Abstract Number: 1639 • 2013 ACR/ARHP Annual Meeting
GWAS In Hispanic and Latin American Individuals Enriched For Amerindian Ancestry Identifies a New Locus Associated With Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE), a chronic autoimmune disease with a strong genetic component, exhibits a 9:1 female to male ratio and disproportionate impact on…Abstract Number: 1621 • 2013 ACR/ARHP Annual Meeting
T Helper 17 Cells and Interferon Type I: Partners In Crime In SLE?
Background/Purpose: A hallmark of systemic autoimmune diseases, such as systemic lupus erythematotsus (SLE), is the increased expression of interferon (IFN) type I inducible genes, the…Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…Abstract Number: 632 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal-Phosphoprotein Autoantibodies Penetrate Into Neuronal Cells Via Neuron Growth Associated Protein (GAP43)
Background/Purpose: Autoantibodies targeting ribosomal phosphoproteins (anti-Ribos.P) are detected in the sera of 10-45% patients with neuropsychiatric-systemice-lupus-erythemathosus-(NPSLE) and correlate with disease-activity. Intracerebroventricular administration of anti-Ribos.P induce…Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting
Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…Abstract Number: 547 • 2013 ACR/ARHP Annual Meeting
Anti Ribosomal P Antibodies Accelerate Lupus Glomerulonephritis and Induce Lupus Nephritis In Naive Mice
Background/Purpose: Circulating anti-phosphoribosomal protein antibodies (anti-Ribos.P) were found to be associated with lupus nephritis. We have assessed the direct role of anti-Ribos.P in the development…Abstract Number: 2893 • 2013 ACR/ARHP Annual Meeting
Intestinal Microbiota Plays a Critical Role In The Production Of Antinuclear Antibodies In Lymphopenia-Induced Autoimmunity
Background/Purpose: Production of antinuclear autoantibodies (ANAs) is one of the major characteristics of the systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), but the…Abstract Number: 2195 • 2013 ACR/ARHP Annual Meeting
Expanding The Spectrum Of Recombination Activating Gene-1 Deficiency To Include Early Onset Autoimmunity
Background/Purpose: We sought to identify the etiology of early onset autoimmunity and T cell lymphopenia in two siblings through genetic and functional studies. Newborn screening…Abstract Number: 2530 • 2012 ACR/ARHP Annual Meeting
Anti-Ribosomal P Antibodies in a Large Cohort of Autoimmune Hepatitis with No Evidence of Lupus: A Common Underlying Mechanism Targeting Liver?
Background/Purpose: Anti-ribosomal P proteins antibody (anti-rib P) is a highly specific marker for systemic lupus erythematosus (SLE) and it is associated with liver involvement in…Abstract Number: 2453 • 2012 ACR/ARHP Annual Meeting
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity
Background/Purpose: Rheumatoid arthritis (RA) is a prototypic autoimmune disease characterized by a prominent humoral autoimmunity. Of particular relevance is the local production of autoantibodies such…Abstract Number: 2345 • 2012 ACR/ARHP Annual Meeting
HRES-1/RAB4-Mediated Loss of DRP1 Inhibits Mitophagy, Promotes Accumulation of Mitochondria and Serves As Target for Treatment in SLE
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit accumulation of mitochondria and activation of the mammalian target of rapamycin (mTOR). Although mTOR…Abstract Number: 2326 • 2012 ACR/ARHP Annual Meeting
Discovery of a Highly Potent, Selective Reversible Covalent Inhibitor of JAK3 Kinase
Background/Purpose: Targeting of the JAK-STAT pathway has been shown to be efficacious for treatment of patients with rheumatoid arthritis through the successful use of pan-JAK…Abstract Number: 1699 • 2012 ACR/ARHP Annual Meeting
Neutropenia After Rituximab in Rheumatoid Arthritis and Other Autoimmune Diseases Is a Rare Events : Date From the Autoimmunity and Rituximab Registry
Background/Purpose: Limited data are available regarding the proportion and severity of late onset neutropenia after RTX in large and unselected populations of patients with various…Abstract Number: 1672 • 2012 ACR/ARHP Annual Meeting
Myosin Skews Effector Immune Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis
Background/Purpose: Myositis is associated with an inflammatory process that results in pronounced muscle weakness and is observed in some regulatory T cell (Treg) deficient mouse…Abstract Number: 1649 • 2012 ACR/ARHP Annual Meeting
French Cohort Study of 141 Cases of Autoimmune Congenital Heart Block
Background/Purpose: Cardiac neonatal lupus manifestations mainly include congenital heart block (CHB), endocardial fibroelastosis and dilated cardiomyopathy. We report the preliminary results of the French registry…
ACR Meeting Abstracts