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Abstracts tagged "Autoantibody(ies)"

  • Abstract Number: 2630 • ACR Convergence 2025

    The Absence of DORIS Remission Is Associated with Greater Risk of Preterm Birth and Preeclampsia in SLE Pregnancies

    Camila Hernández-Blanco1, Philip Carlucci2, Peter Izmirly3, Jessica Dai4, Mala Masson5, Michael Belmont1, Amit Saxena6, Jane Salmon7, Justin Brandt1 and Jill Buyon8, 1NYU Langone Health, New York, NY, 2New York University School of Medicine, New York, NY, 3New York University Grossman School of Medicine, New York, NY, 4New York University Grossman School of Medicine, Tenafly, NJ, 5NYU Langone Medical Center- Division of Rheumatology, New York, NY, 6Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, 7Hospital for Special Surgery, New York, NY, 8NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Systemic Lupus Erythematosus (SLE) primarily affects females of childbearing age and increases the risk of adverse pregnancy outcomes (APOs), particularly in non-White individuals and…
  • Abstract Number: 2397 • ACR Convergence 2025

    Analytical Performance of a Fully Automated Multiplexed Microarray Immunoassay for the Simultaneous Detection of Fifteen Autoantibodies Associated with Connective Tissue Diseases in a Reference Laboratory in Southern France

    Guillaume Nardella1, Gerber Gomez2, Christian Fischer2 and Claire Monat1, 1Inovie Labosud Provence, Specialized Autoimmunity Analyses, Marseille, France, 2Scientific & Medical Affairs, AliveDx Suisse SA, Eysins, Switzerland

    Background/Purpose: Autoantibodies are key diagnostic markers in autoimmune connective tissue diseases (CTD). Conventional testing often requires multiple single-measurand assays, which can be labor-intensive and time-consuming.…
  • Abstract Number: 1931 • ACR Convergence 2025

    COSMOS Prevalence of aTTP in SLE

    Nisha Sapkota1, Yevheniia Andriushchenko2, Saadia Malik2, Sarang Choi2 and Sima Terebelo2, 1Interfaith Medical Center, One Broolyn Health, Brooklyn, NY, 2Brookdale Hospital Medical Center, One Brooklyn Health, Brooklyn

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse manifestations, including thrombotic thrombocytopenic purpura (TTP), a life-threatening hematologic disorder. The pathogenesis of…
  • Abstract Number: 1471 • ACR Convergence 2025

    Prevalence and Clinical Outcomes of Hemophagocytic Lymphohistiocytosis in Systemic Lupus Erythematosus: A Multi-Institutional Cohort Study

    Amir Daneshvar1, Julia Wajsberg1, Chelsea Guan1, Keri Ann Pfeil1, Elleson Harper1, Lindsay Frumker2, Meghan Gump1 and Omer Pamuk3, 1University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, 2University hospitals Cleveland medical center, Highland Heights, OH, 3University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multisystem involvement. A rare but life-threatening hyper-inflammatory hematological complication of SLE is hemophagocytic lymphohistiocytosis…
  • Abstract Number: 0910 • ACR Convergence 2025

    Development of Four Distinct Human IgG4-Producing Mouse Models Recapitulating IgG4-Related Disease

    MIN GANG KIM1, JINA YEO2, HEA RIM KANG3, JAE HYUN MOON3, Seon Uk Kim4, SeoYoon Ban5, MI HYEON KIM6 and Eun Young Lee7, 1Seoul National University College of Medicine, Seoul, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea, 3Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea, 4Seoul National University, Jongno-gu, Seoul, Republic of Korea, 5Department of Cancer biology, Graduate School of College of Medicine, Seoul National University, Korea, Seoul, Republic of Korea, 6Hallym university dongtan sacred heart hospital, Seocho-gu, Seoul, Republic of Korea, 7Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose: IgG4-related disease (IgG4RD) is an immune-mediated fibroinflammatory condition characterized by multi-organ involvement, elevated serum IgG4, and IgG4-positive plasma cell infiltrates that form tumor-like lesions…
  • Abstract Number: 0859 • ACR Convergence 2025

    Trophoblast Dysfunction and Placental Alterations in a Mouse Model of Antiphospholipid Syndrome: The Potential Role of Neutrophil Extracellular Traps

    Bruna Mazetto Fonseca1, Srilakshmi Yalavarthi2, Katarina Kmetova2, NaveenKumar Somanathapura3, Cyrus Sarosh4, Kavya Sugur5, Wenying Liang6, Yu (Ray) Zuo3, Richard W. Lieberman6 and Jason S. Knight3, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, 3University of Michigan, Ann arbor, MI, 4University of Michigan, Temperance, MI, 5Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Ann Arbor, MI, 6University of Michigan, Ann arbor

    Background/Purpose: Neutrophil extracellular traps (NETs) are webs of chromatin and proteases (e.g., neutrophil elastase) that have been implicated in antiphospholipid syndrome (APS)-associated thrombosis; however, their…
  • Abstract Number: 0278 • ACR Convergence 2025

    Classic and Clinically Amyopathic Dermatomyositis: Autoantibody Positivity

    Xiwei Yang1, Shae Chambers2, Aretha On1, Hammad Ali2, Touraj Khosravi3, Lais Lopes Almeida Gomes2, Rui Feng4 and Victoria Werth5, 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, Perelman Shool of Medicine, University of Pennsylvania, Philadelphia, PA, 4Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, Philadelphia, PA, 5University of Pennsylvania, Wynnewood, PA

    Background/Purpose: Dermatomyositis (DM) is an idiopathic inflammatory myopathy subclassified as classic (CDM) and clinically amyopathic (CADM). It can involve myositis-associated (MAA) and myositis-specific (MSA) autoantibodies.…
  • Abstract Number: 2599 • ACR Convergence 2025

    Identification of a New Pathogenic Axis in Antiphospholipid Syndrome Linking Antiphospholipid Antibodies, Liver Function, and Circulating Proatherogenic Metabolites

    Beatriz Vellón-García1, Sagrario Corrales-Díaz-Flores2, MARIA ANGELES AGUIRRE ZAMORANO3, Ismael Sanchez-Pareja3, Laura muñoz-Barrera3, Tomás Cerdó3, Pedro Seguí-Azpilcueta4, Christian Merlo2, Maria del carmen abalos-aguilera2, Nuria Barbarroja5, Rafaela Ortega-Castro6, José-Antonio Gonzalez-Reyes7, Alejandro Escudero-contreras2, Chary López pedrera8, Jose manuel Villalba9 and Carlos Pérez Sánchez10, 1Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain/Department of Cell Biology, Physiology and Immunology, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain, Cordoba, Spain, 2Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain, Cordoba, Spain, 3Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, 4Radiology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba/University of Cordoba, Spain, Córdoba, United Kingdom, 5Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, 6Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 7Department of Cell Biology, Immunology and Physiology, University of Cordoba (UCO), Agrifood Campus of International Excellence, (ceiA3)., Cordoba, Spain, 8Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, 9Department of Cell Biology, Physiology and Immunology, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain, Cordoba, Spain, 10Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain

    Background/Purpose: This study aims to:1- Characterize the circulating metabolomic signature in APS patients; 2- Investigate the role of hepatic involvement in the pathophysiology of APS;…
  • Abstract Number: 2396 • ACR Convergence 2025

    A Machine Learning Algorithm Based on a 15-Autoantibody Profile by a Novel Fully Automated Multiplexed Microarray Immunoassay for the Diagnosis of Autoimmune Connective Tissue Diseases

    Gerber Gomez1, Yipeng Cheng2, Kristiana Nita2, Michael Hausmann3, Christian Fischer1 and Yasemin Ataman-Önal3, 1Scientific & Medical Affairs, AliveDx Suisse SA, Eysins, Switzerland, 2AliveDx, Edinburgh, United Kingdom, 3AliveDx Suisse SA, Eysins, Switzerland

    Background/Purpose: Detection of relevant autoantibodies is key in the identification of autoimmune connective tissue diseases (CTD). The evaluation of multiple autoantibodies for extended serological profiling…
  • Abstract Number: 1865 • ACR Convergence 2025

    Shared and unique molecular signatures across different autoantibody groups in systemic sclerosis: a multi-omics analysis

    Hanlin Yin1, Wanyi Lin2, Zhangyi zhao1, Chenhan Jia1 and Liangjing Lu1, 1Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, Shanghai, China (People's Republic), 2Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China (People's Republic)

    Background/Purpose: Antinuclear antibodies (ANA) are detected in over 95% of systemic sclerosis (SSc) patients. Compared to cutaneous subtype classification, autoantibody-based stratification more accurately predicts survival,…
  • Abstract Number: 1391 • ACR Convergence 2025

    Assessment of Anti-SSA/Ro Testing Across Various Commercial Laboratories in the United States to Reduce the Burden of Surveillance in Pregnant Women with No History of Fetal Atrioventricular Block (fAVB)

    Mala Masson1, Bettina Cuneo2, Philip Carlucci3, Peter Izmirly4, Justin Brandt5, Colin Phoon6, Ashley Roman6, Amit Saxena7, Michael Belmont5, Christina Penfield6, Young Mi Lee6, Julie Nusbaum5, Andrew Rubenstein6, Elena Sinkovskaya8, Alfred Abuhamad8, Gary Satou9, Whitnee Hogan10, Anita Moon-Grady11, Lisa Howley12, Mary Donofrio13, Stephanie Levasseur14, Miwa Geiger15, Sonal Owens16, Kristopher Cumbermack17, Jyothi Matta18, Gary Joffe19, Christopher Lindblade20, Caitlin Haxel21, Katherine Kohari22, Joshua Copel22, James Strainic23, Tam Doan24, Conisha Holloman24, Stacy Killen25, Theresa Tacy26, Michelle Kaplinski26, Nalani Sachan6, Nicola Fraser6, Robert Clancy14 and Jill Buyon6, 1NYU Langone Medical Center- Division of Rheumatology, New York, NY, 2University of Arizona College of Medicine, Tucson, AZ, 3New York University School of Medicine, New York, NY, 4New York University Grossman School of Medicine, New York, NY, 5NYU Langone Health, New York, NY, 6NYU Grossman School of Medicine, New York, NY, 7Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, 8Eastern Virginia Medical School, Norfolk, VA, 9University of California Los Angeles, Los Angeles, CA, 10University of Utah, Salt Lake City, UT, 11University of California San Francisco, San Francisco, CA, 12Midwest Fetal Care Center, Children's Minnesota/Allina Health, Minneapolis, MN, 13Children's National Hospital, Washington, DC, 14Columbia University, New York, NY, 15Mount Sinai School of Medicine, New York, NY, 16University of Michigan, Ann Arbo, MI, 17University of Kentucky, Lexington, KY, 18University of Louisville, Louisville, KY, 19Perinatal Associates of New Mexico, Albuquerque, NM, 20Phoenix Children's Hospital, Phoenix, AZ, 21University of Vermont Children's Hospital, Burlington, VT, 22Yale University, New Haven, CT, 23UH Rainbow Babies, Cleveland, OH, 24Baylor College of Medicine, Houston, TX, 25Vanderbilt University, Nashville, TN, 26Stanford University, Stanford, CA

    Background/Purpose: For women with Sjögren's disease, the risk of Fetal Atrioventricular Block (fAVB) is a critical aspect in pregnancy counseling. To date, the most reliable…
  • Abstract Number: 0911 • ACR Convergence 2025

    A Novel FcRn × Albumin Bispecific Antibody Demonstrates Extended Half-life and Deep IgG Reduction in Preclinical Mouse Models

    Hang Su1, Lulu Li1, Zenglin Pei1, Barry Duplantis2, Yuhao Wang2, Yi Li1 and Quan Yu1, 1Ailux, Shanghai, China (People's Republic), 2Ailux, Boston, MA

    Background/Purpose: Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and Sjögren’s syndrome are characterized by elevated levels of pathogenic autoantibodies that drive inflammation. The…
  • Abstract Number: 0857 • ACR Convergence 2025

    CD14-dependent MAP kinase signaling is required for pathogenic neutrophil extracellular trap formation in APS

    Thalia Newman1, NaveenKumar Somanathapura1, Chao Liu2, Srilakshmi Yalavarthi1, Pooja Kapoor1, Ajay Tambralli1, Jacqueline Madison1, Yu (Ray) Zuo1 and Jason S. Knight1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Superior Charter Twp, MI

    Background/Purpose: Antibodies targeting beta-2-glycoprotein I (anti-β2GPI) promote inflammation and thrombosis in antiphospholipid syndrome (APS). It has been shown that anti-β2GPI activate neutrophils through Toll-like receptor…
  • Abstract Number: 0258 • ACR Convergence 2025

    Performance characteristics of anti-Collagen II antibodies for diagnosing inflammatory and non-inflammatory diseases: a systematic review and meta-analysis

    Karyssa Stonick1, Marcela ferrada2, Alice Fike3, Kaitlin Quinn3, Benjamin Turturice3, Casey Stein4 and Peter Grayson5, 1National Insitute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 2University of Maryland, Bethesda, MD, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4NIAMS, NIH, Chevy Chase, MD, 5National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: Anti-collagen II (Col2) antibodies have been clinically and experimentally associated with relapsing polychondritis (RP), rheumatoid arthritis (RA), and other diseases. Whether anti-Col2 antibodies are…
  • Abstract Number: 2528 • ACR Convergence 2025

    Broad Screening of the Human Proteome Identifies a Cassette of Six Autoantigens that Distinguishes IgG4-Related Disease

    Federica Bonaso1, Zhenrui Zhang2, Mahilan Guha3, Ian Doyle4, Jesse Akaa4, Grace McMahon5, Isha Jha5, Sydney Montesi5, Thomas Guy6, Guy Katz5, Zachary Wallace7, John Stone8, Vinay S. Mahajan9, Shiv Pillai10 and Cory Perugino11, 1University of Brescia, ASST Spedali Civili of Brescia, Massachusetts General Hospital, Monza, Italy, 2Ragon Institute of Mass General Brigham, MIT, and Harvard, Boston, 3Montgomery Blair High School, Brigham and Women’s Hospital, Boston, 4Massachusetts General Hospital (MGH - Mass General) (MGB), Boston, MA, 5Massachusetts General Hospital, Boston, MA, 6Ragon Institute of MGH, MIT and Harvard/ Royal Prince Alfred Hospital Sydney, Sydney, Australia, 7Massachusetts General Hospital, Newton, MA, 8Massachusetts General Hospital , Harvard Medical School, Concord, MA, 9Brigham and Women's Hospital, Boston, MA, 10Harvard Medical School, Cambridge, MA, 11Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a chronic immune-mediated disease typified by mass-forming lesions. Self-antigens driving the oligoclonal expansion of plasmablasts have previously been reported. However,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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