ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting

    Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE

    Hanna Kim1, Yin Liu2, Adriana Almeida de Jesus1, Robert Wesley3, Yan Huang1, Gina A. Montealegre Sanchez1, Dawn C. Chapelle1, Wanxia L. Tsai4, Massimo G. Gadina4, Frederick W. Miller5, Sarfaraz Hasni6, Adeline Vanderver7, Lisa G Rider5 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 2Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 3Clinical Center, National Institutes of Health, Bethesda, MD, 4Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 5Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Pediatric Neurology, Children's National Medical Center, Washington, DC

    Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1  and juvenile dermatomyositis…
  • Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting

    Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements

    Rebecca Baum1, Shruti Sharma1, Ann Marshak-Rothstein1, Katherine A. Fitzgerald1 and Ellen M. Gravallese2, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…
  • Abstract Number: 2585 • 2015 ACR/ARHP Annual Meeting

    Serum 14-3-3η Is an RA Specific Mechanistic Marker

    Bidisha Dasgupta1, Yauheniya Cherkas1, Sarah Lamberth1, Karen Hayden1, Carrie Brodmerkel1, Anthony Marotta2 and Mark Curran1, 1Janssen Research & Development, LLC., Spring House, PA, 2Augurex Life Sciences Corp., Vancouver, BC, Canada

    Background/Purpose: 14-3-3η is an emerging soluble Rheumatoid Arthritis (RA) biomarker that activates intracellular pathways that lead to the upregulation of inflammatory and joint damage factors.…
  • Abstract Number: 271 • 2015 ACR/ARHP Annual Meeting

    Investigating an Auto-Inflammatory Component of COPD That Contributes to Progressive Decline in Lung Function Despite Smoking Cessation

    Pankti Shah1, Andrew Osterburg2, Rebeca Nelson3, Ben Yaniv3, Mauricio Orozco-Levi4 and Michael Borchers3, 1Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, 2Internal Medicine Pulmonary Division, University of Cincinnati Medical Center, Cincinnati, OH, 3University of Cincinnati College of Medicine, Cincinnati, OH, 4IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain

    Background/Purpose: Most Chronic Obstructive Pulmonary Disease (COPD) cases result from amplification of normal inflammatory responses due to noxious stimuli like cigarette smoke. Yet, the mechanism by…
  • Abstract Number: 2754 • 2015 ACR/ARHP Annual Meeting

    Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics of BI 655064, an Antagonistic Anti-CD40 Antibody Following Single-Dose Administration in Chinese and Japanese Healthy Volunteers

    Jiyoon Kim1, Yasuhiro Tsuda2, Kazuhiko Yamamoto3, Ralf Thiedmann4, Corinna Schoelch4, Stephen Norris5, Steven Padula6, Juergen Steffgen4 and In-Jin Jang7, 1Boehringer Ingelheim Korea Ltd., Seoul, South Korea, 2Clinical PK/PD department, Nippon Boehringer-Ingelheim.Co.,Ltd., Kobe, Japan, 3Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, 5Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, 6Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany, 7Seoul National University Hospital, Seoul, South Korea

    Background/Purpose: The CD40-CD40L pathway may play a major role in autoimmune disorders like rheumatoid arthritis or SLE. Blocking this pathway may be a promising new…
  • Abstract Number: 280 • 2015 ACR/ARHP Annual Meeting

    The Fascia Is a Target Organ of Inflammation in Autoimmune Diseases

    Kentaro Noda, Ken Yoshida, Taro Ukichi, Kazuhiro Furuya, Kenichiro Hirai, Isamu Kingetsu and Daitaro Kurosaka, Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose: We previously reported that inflammation occurred early in the fascia of patients with dermatomyositis. We often encounter patients with autoimmune diseases who present with…
  • Abstract Number: 3158 • 2015 ACR/ARHP Annual Meeting

    Impact of Family History of Systemic Lupus Erythematosus on Risk of Autoimmune Diseases: National Cohort Study in Denmark 1977-2012

    Constance Jensina Ulff-Møller1, Jacob Simonsen2, Søren Jacobsen1 and Morten Frisch2, 1Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 2Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease (AID), which develops through the interplay of genetic, epigenetic and environmental factors and may cluster…
  • Abstract Number: 387 • 2015 ACR/ARHP Annual Meeting

    Features of 847 Childhood-Onset Systemic Lupus Erythematousus Patients in Three Age-Related Groups at Diagnosis: A Brazilian Multicenter Study

    Clovis A Silva1, Roberta C. Gomes Sr.2, Marco F. Silva3, Katia T. Kozu4, Eloisa Bonfá5, Rosa M R Pereira6, Maria Teresa Terreri7, Claudia S. Magalhães Sr.8, Silvana B. Sacchetti Sr.9, Roberto Marini Sr.10, Melissa Fraga11, Luciana M. Carvalho Sr.12, Cássia M. Barbosa13 and Magda Carneiro-Sampaio Sr.14, 1Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 2Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Pediatric Rheumatology Unit-Children’s Institute,, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 4Pediatrics, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 5Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 6Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 7Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, 8Pediatric Rheumatology Unit, São Paulo State University – Faculdade de Medicina de Botucatu, São Paulo, Brazil, 9Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil, 10Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, 11Pediatrics, Universidade Federal de São Paulo / UNIFESP, São Paulo, Brazil, 12Pediatric Rheumatology Unit, Ribeirão Preto Medical School – University of São Paulo, São Paulo, Brazil, 13Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, São Paulo, Brazil, 14Pediatric Allergology and Immunology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Previous retrospective evaluations suggested that age at diagnosis may influence disease expression in terms of initial clinical presentation, pattern of organ involvement and serological…
  • Abstract Number: 826 • 2015 ACR/ARHP Annual Meeting

    Systemic Sclerosis Inpatient Mortality Has Not Improved from 1995-2011. Results from a National Irish Audit of Scleroderma Co-Morbidities.

    Len Harty1, Deirdre Fitzgerald2, Michael Henry2, John Ryan3 and Sinead Harney3, 1Cork University Hospital, Cork, Ireland, 2Respiratory, Cork University Hospital, Cork, Ireland, 3Rheumatology, Cork University Hospital, Cork, Ireland

    Background/Purpose: Despite the advent of potent immunosuppressive and vasoactive therapies it is not clear that longevity of patients with systemic sclerosis (SSc) has improved. Therefore…
  • Abstract Number: 1033 • 2015 ACR/ARHP Annual Meeting

    Novel Ligand-Independent Peptide Inhibitors of Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) and T Cell Receptor (TCR): Efficacy in a Collagen-Induced Arthritis Model Suggests New Targeted Treatment for Rheumatoid Arthritis

    Zu T. Shen and Alexander B. Sigalov, SignaBlok, Inc., Shrewsbury, MA

    Background/Purpose: Macrophages and T cells are central to the pathophysiology of autoimmune diseases. Synovial macrophages, synovial fibroblasts and infiltrating T lymphocytes are the most abundant…
  • Abstract Number: 1224 • 2015 ACR/ARHP Annual Meeting

    Infection Rate in HIV Patients Who Received TNF-a Inhibitor Therapy for Concomitant Autoimmune Diseases

    Sintawat Wangsiricharoen1, Colin Ligon2, Ahmad Dehrab3, Lydia Gedmintas4, Marisa Tungsiripat5, Clifton Bingham6, Carlos J. Lozada7 and Leonard H. Calabrese8, 1Chiang Mai University, Chiang Mai, Thailand, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Rheumatology, University of Miami Jackson Memorial Hospital, Miami, FL, 4Rheumatology, Brigham's Women's Hospital, Boston, MA, 5Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH, 6Johns Hopkins University, Baltimore, MD, 7University of Miami Miller School of Medicine, Miami, FL, 8Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Few HIV-infected patients have been treated with tumor necrosis factor (TNF)-α inhibitor therapy for autoimmune diseases refractory to conventional therapies. Evidence supporting the safety…
  • Abstract Number: 1356 • 2015 ACR/ARHP Annual Meeting

    Autoimmune Manifestations in Hepatitis C: A Single-Centered Experience

    Azza Ali1, Reshma Khan1, Kirthi Lilley2, Paul Naylor2, Rajaie Namas1 and Malini Venkatram1, 1Rheumatology, Wayne State University, Detroit, MI, 2Gastroenterology, Wayne State University, Detroit, MI

    Background/Purpose: Hepatitis C infection (HCV) is a leading cause of chronic liver disease. It is associated with a plethora of autoimmune manifestations including clinical, serological…
  • Abstract Number: 1416 • 2015 ACR/ARHP Annual Meeting

    Postoperative Complications Rate in Orthopaedic Surgery Performed in Rheumatic Patients in Use of Biologic Agents

    Clarissa Queiroz Pimentel1, Luiz Eduardo de Paula1, Ana Paula Luppino-Assad2, Gilberto Luis Camanho3, Eloisa Bonfá4 and Marco Antonio Gonçalves Pontes Filho1, 1Division of Rheumatology, University of São Paulo Medical School, São Paulo, Brazil, 2Division of Rheumatology, University of São Paulo, sao paulo, Brazil, 3Division of Orthopedics, University of São Paulo Medical School, São Paulo, Brazil, 4Rheumatology, University of São Paulo, São Paulo, Brazil, Sao Paulo, Brazil

    Background/Purpose: Biologic agents have been associated with an increased risk of infection, thrombosis and delayed wound healing. However, there is no definitive consensus on suspension…
  • Abstract Number: 1512 • 2015 ACR/ARHP Annual Meeting

    Incidence of Co-Morbid Autoimmune Diseases in Patients with Rheumatoid Arthritis

    TA Simon1, H Kawabata1, JM Esdaile2, V Moorthy3 and S Suissa4, 1Bristol-Myers Squibb, Hopewell, NJ, 2Arthritis Research Canada, Vancouver, BC, Canada, 3Mu Sigma, Northbrook, IL, 4McGill University, Montreal, QC, Canada

    Background/Purpose: Rheumatoid arthritis (RA) is one of more than 80 different types of autoimmune diseases, many of which, including RA, share common pathogenic mechanisms, resulting…
  • Abstract Number: 1762 • 2015 ACR/ARHP Annual Meeting

    Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model

    Toshiki Eri1, Kimito Kawahata2, Ei Bannai1, Takeyuki Kanzaki3, Lisa Akahira1, Kazuya Michishita1 and Kazuhiko Yamamoto1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 3Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan

    Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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