ACR Meeting Abstracts

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Abstracts tagged "Autoantibody(ies)"

  • Abstract Number: 1331 • ACR Convergence 2025

    Anti-beta-2-glycoprotein-1 IgA antibodies facilitate macrophage cholesterol loading and influence coronary atherosclerosis progression in a dose-dependent manner in rheumatoid arthritis

    George Karpouzas1, Bianca Papotti2, Sarah Ormseth3, Marcella Palumbo2, Matthew Budoff1 and Nicoletta Ronda2, 1Harbor-UCLA Medical Center, Torrance, CA, 2University of Parma, Parma, Italy, 3The Lundquist Institute for Biomedical Innovation, Torrance, CA

    Background/Purpose: Changes in serum cholesterol loading capacity (CLC) on macrophages were linked to coronary plaque progression in rheumatoid arthritis (RA). Inflammation, LDL oxidation and autoantibodies…
  • Abstract Number: 1838 • ACR Convergence 2025

    Differential Expression Of Activation Markers On dsDNA-reactive B-cells Between Healthy Subjects And SLE Patients Reveals Unconventional Extrafollicular Activation In SLE

    Lars Van Vliet, Annemarie Dorjée, René Toes and Jolien Suurmond, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-dsDNA IgG antibodies are a hallmark of systemic lupus erythematosus (SLE), an autoimmune disease characterized by chronic inflammation and multi-organ damage. Evidence suggests that…
  • Abstract Number: 2335 • ACR Convergence 2025

    The 14-3-3 eta AAb biomarker improves discriminative performance of CRP and HLA-B27 to differentiate people with radiographic axSpA from those with mechanical back pain.

    Walter P. Maksymowych1, Raj Sengupta2, Anthony Marotta3, Stephanie Wichuk4, Charlotte Cavill5, Stephen Bleakley3 and Norma Biln6, 1Department of Medicine, University of Alberta, 568 Heritage Building, Edmonton, AB, Canada, 2Royal National Hospital for Rheumatic Diseases, Bath, England, United Kingdom, 3Augurex Life Sciences Corp, Vancouver, BC, Canada, 4University of Alberta, Edmonton, AB, Canada, 5Royal United Hospitals Bath NHS Foundation Trust, Bath, England, United Kingdom, 6Augurex Life Sciences, Vancouver, BC, Canada

    Background/Purpose: Reducing diagnostic delay for people presenting with back pain who have axial spondyloarthritis (axSpA) has become a clinical imperative since effective treatments can limit…
  • Abstract Number: 2499 • ACR Convergence 2025

    Concomitant Anti-Ro/SSA Antibodies in Systemic Sclerosis Patients is Associated with Risks Beyond Dryness

    Rachael Gordon1, Leah Wunsch2, Maureen Lauffoon1, Thomas Medsger, Jr3 and Robyn Domsic1, 1University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, 3Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, Verona, PA

    Background/Purpose: Sjogren’s disease (SjD) is a common systemic autoimmune disorder characterized by progressive inflammation of the exocrine glands, resulting in dry eyes and dry mouth.…
  • Abstract Number: 0248 • ACR Convergence 2025

    Clinical and serological characteristics of anti-Ku autoantibodies in a Hispanic cohort

    Emmanuel Dominguez-Chapa1, Angel Kevin Garza-Elizondo2, Karina Deciderio-Pavon3, Rosa Arvizu-Rivera4, Jesus Alberto Cardenas-de la Garza5, Miguel Villarreal-Alarcón6 and Dionicio A. Galarza-Delgado7, 1Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 2Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Nuevo Leon, Mexico, 3Rheumatology Service, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo Leon, Mexico, 4Hospital Universitario "Dr. José Eleuterio Gonzalez", Escobedo, Nuevo León, Mexico, 5Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, 6Hospital Universitario UANL, Monterrey, Nuevo León, Mexico, 7Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico

    Background/Purpose: Anti-Ku antibodies are rare myositis-associated antibodies directed against a DNA-binding heterodimer involved in DNA repair. Anti-Ku positivity may be associated with a distinct clinical…
  • Abstract Number: 0853 • ACR Convergence 2025

    Olink Proteomics Identifies Macrophage Pro-inflammatory Proteins in Maternal Sera Predictive of Fetal Atrioventricular Block Independent of Maternal Health Status

    Philip Carlucci1, Mala Masson2, Colin Phoon3, Ashley Roman3, Peter Izmirly4, Amit Saxena5, Michael Belmont6, Christina Penfield3, Young Mi Lee3, Julie Nusbaum6, Andrew Rubenstein3, Nalani Sachan3, Joel Guthridge7, Judith James7, Elena Sinkovskaya8, Alfred Abuhamad8, Gary Satou9, Whitnee Hogan10, Anita Moon-Grady11, Lisa Howley12, Mary Donofrio13, Stephanie Levasseur14, Miwa Geiger15, Sonal Owens16, Kristopher Cumbermack17, Jyothi Matta18, Gary Joffe19, Christopher Lindblade20, Caitlin Haxel21, Katherine Kohari22, Joshua Copel22, James Strainic23, Tam Doan24, Conisha Holloman24, Stacy Killen25, Theresa Tacy26, Michelle Kaplinski26, Nicola Fraser3, Kelly Ruggles27, Bettina Cuneo28, Jill Buyon3 and Robert Clancy14, 1New York University School of Medicine, New York, NY, 2NYU Langone Medical Center- Division of Rheumatology, New York, NY, 3NYU Grossman School of Medicine, New York, NY, 4New York University Grossman School of Medicine, New York, NY, 5Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, 6NYU Langone Health, New York, NY, 7Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Eastern Virginia Medical School, Norfolk, VA, 9University of California Los Angeles, Los Angeles, CA, 10University of Utah, Salt Lake City, UT, 11University of California San Francisco, San Francisco, CA, 12Midwest Fetal Care Center, Children's Minnesota/Allina Health, Minneapolis, MN, 13Children's National Hospital, Washington, DC, 14Columbia University, New York, NY, 15Mount Sinai School of Medicine, New York, NY, 16University of Michigan, Ann Arbo, MI, 17University of Kentucky, Lexington, KY, 18University of Louisville, Louisville, KY, 19Perinatal Associates of New Mexico, Albuquerque, NM, 20Phoenix Children's Hospital, Phoenix, AZ, 21University of Vermont Children's Hospital, Burlington, VT, 22Yale University, New Haven, CT, 23UH Rainbow Babies, Cleveland, OH, 24Baylor College of Medicine, Houston, TX, 25Vanderbilt University, Nashville, TN, 26Stanford University, Stanford, CA, 27NYU Grossman School of Medicine, Brooklyn, NY, 28University of Arizona College of Medicine, Tucson, AZ

    Background/Purpose: Fetal atrioventricular block (fAVB) is presumed dependent on the transplacental passage of SSA/Ro52/60kD autoantibodies that bind to apoptotic fetal cardiomyocytes, triggering macrophage activation and…
  • Abstract Number: 0900 • ACR Convergence 2025

    Profiling of Novel Autoantibodies for Prediction of Disease Activity in ANCA-Associated Vasculitis

    Charlotta Preger1, Maria Aspenberg1, Metta Berenpas1, Armita Dwivedi2, Juliana Bordignon Draibe3, Peter Nilsson1, Mark A. Little2 and Elisa Pin1, 1Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden, 2Trinity Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland, 3Department of Nephrology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain

    Background/Purpose: ANCA-associated vasculitides (AAV) are a heterogenous group systemic autoimmune diseases characterized by necrotizing inflammation of small blood vessels requiring prompt initiation of immunosuppressive treatment…
  • Abstract Number: 1379 • ACR Convergence 2025

    Renal tubular acidosis in Sjögren’s disease and non-Sjögren’s sicca in an Oklahoma cohort

    Biji T Kurien1, Martha Tsaliki2 and R Hal Scofield1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2OMRF, Oklahoma City, OK

    Background/Purpose: Renal involvement in primary Sjögren’s disease (pSjD) is a well-known extraglandular manifestation with a prevalence of 5-14% in several studies. Mostly, it affects the…
  • Abstract Number: 1858 • ACR Convergence 2025

    Antinuclear Antibodies from Systemic Sclerosis Patients Enter Cells via a Clathrin Endocytosis Mechanism and Interact with their Intracellular Antigen.

    Aurélien Chepy1, Marie-Elise Martel1, Solange Vivier1, Meryem Tardivel2, Antonino Bongiovanni2, Marie Mistretta1, Maxime Secq1, Lucile Guilbert3, Eric HACHULLA4, Sylvain Dubucquoi5, David Launay1 and Vincent Sobanski1, 1Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institut de Recherche Translationnelle en Inflammation, Lille, France., Lille, France, 2Univ. Lille, BioImaging Center Lille-Nord de France (BICeL), Lille, France., Lille, France, 3CHU Lille, Institut d'Immunologie, Lille, France., Lille, France, 4CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-Immunes et Auto-Inflammatoires Rares du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), Lille, France, Lille, France, 5Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, Lille, France ; CHU Lille, Institut d’Immunologie, Lille, France, Lille, France

    Background/Purpose: Antinuclear autoantibodies (ANA) are robust biomarkers for the diagnosis and prognosis of systemic sclerosis (SSc), but their role in pathogenesis is still uncertain. Recent…
  • Abstract Number: 2386 • ACR Convergence 2025

    Anti-Trim72 Auto-antibodies In Systemic Lupus Erythematosus Patients and a Lupus Mouse Model with Myocarditis Compromise Membrane Repair in Mouse & Human Cardiomyocytes

    Braden Zeno1, Shane Bruckner2, kassidy Banford3, Hannah Bulgart4, Stacy Ardoin5, noah weisleder4 and Wael Jarjour6, 1Ohio State University, upper arlington, OH, 2OSU, Columbus, OH, 3Loyola University Chicago, Columbus, OH, 4University of Kentucky, Lexington, KY, 5Nationwide Children's Hospital, Columbus, OH, 6The Ohio State University, Columbus, OH

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that causes inflammation in many of the body’s tissues, including the heart. Recent studies attribute…
  • Abstract Number: 2528 • ACR Convergence 2025

    Broad Screening of the Human Proteome Identifies a Cassette of Six Autoantigens that Distinguishes IgG4-Related Disease

    Federica Bonaso1, Zhenrui Zhang2, Mahilan Guha3, Ian Doyle4, Jesse Akaa4, Grace McMahon5, Isha Jha5, Sydney Montesi5, Thomas Guy6, Guy Katz5, Zachary Wallace7, John Stone8, Vinay S. Mahajan9, Shiv Pillai10 and Cory Perugino11, 1University of Brescia, ASST Spedali Civili of Brescia, Massachusetts General Hospital, Monza, Italy, 2Ragon Institute of Mass General Brigham, MIT, and Harvard, Boston, 3Montgomery Blair High School, Brigham and Women’s Hospital, Boston, 4Massachusetts General Hospital (MGH - Mass General) (MGB), Boston, MA, 5Massachusetts General Hospital, Boston, MA, 6Ragon Institute of MGH, MIT and Harvard/ Royal Prince Alfred Hospital Sydney, Sydney, Australia, 7Massachusetts General Hospital, Newton, MA, 8Massachusetts General Hospital , Harvard Medical School, Concord, MA, 9Brigham and Women's Hospital, Boston, MA, 10Harvard Medical School, Cambridge, MA, 11Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a chronic immune-mediated disease typified by mass-forming lesions. Self-antigens driving the oligoclonal expansion of plasmablasts have previously been reported. However,…
  • Abstract Number: 0258 • ACR Convergence 2025

    Performance characteristics of anti-Collagen II antibodies for diagnosing inflammatory and non-inflammatory diseases: a systematic review and meta-analysis

    Karyssa Stonick1, Marcela ferrada2, Alice Fike3, Kaitlin Quinn3, Benjamin Turturice3, Casey Stein4 and Peter Grayson5, 1National Insitute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 2University of Maryland, Bethesda, MD, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4NIAMS, NIH, Chevy Chase, MD, 5National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: Anti-collagen II (Col2) antibodies have been clinically and experimentally associated with relapsing polychondritis (RP), rheumatoid arthritis (RA), and other diseases. Whether anti-Col2 antibodies are…
  • Abstract Number: 0857 • ACR Convergence 2025

    CD14-dependent MAP kinase signaling is required for pathogenic neutrophil extracellular trap formation in APS

    Thalia Newman1, NaveenKumar Somanathapura1, Chao Liu2, Srilakshmi Yalavarthi1, Pooja Kapoor1, Ajay Tambralli1, Jacqueline Madison1, Yu (Ray) Zuo1 and Jason S. Knight1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Superior Charter Twp, MI

    Background/Purpose: Antibodies targeting beta-2-glycoprotein I (anti-β2GPI) promote inflammation and thrombosis in antiphospholipid syndrome (APS). It has been shown that anti-β2GPI activate neutrophils through Toll-like receptor…
  • Abstract Number: 0910 • ACR Convergence 2025

    Development of Four Distinct Human IgG4-Producing Mouse Models Recapitulating IgG4-Related Disease

    MIN GANG KIM1, JINA YEO2, HEA RIM KANG3, JAE HYUN MOON3, Seon Uk Kim4, SeoYoon Ban5, MI HYEON KIM6 and Eun Young Lee7, 1Seoul National University College of Medicine, Seoul, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea, 3Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea, 4Seoul National University, Jongno-gu, Seoul, Republic of Korea, 5Department of Cancer biology, Graduate School of College of Medicine, Seoul National University, Korea, Seoul, Republic of Korea, 6Hallym university dongtan sacred heart hospital, Seocho-gu, Seoul, Republic of Korea, 7Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose: IgG4-related disease (IgG4RD) is an immune-mediated fibroinflammatory condition characterized by multi-organ involvement, elevated serum IgG4, and IgG4-positive plasma cell infiltrates that form tumor-like lesions…
  • Abstract Number: 1390 • ACR Convergence 2025

    Cystic Lung Disease and Autoantibodies in Lymphocytic Interstitial Pneumonia: Exploring the Impact of Sjögren’s Syndrome

    KARLA CHACON1, ALBERTO ALEJANDRO MARQUEZ-SANCHEZ1, Jorge Rojas-Serrano2 and MAYRA MEJÍA1, 1Instituto Nacional de Enfermedades Respiratorias, CIUDAD DE MEXICO, Distrito Federal, Mexico, 2Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

    Background/Purpose: Lymphocytic interstitial pneumonia (LIP) is a rare interstitial lung disease, most commonly associated with Sjögren’s syndrome, but it may also occur in the context…
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All abstracts accepted to PRYSM are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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