ACR Meeting Abstracts

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Abstracts tagged "Autoantibody(ies)"

  • Abstract Number: L11 • ACR Convergence 2024

    Rheumatology Diagnostics Utilizing Artificial Intelligence (ANA Reader©) for ANA Pattern Identification and Titer Quantification

    May Choi1, Farbod Moghaddam1, Mohammad Sajadi1, Ann E. Clarke1, Sasha Bernatsky2, Karen Costenbader3, Irene Chen4, Murray Urowitz5, John Hanly6, Caroline Gordon7, Sang-Cheol Bae8, Juanita Romero-Diaz9, Jorge Sanchez-Guerrero10, Daniel Wallace11, David Isenberg12, Anisur Rahman13, Joan Merrill14, Paul Fortin15, Dafna Gladman16, Ian Bruce17, Michelle Petri18, Ellen Ginzler19, Mary Anne Dooley20, Rosalind Ramsey-Goldman21, Susan Manzi22, Andreas Jönsen23, Graciela Alarcón24, Ronald Van Vollenhoven25, Cynthia Aranow26, Meggan Mackay26, Guillermo Ruiz-Irastorza27, S. Sam Lim28, Murat Inanç29, Kenneth Kalunian30, Soren Jacobsen31, Christine Peschken32, Diane Kamen33, Anca Askanase34, Marvin Fritzler35 and Mina Aminghafari1, 1University of Calgary, Calgary, AB, Canada, 2Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 4UC Berkeley and UCSF, Berkeley, CA, 5Self employed, Toronto, ON, Canada, 6Dalhousie University, Halifax, NS, Canada, 7University of Birmingham, Birmingham, United Kingdom, 8Hanyang University Medical Center, Seoul, South Korea, 9The National Institute of Medical Sciences and Nutrition, Mexico City, Mexico, 10Krembil Research Institute, Toronto, ON, Canada, 11Cedars Sinai Medical Center, Studio City, CA, 12Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, United Kingdom, 13University College London, London, United Kingdom, 14Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Centre ARThrite - CHU de Québec - UniversitéLaval, Quebec, QC, Canada, 16University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 17Queen's University Belfast, Belfast, United Kingdom, 18Johns Hopkins University School of Medicine, Baltimore, MD, 19SUNY Downstate Health Sciences University, New York, NY, 20UNC physician network, Chapel Hill, NC, 21Northwestern University, Chicago, IL, 22Allegheny Health Network, Pittsburgh, PA, 23Lund University, Lund, Sweden, 24The University of Alabama at Birmingham, Oakland, CA, 25Amsterdam UMC, Amsterdam, Netherlands, 26Feinstein Institutes for Medical Research, New York, NY, 27Biobizkaia Health Research Institute, Bilbao, Spain, 28Emory University, Atlanta, GA, 29Istanbul University, Istanbul, Turkey, 30UC San Diego, La Jolla, CA, 31Rigshospitalet, Copenhagen, Denmark, 32University of Manitoba, Winnipeg, MB, Canada, 33Medical University of South Carolina, Johns Island, SC, 34Columbia University Medical Center, New York, NY, 35Mitogen Diagnostics Corp, Calgary, AB, Canada

    Background/Purpose: Antinuclear antibody (ANA) immunofluorescence (IFA) patterns and titers are a key part of rheumatology diagnostics, however, there is considerable intra- and inter-laboratory variability with…
  • Abstract Number: 0048 • ACR Convergence 2024

    Role of the Chemokine CCL22 in Rheumatoid Arthritis Development

    Marcelo Afonso1, Masa Filipovic1, Alexandra Argyriou2, Alexandra Circiumaru3, Mikael Ringh1, Konstantin Carlberg1, Vijay Joshua1, Szu-Jing Chen1, Marianne Engström1, Heidi Wähämaa1, Tomas Ekström1, Marc H Wadsworth II4, Ravi Kumar1, Aaron Winkler5, Vivianne Malmström1, Anca Catrina1, Karine Chemin1, Aase Hensvold1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Solna, Sweden, 3Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden, 4Pfizer, Cambridge, 5Pfizer Inc., Cambridge, MA

    Background/Purpose: Understanding alterations of the immune homeostasis in individuals at risk of rheumatoid arthritis (RA) can be a key to achieve earlier diagnosis and prevention.…
  • Abstract Number: 0343 • ACR Convergence 2024

    An Interlaboratory Variability Study of Detection Methods for Myositis-Specific and Myositis-Associated Autoantibodies in Sera from Patients with Idiopathic Inflammatory Myopathies

    Georgina Harvey1, Idil Ashur2, Xavier Bossuyt3, Martin Bluethner4, Anna Brusch5, Chris Bundell5, hector Chinoy6, Claire Coeshott7, Charmaine Donald2, Juliet Dunphy8, Marvin Fritzler9, Adrian Heaps2, marie Hudson10, Masataka Kuwana11, Océane Landon-Cardinal12, Hui Lu1, FIONNUALA MCMORROW1, Marie Mayrhofer4, Alain Meyer13, Birthe Michiels3, Benoit Nespola14, Susan O'Loughlin15, Ivana Putova16, Johan Rönnelid17, Ross Sadler18, Maria Teresa Sanz-Martinez19, Paul Sciore20, Albert Selva-O’Callaghan21, Helena Storfors22, Ernesto Trallero-Araguás23, Yves Troyanov12, Jade Tyson2, Jiří Vencovský24, Akira Yoshida25 and Sarah Tansley1, 1University of Bath, Bath, United Kingdom, 2Severn Pathology, North Bristol NHS Trust, Bristol, United Kingdom, 3University Hospitals Leuven, Leuven, Belgium, 4MVZ Labor PD Dr. Volkmann und Kollegen GbR, Karlsruhe, Germany, 5Department of Clinical Immunology, PathWest Laboratory Medicine, Perth, Western Australia, Australia, 6The University of Manchester, Manchester, United Kingdom, 7Advanced Diagnostics Laboratories National Jewish Health, Denver, CO, 8Royal United Hospital Bath NHS Foundation Trust, Bath, United Kingdom, 9Mitogen Diagnostics Corp, Calgary, AB, Canada, 10McGill University, Montreal, QC, Canada, 11Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 12Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, 13UR3072, Physiology Department, Rheumatology Department, University Hospital of Strasbourg, Strasbourg, France, 14Laboratoire d’immunologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 15Greater Manchester Immunology Service, Manchester, England, United Kingdom, 16Institute of Rheumatology, Prague, Czech Republic, 17Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 18Laboratory of Immunology, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, England, United Kingdom, 19Immunology Division, Vall d'Hebron Hospital, Barcelona, Spain, 20Mitogen Diagnostics Corp., Calgary, 21Internal Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain, 22Department of Clinical Immunology and Transfusion Medicine, Uppsala University Hospital, Uppsala, Sweden, 23Rheumatology Departament, Vall d'Hebron Hospital, Barcelona, Spain, 24Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 25Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan

    Background/Purpose: In idiopathic inflammatory myopathy (IIM) spectrum diseases, myositis-specific and myositis-associated autoantibodies (MSAs/MAAs) are key markers of disease subtype and prognosis and are considered routine…
  • Abstract Number: 0808 • ACR Convergence 2024

    Confirmation of Second Trimester Trophoblast Transport of Maternal Anti-SSA/Ro52 and 60kD Autoantibodies in Cardiac Neonatal Lupus: Implications for FcRn Blockade

    Nicola Fraser1, Mala Masson2, Robert Clancy3, Philip Carlucci4, Peter Izmirly5, Nalani Sachan6, Justin Brandt1, Kristen Thomas1, Melanie Fox7, Colin Phoon1, Achiau Ludomirsky1, Ranjini Srinivasan1, Garrett Lam8, Bettina Cuneo9 and Jill Buyon10, 1NYU Langone Health, New York, NY, 2NYU Langone Medical Center- Division of Rheumatology, New York, NY, 3Columbia University Medical Center, New York, NY, 4New York University School of Medicine, New York, NY, 5New York University Grossman School of Medicine, New York, NY, 6NYU Grossman School of Medicine, New York, NY, 7Renown Health, Reno, NV, 8Intermountain Health, Provo, UT, 9University of Arizona College of Medicine, Tucson, AZ, 10New York University Grossman School of Medicine, New York, NY

    Background/Purpose: The nearly invariant finding of anti-SSA/Ro52/60kD autoantibodies in pregnancies complicated by cardiac neonatal lupus (cardiac-NL), which manifests as fetal atrioventricular block and endocardial fibroelastosis…
  • Abstract Number: 1298 • ACR Convergence 2024

    What Is an ANA and Why Should I Care? Strategies to Increase Understanding of Basic Rheumatologic Labs Within Medical Education

    Megan Schluentz1 and Sonam Kiwalkar2, 1Ochsner, New Orleans, LA, 2The Vancouver Clinic, Portland, OR

    Background/Purpose: A growing availability crisis in Rheumatology requires consideration of steps and best practices that might be employed to meet high demand. Besides increasing the…
  • Abstract Number: 1650 • ACR Convergence 2024

    IL-33 Expands Plasma Cells, Disrupts Germinal Centers and Increases Autoantibody Production

    Andre Limnander1, Eva Conde1, Seblewongel Asrat2, Andrea Vecchione2, Kaitlyn Gayvert2, Paulina Pedraza2, Carley Tasker2, Sharon Huang2, Dmitry Yarilin2, Dylan Birchard2, Li-Hong Ben2, Wei Keat Lim2, Andrew Murphy2, Matthew Sleeman2 and Jamie orengo1, 1Regeneron Pharmaceuticals, Tarrytown, NY, 2Regeneron Pharmaceuticals, Tarrytown

    Background/Purpose: IL-33 is a pro-inflammatory cytokine that plays a role in asthma, COPD and autoimmune diseases. The role of IL-33 on B cell maturation and…
  • Abstract Number: 2053 • ACR Convergence 2024

    Presence of ANA to Development of Rheumatic Diseases

    Uyen Nguyen1 and Huzaefah Syed2, 1Virginia Commonwealth University, School of Medicine, Richmond, VA, 2Virginia Commonwealth University Medical Center, Richmond, VA

    Background/Purpose: One of the most common referrals seen in rheumatology is for a positive anti-nuclear antibody (ANA). Often, the referral does not yield in a…
  • Abstract Number: 2401 • ACR Convergence 2024

    A Novel Modeling Approach to Elucidate the Role of Autoantibodies in Complement Activation in SLE

    David Pisetsky1, Yuankang Zhao2, Matthew Engelhard3, Amanda Eudy4, Philip Tedeschi5, Alex Verdone5, Megan Clowse6, Lisa Criscione-Schreiber2, Jayanth Doss3, Mithu Maheswaranathan2, Rebecca Sadun3, Kai Sun3 and Jennifer Rogers2, 1Duke University Medical Center, Durham, NC, 2Duke University, Durham, 3Duke University, Durham, NC, 4Duke University, Raleigh, NC, 5Immunovant, Inc, New York, NY, 6Duke University, Chapel Hill, NC

    Background/Purpose: In SLE, ANAs can promote pathogenesis by forming immune complexes (ICs) that activate complement.  While antibodies to DNA (anti-DNA) are known to be associated…
  • Abstract Number: 0049 • ACR Convergence 2024

    Inflammatory Priming by Anti-MAA Antibodies in Rheumatoid Arthritis

    Marcelo Afonso1, Jitong Sun1, Koji Sakuraba1, Alexandra Circiumaru2, Denis Lagutkin1, Masa Filipovic1, Anca Catrina1, Caroline Grönwall1, Aase Hensvold1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden

    Background/Purpose: We have previously shown that autoantibodies targeting malondialdehyde-acetaldehyde protein adducts (anti-MAA) in rheumatoid arthritis (RA) patients boosted osteoclast differentiation and induced bone erosion in mice…
  • Abstract Number: 0344 • ACR Convergence 2024

    Characteristics of Patients with Antisynthetase Antibodies

    Danny Kasto1, Michael McLucas2, Anne-Marie Aubin2, Armando Faigl2 and Gabor Major1, 1Dep of Rheumatology Royal Newcastle Centre / John Hunter Hospital, Rankin Park, New South Wales, Australia, 2Dep of Rheumatology Royal Newcastle Centre / John Hunter Hospital, Rankin Park, Australia

    Background/Purpose: Aminoacyl transfer RNA synthetase antibodies (ASAbs) are associated with a range of clinical manifestations, including severe lung and muscle disease and are postulated to…
  • Abstract Number: 0838 • ACR Convergence 2024

    The Mechanistic Impact of IgA anti-beta-2 Glycoprotein I on Accelerated Atherosclerosis in Primary APS

    Kavya Sugur1, Emily Chong1, Srilakshmi Yalavarthi2, Katarina Kmetova3, Lyndsay Kluge1, Wenying Liang2, Cyrus Sarosh4, NaveenKumar Somanathapura K2, Jacqueline Madison2, Ajay Tambralli2, Jason Knight2 and Yu Zuo2, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI, 4University of Michigan, Temperance, MI

    Background/Purpose: Antiphospholipid syndrome (APS) is an acquired thrombo-inflammatory disease characterized by persistent antiphospholipid antibodies (aPL). APS patients experience significant morbidity and mortality, much of which…
  • Abstract Number: 1427 • ACR Convergence 2024

    Observed and Simulated Pharmacokinetics and Pharmacodynamics of Nipocalimab, a Fully Human FcRn Blocking Monoclonal Antibody, in Adults with Sjögren’s Disease: Results from a Phase 2, Multicenter, Randomized, Placebo-controlled, Double-blind Study

    Sophia G. Liva1, fudan Zheng1, Jocelyn H. Leu2, Kathy Sivils3, Keying Ma1, He Li4, Steven Leonardo5, Kim Lo1, Jada Idokogi1, Kim Campbell1 and Jonathan J. Hubbard1, 1Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, PA, 2Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, PA, 3Johnson & Johnson Innovative Medicine, Edmond, OK, 4Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 5Janssen Research & Development, LLC, a Johnson & Johnson Company, Cambridge, MA

    Background/Purpose: Sjögren’s disease (SjD) is a chronic, progressive autoimmune disease characterized by aberrant B lymphocyte activity, elevated IgG production, and the presence of IgG autoantibodies…
  • Abstract Number: 1652 • ACR Convergence 2024

    Extracellular Vesicles from Lymphocyte B and Neutrophil Presents Ro52, Ro60 and La Autoantigens in Patient Suffering from Sjögren Syndrome

    Lily BRUYERE1, Anne-Claire DUCHEZ2, Martin KILLIAN3 and Stéphane PAUL4, 1université jean-monnet, saint-etienne, 2EFS, saint-etienne, 3chu Saint-Etienne, saint-etienne, 4CIRI, Saint Etienne, France

    Background/Purpose: Extracellular Vesicles (EVs) are double lipid bilayer-enclosed membranous vesicles, produced and discharged from almost all cells. EVs are known for inter-cellular communication by releasing…
  • Abstract Number: 2058 • ACR Convergence 2024

    Association of Anti-Synthetase Antibody Subtypes with Radiographic Progression of Interstitial Lung Disease in Anti-Synthetase Syndrome: An Analysis of the CLASS Project Database

    Daphne Rivero Gallegos1, Francisca Bozan2, Sangmee Bae3, Giovanni Zanframundo4, Sara Faghihi-Kashani5, Iazsmin Bauer Ventura6, Eduardo Dourado7, Gianluca sambataro8, Akira Yoshida9, Tamera J Corte10, Francesco Bonella11, Tracy J Doyle12, david fiorentino13, Miguel Angel Gonzalez-Gay14, marie Hudson15, Masataka Kuwana16, Antonella Notarnicola17, Andrew Mammen18, Neil McHugh19, Frederick Miller20, Carlomaurizio Montecucco21, Chester Oddis22, Jorge Rojas-Serrano23, Jens Schmidt24, Carlo A. Scire25, Albert Selva-O’Callaghan26, Victoria Werth27, Rohit Aggarwal28 and Lorenzo Cavagna29, and CLASS project participating investigators, 1INER, Ciudad de México, Mexico State, Mexico, 2Hospital Clinico Universidad de Chile, Santiago, Chile, 3UCLA, Los Angeles, CA, 4Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, San Francisco, CA, 6University of Chicago, Chicago, IL, 7Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal, 8University of Catania, Catania, Italy, 9Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan, 10Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, 11Center for interstitial and rare lung diseases, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany, 12Brigham and Women's Hospital, West Roxbury, MA, 13Department of Dermatology, Stanford University School of Medicine, Stanford, CA, Palo Alto, CA, 14University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 15McGill University, Montreal, QC, Canada, 16Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 17Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 18NIH, Bethesda, MD, 19University of Bath, Bath, United Kingdom, 20NIH, NIEHS, Chapel Hill, NC, 21IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, 22Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 23National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico, 24University Medical Center Goettingen, Göttingen, Germany, 25University of Milano Bicocca, Milan, Italy, 26Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, 27University of Pennsylvania, Wynnewood, PA, 28Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 29University of Pavia and Fondazione IRCCS Policlinico San Matteo Hospital of Pavia, Pavia, Pavia, Italy

    Background/Purpose: In anti-synthetase syndrome (ASSD), clinical presentations vary from isolated interstitial lung disease (ILD) to systemic multi-organ manifestations. Several studies emphasize the crucial role of…
  • Abstract Number: 2443 • ACR Convergence 2024

    The Clinical Phenotype of Anti-Th/To+ Patients in Systemic Sclerosis: A Case-control Study Within the European Scleroderma Trials and Research (EUSTAR) Cohort

    Liala Moschetti1, Eleonora Pedretti2, Francesco Bonomi3, María Martín López4, Fabio Cacciapaglia5, cristiana sieiro santos6, Gianluca Moroncini7, Yannick Allanore8, Joana Caetano9, Brigitte Granel10, Laura Groseanu11, Maria De Santis12, Masataka Kuwana13, Veronica Codullo14, Mariana Pereira Silva15, Pietro Bearzi16, Laura Belloli17, Alida Taberner-Cortés18, Cristina Maglio19, Francesco Del Galdo20, Corrado Campochiaro21, Marie-Elise Truchetet22, Giovanna Cuomo23, Magda Parvu24, Florenzo Iannone25, Patricia Carreira26, Serena Guiducci27, Franco Franceschini1, Paolo Airò1 and Maria-Grazia Lazzaroni1, 1Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, 2Scleroderma Unit, Rheumatology Unit, ERN ReCONNET, ASST Spedali Civili and University of Brescia; Italy, Brescia, Italy, 3Division of Rheumatology, Scleroderma Unit, University of Florence, AOU Careggi Firenze; Italy, Firenze, Italy, 4General University Hospital of Ciudad Real, Ciudad de México, Spain, 5Rheumatology Unit � DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 6Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 7Marche Polytechnic University, Ancona, Italy, 8Rheumatology department, Université Paris Cité, Cochin Hospital of Paris; France, Paris, France, 9Systemic Autoimmune Diseases Unit, Fernando Fonseca Hospital, Amadora; Portugal, Amadora, Portugal, 10Service de Médecine Interne Hôpital Nord de Marseille; France, Marseille, France, 11Spitalul Sfanta Maria, Bucharest, Romania, 12Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital and Biomedical Sciences, Hu-manitas University, Milan; Italy, Milan, Italy, 13Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 14Unit of Rheumatology, San Matteo Hospital, Pavia, Italy, 15Rheumatology Department, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa; Portugal, Lisboa, Portugal, 16Immunorheumatology Unit, Università Campus Bio-Medico University of Roma; Italy, Roma, Italy, 17Niguarda Hospital, Milan, Milan, Italy, 18Hospital Universitario Doctor Peset, Valencia, Spain, 19University of Gothenburg, Gothenburg, Sweden, 20University of Leeds, Leeds, United Kingdom, 21IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 22Bordeaux University Hospital, Bordeaux, France, 23Università degli studi della Campania Luigi Vanvitelli, Napoli, Italy, 24Colentina Clinical Hospital, Rheumatology Department, Bucharest; Romania, Bucharest, Romania, 25Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 26Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain, 27Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Background/Purpose: To evaluate clinical associations of anti-Th/To antibodies in SSc patients in a multicentre international cohort, focusing on interstitial lung disease (ILD), pulmonary arterial hypertension…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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