ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 1356 • 2015 ACR/ARHP Annual Meeting

    Autoimmune Manifestations in Hepatitis C: A Single-Centered Experience

    Azza Ali1, Reshma Khan1, Kirthi Lilley2, Paul Naylor2, Rajaie Namas1 and Malini Venkatram1, 1Rheumatology, Wayne State University, Detroit, MI, 2Gastroenterology, Wayne State University, Detroit, MI

    Background/Purpose: Hepatitis C infection (HCV) is a leading cause of chronic liver disease. It is associated with a plethora of autoimmune manifestations including clinical, serological…
  • Abstract Number: 1416 • 2015 ACR/ARHP Annual Meeting

    Postoperative Complications Rate in Orthopaedic Surgery Performed in Rheumatic Patients in Use of Biologic Agents

    Clarissa Queiroz Pimentel1, Luiz Eduardo de Paula1, Ana Paula Luppino-Assad2, Gilberto Luis Camanho3, Eloisa Bonfá4 and Marco Antonio Gonçalves Pontes Filho1, 1Division of Rheumatology, University of São Paulo Medical School, São Paulo, Brazil, 2Division of Rheumatology, University of São Paulo, sao paulo, Brazil, 3Division of Orthopedics, University of São Paulo Medical School, São Paulo, Brazil, 4Rheumatology, University of São Paulo, São Paulo, Brazil, Sao Paulo, Brazil

    Background/Purpose: Biologic agents have been associated with an increased risk of infection, thrombosis and delayed wound healing. However, there is no definitive consensus on suspension…
  • Abstract Number: 1512 • 2015 ACR/ARHP Annual Meeting

    Incidence of Co-Morbid Autoimmune Diseases in Patients with Rheumatoid Arthritis

    TA Simon1, H Kawabata1, JM Esdaile2, V Moorthy3 and S Suissa4, 1Bristol-Myers Squibb, Hopewell, NJ, 2Arthritis Research Canada, Vancouver, BC, Canada, 3Mu Sigma, Northbrook, IL, 4McGill University, Montreal, QC, Canada

    Background/Purpose: Rheumatoid arthritis (RA) is one of more than 80 different types of autoimmune diseases, many of which, including RA, share common pathogenic mechanisms, resulting…
  • Abstract Number: 1762 • 2015 ACR/ARHP Annual Meeting

    Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model

    Toshiki Eri1, Kimito Kawahata2, Ei Bannai1, Takeyuki Kanzaki3, Lisa Akahira1, Kazuya Michishita1 and Kazuhiko Yamamoto1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 3Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan

    Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
  • Abstract Number: 1937 • 2015 ACR/ARHP Annual Meeting

    Dalazatide (ShK-186), a First-in-Class Blocker of Kv1.3 Potassium Channel on Effector Memory T Cells: Safety, Tolerability and Proof of Concept of Immunomodulation in Patients with Active Plaque Psoriasis

    Ernesto J. Munoz-Elias1, David Peckham1, Kayla Norton1, Judilyn Duculan2, Inna Cueto2, Xuan Li3, James Qin4, Kurt Lustig5, Eric Tarcha1, Jared Odegard4, James G. Krueger2 and Shawn P. Iadonato1, 1Kineta Inc, Seattle, WA, 2Rockefeller University, New York, NY, 3Rockefeller University, New York, WA, 4Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Kineta Inc., Seattle, WA

    Background/Purpose: Effector memory T cells of both CD4 and CD8 lineages are key drivers of autoimmunity and are pathogenic in several autoimmune diseases including psoriasis,…
  • Abstract Number: 1947 • 2015 ACR/ARHP Annual Meeting

    Hypermethylation of Treg-Specific Demethylated Regions in the Ikaros Transcription Factor Family Members, Helios and Eos, in Rheumatoid Arthritis Tregs

    Alla Skapenko1, Viktoria Soentgerath1, Sonja Haupt2, Jan Leipe1 and Hendrik Schulze-Koops1, 1Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany

    Background/Purpose: Foxp3 is the signature transcription factor of regulatory T cells (Tregs) and facilitates many of the characteristic functions of Tregs. Members of the Ikaros…
  • Abstract Number: 2101 • 2015 ACR/ARHP Annual Meeting

    HLA Associations in Mothers of Children with Cardiac Manifestations of Neonatal Lupus

    Hannah C. Ainsworth1, Carl D. Langefeld1, Miranda C. Marion2, Nathalie Costedoat-Chalumeau3, Antonio Brucato4, Jill P. Buyon5 and Robert M. Clancy5, 1Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 2Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University Health Sciences, Winston-Salem, NC, 3Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, 4Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, 5Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Cardiac manifestations of neonatal lupus, comprising atrioventricular conduction defects and cardiomyopathy, occur in fetuses exposed to anti-Ro/SSA antibodies, and carry substantial mortality. There is…
  • Abstract Number: 2125 • 2015 ACR/ARHP Annual Meeting

    Rheumatic and Non-Rheumatic Autoimmune Diseases in SLE Offspring

    Julie Couture1, Sasha Bernatsky2, Susan Scott3, Christian A. Pineau2 and Evelyne Vinet2, 1McGill University Health Centre, Montreal, QC, Canada, 2Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 3Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Autoimmune diseases (AID) have familial aggregation and frequently share a common genetic predisposition. Only few small uncontrolled studies have evaluated the risk of AID…
  • Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting

    Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE

    Hanna Kim1, Yin Liu2, Adriana Almeida de Jesus1, Robert Wesley3, Yan Huang1, Gina A. Montealegre Sanchez1, Dawn C. Chapelle1, Wanxia L. Tsai4, Massimo G. Gadina4, Frederick W. Miller5, Sarfaraz Hasni6, Adeline Vanderver7, Lisa G Rider5 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 2Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 3Clinical Center, National Institutes of Health, Bethesda, MD, 4Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 5Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Pediatric Neurology, Children's National Medical Center, Washington, DC

    Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1  and juvenile dermatomyositis…
  • Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting

    Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements

    Rebecca Baum1, Shruti Sharma1, Ann Marshak-Rothstein1, Katherine A. Fitzgerald1 and Ellen M. Gravallese2, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…
  • Abstract Number: 2585 • 2015 ACR/ARHP Annual Meeting

    Serum 14-3-3η Is an RA Specific Mechanistic Marker

    Bidisha Dasgupta1, Yauheniya Cherkas1, Sarah Lamberth1, Karen Hayden1, Carrie Brodmerkel1, Anthony Marotta2 and Mark Curran1, 1Janssen Research & Development, LLC., Spring House, PA, 2Augurex Life Sciences Corp., Vancouver, BC, Canada

    Background/Purpose: 14-3-3η is an emerging soluble Rheumatoid Arthritis (RA) biomarker that activates intracellular pathways that lead to the upregulation of inflammatory and joint damage factors.…
  • Abstract Number: 271 • 2015 ACR/ARHP Annual Meeting

    Investigating an Auto-Inflammatory Component of COPD That Contributes to Progressive Decline in Lung Function Despite Smoking Cessation

    Pankti Shah1, Andrew Osterburg2, Rebeca Nelson3, Ben Yaniv3, Mauricio Orozco-Levi4 and Michael Borchers3, 1Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, 2Internal Medicine Pulmonary Division, University of Cincinnati Medical Center, Cincinnati, OH, 3University of Cincinnati College of Medicine, Cincinnati, OH, 4IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain

    Background/Purpose: Most Chronic Obstructive Pulmonary Disease (COPD) cases result from amplification of normal inflammatory responses due to noxious stimuli like cigarette smoke. Yet, the mechanism by…
  • Abstract Number: 2754 • 2015 ACR/ARHP Annual Meeting

    Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics of BI 655064, an Antagonistic Anti-CD40 Antibody Following Single-Dose Administration in Chinese and Japanese Healthy Volunteers

    Jiyoon Kim1, Yasuhiro Tsuda2, Kazuhiko Yamamoto3, Ralf Thiedmann4, Corinna Schoelch4, Stephen Norris5, Steven Padula6, Juergen Steffgen4 and In-Jin Jang7, 1Boehringer Ingelheim Korea Ltd., Seoul, South Korea, 2Clinical PK/PD department, Nippon Boehringer-Ingelheim.Co.,Ltd., Kobe, Japan, 3Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, 5Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, 6Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany, 7Seoul National University Hospital, Seoul, South Korea

    Background/Purpose: The CD40-CD40L pathway may play a major role in autoimmune disorders like rheumatoid arthritis or SLE. Blocking this pathway may be a promising new…
  • Abstract Number: 280 • 2015 ACR/ARHP Annual Meeting

    The Fascia Is a Target Organ of Inflammation in Autoimmune Diseases

    Kentaro Noda, Ken Yoshida, Taro Ukichi, Kazuhiro Furuya, Kenichiro Hirai, Isamu Kingetsu and Daitaro Kurosaka, Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose: We previously reported that inflammation occurred early in the fascia of patients with dermatomyositis. We often encounter patients with autoimmune diseases who present with…
  • Abstract Number: 3158 • 2015 ACR/ARHP Annual Meeting

    Impact of Family History of Systemic Lupus Erythematosus on Risk of Autoimmune Diseases: National Cohort Study in Denmark 1977-2012

    Constance Jensina Ulff-Møller1, Jacob Simonsen2, Søren Jacobsen1 and Morten Frisch2, 1Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 2Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease (AID), which develops through the interplay of genetic, epigenetic and environmental factors and may cluster…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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