ACR Meeting Abstracts

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Abstracts tagged "autoantigens"

  • Abstract Number: 630 • 2013 ACR/ARHP Annual Meeting

    Galectin-3-Binding Protein Is Highly Increased On Circulating Microparticles In SLE Patients and Co-Localizes With IgG In Glomerular Deposits In Human Lupus Nephritis

    Christoffer T. Nielsen1,2, Ole Østergaard3, Ole Petter Rekvig4, Gunnar K. Sturfelt5, Søren Jacobsen6 and Niels H. H. Heegaard7, 1Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen S, Denmark, 2Infectious Diseases and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark, 3Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, 4Department of Biochemistry and Medical Biology, University Hospital, Tromsø, Norway, 5Department of Rheumatology, University Hospital Lund, Lund, Sweden, 6Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 7Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark

    Background/Purpose: The origin of autoantigens in glomerular immune complex (IC) deposits in lupus nephritis patients is unknown. They may derive from the circulation (microparticle (MP)-ICs…
  • Abstract Number: 37 • 2013 ACR/ARHP Annual Meeting

    Follicular Entry Of Lymphotoxin-Expressing B Cells Via Type I Interferon Disrupts Marginal Zone Barrier Integrity and Exacerbates Systemic Autoimmunity

    Hao Li1, Hui-Chen Hsu2, Qi Wu3, Jun Li3, PingAr Yang3, Yang-Xin Fu4 and John D. Mountz5, 1Dept. Med - Immunology/Rheumatology division, University of Alabama at Birmingham, Birmingham, AL, 2Birmingham VA Medical Center, Birmingham, AL, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Department of Pathology, The University of Chicago, Chicago, IL, 5Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Marginal zone macrophages (MZMs), a small subset of specialized splenic macrophages located in the MZ, act as final follicular entry barrier to clear apoptotic…
  • Abstract Number: 2577 • 2012 ACR/ARHP Annual Meeting

    Characterization of Circulating Human B Cells That Bind Cyclic Citrullinated Peptide Antigens in Clinically Active Rheumatoid Arthritis

    Gregg J. Silverman1, John Jung2, Jeffrey D. Greenberg3, Adam J. Pelzek4, Caroline Gronwall5 and Jaya Vas5, 1Medical and Pathology, NYU School of Medicine, New York, NY, 2School of Medicine, NYU, New York, NY, 3New York Hospital for Joint Disease, New York, NY, 4School of Medicine, NYU School of Medicine, New York, NY, 5Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) were first identified based on their high specificity for RA and now are commonly used as a diagnostic tool. Yet,…
  • Abstract Number: 1391 • 2012 ACR/ARHP Annual Meeting

    Anti-Ku Autoantibodies in Systemic Lupus Erythematosus Versus Autoimmune Myositis As Measured by a Novel Chemiluminescence Assay

    Michael Mahler1, Jason Wu2, Magdalena Szmyrka-Kaczmarek3, Andreas Swart4, Marvin J. Fritzler5, Jean-Luc Senécal6 and John G. Hanly7, 1Research, INOVA Diagnostics, San Diego, CA, 2Research, INOVA Diagnostics, San Diego, 3Rheumatology, Wroclaw Medical University, Wroclaw, Poland, 4Rheumatology clinic Neuss, Neuss, Germany, 5Medicine, University of Calgary, Calgary, AB, Canada, 6Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 7Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada

    Background/Purpose: Autoantibodies targeting Ku, an abundant nuclear protein with DNA helicase activity, have been reported in patients with systemic autoimmune rheumatic diseases. Little is known…
  • Abstract Number: 1081 • 2012 ACR/ARHP Annual Meeting

    Toll-Like Receptor 7, 8 and 9 Activation of Primary Human Cells by Lupus Immune Complexes Is Dependent On Interleukin 1 Receptor Associated Kinase 4 Activity

    Aaron Winkler1, Weiyong Sun1, Ken Dower2, Elizabeth A. Murphy1, Julia Shin1, Michael Luong1, Michael J. Primiano1, Varenka A. Rodriguez2, Tatyana Souza1, Lih-Ling Lin3, J. Perry Hall1, Katherine Lee4, Vikram R. Rao1 and Margaret Fleming1, 1Inflammation & Remodeling, Pfizer, Cambridge, MA, 2Inflammation and Remodeling, Pfizer, Cambridge, MA, 3Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA, 4Worldwide Medicinal Chemistry, Pfizer, Cambridge, MA

    Background/Purpose: Genetic, in vitro and in vivo evidence strongly implicate the activation of nucleic acid sensing toll like receptors (TLR) 7, 8, and 9 in…
  • Abstract Number: 889 • 2012 ACR/ARHP Annual Meeting

    Modeling Environmental and Genetic Determinants to Identify the Association of Risk Genes in Anti-Ro60-Mediated Injury: Relaxin Receptor I and Tumor Necrosis Factor

    Joanne H. Reed1, Paula S. Ramos2, Jiri Zavadil3, Jill P. Buyon4 and Robert M. Clancy1, 1Medicine, New York University School of Medicine, New York, NY, 2Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Pathology and Center for Health Informatics and Bioinformtics, New York University School of Medicine, New York, NY, 4Department of Medicine, New York University School of Medicine, New York, NY

    Background/Purpose: Fetuses exposed to maternal anti-Ro60 antibodies can develop cardiac conduction abnormalities and life threatening cardiomyopathy; manifestations of neonatal lupus (NL). Recent data support an injury…
  • Abstract Number: 713 • 2012 ACR/ARHP Annual Meeting

    Rpp25 Is a Major Target of Autoantibodies to the Th/to Complex As Measured by ELISA and a New Chemilumiscence Assay

    Michael Mahler1, Cristina Gascon2, Sima Patel2, Angela Ceribelli3, Edward K.L. Chan3 and Minoru Satoh4, 1Research, INOVA Diagnostics, San Diego, CA, 2Research, INOVA Diagnostics, Inc., San Diego, CA, 3Oral Biology, University of Florida, Gainesville, FL, 4Medicine, University of Florida, Gainesville, FL

    Background/Purpose: Anti-nuclear antibodies (ANA) play an important role in the diagnosis of systemic autoimmune diseases including systemic sclerosis (SSc). A significant portion of ANA in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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