Abstracts tagged "autoimmune diseases"

Abstract Number: 0902 • ACR Convergence 2025
A Novel Approach to study ANA+ B Cells in Lupus Integrating Flow Cytometry with Single-Cell culture
Deisy Muriel Velez arteaga¹, Yemil Atisha Fregoso², Hasret Gunduz³ and Betty Diamond⁴, ¹The Elmezzi School of Molecular Medicine, New Rochelle, NY, ²The Feinstein Institute, Long Island, NY, ³The Feinstein Institute, Long Island, ⁴The Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Studying antinuclear antibody (ANA) producing B cells at the single-cell level offers critical insights into their fine specificity and functional characteristics. However, conventional techniques…
Abstract Number: 0558 • ACR Convergence 2025
Early Systemic and Skin Pharmacodynamic Effects of Icotrokinra in Participants with Moderate-to-Severe Plaque Psoriasis: Results Through Week 24 of the Phase 3, ICONIC-LEAD Study
Julianty Angsana¹, Marta Polak¹, Sharan Nischal¹, Elizabeth Chen¹, Deepika Balakrishna², Ching-Heng Chou¹, Christopher Sisk³, Lynn Tomsho¹, Arun Kannan¹, Cynthia DeKlotz¹, Megan Miller⁴, Joseph Cafone³, Paul Newbold¹, Ya-Wen Yang¹, Monica Leung¹, Dawn Waterworth¹, Nina Sabins¹, Anna Perillo⁵, Andreas Pinter⁶ and Robert Bissonnette⁷, ¹Johnson & Johnson, San Diego, CA, USA, San Diego, CA, ²Johnson & Johnson, San Diego, CA, USA, San Diego, USA, ³Johnson & Johnson, San Diego, CA, USA, San Diego, CA, CA, ⁴Johnson & Johnson, San Diego, CA, USA, San Diego, CA,, CA, ⁵The Rockefeller University, New York, NY, USA, New York, NY, ⁶Goethe University Frankfurt, Frankfurt, Germany, Frankfurt, Germany, ⁷Innovaderm Research, Montreal, QC, Canada, Montreal, QC
Background/Purpose: Icotrokinra (ICO), a first-in-class targeted oral peptide that blocks the interleukin (IL)-23R and inhibits IL-23 pathway signaling, is being evaluated in the phase 3…
Abstract Number: 0510 • ACR Convergence 2025
A risk estimation tool for clinical practice to improve early ILD detection in Sjögren Disease
Anna-Maria Hoffmann-Vold¹, Kastriot Kastrati², Marco Sprecher³, Emily Violette Langballe¹, Phuong Diep¹, Havard Fretheim¹, Helena Andersson¹, Paul Studenic⁴, Bojana Müller-Durovic³, Cathrine Brunborg¹, Cosimo Bruni⁵, Christian Clarenbach³, Thomas Frauenfelder⁶, Trond Mogens Aaløkken¹, Natasha Moe¹, Helmut Prosch⁴, Helga Radner², Øyvind Molberg⁷ and Oliver Distler⁸, ¹Oslo University Hospital, Oslo, Norway, ²Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ³Univeristy Hospital Zurich, Zurich, Switzerland, ⁴Medical University of Vienna, Vienna, Austria, ⁵Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁶Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Zurich, Switzerland, Zurich, Switzerland, ⁷Department of Rheumatology, Oslo University Hospital, Oslo, Norway, ⁸Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: Interstitial lung disease (ILD) affects 10-15% of Sjögren disease (SjD) patients, leading to increased morbidity and reduced survival. The true prevalence may be higher…
Abstract Number: 0300 • ACR Convergence 2025
Exploring Malignancy in Anti-synthetase Syndrome: A Multisite Retrospective Study
Reena Yaman¹, Archit Srivastava², Alejandro Arango Martinez³, Caroyln Harvey⁴, Ronald Butendieck⁵, Vikas Majithia⁶ and Florentina Berianu¹, ¹Mayo Clinic Florida, Jacksonville, FL, ²Mayo Clinic, Florida, Jacksonville, FL, ³Universidad Pontificia Bolivariana, Medellín, Colombia, ⁴Mayo Clinic, Phoenix, AZ, ⁵Mayo Clinic Florida, Jacksonville, ⁶Mayo Clinic Hospital, Jacksonville, FL
Background/Purpose: Anti-synthetase syndrome (ASyS) is a rare, heterogeneous inflammatory myopathy characterized by presence of anti-aminoacyl transfer RNA synthetase autoantibodies with multisystem disease manifestations including myositis,…
Abstract Number: 0256 • ACR Convergence 2025
The Role of Extracorporeal Membrane Oxygenation in Cardiopulmonary Dysfunction Due to Rheumatologic Diseases: A Systematic Review
Kari Falaas¹, Lyubov Tiegs² and Elie Gertner³, ¹University of Minnesota, Minneapolis, ²University of Minnesota, Mineapolis, ³Regions Hospital, St. Paul, MN
Background/Purpose: Rheumatologists are increasingly involved in the management of patients with severe manifestations of rheumatologic disease treated with Extracorporeal Membrane Oxygenation (ECMO). A 2020 systematic…
Abstract Number: 0161 • ACR Convergence 2025
Risk Factors and Clinical Predictors of Lung Cancer in Systemic Sclerosis: A Matched Case-Control Study from a Michigan Cohort
Madiha Naqsh Siddiqui¹, Yen Chen¹, Rosemary Gedert², Suiyuan Huang², Dinesh Khanna² and John Varga², ¹University of Michigan, Ann Arbor, ²University of Michigan, Ann Arbor, MI
Background/Purpose: Malignancies are one of the leading causes of non-systemic sclerosis-related mortality in patients with systemic sclerosis (SSc)1, with lung cancer being the most common…
Abstract Number: 0044 • ACR Convergence 2025
DNA Methylation Signatures in Systemic Lupus Erythematosus and Rheumatoid Arthritis Highlight Divergent Immune Pathways
Rufei Lu¹, Tayte Stephens², Carla Guthridge¹, Miles Smith¹, Joseph Kheir¹, Cristina Arriens¹, Joan Merrill³, Marci Beel⁴, Susan Macwana¹, Wade DeJager⁵, Nicholas Domingez¹, Teresa Aberle¹, Joel Guthridge¹ and Judith James¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Science Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City ⁷³¹⁰⁴, OK, ⁴Oklahoma Medical Research Foun, Oklahoma City, OK, ⁵Oklahoma Medical Research Foundation, Oklahoma City
Background/Purpose: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are autoimmune diseases with distinct clinical and immunopathological features. Epigenetic modifications, particularly DNA methylation, contribute to…
Abstract Number: 0005 • ACR Convergence 2025
LBL-047, A First-In-Class Anti-BDCA2/TACI Fusion Protein, Inhibits the Function of Both pDCs and B cells
Fengxia Li¹, Jianming Sun¹, Hailin Wang¹, Yan Zhu¹, Xiaoxiao Liu¹, Jing Li¹, Yurong Qin¹, Guojin Wu¹, Jing Guan¹, Min Chen¹, Jordan Zhu², Xiaoqiang Kang¹, Xiao Huang¹ and Hong Ling¹, ¹Nanjing Leads Biolabs Co., Ltd., Nan Jing, China (People's Republic), ²Nanjing Leads Biolabs Co., Ltd., Nan Jing
Background/Purpose: Blood dendritic cell antigen 2 (BDCA2) is specifically expressed on pDCs whose uncontrolled production of type I IFN play a crucial role in the…
Abstract Number: 2669 • ACR Convergence 2025
RESET-Myositis: Clinical Trial Evaluating Rese-cel (Resecabtagene Autoleucel), A Fully Human, Autologous 4-1BB CD19-CAR T Cell Therapy in Idiopathic Inflammatory Myopathies
Erin Wilfong¹, Tahseen Mozaffar², Elie Naddaf³, Nizar Chahin⁴, Huifang Lu⁵, Iazsmin Bauer Ventura⁶, Courtney Little⁷, Carl diCasoli⁷, Claire Miller⁸, Jenell Volkov⁷, Daniel Nunez⁷, Thomas Furmanak⁷, Jason Stadanlick⁷, Larissa Ishikawa⁷, Zachary Vorndran⁷, Alexandra Ellis⁷, Jazmean Williams⁷, Steve Flanagan⁷, Quynh Lam⁸, Fatemeh Hadi-Nezhad⁸, Raj Tummala⁸, Samik Basu⁷ and David Chang⁹, ¹Vanderbilt University Medical Center, Nashville, TN, USA, Nashville, TN, ²University of California, irvine, Orange, CA, ³Mayo Clinic, Rochester, MN, ⁴Oregon Health & Science University, Portland, ⁵UT MD Anderson Cancer Center, Houston, TX, ⁶University of Chicago, Chicago, IL, ⁷Cabaletta Bio, Philadelphia, PA, ⁸Cabaletta Bio, Philadelphia, ⁹Cabaletta Bio, Bryn Mawr, PA
Background/Purpose: The goals of treatment for idiopathic inflammatory myopathy (IIM) are to eliminate or reduce inflammation, restore muscle performance, reduce morbidity, and improve a patient’s…
Abstract Number: 2574 • ACR Convergence 2025
Differences in SARS-CoV-2 Antigen Persistence in Individuals with Systemic Autoimmune Rheumatic Diseases Compared to the General Population
Naomi Patel¹, Zoe Swank², Jiaqi Wang¹, Xiaosong Wang³, Lauren O'Keeffe², Madison Negron⁴, Liya Sisay Getachew⁵, Louise Hansen⁶, Grace Qian², Alene Saavedra², Kevin Mueller², Natalie Davis⁷, Kathleen Vanni⁵, Zachary Wallace⁸, David Walt² and Jeffrey Sparks⁵, ¹Massachusetts General Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital, Natick, MA, ⁴Harvard Extension School, Medford, MA, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, B, ⁷Brigham and Women's Hospital, Brookline, MA, ⁸Massachusetts General Hospital, Newton, MA
Background/Purpose: Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post-acute COVID-19 outcomes due to use of immunosuppressive medications and…
Abstract Number: 2443 • ACR Convergence 2025
Mitochondrial dysfunction drives natural killer cell dysfunction in systemic lupus erythematosus
Natalia Fluder¹, Morgane Humbel², Camillo Ribi¹ and Denis Comte¹, ¹Lausanne University Hospital / University of Lausanne, Lausanne, Switzerland, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and widespread inflammation. Natural killer (NK) cells, essential for immune surveillance,…
Abstract Number: 2223 • ACR Convergence 2025
Improving collaboration between rheumatology and OBGYN in the reproductive health care of patients with rheumatic disease
Sara Heard¹, Isha Vasudeva², Juvena Hitt² and Jeanne Gosselin³, ¹University of Vermont Medical Center, Burlington, VT, ²University of Vermont Medical Center, Burlington, ³University of Vermont Medical Center, Waterbury, VT
Background/Purpose: Contraception management, preconception planning, and prenatal, antenatal, and postnatal care vary significantly in clinical practice for patients with rheumatic disease. Rheumatologists recognize the need…
Abstract Number: 1904 • ACR Convergence 2025
Mapping CTD-ILD in a Spanish Cohort – the NIRRVANA Registry
Paula García-Escudero¹, Marta López-Maraver², Tetyana Lozinska-Lozinska², Carlos Maria Lizasoain Alustiza³, César Antonio Egües Dubuc⁴, Leire Suárez Zorrilla⁵, Mayra Nathali Rivas Zavaleta⁵, Elena Garmendia Sánchez⁵, Nuria Vegas Revenga⁶, Myriam Aburto Barreneche⁷, Guillén Sada Urmeneta⁸, Elena Abad Plou⁹, Maria Luz Garcia Vivar¹⁰, Inmaculada Paniagua Zudaire¹¹, Marta Inchausti Iguiñiz¹², Iñaki Salegi Etxebeste¹² and Jaime Calvo¹³, ¹Hospital Universitario Álava, Bilbao, Spain, ²Hospital Universitario Araba, Vitoria, Spain, ³Donostia University Hospital, San Sebastian, Pais Vasco, Spain, ⁴Rheumatology Department, Donostia University Hospital., San Sebastian, Spain, ⁵Hospital Universitario Cruces, Barakaldo, Spain, ⁶Galdakao- Usansolo University Hospital, Galdakao, Spain, ⁷Hospital Galdakao-Usansolo, Galdakao, Spain, ⁸Hospital Reina Sofía de Tudela, Tudela, Spain, ⁹Hospital Universitario Basurto, Bilbao, Spain, ¹⁰Basurto Hospital, Bilbao, Spain, ¹¹Hospital Universitario de Navarra, Pamplona, Spain, ¹²Hospital Universitario Donosti, Donosti, Spain, ¹³Department of Rheumatology, Hospital Universitario Araba, School of Medicne, Universidad del País Vasco, BIOARABA Health Research Institute, Vitoria, Spain, Vitoria, Pais Vasco, Spain
Background/Purpose: Interstitial lung disease (ILD) is a prevalent feature among patients suffering from connective tissue diseases (CTD), associated with considerable morbi-mortality. Nonetheless, this complication is…
Abstract Number: 1760 • ACR Convergence 2025
Targeting the Female-biased Factor VGLL3 in Cutaneous and Systemic Lupus
Vincent van Drongelen¹, Joanna Rew¹, Emma Griffin², Kelly Young², Olesya Plazyo¹, Mehrnaz Gharaee-Kermani¹, Li-Jyun Syu², Stefan Stoll², Jiliang Zhou³, Nicole Ward⁴, J. Michelle Kahlenberg¹, Lam Tsoi¹, Andrzej A Dlugosz², Johann Gudjonsson¹ and Allison C Billi¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, ³Augusta University, Augusta, ⁴Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Approximately 90% of patients with systemic lupus erythematosus are women, and skin is one of the most frequently affected organs. We previously found that…
Abstract Number: 1576 • ACR Convergence 2025
Impact of COVID-19 Infection on Fibrosis Progression in CTD-Associated ILD: An AI-Based Quantitative CT Study
kyung-Ann Lee¹, Hyun-Sook Kim² and Boda Nam³, ¹Soonchunhyang University Hospital Seoul: Soonchunhyang University Hospital, Seoul, Republic of Korea, ²Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea, ³Chung-Ang University Hospital, Seoul, Republic of Korea
Background/Purpose: Pulmonary fibrosis is a recognized sequela of severe COVID-19 pneumonia, but its additive impact on pre-existing interstitial lung disease (ILD)—particularly in patients with connective…

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