ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "autoantigens"

  • Abstract Number: 0892 • ACR Convergence 2024

    Peptides from Candidate Sjögren’s Disease Autoantigens and Salivary Gland Tissue-Enriched Proteins Eluted from Human Salivary Gland HLA-DR

    Tommi C. Taylor1, Sri Ramarathinam2, Shan Zou Chung2, Kirti Pandey2, Ananth Aditya Jupudi1, Bhuwan Khatri3, Sherri Longobardi3, Charmaine Lopez-Davis3, Astrid Rasmussen3, Kiely Grundahl3, Robert Hal Scofield3, Christopher Lessard3, Linda F. Thompson3, Anthony W. Purcell2 and A. Darise Farris3, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Monash University, Clayton, Victoria, Australia, 3Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjögren’s Disease (SjD) is characterized by aberrant autoimmune reactions in lacrimal and salivary glands (SG) leading to severe dryness. Evidence for B cell help…
  • Abstract Number: 0923 • ACR Convergence 2024

    Immunization of Arthritis Prone Mice with Malondialdehyde-Acetaldehyde Modified Vimentin Induces Post-Translational Protein Modifications and Extracellular Matrix Deposition in Heart Tissues

    Kimberley Sinanan1, Wenxian Zhou2, Michael Duryee1, Nozima Aripova1, Jill Poole1, Carlos Hunter1, Amy Nelson1, Tate Johnson1, Daniel Anderson3, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Bellevue, NE, 3University of Nebraska Medical Center, Durham, NC

    Background/Purpose: Recent studies have highlighted the importance of malondialdehyde-acetaldehyde (MAA)-modified proteins and resulting immune responses in the pathogenesis of rheumatoid arthritis (RA). MAA adducts have…
  • Abstract Number: 0963 • ACR Convergence 2024

    Stratification According to Autoantibody Status in Systemic Sclerosis Reveals Distinct Molecular Signatures

    Bénédicte ROUVIERE1, Christelle Le dantec2, Eléonore Bettacchioli3, Lorenzo Beretta4, Céline Cao2, Christophe Jamin2, Jacques-Olivier Pers5, Nathan Foulquier2, Martin Kerick6, Javier Martin6, Marta Alarcon-Riquelme7, Claire de Moreuil8, Divi Cornec3 and Sophie Hillion2, and PRECISESADS Clinical Consortium, PRECISESADS Metabolomic Study Group, 1CHRU de Brest, LBAI. UMR 1227, University of Brest, Brest, France, 2LBAI. UMR 1227, University of Brest, Brest, France, 3Service de Rhumatologie, CHU de Brest, Brest, France, 4Scleroderma Unit, Fondazione IRCCS Ca' Granda, University of Milan, Milan, Italy, 5University of Brest, Brest, France, 6Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Spain, Granada, Spain, 7Fundación Progreso y Salud, Andalusian Government, Granada, Spain, 8Service de médecine interne, CHU de Brest, Brest, France

    Background/Purpose: Systemic sclerosis is a heterogeneous disease, complicating its management. Its complexity and the insufficiency of clinical manifestations alone to delineate homogeneous patient groups further…
  • Abstract Number: 1652 • ACR Convergence 2024

    Extracellular Vesicles from Lymphocyte B and Neutrophil Presents Ro52, Ro60 and La Autoantigens in Patient Suffering from Sjögren Syndrome

    Lily BRUYERE1, Anne-Claire DUCHEZ2, Martin KILLIAN3 and Stéphane PAUL4, 1université jean-monnet, saint-etienne, 2EFS, saint-etienne, 3chu Saint-Etienne, saint-etienne, 4CIRI, Saint Etienne, France

    Background/Purpose: Extracellular Vesicles (EVs) are double lipid bilayer-enclosed membranous vesicles, produced and discharged from almost all cells. EVs are known for inter-cellular communication by releasing…
  • Abstract Number: 1764 • ACR Convergence 2024

    Reduction in Circulating Neutrophil Extracellular Traps and Restored Degradation Post-treatment in Pediatric Lupus

    Tatiana Borja1, Bharati Matta2, Lydia Thomas3, Jenna Battaglia4, Amanda Huang5, Kim Simpfendorfer6, Hongxiu Wen5, Joyce Hui-Yuen7, Boris Reizis8, Sohei Makita8 and Betsy Barnes5, 1Northwell- Cohen Children's Medical Center, Elmhurst, NY, 2The Feinstein Institutes for Medical Research, Manhasset, NY, 3Northwell Health - Cohen Children's Medical Center, Lake Success, NY, 4Feinstein Institutes for Medical Science, Manhasset, 5Feinstein Institutes for Medical Science, Manhasset, NY, 6Feinstein Institutes for Medical Research, Manhasset, NY, 7Northwell Health, Cohen Children's Medical Center, Great Neck, NY, 8New York University Grossman School of Medicine, New York, NY

    Background/Purpose: Pediatric lupus (pSLE) is a multisystemic, chronic, autoimmune disease in which over 50% of pSLE patients develop lupus nephritis (pLN). Neutrophil extracellular traps (NETs)…
  • Abstract Number: 1855 • ACR Convergence 2024

    ­Identification of Autoreactive Cytotoxic T Cells in ANCA-Associated Vasculitis

    Laura van Dam1, Shady Younis2, Jae-Seung Moon3, Mengrui Zhang4, Shima Parfasar4, Audra Horomanski3, orr Sharpe3, Jolijn van Leeuwen5, Tobias Lanz4, Cees van Kooten6, Onno Teng7 and William Robinson8, 1Stanford, Palo Alto, CA, 2Stanford University, Stanford, CA, 3Department of Immunology and Rheumatology, Stanford University, Stanford, CA, 4Department of Immunology and Rheumatology, Stanford University, Stanford, 5Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Nephrology, Leiden University Medical Center, Leiden, 7Leiden University Medical Center, Leiderdorp, Netherlands, 8Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA

    Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and severe autoimmune disease, characterized by a pauci-immune necrotizing vasculitis leading to inflammation and damage…
  • Abstract Number: 1858 • ACR Convergence 2024

    Co-modification of Citrullinated Proteins with Malondialdehyde-Acetaldehyde Leads to Amplified T Cell Responses and Increased Disease-specific Autoantibody Concentrations

    Breanna Butler1, Wenxian Zhou2, Michael Duryee1, Nozima Aripova1, Engle Sharp1, Carlos Hunter1, Bridget Kramer1, Harlan Sayles1, James O'Dell1, Geoffrey Thiele1, Bryant England1, Joshua Baker3, Andreas Reimold4, Gail Kerr5 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Bellevue, NE, 3University of Pennsylvania, Philadelphia, PA, 4Dallas VA Medical Center, Dallas, TX, 5Washington DC VAMC/Georgetown and Howard Universities, Washington, DC

    Background/Purpose: Anti-citrullinated protein antibody (ACPA) is highly specific to rheumatoid arthritis (RA). Beyond citrullination, other post-translational protein modifications including malondialdehyde-acetaldehyde (MAA) are targeted by T…
  • Abstract Number: 1866 • ACR Convergence 2024

    Identification of Sjögren’s Disease-Associated CD4+ T Cell Receptor (TCR) Motifs and Repertoire Landscape Through TCR Deep Sequencing

    Ananth Aditya Jupudi1, Michelle L. Joachims2, Christina Lawrence2, Charmaine Lopez-Davis2, Bhuwan Khatri2, Astrid Rasmussen2, Kiely Grundahl2, Robert Hal Scofield2, Judith James2, Joel Guthridge2, Christopher Lessard2, Linda F. Thompson2 and A. Darise Farris2, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjögren’s disease (SjD) is a chronic rheumatic autoimmune disorder characterized by focal lymphocytic infiltration of the lacrimal and salivary glands (SG). CD4+ T cells…
  • Abstract Number: 1879 • ACR Convergence 2024

    Prevalence of Relapsing Polychondritis in Colombia: Data from the National Health Registry 2018 – 2023

    Mario Bautista-Vargas1, Adrian Romero-Ocampo2, Juan José Pino Vélez3, juliana Muñoz-Bedoya4 and Diego Rosselli5, 1Mayo Clinic, Rochester, Minnesota, USA., Rochester, MN, 2Universidad de Antioquia, Medellín – Colombia, Medellin, Antioquia, Colombia, 3Universidad de Antioquia, Envigado, Antioquia, Colombia, 4Universidad Corpas, Bogotá, Colombia, 5Pontificia Universidad Javeriana, Bogotá, Colombia

    Background/Purpose: The implementation of the SISPRO system enables it to function as a tool capable of collecting pertinent health system data. This information is publicly…
  • Abstract Number: 0009 • ACR Convergence 2024

    Comprehensive Autoantibody Profiling Highlights Clinical Relevance of Autoantibodies to G Protein-coupled Receptors in Systemic Sclerosis: Insights from a B-cell Depletion Clinical Trial

    Kazuki Matsuda, Shinichi Sato and Ayumi Yoshizaki, The University of Tokyo, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) affects the skin and internal organs with a poor prognosis. While the exact cause remains unclear, increasing evidence indicates that B…
  • Abstract Number: 2391 • ACR Convergence 2024

    Identification of Patients with ANA Negative and Double Stranded DNA Positive: What Is the Significance in Daily Rheumatology Practise

    Güllü Sandal Uzun1, Emily Apsley2 and David Isenberg2, 1University College London, London, England, United Kingdom, 2University College London, London, United Kingdom

    Background/Purpose: The anti-nuclear antibody (ANA test)  is a sensitive screening tool used when assessing patients with possible autoimmune rheumatic diseases (ARD). Homogeneous staining positivity is…
  • Abstract Number: 0011 • ACR Convergence 2024

    Preclinical Manufacturability and Activity of KYV-102 from Patients with Systemic Lupus Erythematosus Using Ingenui-T: A Rapid, Autologous Chimeric Antigen Receptor T-Cell Manufacturing Solution Utilizing Whole Blood

    Brandon Kwong1, Daniel Anaya1, Soo Park2, Sunetra Biswas2, Jeevitha Jeevan2, Jesus Banuelos2, Madison Strobach2, Nicole Khoshnoodi1, Timothy Klasson1, Santiago Foos-Russ1, Jennifer Zeng1, Candice Gibson3, Jazmin Bravo2, Simone Sandoval1, Shouvonik Sengupta1, Shairaz Shah1, Tom Van Blarcom2 and Karen Walker2, 1Kyverna Therapeutics, Inc., Emeryville, CA, 2Kyverna Therapeutics, Inc., Emeryville, 3Kyverna Therapeutics, Inc., Emerybille

    Background/Purpose: Apheresis in conventional chimeric antigen receptor (CAR) T-cell therapy can be burdensome, and conventional manufacturing cultures apheresis-derived cells for 7-14 days, leading to a…
  • Abstract Number: 2665 • ACR Convergence 2024

    Autoantibody Titers Against Specific Epitope Peptides Predict Treatment Resistance in Interstitial Lung Disease Associated with Anti-MDA5 Dermatomyositis

    Tsuneo Sasai1, Ran Nakashima1, Atsubumi Ogawa2, Motohiro Nonaka2, Norimichi Nomura2, Yasuhiro Nohda2, Mirei Shirakashi3, Ryosuke Hiwa2, Hideaki Tsuji1, Shuji Akizuki4, Hajime Yoshifuji1, Tsuneyo Mimori5 and Akio Morinobu6, 1Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Kyoto University, Kyoto, Japan, 3Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, 4Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto City, Japan, 5Takeda Clinic for Rheumatic Diseases, Kyoto, Japan, 6Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kyoto, Japan

    Background/Purpose: Anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is frequently associated with rapidly progressive interstitial lung disease (RP-ILD), leading to poor prognosis. Initial combinational therapy…
  • Abstract Number: 0032 • ACR Convergence 2024

    Increased Expression of Malondialdehyde-Acetaldehyde and Citrullinated Proteins in Myocardial Tissues During the Early Evolution of Collagen-Induced Arthritis

    Wenxian Zhou1, Michael Duryee2, Nozima Aripova2, Jill Poole2, Carlos Hunter2, Amy Nelson2, Tate Johnson2, Daniel Anderson3, Geoffrey Thiele2 and Ted Mikuls2, 1University of Nebraska Medical Center, Bellevue, NE, 2University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Durham, NC

    Background/Purpose: The risk of heart failure (HF) is increased in patients with rheumatoid arthritis (RA), although mechanisms of myocardial dysfunction underlying HF development in RA…
  • Abstract Number: 2667 • ACR Convergence 2024

    Anti-Mi2 Autoantibodies in Dermatomyositis Patients Also Recognize Autoimmune Regulator (AIRE) Protein

    Jon Musai1, Sahana Jayaraman2, katherine Pak3, Iago Pinal-Fernandez4, Sandra Muñoz-braceras5, Maria Casal-Dominguez6, Eric Cho5, Fa'alataitaua Fitisemanu5, jose milisenda7, Lisa Rider8, Adam Schiffenbauer3, Albert Selva-O’Callaghan9, Thomas E Lloyd10, Lisa Christopher-Stine11, Peter Burbelo12, Benjamin Larman11 and Andrew Mammen13, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3National Institutes of Health, Bethesda, MD, 4NIAMS/National Institutes of Health, Bethesda, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD, 6NIAMS, NIH, Bethesda, MD, 7Hospital Clinic de Barcelona, Barcelona, Spain, 8NIEHS, NIH, Garrett Park, MD, 9Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, 10Johns Hopkins University School of Medicine, Lutherville, MD, 11Johns Hopkins University, Baltimore, MD, 12National Institute of Dental and Craniofacial Research, Bethesda, MD, 13NIH, Bethesda, MD

    Background/Purpose: Many myositis patients have myositis-specific autoantibodies (MSA) that define unique clinical phenotypes. For instance, dermatomyositis (DM) patients with anti-Mi2 autoantibodies have weaker muscles, higher…
  • 1
  • 2
  • 3
  • …
  • 8
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology