ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 2432 • ACR Convergence 2024

    In Vitro and In Vivo Evidence of the Steroid-Sparing Potential of Afimetoran, an Equipotent Toll-Like Receptor 7/8 Dual Antagonist

    Shailesh Dudhgaonkar1, Siva Subramani2, Puneet Chopra2, Anjuman Rudra2, Sourabha Palachandra2, Nikita Sanjay Bhatt2, Veeresh Pabbala2, Sabariya Selvam2, Mobeen Shaik2, Amit Anand2, Benjamin King3, Kristina Chadwick3, Alaric Dyckman3, Qihong Zhao3, Frédéric Baribaud3, Ramya Janardhana4 and Vineeta Shobha5, 1Bristol Myers Squibb, Bangalore, India, 2Biocon BMS Research Center, Syngene International Ltd, Bangalore, India, 3Bristol Myers Squibb, Princeton, NJ, 4St. John’s Medical College, Bengaluru , India, Bangalore, India, 5St. John’s Hospital, Bangalore, India

    Background/Purpose: SLE is a highly heterogeneous chronic autoimmune disease, with glucocorticoid therapy as the standard of care. SLE control requires high steroid doses; long-term use…
  • Abstract Number: 2594 • ACR Convergence 2024

    A Novel Therapeutically Active CSF-1R Agonist Promotes Tissue Macrophages Inflammation Resolution and Induces Tissue Repair Pathways

    Saul Kivimae1, Sandip Mukherjee2, Phi Quach3, Rhoneil Pena4, Olga Zemska3, Michal Olszewski5, Jicai Huang3, Michael Labson6, Donald Walker1, Mekhala Maiti7, Chakrapani Tripathi8, Thomas Chang3, Suresh Adapala9, Damon Hamel3, Katherine Brendza3, Takahiro Miyazaki3 and Jonathan Zalevsky1, 1Nektar Therapeutics, San Francisco, CA, 2Nurix Therapeutics, San Francisco, 3Nektar Therapeutics, San Francisco, 4Sutro Biopharma, South San Francisco, 5Vaxcyte, San Francisco, 6Guardant Health, Palo Alto, 7Alumis, Inc, South San Francisco, 8Theragent Inc, Arcadia, CA, 9Inotiv, Rockville, MD

    Background/Purpose: Current standard of care chronic inflammatory disease therapies are designed to suppress inflammation and are not optimized for inflammation resolution and restoration of tissue…
  • Abstract Number: PP11 • ACR Convergence 2024

    Living Well with Chronic Illness: Decades with MCTD

    Carol KAMINSKI, HP (Hewlett Packard) Retired, Wilmington, NC

    Background/Purpose: In the fall of 1985, I was not feeling well. I attributed my tiredness, weakness and malaise to stress and carried on. Walking upstairs I…
  • Abstract Number: 0014 • ACR Convergence 2024

    Phenotypic Validation of Humanized IgA1 and CD89 Transgenic Mice as a Model for IgA Nephropathy-Like Autoimmune Disease

    Kaiyuan Zi and Juan Liang, GemPharmatech, San Diego

    Background/Purpose: The etiology of IgA nephropathy (IgAN) remains only partly understood, but the presence of IgA antibodies together with the myeloid IgA-receptor FcαRI/CD89 complexes in…
  • Abstract Number: 0138 • ACR Convergence 2024

    SARS-CoV-2 Vaccine Acceptance, Hesitancy and Uptake in a Cohort of Patients with Inflammatory Rheumatic Diseases (IRD)

    iulia roman1, Xenofon Baraliakos2, Uta Kiltz3, Juergen Braun4 and Ioana Andreica5, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-University, D-44649 Herne, Germany, 4Rheuma Praxis, Ruhr-University Bochum, Berlin, Germany, 5Rheumazentrum Ruhrgebiet Herne, Herne, Germany

    Background/Purpose: Vaccine acceptance is important to achieve high vaccination coverage and possibly herd immunity. Related to the evolution of the SARS-CoV-2 pandemic with its socio-political…
  • Abstract Number: 0288 • ACR Convergence 2024

    Hypersensitivity Pneumonitis with Autoimmune Features: A New Entity?

    Pol Maymó1, Javier Narvaez-García2, Guadalupe Bermudo1, Vanesa Vicens-Zygmunt3, Santiago Bolivar4, Belen del Río5, Judith Palacios5, Martí Aguilar Coll2, Monserrat Roig Kim2, Laia De Daniel2, Paola Vidal1, Joan Miquel Nolla2 and María Molina1, 1Hospital Universtiario de Bellvitge, Barcelona, Spain, 2Hospital Universitario de Bellvitge, Barcelona, Spain, 3Hospital Universitario de Bellvitge., Barcelona, Spain, 4Bellvitge University Hospital, L'Hospitalet de Llobregat, Catalonia, Spain, 5Hospital Universtiario de Bellvitge, Hosptalet de Llobregat, Catalonia, Spain

    Background/Purpose: Hypersensitivity pneumonitis (HP) is an interstitial lung disease induced by inhaled antigens that trigger an interstitial and bronchoalveolar lymphocytic inflammatory response. This immune response…
  • Abstract Number: 0366 • ACR Convergence 2024

    Factors Associated with Participation in Rheumatology Clinical Trials: A UK-based Study

    Koushan Kouranloo1 and Chris Wincup2, 1Internal Medicine Resident., London, United Kingdom, 2King's College Hospital, London, United Kingdom

    Background/Purpose: Clinicians are encouraged to consider patient preferences for offering face-to-face vs virtual consultations. This adaptability is particularly important to rheumatologists caring for patients with…
  • Abstract Number: 0570 • ACR Convergence 2024

    Prevalence of Comorbidities and Racial Disparities in Anterior Uveitis Risk Among Ankylosing Spondylitis Patients

    Halah Alfatlawi1, abdulmajeed alharbi2, eun seo kwak2, rawnag el sheikh2 and nezam altorok2, 1the university of toledo, Toledo, OH, 2the university of toledo, Toledo

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the axial spine, commonly associated with extra-articular manifestations such as anterior uveitis (AU). Racial…
  • Abstract Number: 0778 • ACR Convergence 2024

    Comprehensive Immune Profiling of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy in Patients with Autoimmune Disease

    Justin Chou1, Ricardo Grieshaber-Bouyer2, Michelle J Wu3, Christina Bergmann2, Jule Taubmann4, Fabian Müller5, Aline Bozec4, Tobias Rothe2, Andreas MAckensen6, Amber Podoll7, Jonathan Gutman7, Aiden Haghikia8, Dimitrios Mougiakakos9, Gary Tong3, Pouya Kheradpour3, Francis Kim10, Prameela Ramesan10, Brandon Kwong10, Kunbin Qu10, Bishwa Ganguly10, Dominic Borie10, James Chung10 and Georg Schett11, 1Kyverna Therapeutics, Emeryville, CA, 2Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 3Verily Life Sciences, South San Francisco, CA, 4Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 5Department of Medicine 5 - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Uniklinikum Erlangen, Erlangen, Germany, 6Department of Medicine 5 - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Uniklinikum Erlangen, Erlangen, Bayern, Germany, 7University of Colorado Anschutz Medical Campus, Aurora, CO, 8Otto-von-Guericke University, Magdeburg, Germany, 9Otto-von-Guericke University, Magdeburg, Germany, Magdeburg, Germany, 10Kyverna Therapeutics, Inc., Emeryville, CA, 11Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy represents a promising advancement in the treatment of autoimmune diseases, including systemic sclerosis (SSc), idiopathic inflammatory myopathy…
  • Abstract Number: 0879 • ACR Convergence 2024

    A Novel, Oral, Allosteric Inhibitor of Tyrosine Kinase 2 (TYK2) Demonstrates In Vitro Potency, Selectivity, and In Vivo Efficacy in Mouse Models of Psoriasis

    Razika Hussein1, Pamela Tsuruda1, Shahab Mortezaei1, Nicky Ferdyan1, Christopher Wegerski2, Karthik Srinivasan1, Gavin Hirst1 and Neelufar Mozaffarian1, 1Atomwise Inc., San Francisco, 2Atomwise Inc., San Francisco, CA

    Background/Purpose: Tyrosine kinase 2 (TYK2), a member of the Janus kinase (JAK) family, plays a key role in several inflammatory diseases.  Orthosteric, small molecule inhibitors…
  • Abstract Number: 0966 • ACR Convergence 2024

    CDDO-Me Attenuates Pro-fibrotic Activation in Macrophages and Fibroblasts in Systemic Sclerosis

    Heetaek Yang1, Chanhyuk Park2, Chen-Yu Wang3, Emily Morris4, Karen Liby5, Michael Whitfield6 and Patricia Pioli2, 1Dartmouth College, West Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH, 3Dartmouth College, Lebanon, NH, 4Dartmouth College, Enfield, NH, 5Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, 6Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by dysfunctional immune activation, oxidative stress, and fibrosis. In prior work, we have shown that SSc macrophages (MØs) have…
  • Abstract Number: 1117 • ACR Convergence 2024

    JAK Inhibitor Therapy in Refractory Uveitis Due to Immune-mediated Inflammatory Disorders. Multicenter Study and Literature Review

    Nuria Barroso Garcia1, Lara Sanchez Bilbao2, Jose Luis Martin Varillas3, Vanesa Calvo-Rio4, Mar Esteban Ortega5, Santiago muñoz Fernández5, Jose Luis álvarez Vega6, Emma Beltran Catalan7, Vega Jovani8, Olga Maiz Alonso9, Raúl Veroz González10, Carmen Alvarez Reguera11, Rosalia Demetrio Pablo12 and Ricardo Blanco-Alonso13, 1Rheumatology, Hospital Regional Universitario, Universidad de Málaga UMA, Málaga, Spain, Malaga, Spain, 2Rheumatology and Ophthalmology. Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 3Rheumatology. Hospital de Laredo. IDIVAL, Immunopathology Group. Laredo, Spain, Santander, Spain, 4Valdecilla Hospital, Santander, Cantabria, Spain, 5Rheumatology and Ophthalmology. Hospital Infanta Sofía, Madrid. Spain, Madrid, Spain, 6Rheumatology. Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, Badajoz, Spain, 7Rheumatology. Hospital del Mar. Barcelona, Spain, Barcelona, Spain, 8National Health system, Alicante, Spain, 9Rheumatology. Hospital de Donostia. San Sebastián, Spain, San Sebastián, Spain, 10Hospital Mérida, Badajoz, Spain, 11Hospital Universitario Marqués de Valdecilla, Santander, Spain, 12Rheumatology and Ophthalmology. Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology Group. Santander. Spain, Santander, Spain, 13Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Non-infectious uveitis refractory to conventional immunosuppressants and even biologic therapy can lead to severe ocular conditions. Janus Kinase inhibitors (JAKINIBs) appear to be effective…
  • Abstract Number: 1372 • ACR Convergence 2024

    Upadacitinib and Other JAK Inhibitors in the Treatment of Rheumatoid Arthritis – Interstitial Lung Disease. National Multicenter Study Clinical Practice.

    Ana Serrano-Combarro1, Belén Atienza-Mateo2, Jesús Loarce3, Leticia del Olmo Perez4, Sara García-Pérez5, Guillermo Gonzalez Mozo de Rosales6, José Rosas-Gómez de Salazar7, Ana Urruticoechea-Arana8, Andrea García-Valle9, Juan Moreno Morales10, María Martín López11, Patricia Lopez Viejo12, Virginia Ruiz-Esquide13, Julia Fernandez Melon14, David Castro-Corredor15, Ana Fernández-Ortiz16, Rafael Benito Melero-Gonzalez17, Carolina Díez Morrondo18, Desiree Palma19, Natividad del Val del Amo20, Natalia Mena Vázquez21, Alicia García Dorta22, MARÍA JOSÉ PÉREZ GALÁN23, MARINA SOLEDAD MORENO GARCIA24 and Ricardo Blanco-Alonso25, and on behalf of JAKi in Interstitial Lung Disease Associated with Rheumatoid Arthritis, 1Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 3Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 4HOSPITAL NUESTRA SEÑORA DEL PRADO, TALAVERA DE LA REINA, Spain, 5Complejo Hospitalario de Vigo, Vigo, Galicia, Spain, 6Basurto University Hospital, Bilbao, Spain, 7Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain, 8Hospital Son Espases, Palma de Mallorca, Islas Baleares, Spain, 9Hospital General Río Carrión, Palencia, Spain, 10Hospital Universitario Santa Lucia Cartagena, Murcia, Murcia, Spain, 11General University Hospital of Ciudad Real, Ciudad de México, Spain, 12Hospital Severo Ochoa, Madrid, Madrid, Spain, 13Hospital Clinic de Barcelona, Barcelona, Spain, 14Hospital Son Espases, Palma, Spain, 15General University Hospital of Ciudad Real, Santa Cruz de Mudela (Ciudad Real), Spain, 16Hospital Universitario de Badajoz, Badajoz, Spain, 17CHU Ourense, O Carballino, Spain, 18Complejo Asistencial Universitario de Leon, Leon, 19Hospital Rafael Méndez, Lorca, Murcia, Spain, 20Complejo Hospitalario de Navarra, Pamplona, Spain, 21IBIMA, Málaga, Andalucia, Spain, 22Rheumatologist, La Laguna, Spain, 23SERVICIO ANDALUZ DE SALUD, GRANADA, Andalucia, Spain, 24Hospital Universitario Miguel Servet, GIJON, Asturias, Spain, 25Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). Abatacept and rituximab are the recommended drugs. JAK inhibitors (JAKi) have…
  • Abstract Number: 1548 • ACR Convergence 2024

    Anifrolumab in Systemic Lupus Erythematosus. Spanish National Registry in a Real-world Setting

    Carmen Secada Gómez1, Vanesa Calvo-Rio2, Miriam Retuerto Guerrero3, Judit Font4, Ivette Casafont-Sole5, Adrián Mayo-Juanatey6, Juan José Alegre Sancho6, Dalifer Freites Nuñez7, Cristina Hormigos8, Noemí Garrido-Puñal9, GUILLERMO GONZALEZ ARRIBAS10, Andrea García-Valle11, Juan Roberto Miguelez Sanchez12, Marta Ibáñez Martínez13, Fernando Lozano Morillo14, Ángel García Manzanares15, Sebastián Sandoval-Moreno16, Josefina Cortés-Hernández17, Desiree Palma18, Leticia Lojo Oliveira19, EVELIN CERVANTES PEREZ20, PAZ COLLADO21, Cristina Arciniega Larios22, Luis Sala Icardo23, Eztizen Labrador-Sánchez24, Cilia Peralta Ginés25, Nahia Plaza-Aulestia26, Miguel Medina Malone27, José Rosas-Gómez de Salazar28, Montserrat Corteguera29, Laura Cebrián19, Fred Anton Pages30, JOSE RAMON LAMUA RIAZUELO31, maria Dolores Fábregas canales32, María José Alados Hernández33, Marta Garijo Bufort34, Anna Pamies Corts35, Luis Sarabia De Ardanaz36, Rodrigo Aguirre-del-Pino37, José Ángel Cabezas Lefler38, Álvaro Seijas-Lopez37, Carmen Carrasco-Cubero39, Ana López-Cerón Cofiño40, Vera Ortiz-Santamaria41, Santos Castañeda42, María Laiño Piñeiro43, Carmen Ordás Calvo44, Celia Arconada Lopez45, Carmen Bejerano46 and Ricardo Blanco-Alonso47, ANA URRUTICOECHEA48, Blanca Garcia-Magallon49, Ana Valeria Acosta Alfaro50, Samuel Leal Rodriguez51, Marina Salido Olivares52 and Patricia Lavilla53 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Valdecilla Hospital, Santander, Cantabria, Spain, 3Complejo Asistencial Universitario de León, Leon, Spain, 4Hospital Germans Trias i Pujol, Barcelona, Spain, 5Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 6Hospital Universitario Doctor Peset, Valencia, Spain, 7Hospital Clínico San Carlos. Madrid. Spain., Madrid, Spain, 8Hospital Clínico San Carlos, Madrid, Madrid, Spain, 9Hospital Universitario Virgen del Rocío, Sevilla, Spain, 10Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, 11Hospital General Río Carrión, Palencia, Spain, 12Hospital Universitario de Móstoles, Madrid, Spain, 13Hospital Clínico Universitario de Salamanca, Salamanca, Spain, 14Hospital Central de La Defensa Gómez Ulla, Madrid, Spain, 15Hospital Universitario de Torrevieja, Alicante, Spain, 16Hospital Universitario Vall d´Hebrón, Barcelona, Spain, 17Hospital Universitario Vall d´Hebrón Hospitals, Barcelona, ES, Barcelona, Spain, 18Hospital Rafael Méndez, Lorca, Murcia, Spain, 19Hospital Universitario Infanta Leonor, Madrid, Spain, 20Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Galicia, Spain, 21Hospital Universitario Severo Ochoa, MADRID, Spain, 22Hospital de Mérida, Badajoz, Spain, 23Hospital Universitario de Torrejón, Madrid, Spain, 24Hospital General de La Rioja, Logroño, Spain, 25Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 26Hospital Galdakao, Vizcaya, Spain, 27Hospital Calahorra, La Rioja, Spain, 28Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain, 29ComplejoAsistencial de Ávila, Ávila, Spain, 30Complejo Asistencial De Segovia, Segovia, Spain, 31Hospital Universitario del Henares, Madrid, Spain, 32Hospital de Barbastro, Huesca, Spain, 33Hospital Universitario Puerta del Mar, Cádiz, Spain, 34Hospital de Sagunto, Valencia, Spain, 35Hospital Verge de la Cinta, Tortosa, TARRAGONA, Spain, 36Complejo Hospitalario de Jaén, Jaén, Spain, 37Hospital Universitario Lucus Augusti, Lugo, Spain, 38Complejo Asistencial de Zamora, Zamora, Spain, 39Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 40Hospital Santa Bárbara, Soria, Spain, 41Hospital General de Granollers, Barcelona, Spain, 42Hospital Universitario de la Princesa, Madrid, Spain, 43Hospital Universitario de Navarra, Pamplona, Spain, 44Hospital Universitario de Cabueñes, Gijón, Spain, 45Hospital Universitario Infanta Elena, Valdemoro, Madrid, Spain, 46Hospital Universitario Marques de Valdecilla, Immunopathology group, IDIVAL, Santander, Cantabria, Spain, 47Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, 48Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares, Spain, 49Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Spain, 50Hospital Universitario Infanta Sofía, Madrid, Spain, 51HUP La Fe, Valencia, Spain, 52Hospital Infanta Cristina, Parla, Spain, 53Hospital General de Villalba, Collado Villalba, Spain

    Background/Purpose: Anifrolumab (ANI) is a human monoclonal antibody that binds to the type I interferon receptor subunit 1 (IFNAR1), thus blocking the biological activity of…
  • Abstract Number: 1681 • ACR Convergence 2024

    Safe Switching from Originator Tocilizumab to MSB11456 Tocilizumab Biosimilar in Subjects with Moderate-to-Severe Rheumatoid Arthritis: Efficacy, Safety and Immunogenicity Data Following Treatment Transition in a Pivotal, Randomized, Double-blind, Phase III Study

    Anna Zubrzycka-Sienkiewicz1, Kamilla Klama2, Martin Ullmann3, Corinne Petit-Frere3, Andras Illes3, Olga Menang3, Joëlle Monnet3 and Peter Baker3, 1Reumatika - Centrum Reumatologil", NZOZ, Warszawa, Poland, 2Solumed Centrum Medyczne, Poznań, Poland, 3Fresenius Kabi SwissBioSim GmbH, Eysins, Switzerland

    Background/Purpose: A therapy transition from the originator to a biosimilar offers significant advantages for patients by lowering medication costs and improving accessibility to treatments. MSB11456…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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