ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 1831 • ACR Convergence 2024

    Role of Long Non-Coding RNA H19 in Mediating Skin Fibrosis in Systemic Sclerosis

    Begoña Caballero-Ruiz1, Christopher Wasson2, Rebecca Ross3 and Francesco Del Galdo2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2University of Leeds, Leeds, United Kingdom, 3Medicine and Health, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is an immune driven condition leading to skin fibrosis, as well as internal organs. Dermal fibroblasts are the key cellular elements…
  • Abstract Number: 1897 • ACR Convergence 2024

    People Living with Autoimmune Disease Are at Higher Risk of Suffering from Post-Acute Sequelae of SARS-CoV-2 but Immunization Is Protective

    Shahdi Malakooti1, Marc Abboud2, Jennifer Murphy3, Nora Singer4 and Grace McComsey5, 1MetroHealth at Case Western Reserve University, Cleveland, 2Saint Joseph Medical School, Beirut, Lebanon, 3University Hospitals, Cleveland, OH, 4MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH, 5University Hospitals at Case Western Reserve University, Cleveland

    Background/Purpose: Post-Acute Sequelae of SARS-CoV-2 (PASC) include new or worsening of existing symptoms 3 months or more after SARS-CoV-2 infection. We have shown that vaccination…
  • Abstract Number: 2049 • ACR Convergence 2024

    Genetically Proxied Glucose‑lowering Drug Target and Risk of Immune Mediated Inflammatory Disease: A Mendelian Randomization Study

    Dongze Wu1 and Yingzhao jin2, 1Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China (People's Republic), 2Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: There are conflicting findings on the relationship between glucose-lowering drugs and risk of development of immune mediated inflammatory diseases (IMIDs). The study aimed to…
  • Abstract Number: 2307 • ACR Convergence 2024

    Deep Spatial Profiling Unveils Dominant Double Negative B Cells in Severe Forms of Sjögren’s Syndrome

    Loukas chatzis1, Patrice Hemon2, Yvonne Scuiller3, Andreas Goules4, Divi Cornec5, Athanasios Tzioufas6 and Jacques-Olivier Pers3, 1Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, 2LBAI, UMR1227, Univ Brest, INSERM, Brest, France, Paris, 3LBAI, UMR1227, Univ Brest, INSERM, Brest, France, Paris, France, 4GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, 5Service de Rhumatologie, CHU de Brest, Brest, France, 6LAIKO HOSPITAL, Athens, Greece

    Background/Purpose: Imaging mass cytometry (IMC) is a powerful high throughput technique that enables in-situ multiparametric analysis of a single fixed tissue section while preserving spatial…
  • Abstract Number: 2474 • ACR Convergence 2024

    High-throughput Screening Identifies Specific Molecular Markers for ILD in Patients with Rheumatic Diseases

    Anna-Maria Hoffmann-Vold1, Vyacheslav Palchevskiy2, Phuong Phuong Diep3, Henriette Didriksen1, Mona Lovise Talaro Ramsli1, Jin Zhou4, Shahrzad Lari4, Elena Pachera5, Michael T Durheim1, Øyvind Molberg6, Oliver Distler7, S. Samuel Weigt2 and John A Belperio4, 1Oslo University Hospital, Oslo, Norway, 2University of California Los Angeles, Los Angeles, CA, 3Oslo University Hospital, Department of Respiratory Disease, Oslo, Norway, 4University of California Los Angeles, Los Angeles, 5University Hospital Zurich, Zurich, Switzerland, 6Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 7Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland

    Background/Purpose: Molecular expression patterns of lung tissue across rheumatic musculoskeletal diseases (RMDs) have not been extensively studied. Lung sampling is invasive and not always practical…
  • Abstract Number: 2614 • ACR Convergence 2024

    Risk of New Onset of Immune-Mediated Diseases After Sars-Cov-2 Infection: A Systematic Review and Meta-Analysis

    Ana Milena Gil1, Julián Barahona-Correa2, Jorge Bruce Flórez-Suárez3, Daniel Fernández-Ávila4 and Zulma Cucunubá1, 1Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia, 2Division of Rheumatology, Pontificia Universidad Javeriana - Hospital Universitario San Ignacio, Bogotá, Colombia, 3Department of Immunology, Universidad Nacional de Colombia, Bogotá, Colombia, 45Hospital San Ignacio, Colombia, BOGOTA, Colombia

    Background/Purpose: The association between SARS-CoV-2 infection and the new onset of immune-mediated diseases is a topic of interest given the conflicting evidence available. This systematic…
  • Abstract Number: 0081 • ACR Convergence 2024

    The Axial Spondyloarthritis Risk Variant CARD9 S12N Enhances Neutrophil-mediated Th Responses

    Hillary Struthers1, Kofi Asare-Konadu2, Emily Vance1 and Ruth Napier3, 1Oregon Health & Science University, Portland, OR, 2Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 3Department of Molecular Microbiology and Immunology and Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, VA Portland Health Care System, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) is a type of inflammatory arthritis that primarily affects the entheses of the spine and/or sacroiliac joints. The cause of axSpA…
  • Abstract Number: 0186 • ACR Convergence 2024

    Development of a Novel Dried Blood Spot Method to Improve Capacity for ANA Testing in Lower-Resource Settings

    Ekemini Ogbu1, Stela Florea2, Donna Diorio2, Somak Roy2, Dhriti Sharma2, Michael Henrickson2, Patricia Vega-Fernandez2, Angela Migowa3, Sarangarajan Ranganathan2 and hermine brunner1, 1Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3AGA KHAN UNIVERSITY, Nairobi, Kenya

    Background/Purpose: Timely diagnosis of children and young adults with rheumatologic disorders remains a global challenge especially in lower-resource settings. There is limited access to diagnostic…
  • Abstract Number: 0303 • ACR Convergence 2024

    Phase 2b, Long-term Extension, Dose-ranging Study of Oral JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis: FRONTIER-2

    Laura K. Ferris1, Jerry Bagel2, Yu-Huei Huang3, Andrew E. Pink4, Stephen K. Tyring5, Georgios Kokolakis6, Amy M. DeLozier7, Daniel Kakaley8, Shu Li9, Yaung-Kaung Shen10, Takayuki Ota7 and Robert Bissonnette11, 1University of Pittsburgh, Pittsburgh, PA, 2Psoriasis Treatment Center of Central NJ, East Windsor, NJ, 3Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taoyuan City, Taiwan (Republic of China), 4NHS Foundation Trust Great Maze Pond, London, United Kingdom, 5Center for Clinical Studies, Webster, TX, 6Psoriasis Research and Treatment Center, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 7Janssen Research & Development, LLC, San Diego, CA, 8Janssen Scientific Affairs, LLC, Horsham, PA, 9Janssen Research & Development, LLC, Spring House, PA/San Diego, CA, 10Janssen Research & Development, LLC, Spring House, PA, 11Innovaderm Research, Montreal, QC, Canada

    Background/Purpose: JNJ-77242113, a targeted oral peptide, inhibits IL-23 signaling by binding the IL-23 receptor. At all doses, JNJ-77242113 showed superior efficacy at Week 16 versus…
  • Abstract Number: 0433 • ACR Convergence 2024

    Male Perspective on Reproductive Health in Rheumatology Patients: A Cross-sectional Study

    Eleonora Giacobbe1, Maria Chiara Gerardi2, Clizia Gagliardi2, Sara Benedetti2, Giuseppina Di Raimondo2, Assunta Ascione3, Monica Barichello2, Nicola Ughi4, Antonella Adinolfi2, Laura Belloli2, Cinzia Casu2, Maria Di Cicco2, Davide antonio Filippini2, Matteo Longhi2, Bianca Lucia Palermo2, Martina Schettino2, Giulia Segatto2, Elisa Verduci2 and Oscar Massimiliano Epis2, 1Niguarda Hospital, Milan, Milan, Lombardia, Italy, 2Niguarda Hospital, Milan, Milan, Italy, 3Niguarda Hospital, Milan, Milan, 4Niguarda Hospital, Milan, Mila, Italy

    Background/Purpose: As reproductive health is gathering attention in rheumatology and all medical fields, the male perspective on the matter is often overlooked as not directly…
  • Abstract Number: 0667 • ACR Convergence 2024

    Early Introduction of Biologic Agents in Systemic Lupus Erythematosus Reduces Relapse and Glucocorticoid Maintenance Dose: A Cohort Study from the PLEAJURE J Registry

    Takehiro HIrayama1, Kohei Tsujimoto2, Kayoko Kaneko3, Sakiko Isojima4, Kunihiro Ichinose5, Yasunori Iwata6, Kenji Oku7, Kenei Sada8, Yoshiya Tanaka9, Ayako Nakajima10, Keishi Fujio11, Masakazu Matsushita12, Takako Miyamae13, Atsuko Murashima3 and Atsushi Kumanogoh14, 1Osaka university, Ibaraki City, Japan, 2Osaka University, Toyonaka, Osaka, Osaka, Japan, 3National Center for Child Health and Development, Setagaya, Tokyo, Japan, 4Showa Univeristy, Shinagawa, Tokyo, Japan, 5Shimane University, Izumo, Shimane, Japan, 6Kanazawa University, kanazawa, Japan, 7Kitazato University, Sagamihara, Kanagawa, Japan, 8Department of Clinical Epidemiology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan, 9Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 10Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan, 11Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Bunkyo, Tokyo, Japan, 12Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan., TOKYO, Japan, 13Tokyo Women's Medical University, Tokyo, Japan, 14Osaka University, Osaka, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with diverse clinical manifestations and organ involvement, posing significant challenges in its management. The emergence…
  • Abstract Number: 0830 • ACR Convergence 2024

    Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Expressing Radioresistant Cells

    Kevin Gao1, Kristy Chiang1, Sharon Subramanian1, Xihui Yin2, Paul Utz3, Kerstin Nundel1, Katherine A. Fitzgerald4 and Ann Marshak-Rothstein1, 1UMass Chan Medical School, Worcester, MA, 2Stanford University School of Medicine, Palo Alto, CA, 3Stanford University, Stanford, CA, 4UMass Chan Medical School, Worchester, MA

    Background/Purpose: Gain-of-function mutations in STING, a critical mediator of dsDNA sensing, lead to a severe autoinflammatory syndrome known as STING-Associated Vasculopathy with onset in Infancy…
  • Abstract Number: 0902 • ACR Convergence 2024

    Novel Role of TYK2mechanism in SLE Pathogenesis via T Cell and B Cell Pathways

    Joshua Hoffman1, Nicole Narayan2 and Mera Tilley1, 1Alumis Inc, South San Francisco, CA, 2Alumis, South San Francisco, CA

    Background/Purpose: SLE is a complex disease in need of novel therapies. Previously reported genome-wide association studies (GWAS) have identified a strong association between SLE and…
  • Abstract Number: 0977 • ACR Convergence 2024

    Vaccine Effectiveness and Safety of Recombinant Zoster Vaccine (RZV) in Rheumatoid Arthritis (RA) Patient Populations Aged 50 Years and Older

    Emily Rayens1, Lina Sy1, Lei Qian1, Jun Wu1, Bradley Ackerson1, Yi Luo1, Yanjun Cheng1, Antony Lin1, Zendi Solano1, Justine De Jesus1, Britta Amundsen1, Ana Florea1, Jen Ku1, Elizabeth Chmielewski-Yee2, Driss Oraichi2, Harry Seifert2, Huifeng Yun2 and Hung-Fu Tseng1, 1Kaiser Permanente Southern California, Pasadena, CA, 2GSK, Rockville, MD

    Background/Purpose: Individuals with rheumatoid arthritis (RA) are at higher risk of herpes zoster (HZ) compared to the general population. This interim analysis evaluated the vaccine…
  • Abstract Number: 1138 • ACR Convergence 2024

    Association Between Long-Term Exposure to Fine Particles and Its Components and the Onset of Systemic Autoimmune Rheumatic Diseases in Quebec

    Mareva geslin1, Julien Vachon2, Naizhuo Zhao3, Elhadji Anassour Laouan Sidi2, Sonia Jean4, audrey smargiassi2 and Sasha Bernatsky5, 1Universite de Montreal, Montreal, QC, Canada, 2Université de Montréal, Montreal, QC, Canada, 3McGill University, Montreal, QC, Canada, 4Institut national de santé publique du Québec, Montreal, QC, Canada, 5Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Exposure to fine particles (PM2.5) has been associated with numerous health effects including with autoimmune rheumatic diseases (SARDs). While PM2.5 are composed of various…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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