ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 374 • 2019 ACR/ARP Annual Meeting

    The INBUILD Trial of Nintedanib in Patients with Progressive Fibrosing Interstitial Lung Diseases: Subgroup with Autoimmune Diseases

    Eric Matteson1, Clive Kelly 2, Jörg Distler 3, Anna Maria Hoffmann-Vold 4, James Seibold 5, Shikha Mittoo 6, Oliver Distler 7, Rainer-Georg Goeldner 8, Rozsa Schlenker-Herceg 9, Susanne Stowasser 10, Manuel Quaresma 10 and Kevin Flaherty 11, 1Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, Rochester, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, Newcastle, United Kingdom, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 5Scleroderma Research Consultants LLC, Aiken, South Carolina, USA, Aiken, 6University Health Network, Toronto, Ontario, Canada, Toronto, Canada, 7Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 8Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, Biberach, Germany, 9Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA, Ridgefield, 10Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 11University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI

    Background/Purpose: Some patients with autoimmune disease develop progressive fibrosing interstitial lung disease (ILD) characterized by increasing fibrosis on HRCT, decline in lung function, worsening symptoms…
  • Abstract Number: 2033 • 2019 ACR/ARP Annual Meeting

    IRAK4 Inhibition Suppresses TLR7, TLR9, and SLE Serum-Induced IFNA Production in Primary Human Plasmacytoid Dendritic Cells

    Angie Hammond1, Sean Parghi 1, Nathan Wright 1, Ethan Grant 1, James Taylor 1 and Matthew Warr 1, 1Gilead Sciences, Inc., Foster City, CA

    Background/Purpose: A hallmark of lupus is the presence of antinuclear autoantibodies, including those against RNA-protein complexes and double-stranded DNA (dsDNA).1,2 FcγR-mediated internalization of these nucleic…
  • Abstract Number: 712 • 2019 ACR/ARP Annual Meeting

    Safety and Tolerability of Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease in the SENSCIS Trial: Subgroup Analysis Based on Demographic Characteristics

    Oliver Distler1, Kristin Highland 2, Maureen Mayes 3, Masataka Kuwana 4, Lesley Saketkoo 5, Madelon Vonk 6, Michael Kreuter 7, Laura Hummers 8, Ute von Wangenheim 9, Martina Gahlemann 10, Veronika Kohlbrenner 11, Margarida Alves 12, Emmanuelle Clerisme-Beaty 12 and Arata Azuma 13, 1Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 2Cleveland Clinic, Cleveland, Ohio, USA, Cleveland, OH, 3Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan, 5New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans; Tulane University School of Medicine, University Medical Center – Comprehensive Pulmonary Hypertension Center, USA, New Orleans, 6Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen, Gelderland, Netherlands, 7Center for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Member of the German Center for Lung Research, Germany, Germany, Germany, 8Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, USA, Baltimore, MD, 9Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Biberach an der Riss, 10Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, 11Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA, Ridgefield, 12Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 13Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, Tokyo, Japan

    Background/Purpose: In the SENSCIS trial in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD), the adverse events associated with nintedanib were manageable for most patients…
  • Abstract Number: 2075 • 2019 ACR/ARP Annual Meeting

    Cross-sectional Study and Mendelian Randomization Analysis of Diet in Six Prevalent Autoimmune Diseases

    Antonio Julià1, Sergio H Martinez 2, Jesús Tornero 3, Juan Cañete 4, Antonio Fernández-Nebro 5, Francisco J. Blanco 6, Jesús Rodríguez 7, Francisco Javier Lopez-Longo 8, Benjamín Fernandez-Gutierrez 9, Jordi Gratacós 10, Jose J Pérez Venegas 11, Carolina Pérez 12, Ruben Queiró 13, Alejandro Olivé-Marqués 14, Mercedes Alperi-López 15, Carlos Montilla 16, José Luís Andreu 17, Juan Carlos Torre-Alonso 18, Mª Ángeles Aguirre-Zamorano 19, Hèctor Corominas 20, Paloma Vela 21, Víctor Martínez-Taboada 22, Sara Marique 23, Joan M Nolla 24, Isidoro Gonzalez 25, Santiago Muñoz-Fernandez 26, José Luís Marenco de la Fuente 27, Carlos González 28, Antonio Zea 29, Maria Lopez Lasanta 30, Daniel Roig 31, Jose Maria Pego-Reigosa 32, Mireia Lopez Corbeto 33, Pedro Zarco 34, Mercedes Freire González 35, Alba Erra 36, Elvira Díez 37, Santos Castañeda 38, Esther Rodriguez 39, Alicia García 40, Patricia Carreira 39, Georgina Salvador 41, Ricardo Blanco 42, Cesar Diaz-Torne 43, Alfredo Willisch Domínguez 44, Joan Antonio Mosquera 45, Simón Sánchez-Fernández 46, Júlio Ramírez 47 and Sara Marsal 48, 1Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Catalonia, Spain, 2Hospital Vall d'Hebron, Barcelona, Barcelona, Spain, 3Hospital Universitario Guadalajara, Guadalajara, Spain., Guadalajara, Castilla-La Mancha, Spain, 4Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, 5Hospital Carlos Haya, Malaga, Spain, 6Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 7Hospital Universitario de Bellvitge, Hospitalet, Spain, 8Hospital Universitario Gregorio Marañón, Madrid, Madrid, Spain, 9Hospital Clínico San Carlos, Madrid, Madrid, Spain, 10Hospital Parc Taulí, Sabadell, Catalonia, Spain, 11Hospital Jerez de la Frontera, Jerez de la Frontera, Spain, 12Parc de Salut Mar, Barcelona, Barcelona, Spain, 13Hospital Universitario Central de Asturias, Oviedo, Oviedo, Spain, 14Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain, 15Hospital Universitario Central de Asturias, Oviedo, Spain, 16Hospital Clínico Universitario de Salamanca, Salamanca, Spain, 17Hospital Puerta de Hierro, Madrid, Madrid, Spain, 18Hospital Monte Naranco, Oviedo, Spain, 19IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 20Hospital de la Santa Creu i Sant Pau, Barcelona, Barcelona, Spain, 21Hospital General Universitario de Alicante, Alicante, Spain, 22Hospital Universitario Marqués de Valdecilla, Santander, Spain, 23Hospital Regional Univeristario de Málaga, Málaga, Spain, 24Hospital Universitari de Bellvitge, Hospitalet, Spain, 25Hospital Universitario La Princesa, Madrid, Spain, 26Hospital Universitario Infanta Sofía, Madrid, Madrid, Spain, 27Hospital Valme, Sevilla, Sevilla, Spain, 28Hospital Universitario Gregorio Marañón, Madrid, Spain, 29Hospital Universitario Ramón y Cajal, Madrid, Madrid, Spain, 30Hospital Universitari Vall Hebrón, Barcelona, Barcelona, Catalonia, Spain, 31Hospital Moisès Broggi, Barcelona, Sant Joan Despí, Barcelona, Singapore, 32Complexo Hospitalario Universitario, Vigo, Spain, 33Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain, 34Hospital Universitario Fundación Alcorcón, Madrid, Madrid, Spain, 35Hospital Universitario Juan Canalejo, La Coruña, Spain, 36H Sant Rafael, Barcelona, Barcelona, Spain, 37Complejo Asistencial Universitario de León, León, Castilla y Leon, Spain, 38Rheumatology, Hospital Universitario La Princesa, Madrid, Madrid, Spain, 39Hospital Universitario 12 de Octubre, Madrid, Spain, 40Centro de Salud Virgen de los Reyes, Sevilla, Sevilla, Spain, 41Hospital Mútua Terrassa, Terrassa, Spain, 42Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 43Hospital de la Santa Creu i Sant Pau, barcelona, Catalonia, Spain, 44Complexo Hospitalario de Ourense, Ourense, Spain, 45Complejo Hospitalario Hospital Provincial de Pontevedra, Pontevedra, Spain, 46Hospital La Mancha Centro, Alcázar de San Juan, Alcázar de San Juan, Spain, 47Hospital Clínic de Barcelona, Barcelona, Spain, 48Vall d’Hebron Hospital, Barcelona, Catalonia, Spain

    Background/Purpose: Autoimmune diseases (AD) are complex diseases associated with both genetic and environmental risk factors. In the last 10 years major advances have been made…
  • Abstract Number: 826 • 2019 ACR/ARP Annual Meeting

    Immune-Mediated Inflammatory Diseases (IMID) Collectively Rank Among the Leading Causes of Death

    Meifang Wu1, Eric Yen 2 and Ram Raj Singh 2, 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2UCLA, Los Angeles

    Background/Purpose: Almost every organ system can be affected by primary immune-mediated diseases characterized by inflammation and therapeutic response to immune-suppressive or anti-inflammatory drugs. These diseases…
  • Abstract Number: 2114 • 2019 ACR/ARP Annual Meeting

    Risk Factors for Cytomegalovirus Infection in Patients with Autoimmune Diseases

    Daisuke Kobayashi1, Sayuri Takamura 2, Yoko Wada 3, Takeshi Kuroda 4 and Ichiei Narita 1, 1Division of Clinical Nephrology and Rheumatology, Niigata University, Niigata, Niigata, Japan, 2Division of Clinical Nephrology and Rheumatology, Niigata University, Niigata, Japan, 3Niigata Rinko Hospital, Niigata, Niigata, Japan, 4Health administration office, Niigata University, Niigata, Niigata, Japan

    Background/Purpose: Intensive immunosuppressive treatment is often required for patients with autoimmune diseases, and those who are thus treated have a high risk of opportunistic infections.…
  • Abstract Number: 880 • 2019 ACR/ARP Annual Meeting

    Diseased Lupus Nephritis Kidneys Serve as a Primary Site of Systemic Autoimmune Development

    Matthew Woodruff1, Christopher Tipton 1, Jennifer Hom 1 and Iñaki Sanz 1, 1Emory University, Atlanta, GA

    Background/Purpose: Lupus nephritis (LN) is an autoimmune destruction of the kidney glomeruli and loss of kidney function affecting almost half of lupus patients. Although the…
  • Abstract Number: 2150 • 2019 ACR/ARP Annual Meeting

    Frequency of Polyautoimmunity in a Tertiary Hospital

    Elena Grau García1, José Ivorra Cortés 1, Jorge Juan Fragio Gil 1, Roxana Gonzalez Mazarío 1, Marta de la Rubia Navarro 1, Cristóbal Pavez Perales 1, Cristina Alcañiz Escandell 1, Inmaculada Chalmeta Verdejo 1, Luis González Puig 1, Isabel Martínez Cordellat 1, Rosa Negueroles Albuixech 1, José Eloy Oller Rodríguez 2, Francisco Miguel Ortiz-Sanjuán 1, Elvira Vicens Bernabeu 1, Carmen Nájera Herranz 1, Inés Cánovas Olmos 1, Samuel Leal Rodriguez 1 and José Andrés Román Ivorra 1, 1Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, 2Rheumatology Department. HUP La Fe, v, Comunidad Valenciana, Spain

    Background/Purpose: Polyautoimmunity (PAI) is the presence of more than one Autoimmune Disease (AID) in one patient. PAI have been reported in different AIDs as systemic…
  • Abstract Number: 1076 • 2019 ACR/ARP Annual Meeting

    Incidence of Non-serious Infections Among Live Born Infants Born to Mothers Who Used Biologic Medications During Pregnancy for the Treatment of Autoimmune Diseases

    Christina Chambers1, Yunjun Luo 2, Diana L. Johnson 2, Kenneth Lyons Jones 2 and Ronghui Xu 2, 1University of California San Diego, La Jolla, 2University of California, San Diego, La Jolla

    Background/Purpose: In infants whose mothers were treated with biologic therapies during pregnancy, there has been a theoretical concern regarding potential risk of infections.  Several recent…
  • Abstract Number: 2155 • 2019 ACR/ARP Annual Meeting

    The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3-Year-Prospective Study from a Referral Center of Lung Transplantation

    Sara Remuzgo-Martínez1, Diana Prieto-Peña 2, Mónica Calderón-Goercke 2, Victor Manuel Mora Cuesta 3, David Iturbe Fernández 1, Sonia M. Fernández Rozas 3, Jose Manuel Cifrian Martínez 3 and Miguel Angel González-Gay 4, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 2Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL; and Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, 3Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL; and Pneumology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, 4Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) occurs in approximately 15% of patients with autoimmune diseases (AD) [1]. Its presence is associated with an increased risk of…
  • Abstract Number: 1915 • 2018 ACR/ARHP Annual Meeting

    Big Data Analysis of Autoimmune Diseases Induced By Cancer Immunotherapies: Identifying Pharmacological Patterns of Organ-Specific Involvement

    Soledad Retamozo1,2,3, Alejandra Flores-Chavez4,5,6, Belchin Kostov7, Antoni Sisó-Almirall8, Marta Pérez-de-Lis9, Roberto Pérez-Alvarez10, Pilar Brito-Zerón11,12, Munther A Khamashta13 and Manuel Ramos-Casals14, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 5Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, 6Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, 7ABS Les Corts, CAPSE, Research Group in Primary Care, IDIBAPS, ABS Les Corts, CAPSE, Barcelona, Spain, 8Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC, Barcelona, Barcelona, Spain, 9Department of Anesthesia, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain, 10Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, 11Autoimmune Diseases Unit, Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, 12Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Barcelona, Spain, 13Lupus Research Unit, The Rayne Institute, Lupus Research Unit, The Rayne Institute, Kings' College London School of Medicine, St Thomas' Hospital, London, United Kingdom, 14Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona., Barcelona, Spain

    Background/Purpose: The scenario of biological-triggered autoimmune diseases has dramatically changed in recent years due to the increasing use of biologics in patients with solid cancers. Methods:…
  • Abstract Number: 2167 • 2018 ACR/ARHP Annual Meeting

    Incidence and Baseline Characteristics of Exacerbation in Patients with Interstitial Pneumonia with Autoimmune Features: A Single Center Large-Scale Cross-Sectional Cohort Study

    Okinori Murata, Nobuhito Sasaki and Makoto Maemondo, Division of Pulmonary medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan

    Background/Purpose: Patients with idiopathic interstitial pneumonia (IIP) may have features of connective tissue diseases (CTDs). The term interstitial pneumonia with autoimmune features (IPAF) has been…
  • Abstract Number: 2256 • 2018 ACR/ARHP Annual Meeting

    Rheumatic Diseases Associated with Neuromyelitis Optica Spectrum Disorders (NMOSD): Prevalence, Clinical, Laboratory and Imaging Characteristics

    Milena Rodriguez Alvarez1, Su Zhaz Leon1, Fernando Cuascut2, Naureen Kabani3, Joshy Pathiparampil3, Kristaq Koci4, Manjeet Bhamra5, Latoya Freeman4, Alexandra Kreps6, Justin Levinson6, Sophia Francis6, Vinodkumar Velayndhan6, Steve Xie7, Abhimanyu Amarnani6, Helen Valsamis8, Yaacov Anziska6, Ellen M. Ginzler9 and Isabel M. McFarlane9, 1Rheumatology, SUNY Downstate, Brooklyn, NY, 2Neurology, SUNY Downstate, Brooklyn, NY, 3Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 4Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 5Medicine, SUNY Downstate, Brooklyn, NY, 6SUNY Downstate, Brooklyn, NY, 7NYC Health + Hospitals Kings County, Brooklyn, NY, 8Neurology, NYC Health + Hospitals Kings County, Brooklyn, NY, 9Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY

     Background/Purpose: NMOSD are autoimmune disorders characterized by optic neuritis (ON), longitudinal extensive transverse myelitis (LETM), and other clinical features. Aquaporin 4 antibodies (AQP4 Ab) have…
  • Abstract Number: 2257 • 2018 ACR/ARHP Annual Meeting

    Prevalence and Distinct Clinical Phenotype of Concomitant Sarcoidosis in Other Autoimmune Rheumatic Diseases

    Kristina E.N. Clark1, Huw Beynon2, Christopher P. Denton3 and Voon H. Ong4, 1Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Department of Rheumatology, Royal Free Hospital, London, United Kingdom, 3UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 4Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Lung involvement is common in both sarcoidosis (up to 90%) and autoimmune rheumatic diseases (ARDs). Case reports have suggested distinct clinical manifestations when sarcoidosis…
  • Abstract Number: 2972 • 2018 ACR/ARHP Annual Meeting

    Multicentric Reticulohistiocytosis (1980-2017): A Rare Disease, Commonly Associated with Malignancy and Autoimmunity

    Avneek Singh Sandhu1, Cynthia S. Crowson2, David Wetter3, Gavin McKenzie4 and Ashima Makol1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 3Dermatology, Mayo Clinic, Rochester, MN, 4Radiology, Mayo Clinic, Rochester, MN

    Background/Purpose: Multicentric reticulohistiocytosis (MRH) is a systemic disease characterized by papulo-nodular skin eruptions and progressive, deforming arthritis. We aimed to examine the clinical correlates and…
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