract Number: 2167 • 2014 ACR/ARHP Annual Meeting

    Snapin Is Critical for Cathepsin D Activation and the Normal Lysosomal Function

    Bo Shi1, Qi Quan Huang2, Robert Birkett2, Renee E. Koessler1, Andrea Dorfleutner1, Christian Stehlik1 and Richard M. Pope1, 1Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, 2Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose:  Our recent data indicates that Snapin, a SNAP associated protein, is critical for maintaining healthy autophagy and monocytes to macrophage (MFs) differentiation which requires…
  • Abstract Number: 2555 • 2013 ACR/ARHP Annual Meeting

    Development and Validation Of a Questionnaire To Screen For The Presence Of Autoimmune Disease

    Alan Boroway1, Aileen M. Davis2, Carolina Landolt-Marticorena1 and Joan E. Wither3, 1Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 2Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 31E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose:   Healthy family members of patients with systemic autoimmune rheumatic diseases (SARDs) are at higher risk of developing autoimmune disease than the general population. …
  • Abstract Number: 2044 • 2013 ACR/ARHP Annual Meeting

    Birth Outcomes In Childbearing Women Treated With Thiopurines: A Meta-Analysis

    Zeinab F. Saleh1, Raveendhara R. Bannuru2, William F. Harvey2 and Timothy E. McAlindon3, 1Adult Rheumatology, Tufts Medical Center, Boston, MA, 2Rheumatology, Tufts Medical Center, Boston, MA, 3Division of Rheumatology, Tufts Medical Center, Boston, MA

     Background/Purpose: The thiopurines azathioprine (AZA) and 6-mercaptopurine (6-MP) are effective treatments for many rheumatic and autoimmune conditions. These medications have a category D classification from…
  • Abstract Number: 1914 • 2013 ACR/ARHP Annual Meeting

    Patient and Physician Perspectives On Family Planning and Pregnancy Issues In Systemic Inflammatory Diseases: Mind The Gap!

    Megan E. B. Clowse1, Eliza Chakravarty2, Daphnee S. Pushparajah3, Sarah Mertens3 and Caroline Gordon4, 1Duke University Medical Center, Durham, NC, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3UCB Pharma, Brussels, Belgium, 4School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Autoimmune and inflammatory diseases often affect women of reproductive age and can impact pregnancy outcomes. This patient (pt) group has important concerns about family…
  • Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting

    Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis

    Paulina Chalan1, Bart-Jan Kroesen2, Kornelis S.M. van der Geest1, Minke G. Huitema1, Wayel H. Abdulahad3, Elisabeth Brouwer1 and Annemieke M.H. Boots4, 1Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…
  • Abstract Number: 1612 • 2013 ACR/ARHP Annual Meeting

    Rituximab For Treatment Of Refractory Auto-Immune Hepatitis

    Chadi Rakieh1, Edward M. Vital2, Paul Emery3 and Michael Martin1, 1Rheumatology, Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom, 2Section of Musculoskeletal Disease, Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom, 3Division of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, LTHT, Leeds, United Kingdom, Leeds, United Kingdom

    Background/Purpose: Auto-immune hepatitis (AIH), also known as lupoid hepatitis, is a chronic progressive disease of unknown aetiology. First-line therapy consists of corticosteroids alone or in…
  • Abstract Number: 1046 • 2013 ACR/ARHP Annual Meeting

    Comparison Of The Incidence Of Influenza Like Illness In Pregnant Women With Rheumatoid Arthritis and Women Without Rheumatoid Arthritis Who Receive An Influenza Vaccination

    Yunjun Luo1, Diana L. Johnson2, Ronghui Xu3 and Christina D. Chambers1, 1Pediatrics, University of California, San Diego, La Jolla, CA, 2University of California San Diego Department of Pediatrics, La Jolla, CA, 3Family and Preventive Medicine, University of California, San Diego, La Jolla, CA

    Background/Purpose: Influenza infection poses significant risk to pregnant women, therefore it is recommended that all pregnant women be vaccinated. However, it is unknown whether the…
  • Abstract Number: 848 • 2013 ACR/ARHP Annual Meeting

    Human Papillomavirus Vaccine Uptake Among Children and Young Adults With Autoimmune Diseases

    Candace H. Feldman1, Linda T. Hiraki2, Joyce Lii3 and Seoyoung C. Kim4, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 3Department of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 4Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Autoimmune diseases such as lupus and inflammatory bowel disease are associated with increased rates of human papillomavirus (HPV), the most common sexually transmitted disease…
  • Abstract Number: L17 • 2013 ACR/ARHP Annual Meeting

    Safety and Immunogenicity of Inactivated Varicella-Zoster Virus Vaccine in Adults with Autoimmune Disease

    Lawrence McAdam1, Michael Eberhardson2, William Grainger3, Kim Papp4, Stephen Hall5, Tina Sterling6, Jon Stek6, Lei Pang6, Yanli Zhao6, Ivan Chan6, Richard Haupt6, Janie Parrino6 and Jeffrey Silber6, 1Advanced Rheumatology, Infusion and Clinical Research Center, Thousand Oaks, CA, 2Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Neurological Physicians of Arizona, Gilbert, AZ, 4K. Papp Clinical Research,, Waterloo, ON, Canada, 5Emeritus Research, Malvern, Australia, 6Merck & Co., Inc., Whitehouse Station, NJ

    Background/Purpose: Patients with autoimmune diseases are often immunocompromised, resulting in higher incidence of HZ than in immunocompetent individuals with significant morbidity and occasional mortality from…
  • Abstract Number: 154 • 2013 ACR/ARHP Annual Meeting

    Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina

    Paula S. Ramos1, Nathan Titus2, Satria Sajuthi3, Jasmin Divers3, Yiqi Huang4, Uma Nayak5, Wei-Min Chen5, Kelly J. Hunt6, Diane L. Kamen7, Gary S. Gilkeson7, Jyotika K. Fernandes8, Ida J. Spruill8, W. Timothy Garvey9, Michèle M. Sale4 and Carl D. Langefeld3, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 4Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 5Public Health Sciences, University of Virginia, Charlottesville, VA, 6Public Health Sciences, Medical University of South Carolina, Charleston, SC, 7Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 8Medical University of South Carolina, Charleston, SC, 9Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Most autoimmune diseases (ADs) are more prevalent in specific ethnic groups. We hypothesize that one reason for the ethnic disparity may be an effect…
  • Abstract Number: 2655 • 2013 ACR/ARHP Annual Meeting

    Therapeutic Effect Of β2GPI and Its Synthetic derivative  Loaded Tolerogenic Dendritic Cells In Experimental Antiphospholipid Syndrome, Is Associated With miRNA 23b, 142-3p and 221 Expression and Tregs Upregulation

    Miri Blank1, Silvia S. Pierangeli2, Honorio Torres-Aguilar3 and Yehuda Shoenfeld4, 1Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Ramat Gan, Israel, 2Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, 3National Center for Blood Transfusion, Mexico City, Mexico, 4Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel

    Background/Purpose: The importance of beta-glycoprotein I (beta2GPI)-specific CD4+ T cells in the development of pathogenic processes in patients with antiphospholipid syndrome (APS) and APS mice…
  • Abstract Number: 936 • 2012 ACR/ARHP Annual Meeting

    Autoimmune Diseases: Declining Mortality Between 1999 and 2008 However Continuing to be a Leading Cause of Death in Children-A 10-Year Retrospective Review

    Eric Y. Yen1 and Deborah K. McCurdy2, 1Pediatrics/Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, 2Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA

    Background/Purpose: Autoimmune diseases are chronic illnesses that cause significant and chronic disability in children and may lead to death. Using mortality data from 1995, Walsh…
  • Abstract Number: 729 • 2012 ACR/ARHP Annual Meeting

    Apolipoprotein L1 Risk Variants Underlie Racial Disparities in Lupus Nephritis-Induced End-Stage Renal Disease

    Robert P. Kimberly1, Barry I. Freedman2, Carl D. Langfeld3, Devin Absher4, Kelly K. Andringa1, Daniel Birmingham5, Elizabeth E. Brown6, Mary E. Comeau7, Karen H. Costenbader8, Lindsey A. Criswell9, Jeffrey C. Edberg10, John B. Harley11, Judith A. James12, Diane L. Kamen13, Joan T. Merrill14, Timothy B. Niewold15, Neha Patel16, Michelle Petri17, Rosalind Ramsey-Goldman18, Jane E. Salmon19, Mark Segal20, Kathy Moser Sivils12, Betty P. Tsao21, Bruce A. Julian1 and Lupus Nephritis-ESRD Consortium22, 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Biostatistics, Wake Forest University Health Sciences, Winston-Salem, NC, 4HudsonAlpha Institute for Biotechnology, Huntsville, AL, 5Medicine, Ohio State University Medical Center, Columbus, OH, 6University of Alabama at Birmingham, Birmingham, AL, 7Wake Forest University Health Sciences, Winston-Salem, NC, 8Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 9Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, 10Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 11Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Oklahoma Medical Research Foundation, Oklahoma City, OK, 13Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, 14Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 16Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, 17Johns Hopkins University School of Medicine, Baltimore, MD, 18Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 19Rheumatology, Hospital for Special Surgery, New York, NY, 20Medicine/Nephrology, University of Florida, Gainesville, FL, 21Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, 22Medicine, Birmingham, AL

    Background/Purpose: The G1 and G2 coding variants in the apolipoprotein L1 gene (APOL1;  G1: a compound missense allele (glycine-342/methionine-384) and G2: an in-frame deletion (deletion…
  • Abstract Number: 671 • 2012 ACR/ARHP Annual Meeting

    Differences in the SLE Clinical Phenotype by Age of Diagnosis

    T. Clark Powell1, Elizabeth E. Brown on behalf of PROFILE2, Gerald McGwin Jr.3, Luis M. Vila4, Yesenia C. Santiago-Casas4, Michelle Petri5, Rosalind Ramsey-Goldman6, John D. Reveille7, Sergio Duran8, Sergio M.A. Toloza9, Robin L. Brey10, Agustin Escalante11, Randy Q. Cron12, Robert P. Kimberly on behalf of PROFILE investigators13 and Graciela S. Alarcon14, 1Medicine, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 4Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 5Johns Hopkins University School of Medicine, Baltimore, MD, 6Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 7Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, 8UIECD, Guadalajara, Mexico, Guadalajara, Mexico, 9Medicine, Hospital San Juan Bautista, Catamarca, Argentina, 10Medicine/Neurology, UTHSCSA, San Antonio, TX, 11Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 12Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 13Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 14Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the presence of antinuclear autoantibodies, complement activation and the formation and…
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