Abstracts tagged "Auto-immunity"

Abstract Number: 1672 • 2012 ACR/ARHP Annual Meeting
Myosin Skews Effector Immune Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis
Nicholas Young¹, Rahul Sharma², Alexandra Friedman³, Benjamin Kaffenberger¹ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, ²Medicine, University of Virginia Health System, Charlottesville, VA, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Myositis is associated with an inflammatory process that results in pronounced muscle weakness and is observed in some regulatory T cell (Treg) deficient mouse…
Abstract Number: 1649 • 2012 ACR/ARHP Annual Meeting
French Cohort Study of 141 Cases of Autoimmune Congenital Heart Block
Kateri Levesque¹, Alice Maltret², Mohamed Hamidou³, Moez Jallouli⁴, Jean Loup Pennaforte⁵, Pauline Orquevaux⁵, Jean-Charles Piette⁶, Zahir Amoura⁴, Francois Barriere⁷, Jérome Le Bidois², Laurent Fermont², Laurence Cohen⁸, Olivier Meyer⁹, Olivier Fain¹⁰, Arnaud Theulin¹¹, Hugues Lucron¹², Francois Sassolas¹³, Holly Bezanahary¹⁴, Gaëlle Guettrot-Imbert¹⁵, Pascal Seve¹⁶, Elizabeth Diot¹⁷, Nathalie Morel¹, Christophe Deligny¹⁸, Elisabeth Villain² and Nathalie Costedoat-Chalumeau¹⁹, ¹Internal Medicine, Groupe Hospitalier Pitié-Salpétrière, Paris, France, ²Cardiology, Groupe Hospitalier Necker - Enfants Malades, Paris, France, ³Internal Medicine Department, Nantes University Hospital, Nantes, France, ⁴Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ⁵Hu Robert Debre, CHU Reims, Reims, France, ⁶Hospital Pitie, Paris, ⁷Pediatry, CHU Nantes, Nantes, France, ⁸Cardiology, Institut Jacques Cartier, ⁹Rheumatology, Hopital Bichat, Paris, France, ¹⁰Internal Medicine, Service de médecine interne, Université Paris 13, AP-HP, Hôpital Jean Verdier, Bondy, France, ¹¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹²Cardiology, CHU Fort-de-France, Fort de France, Martinique, ¹³Cardiology, CHU Lyon, Lyon, France, ¹⁴Internal Medicine, University Hospital of Limoges, Limoges, France, ¹⁵Internal Medicine, Hopital Gabriel Montpied, Clermont-Ferrand, France, ¹⁶Internal medicine, CHU Lyon, Lyon, France, ¹⁷Department of Internal Medicine, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, Tours, France, Tours, France, ¹⁸Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ¹⁹Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France
Background/Purpose: Cardiac neonatal lupus manifestations mainly include congenital heart block (CHB), endocardial fibroelastosis and dilated cardiomyopathy. We report the preliminary results of the French registry…
Abstract Number: 1072 • 2012 ACR/ARHP Annual Meeting
Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function
Stefan Uderhardt¹, Tobias Rothe¹, Elisabeth Zinser², Olga Oskolkova³, Martin Herrmann⁴, Alexander Steinkasserer⁵, Valery Bochkov³, Georg Schett⁶ and Gerhard Kronke¹, ¹Internal Medicine 3, University of Erlangen, Erlangen, Germany, ²University of Erlangen, Erlangen, Germany, ³Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria, Vienna, Austria, ⁴Instiute for Immunology, PhD, Erlangen, Germany, ⁵Department of Immune Modulation at the Department of Dermatology, University Hospital Erlangen, Erlangen, Germany, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: During inflammation and tissue damage, pathogens as well as dying cells are ingested by different phagocytes such as macrophages and dendritic cells. The uptake…
Abstract Number: 979 • 2012 ACR/ARHP Annual Meeting
Cell-Type Specific Type I Interferon Signatures in Systemic Lupus Erythematosus and Viral Infection: What Makes the Difference?
Chieko Kyogoku¹, Joachim R. Grün¹, Tobias Alexander², Robert Biesen³, Falk Hiepe⁴, Thomas Häupl³, Andreas Radbruch¹ and Andreas Grützkau¹, ¹German Rheumatism Research Centre Berlin (DRFZ), an institute of the Leibniz Association, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Gene expression profiling experiments using peripheral blood mononuclear cells (PBMCs) revealed a crucial role of type I interferon (IFN) in the pathogenesis of systemic…
Abstract Number: 685 • 2012 ACR/ARHP Annual Meeting
Using a Library of Synthetic Autoantigen Mimics to Discover Biomarkers of Systemic Lupus Erythematosus
Akshai Lakhanpal¹, Jiexia Quan², Sayed Zaman¹, Nancy J. Olsen³ and David R. Karp², ¹Rheumatic Diseases Divsion, UT Southwestern Medical Center, Dallas, TX, ²Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ³Medicine, Penn State MS Hershey Medical Center, Hershey, PA
Background/Purpose: The natural history of systemic lupus erythematosus (SLE) is felt to evolve from a state of normal immunity to serologic autoimmunity and then…
Abstract Number: 686 • 2012 ACR/ARHP Annual Meeting
Cell-Type Specific Type I Interferon Signatures in Autologous Stem Cell Transplanted Lupus Patients: Different Molecular Behavior Between CD4+ T Cells and Monocytes
Chieko Kyogoku¹, Joachim R. Grün¹, Tobias Alexander², Robert Biesen³, Falk Hiepe⁴, Thomas Häupl³, Andreas Radbruch¹ and Andreas Grützkau¹, ¹German Rheumatism Research Centre Berlin (DRFZ), an institute of the Leibniz Association, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that affects multiple organs, whose pathology is mainly caused by the augmented interferon (IFN)…
Abstract Number: 670 • 2012 ACR/ARHP Annual Meeting
Prolidase Deficiency Induces Antibodies to Sm, Ro60 and Double Stranded DNA
Biji T. Kurien¹, Anil D'souza², Skyler P. Dillon¹, Benjamin F. Bruner³, Timothy Gross⁴, Judith A. James⁵, Ira N. Targoff⁶, Jacen S. Maier-Moore⁷, Isaac T.W. Harley⁸, Heng Wang⁹ and Robert H. Scofield⁷, ¹Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ²Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Harding University, Searcy, AR, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Arthritis and Immunology, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁷Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁸Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, ⁹Das Deutsch Center Clinic for Special Needs Children, Middlefield, OH
Background/Purpose: Prolidase is a ubiquitous enzyme found in the cytoplasm. The enzyme specifically cleaves dipeptides containing C-terminal proline or hydroxyproline, in one of the last…

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